Protection of lung epithelial cells from protease-mediated injury by trappin-2 A62L, an engineered inhibitor of neutrophil serine proteases

Biochemical Pharmacology

Volumn 83, Issue 12, 2012, Pages 1663-1673

  Tanga, Annabelle ^a   Saidi, Ahlame ^a   Jourdan, Marie Lise ^a,b   Dallet Choisy, Sandrine ^a   Zani, Marie Louise ^a   Moreau, Thierry ^a  

^a Jeune Equipe 409   (France)

^b UNIVERSITY HOSPITAL OF TOURS   (France)

Author keywords

Elafin; Inflammatory lung diseases; Protease inhibitor; Serine proteases; Trappin 2

Indexed keywords

BETA CATENIN; ELASTASE; INTERLEUKIN 6; INTERLEUKIN 8; NEUTROPHIL SERINE PROTEASE; NEUTROPHIL SERINE PROTEASE INHIBITOR; PROTEIN ZO1; PROTEINASE; PROTEINASE INHIBITOR; TRAPPIN 2; TRAPPIN 2 A62D; TRAPPIN 2 A62L; UNCLASSIFIED DRUG; UVOMORULIN;

ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CELL ADHESION; CELL PROTECTION; CELL STIMULATION; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LEUKOCYTE ACTIVATION; LUNG ALVEOLUS EPITHELIUM; LUNG INJURY; NEUTROPHIL; PNEUMONIA; PRIORITY JOURNAL; PROTEIN DEGRADATION; TIGHT JUNCTION;

APOPTOSIS; CELL LINE; ELAFIN; EPITHELIAL CELLS; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; LUNG; NEUTROPHILS; PROTEOLYSIS; RECOMBINANT FUSION PROTEINS; RECOMBINANT PROTEINS; SECRETORY LEUKOCYTE PEPTIDASE INHIBITOR; SERINE PROTEINASE INHIBITORS;

EID: 84860202479     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.03.009     Document Type: Article

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