Synthesis and pharmacological characterization of 2-aminobenzaldehyde oxime analogs as dual inhibitors of neutrophil elastase and proteinase 3

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 5, 2015, Pages 1123-1134

  Hwang, Tsong Long ^a,c,d   Wang, Wen Hui ^a   Wang, Ting Yi ^a   Yu, Huang Ping ^a,b   Hsieh, Pei Wen ^a,c,d  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^c CHANG GUNG UNIVERSITY   (Taiwan)

^d CHANG GUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

Author keywords

2 Aminobenzaldehyde oxime analogs; Acute lung injury; Neutrophil elastase; Proteinase 3

Indexed keywords

2 AMINOBENZALDEHYDE OXIME DERIVATIVE; 2 HYDROYXYETHYL 2 [4 (PYVALOYLOXY)PHENYLSULFONAMIDO]BENZOATE; 4 [N (2 ACETYLPHENYL)SULFAMOYL]PHENYL 2 METHYLPROPANE 2 SULFINATE; 4 [N (2 FORMYLPHENYL)SULFAMOYL]PHENYL 2 METHYLPROPANE 2 SULFINATE; 4 [N [2 (2 HYDROXYETHYLCARBAMOYL)PHENYL]SULFAMOYL]PHENYLPIVALATE; LEUKOCYTE ELASTASE; LEUKOCYTE ELASTASE INHIBITOR; LIPOPOLYSACCHARIDE; METHYL 2 (4 PIVALAMIDOPHENYLSULFONAMIDO)BENZOATE; MYELOBLASTIN; MYELOPEROXIDASE; OXIME DERIVATIVE; PLACEBO; PROTEINASE INHIBITOR; SERINE PROTEINASE; SIVELESTAT; THROMBIN; TRYPSIN; UNCLASSIFIED DRUG; 2-AMINOBENZALDEHYDE; BENZALDEHYDE DERIVATIVE; ENZYME INHIBITOR; OXIME; PEROXIDASE; SUPEROXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DOWN REGULATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; HYDROGEN BOND; IC50; IN VITRO STUDY; IN VIVO STUDY; LIGAND BINDING; LUNG INJURY; MALE; MOUSE; MOUSE MODEL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PAW EDEMA; PHARMACOLOGICAL BLOCKING; ACUTE LUNG INJURY; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICALLY INDUCED; CHEMISTRY; DRUG EFFECTS; EDEMA; ENZYMOLOGY; HUMAN; LUNG; METABOLISM; NEUTROPHIL; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ACUTE LUNG INJURY; ANIMALS; BENZALDEHYDES; EDEMA; ENZYME INHIBITORS; HUMANS; LEUKOCYTE ELASTASE; LIPOPOLYSACCHARIDES; LUNG; MICE; MYELOBLASTIN; NEUTROPHILS; OXIMES; PEROXIDASE; STRUCTURE-ACTIVITY RELATIONSHIP; SUPEROXIDES;

EID: 84923115199     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.12.056     Document Type: Article

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