Synthesis and evaluation of silanediols as highly selective uncompetitive inhibitors of human neutrophil elastase

Journal of Medicinal Chemistry

Volumn 55, Issue 17, 2012, Pages 7900-7908

  Madsen, Julie L H ^a   Andersen, Thomas L ^a   Santamaria, Salvatore ^b,c   Nagase, Hideaki ^b,c   Enghild, Jan J ^a   Skrydstrup, Troels ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

LEUKOCYTE ELASTASE INHIBITOR; SILANEDIOL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING COMPETITION; DRUG COMPETITION; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; STRUCTURE ACTIVITY RELATION;

ENZYME INHIBITORS; HUMANS; LEUKOCYTE ELASTASE; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; SILANES;

EID: 84866328851     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301000k     Document Type: Article

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