The T-body approach: Potential for cancer immunotherapy

Springer Seminars in Immunopathology

Volumn 18, Issue 2, 1996, Pages 199-209

  Eshhar, Zelig ^a   Bach, Nathan ^a,b   Fitzer Attas, Cheryl J ^a   Gross, Gidi ^a,c   Lustgarten, Joseph ^a,d   Waks, Tova ^a   Schindler, Daniel G ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b BRISTOL MYERS SQUIBB   (United States)

^c MIGAL GALILEE TECHNOLOGY CENTER   (Israel)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER IMMUNOTHERAPY; CELLULAR IMMUNITY; HUMORAL IMMUNITY; PRIORITY JOURNAL; REVIEW; TUMOR IMMUNITY;

ANIMALS; ANTIBODY FORMATION; HUMANS; IMMUNITY, CELLULAR; IMMUNOTHERAPY, ADOPTIVE; T-LYMPHOCYTES;

EID: 0029788940     PISSN: 03444325     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00820666     Document Type: Review

References (31)

1. Bach N, Waks T, Eshhar Z (1995) Specific lysis of tumor cells by a natural-killer-like cell line transfected with chimeric receptor genes. Tumor Targetting. 1: 203
2. Bach NL, Waks T, Schindler DG, Eshhar Z (1994) Functional expression in mast cells of chimeric receptors with antibody specificity. Cell Biophys. 24: 229
3. Becker MLB, Near R, Mudgett-Hunter M, Margolies MN, Kubo RT, Kaye J, Hedrick SM (1989) Expression of a hybrid immunoglobulin-T cell receptor protein in transgenic mice. Cell 58: 911
4. Bird RE, Hardman KD, Jacobson JW, Johnson S, Kaufman BM, Lee S-M, Lee T, Pope SH, Riordan GS, Whitlow M (1988) Single chain antigen binding proteins. Science 242: 423
5. Brocker T, Peter A, Traunecker A, Karjalainen K (1993) A new simplified molecular design for functional T cell receptor. Eur J Immunol 23: 1435
6. Brocker T, Karjalainen K (1995) Signals through T cell receptor-zeta chain alone are insufficient to prime resting T lymphocytes. J Exp Med 181: 1653
7. Classon BJ, Brown MH, Garnett D, Somoza C, Barclay AN, Willis AC, Williams AF (1992) The hinge region of the CD8α chain: structure, antigenicity, and utility in expression of immunoglobulin superfamily domains. International Immunol 2: 215
8. Eshhar Z, Waks T, Gross G, Schindler DG (1993) Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors. Proc Natl Acad Sci USA 90: 720
9. Eshhar Z, Gross G, Waks T, Lustgarten J, Bach N, Ratner A, Treisman J, Schindler DG (1995) T-bodies: chimeric T-cell receptors with antibody-type specificity. METHODS - A Companion to Meth. in Enzymol. 8: 133
10. Goverman J, Gomez SM, Segesman KD, Hunkapiller T, Laug WE, Hood L (1990) Chimeric immunoglobulin-T cell receptor proteins form functional receptors: implications for T cell receptor complex formation and activation. Cell 60: 929
11. Gross G, Gorochov,G, Waks T, Eshhar Z (1989) Generation of effector T cells expressing chimeric T cell receptors with antibody type specificity. Transplant Proc 21: 127
12. Gross G, Waks T, Eshhar Z (1989) Expression of immunoglobulin/T cell receptor chimeric molecules as functional receptors with antibody-type specificity. Proc Natl Acad Sci USA 86: 10 024
13. Gross G, Eshhar Z (1992) Endowing T cells with antibody specificity using chimeric T cell receptors. FASEB J 6: 3370
14. Gross G, Levy S, Levy R, Waks T, Eshhar Z (1995) Chimeric T cell receptors specific to a B lymphoma idiotype: A model for tumor immunotherapy. Biochem Soc Trans 23: 1079
15. Huston JS, Levinson D, Mudget-Hunter M, Tai M-S, Novotny J, Margolies MN, Ridge RJ, Bruccoleri RE, Haber E, Crea R, Oppermann H (1988) Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single chain Fv analogue produced in Escherichia coli. Proc Natl Acad Sci USA 85: 5879
16. Hwu P, Shafer GE, Treisman J, Schindler DG, Gross G, Cowhead R, Rosenberg SA, Eshhar Z (1993) Lysis of ovarian cancer cells by human lymphocytes redirected with a chimeric gene composed of an antibody variable region and the Fc receptor γ chain. J Exp Med 178: 361
17. Hwu P, Yang JC, Cowherd R, Treisman J, Shafer GE, Eshhar Z, Rosenberg SA (1995) In vivo antitumor activity of T cells redirected with chimeric antibody/T-cell receptor genes. Cancer Res 55: 3369
18. Jain RK (1994) Barriers to drug delivery in solid tumors. Sci Am 271: 42
19. Kuwana Y, Asakura Y, Utsunomiya N, Nakanishi M, Arata Y, Itoh S, Nagase F, Kurosawa Y (1987) Expression of chimeric receptor composed of immunoglobulin-derived V regions and T-cell receptor-derived C regions. Biochem Biophys Res Commun 149: 960
20. Lustgarten J, Eshhar Z (1995) Specific elimination of IgE production using T cell lines expressing chimeric T cell receptor genes. Eur J Immunol. 25: 2985
21. Miller AD (1992) Human gene therapy comes of age. Nature 357: 455
22. Moritz D, Wels W, Mattern J, Groner B (1994) Cytotoxic T lymphocytes with a grafted recognition specificity for ErbB-2-expressing tumor cells. Proc Natl Acad Sci USA 91: 4318
23. Moritz D, Groner B (1995) A spacer region between the single chain antibody and the CD3 ζ chain domain of chimeric T cell receptor components is required for efficient ligand binding and signalling activity. Gene Ther 2: 539
24. Orloff DG, Ra C, Frank SJ, Klausner RD, Kinet J-P (1990) Family of disulphide-linked dimers containing the zeta and eta chains of the T-cell receptor and the gamma chain of Fc receptors. Nature 347: 189
25. Ravetch JV, Kinet J-P (1991) Fc receptors. Annu Rev Immunol 9: 457
26. Riethmuller G (1993) Monoclonal antibodies in cancer therapy. Curr Opin Immunol 5: 732
27. Romeo C, Seed B (1991) Cellular immunity to HIV activated by CD4 fused to T cell or Fc receptor polypeptides. Cell 64: 1037
28. Rosenberg SA, Packard BS, Aebersold PM, Solomon D, Topalian SL, Toy ST, Simon P, Lotze MT, Yang JC, Seipp CA, et al (1989) Use of tumor infiltrating lymphocytes and interleukin-2 in the immunotherapy of patients with metastatic melanoma. A preliminary report. N Engl J Med 319: 1676
29. Stancovski I, Schindler DG, Waks T, Yarden Y, Sela M, Eshhar Z (1993) Targeting of T lymphocytes to Neu/HER2-expressing cells using chimeric single chain Fv receptors. J Immunol 151: 6577
30. Tran A-C, Zhang D, Byrn R, Roberts MR (1995) Chimeric ζ-receptors direct human natural killer (NK) effector function to permit Killing of NK-resistant tumor cells and HIV-infected T lymphocytes. J Immunol 155: 1001
31. Winter G, Griffiths AD, Hawkins RE, Hoogenboom HR (1994) Making antibodies by phage display technology. Annu Rev Immunol 12: 433