Optimization of O3-acyl kojic acid derivatives as potent and selective human neutrophil elastase inhibitors

Journal of Medicinal Chemistry

Volumn 56, Issue 23, 2013, Pages 9802-9806

  Lucas, Susana D ^a   Gonçalves, Lídia M ^a   Carvalho, Luís A R ^a   Correia, Henrique F ^a   Da Costa, Eduardo M R ^a   Guedes, Romina A ^a   Moreira, Rui ^a   Guedes, Rita C ^a  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

6 [(BENZO[D]THIAZOL 2 YLTHIO)METHYL] 4 OXO 4H PYRAN 3 YL PIVALATE; KOJIC ACID; LEUKOCYTE ELASTASE; LEUKOCYTE ELASTASE INHIBITOR; UNCLASSIFIED DRUG; PYRIDONE DERIVATIVE; PYRONE DERIVATIVE;

ACYLATION; ANIMAL CELL; CELL STRAIN 3T3; CELL STRAIN HEK293; CYTOTOXICITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; LIVER MICROSOME; NONHUMAN; PLASMA; RAT; REVIEW; STRUCTURE ACTIVITY RELATION; ANIMAL; ARTICLE; CELL LINE; CHEMISTRY; DRUG STABILITY; KINETICS; METABOLISM; MOLECULAR DOCKING; SYNTHESIS;

ANIMALS; CELL LINE; DRUG STABILITY; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; LEUKOCYTE ELASTASE; MICROSOMES, LIVER; MOLECULAR DOCKING SIMULATION; PROTEINASE INHIBITORY PROTEINS, SECRETORY; PYRIDONES; PYRONES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84890506159     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm4011725     Document Type: Review

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