메뉴 건너뛰기




Volumn 5, Issue 1, 2010, Pages 45-51

Challenges in the frontline treatment of patients with chronic lymphocytic leukemia

Author keywords

Chronic lymphocytic leukemia; Frontline treatment

Indexed keywords

ALEMTUZUMAB; BENDAMUSTINE; CHLORAMBUCIL; CLADRIBINE; CORTICOSTEROID; CYCLOPHOSPHAMIDE; FLUDARABINE; LENALIDOMIDE; PENTOSTATIN; PREDNISONE; RITUXIMAB; THALIDOMIDE;

EID: 76649132640     PISSN: 15588211     EISSN: 1558822X     Source Type: Journal    
DOI: 10.1007/s11899-009-0040-3     Document Type: Review
Times cited : (3)

References (57)
  • 1
    • 0026038974 scopus 로고
    • The French Cooperative Group on CLL: B-cell chronic lymphocytic leukemia: Present status and future directions
    • 1912574 1:STN:280:DyaK38%2Fgtl2gug%3D%3D
    • G Dighiero P Travade S Chevret, et al. 1991 The French Cooperative Group on CLL: B-cell chronic lymphocytic leukemia: Present status and future directions Blood 78 1901 1914 1912574 1:STN:280:DyaK38%2Fgtl2gug%3D%3D
    • (1991) Blood , vol.78 , pp. 1901-1914
    • Dighiero, G.1    Travade, P.2    Chevret, S.3
  • 2
    • 0028931830 scopus 로고
    • Review article: Advances in the biology and treatment of B-cell chronic lymphocytic leukemia
    • 7811987
    • S O'Brien A del Giglio M Keating 1995 Review article: Advances in the biology and treatment of B-cell chronic lymphocytic leukemia Blood 85 307 318 7811987
    • (1995) Blood , vol.85 , pp. 307-318
    • O'Brien, S.1    Del Giglio, A.2    Keating, M.3
  • 3
    • 0024216099 scopus 로고
    • Fludarabine monophosphate: A potentially useful agent in chronic lymphocytic leukemia
    • 2464793 1:STN:280:DyaL1M7ivVCisw%3D%3D
    • MR Grever KJ Kopecky CA Coltman, et al. 1988 Fludarabine monophosphate: a potentially useful agent in chronic lymphocytic leukemia Nouv Rev Fr Hematol 30 457 459 2464793 1:STN:280:DyaL1M7ivVCisw%3D%3D
    • (1988) Nouv Rev Fr Hematol , vol.30 , pp. 457-459
    • Grever, M.R.1    Kopecky, K.J.2    Coltman, C.A.3
  • 4
    • 0024319910 scopus 로고
    • Fludarabine: A new agent with major activity against chronic lymphocytic leukemia
    • 2473795 1:STN:280:DyaL1Mzitlegtw%3D%3D
    • MJ Keating H Kantarjian M Talpaz, et al. 1989 Fludarabine: a new agent with major activity against chronic lymphocytic leukemia Blood 74 19 25 2473795 1:STN:280:DyaL1Mzitlegtw%3D%3D
    • (1989) Blood , vol.74 , pp. 19-25
    • Keating, M.J.1    Kantarjian, H.2    Talpaz, M.3
  • 5
    • 0027465143 scopus 로고
    • High complete remission rate from 2-chloro-2'deoxyadenosine in previously treated patients with B-cell chronic lymphocytic leukemia: Response predicted by rapid decrease of blood lymphocyte count
    • 8097528 1:STN:280:DyaK3s3ktVWqsw%3D%3D
    • G Juliusson J Liliemark 1993 High complete remission rate from 2-chloro-2'deoxyadenosine in previously treated patients with B-cell chronic lymphocytic leukemia: response predicted by rapid decrease of blood lymphocyte count J Clin Oncol 11 679 689 8097528 1:STN:280:DyaK3s3ktVWqsw%3D%3D
    • (1993) J Clin Oncol , vol.11 , pp. 679-689
    • Juliusson, G.1    Liliemark, J.2
  • 6
    • 0028945716 scopus 로고
    • 2-chlorodeoxyadenosine activity in patients with untreated chronic lymphocytic leukemia
    • 7884417 1:STN:280:DyaK2M7ptVGjtg%3D%3D
    • A Saven RH Lemon M Kosty, et al. 1995 2-chlorodeoxyadenosine activity in patients with untreated chronic lymphocytic leukemia J Clin Oncol 13 570 574 7884417 1:STN:280:DyaK2M7ptVGjtg%3D%3D
    • (1995) J Clin Oncol , vol.13 , pp. 570-574
    • Saven, A.1    Lemon, R.H.2    Kosty, M.3
  • 7
    • 0021933387 scopus 로고
    • Low-dose deoxycoformycin in lymphoid malignancy
    • 2993534 1:STN:280:DyaL2M3ptF2lsg%3D%3D
    • MR Grever JM Leiby EH Kraut, et al. 1985 Low-dose deoxycoformycin in lymphoid malignancy J Clin Oncol 3 1196 1201 2993534 1:STN:280: DyaL2M3ptF2lsg%3D%3D
    • (1985) J Clin Oncol , vol.3 , pp. 1196-1201
    • Grever, M.R.1    Leiby, J.M.2    Kraut, E.H.3
  • 8
    • 0024551346 scopus 로고
    • Ross McIntyre OR: Pentostatin in chronic lymphocytic leukemia: A phase II trial of Cancer and Leukemia Group B
    • 2784491 1:STN:280:DyaL1M7nslChtg%3D%3D
    • RO Dillman R Mick 1989 Ross McIntyre OR: Pentostatin in chronic lymphocytic leukemia: a phase II trial of Cancer and Leukemia Group B J Clin Oncol 7 433 438 2784491 1:STN:280:DyaL1M7nslChtg%3D%3D
    • (1989) J Clin Oncol , vol.7 , pp. 433-438
    • Dillman, R.O.1    Mick, R.2
  • 9
    • 0345337254 scopus 로고    scopus 로고
    • Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: Half of patients respond to a four-dose treatment program
    • 9704735 1:CAS:528:DyaK1cXlsFCgu7c%3D
    • P McLaughlin AJ Grillo-Lopez BK Link, et al. 1998 Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program J Clin Oncol 16 2825 2833 9704735 1:CAS:528:DyaK1cXlsFCgu7c%3D
    • (1998) J Clin Oncol , vol.16 , pp. 2825-2833
    • McLaughlin, P.1    Grillo-Lopez, A.J.2    Link, B.K.3
  • 10
    • 0032931320 scopus 로고    scopus 로고
    • IDEC-C2B8 anti-CD20 (rituximab) immunotherapy in patients with low-grade non-Hodgkin's lymphoma and lymphoproliferative disorders: Evaluation of response on 48 patients
    • 10052709 1:CAS:528:DyaK1MXht12qsL0%3D
    • DT Nguyen JA Amess H Doughty, et al. 1999 IDEC-C2B8 anti-CD20 (rituximab) immunotherapy in patients with low-grade non-Hodgkin's lymphoma and lymphoproliferative disorders: evaluation of response on 48 patients Eur J Haematol 62 76 82 10052709 1:CAS:528:DyaK1MXht12qsL0%3D
    • (1999) Eur J Haematol , vol.62 , pp. 76-82
    • Nguyen, D.T.1    Amess, J.A.2    Doughty, H.3
  • 11
    • 0030897222 scopus 로고    scopus 로고
    • Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia. European Study Group of CAMPATH-1H Treatment in Chronic Lymphocytic Leukemia
    • 9193354 1:STN:280:DyaK2szjs1KjtQ%3D%3D
    • A Osterborg MJ Dyer D Bunjes, et al. 1997 Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia. European Study Group of CAMPATH-1H Treatment in Chronic Lymphocytic Leukemia J Clin Oncol 15 1567 1574 9193354 1:STN:280:DyaK2szjs1KjtQ%3D%3D
    • (1997) J Clin Oncol , vol.15 , pp. 1567-1574
    • Osterborg, A.1    Dyer, M.J.2    Bunjes, D.3
  • 12
    • 0031790767 scopus 로고    scopus 로고
    • Cross-linking of the CAMPATH-1 antigen (CD52) mediates growth inhibition in human B- and T-lymphoma cell lines, and subsequent emergence of CD52- deficient cells
    • DOI 10.1046/j.1365-2567.1998.00615.x
    • W Rowan J Tite P Topley SJ Brett 1998 Cross-linking of the CAMPATH-1 antigen (CD52) mediates growth inhibition in human B- and T-lymphoma cell lines, and subsequent emergence of CD52-deficient cells Immunology 95 427 436 10.1046/j.1365-2567.1998.00615.x 9824507 1:CAS:528:DyaK1cXnsVyhtrw%3D (Pubitemid 28505700)
    • (1998) Immunology , vol.95 , Issue.3 , pp. 427-436
    • Rowan, W.1    Tite, J.2    Topley, P.3    Brett, S.J.4
  • 14
    • 45149100665 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: A report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines
    • 10.1182/blood-2007-06-093906 18216293 1:CAS:528:DC%2BD1cXnsVOktrk%3D
    • M Hallek BD Cheson D Catovsky, et al. 2008 Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines Blood 111 12 5446 5456 10.1182/blood-2007-06-093906 18216293 1:CAS:528:DC%2BD1cXnsVOktrk%3D
    • (2008) Blood , vol.111 , Issue.12 , pp. 5446-5456
    • Hallek, M.1    Cheson, B.D.2    Catovsky, D.3
  • 16
    • 0033567968 scopus 로고    scopus 로고
    • Ig v gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia
    • 10477712 1:CAS:528:DyaK1MXlvFCnur0%3D
    • RN Damle T Wasil F Fais, et al. 1999 Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia Blood 94 1840 1847 10477712 1:CAS:528:DyaK1MXlvFCnur0%3D
    • (1999) Blood , vol.94 , pp. 1840-1847
    • Damle, R.N.1    Wasil, T.2    Fais, F.3
  • 17
    • 0033567907 scopus 로고    scopus 로고
    • Unmutated Ig VH genes are associated with a more aggressive form of chronic lymphocytic leukemia
    • 10477713 1:CAS:528:DyaK1MXlvFCnuro%3D
    • TJ Hamblin Z Davis A Gardiner, et al. 1999 Unmutated Ig VH genes are associated with a more aggressive form of chronic lymphocytic leukemia Blood 94 1848 1854 10477713 1:CAS:528:DyaK1MXlvFCnuro%3D
    • (1999) Blood , vol.94 , pp. 1848-1854
    • Hamblin, T.J.1    Davis, Z.2    Gardiner, A.3
  • 18
    • 0037103212 scopus 로고    scopus 로고
    • VH mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia
    • 12149225 1:CAS:528:DC%2BD38Xmt12iur0%3D
    • A Krober T Seiler A Benner, et al. 2002 VH mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia Blood 100 1410 1416 12149225 1:CAS:528:DC%2BD38Xmt12iur0%3D
    • (2002) Blood , vol.100 , pp. 1410-1416
    • Krober, A.1    Seiler, T.2    Benner, A.3
  • 19
    • 33746589459 scopus 로고    scopus 로고
    • Clinical significance of ZAP-70 protein expression in B-cell chronic lymphocytic leukemia
    • MI Del Principe G Del Poeta F Buccisano, et al. 2006 Clinical significance of ZAP-70 protein expression in B-cell chronic lymphocytic leukemia Blood 108 843 861
    • (2006) Blood , vol.108 , pp. 843-861
    • Del Principe, M.I.1    Del Poeta, G.2    Buccisano, F.3
  • 22
    • 84870006793 scopus 로고    scopus 로고
    • National Cancer Institute: Early or delayed fludarabine and rituximab in treating patients with previously untreated chronic lymphocytic leukemia [clinical trial]. Available at
    • National Cancer Institute: Early or delayed fludarabine and rituximab in treating patients with previously untreated chronic lymphocytic leukemia [clinical trial]. Available at: http://www.clinicaltrials.gov/ct2/results?term= NCT00513747. Accessed November 13, 2009.
  • 23
    • 0026015638 scopus 로고
    • Fludarabine: A new agent with marked cytoreductive activity in untreated chronic lymphocytic leukemia
    • 1702145 1:STN:280:DyaK3M%2Fos12ltg%3D%3D
    • MJ Keating H Kantarjian S O'Brien, et al. 1991 Fludarabine: a new agent with marked cytoreductive activity in untreated chronic lymphocytic leukemia J Clin Oncol 9 44 49 1702145 1:STN:280:DyaK3M%2Fos12ltg%3D%3D
    • (1991) J Clin Oncol , vol.9 , pp. 44-49
    • Keating, M.J.1    Kantarjian, H.2    O'Brien, S.3
  • 24
    • 0034649696 scopus 로고    scopus 로고
    • Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia
    • 10.1056/NEJM200012143432402 11114313 1:CAS:528:DC%2BD3cXptVehs7k%3D
    • KR Rai BL Peterson FR Appelbaum, et al. 2000 Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia N Engl J Med 343 1750 1757 10.1056/NEJM200012143432402 11114313 1:CAS:528: DC%2BD3cXptVehs7k%3D
    • (2000) N Engl J Med , vol.343 , pp. 1750-1757
    • Rai, K.R.1    Peterson, B.L.2    Appelbaum, F.R.3
  • 25
    • 0026776598 scopus 로고
    • Response assessment in chronic lymphocytic leukemia after fludarabine plus prednisone: Clinical, immunophenotypic, and molecular analysis
    • 1377051 1:STN:280:DyaK38zgsFentQ%3D%3D
    • LE Robertson YO Huh JJ Butler, et al. 1992 Response assessment in chronic lymphocytic leukemia after fludarabine plus prednisone: clinical, immunophenotypic, and molecular analysis Blood 80 29 36 1377051 1:STN:280:DyaK38zgsFentQ%3D%3D
    • (1992) Blood , vol.80 , pp. 29-36
    • Robertson, L.E.1    Huh, Y.O.2    Butler, J.J.3
  • 26
    • 0033828586 scopus 로고    scopus 로고
    • Consolidation therapy with high-dose cyclophosphamide improves the quality of response in patients with chronic lymphocytic leukemia treated with fludarabine as induction therapy
    • 10.1038/sj.leu.2401892 1:CAS:528:DC%2BD3cXntFOhsbk%3D
    • M Weiss M Glenn P Maslak, et al. 2000 Consolidation therapy with high-dose cyclophosphamide improves the quality of response in patients with chronic lymphocytic leukemia treated with fludarabine as induction therapy Leukemia 14 557 582 10.1038/sj.leu.2401892 1:CAS:528:DC%2BD3cXntFOhsbk%3D
    • (2000) Leukemia , vol.14 , pp. 557-582
    • Weiss, M.1    Glenn, M.2    Maslak, P.3
  • 27
    • 0027323550 scopus 로고
    • Results of fludarabine and prednisone therapy in 264 patients with chronic lymphocytic leukemia with multivariate analysis-derived prognostic model for response to treatment
    • 8400226
    • S O'Brien H Kantarjian M Beran, et al. 1993 Results of fludarabine and prednisone therapy in 264 patients with chronic lymphocytic leukemia with multivariate analysis-derived prognostic model for response to treatment Blood 82 1695 1700 8400226
    • (1993) Blood , vol.82 , pp. 1695-1700
    • O'Brien, S.1    Kantarjian, H.2    Beran, M.3
  • 28
    • 0027483579 scopus 로고
    • A phase i trial of combination fludarabine monophosphate and chlorambucil in chronic lymphocytic leukemia: A Southwest Oncology Group study
    • 7680398 1:STN:280:DyaK3s7ovVGgsw%3D%3D
    • L Elias D Stock-Novack DR Head, et al. 1993 A phase I trial of combination fludarabine monophosphate and chlorambucil in chronic lymphocytic leukemia: a Southwest Oncology Group study Leukemia 7 361 365 7680398 1:STN:280:DyaK3s7ovVGgsw%3D%3D
    • (1993) Leukemia , vol.7 , pp. 361-365
    • Elias, L.1    Stock-Novack, D.2    Head, D.R.3
  • 29
    • 0028022841 scopus 로고
    • Concomitant administration of chlorambucil limits dose intensity of fludarabine in previously treated patients with chronic lymphocytic leukemia
    • 8057664 1:STN:280:DyaK2czjsFeitA%3D%3D
    • M Weiss T Spiess E Berman S Kempin 1994 Concomitant administration of chlorambucil limits dose intensity of fludarabine in previously treated patients with chronic lymphocytic leukemia Leukemia 8 1290 1293 8057664 1:STN:280:DyaK2czjsFeitA%3D%3D
    • (1994) Leukemia , vol.8 , pp. 1290-1293
    • Weiss, M.1    Spiess, T.2    Berman, E.3    Kempin, S.4
  • 30
    • 0035282055 scopus 로고    scopus 로고
    • Results of the fludarabine and cyclophosphamide combination regimen in chronic lymphocytic leukemia
    • 11230486
    • S O'Brien HM Kantarjian MC Cortes, et al. 2001 Results of the fludarabine and cyclophosphamide combination regimen in chronic lymphocytic leukemia J Clin Oncol 19 1414 1420 11230486
    • (2001) J Clin Oncol , vol.19 , pp. 1414-1420
    • O'Brien, S.1    Kantarjian, H.M.2    Cortes, M.C.3
  • 33
    • 0034235909 scopus 로고    scopus 로고
    • Fludarabine and cyclophosphamide with filgrastim support in patients with previously untreated indolent lymphoid malignancies
    • 10891432 1:CAS:528:DC%2BD3cXksVKjsL0%3D
    • IW Flinn JC Byrd C Morrison, et al. 2000 Fludarabine and cyclophosphamide with filgrastim support in patients with previously untreated indolent lymphoid malignancies Blood 96 71 75 10891432 1:CAS:528:DC%2BD3cXksVKjsL0%3D
    • (2000) Blood , vol.96 , pp. 71-75
    • Flinn, I.W.1    Byrd, J.C.2    Morrison, C.3
  • 34
    • 59149106873 scopus 로고    scopus 로고
    • Sequential therapy with fludarabine, high dose cyclophosphamide, and rituximab in previously untreated patients with chronic lymphocytic leukemia produces high-quality responses: Molecular remissions predict for durable complete responses
    • 10.1200/JCO.2008.16.4459 19075280 1:CAS:528:DC%2BD1MXivFyjtbw%3D This study demonstrated that PCR negativity confers a 90% likelihood of a 5-year or greater duration of complete response
    • N Lamanna MA Weiss PG Maslak, et al. 2009 Sequential therapy with fludarabine, high dose cyclophosphamide, and rituximab in previously untreated patients with chronic lymphocytic leukemia produces high-quality responses: molecular remissions predict for durable complete responses J Clin Oncol 27 491 497 10.1200/JCO.2008.16.4459 19075280 1:CAS:528:DC%2BD1MXivFyjtbw%3D This study demonstrated that PCR negativity confers a 90% likelihood of a 5-year or greater duration of complete response
    • (2009) J Clin Oncol , vol.27 , pp. 491-497
    • Lamanna, N.1    Weiss, M.A.2    Maslak, P.G.3
  • 35
    • 0037220152 scopus 로고    scopus 로고
    • Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: Results from cancer and leukemia group B 9712 (CALGB 9712)
    • DOI 10.1182/blood-2002-04-1258
    • JC Byrd BL Peterson VA Morrison, et al. 2003 Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: results from Cancer and Leukemia Group B 9712 (CALGB 9712) Blood 101 6 14 10.1182/blood-2002-04-1258 12393429 1:CAS:528:DC%2BD3sXhtFSrtw%3D%3D (Pubitemid 36025880)
    • (2003) Blood , vol.101 , Issue.1 , pp. 6-14
    • Byrd, J.C.1    Peterson, B.L.2    Morrison, V.A.3    Park, K.4    Jacobson, R.5    Hoke, E.6    Vardiman, J.W.7    Rai, K.8    Schiffer, C.A.9    Larson, R.A.10
  • 36
    • 19944429446 scopus 로고    scopus 로고
    • Addition of rituximab to fludarabine may prolong progression-free survival and overall survival in patients with previously untreated chronic lymphocytic leukemia: An updated retrospective comparative analysis of CALGB 9712 and CALGB 9011
    • DOI 10.1182/blood-2004-03-0796
    • JC Byrd K Rai BL Peterson, et al. 2005 Addition of rituximab to fludarabine may prolong progression-free survival and overall survival in patients with previously untreated chronic lymphocytic leukemia: an updated retrospective comparative analysis of CALGB 9712 and CALGB 9011 Blood 105 49 53 10.1182/blood-2004-03-0796 15138165 1:CAS:528:DC%2BD2MXis1Gksw%3D%3D (Pubitemid 40053062)
    • (2005) Blood , vol.105 , Issue.1 , pp. 49-53
    • Byrd, J.C.1    Rai, K.2    Peterson, B.L.3    Appelbaum, F.R.4    Morrison, V.A.5    Kolitz, J.E.6    Shepherd, L.7    Hines, J.D.8    Schiffer, C.A.9    Larson, R.A.10
  • 37
    • 61849091076 scopus 로고    scopus 로고
    • Immunochemotherapy with fludarabine, cyclophosphamide, and rituximab versus fludarabine and cyclophosphamide improves response rates and progression free survival of previously untreated patients with advanced chronic lymphocytic leukemia
    • [abstract] Abstract 325
    • Hallek M, Fingerle-Rowson G, Fink AM, et al.: Immunochemotherapy with fludarabine, cyclophosphamide, and rituximab versus fludarabine and cyclophosphamide improves response rates and progression free survival of previously untreated patients with advanced chronic lymphocytic leukemia [abstract]. Blood (ASH Annual Meeting Abstracts) 2008, 112:Abstract 325.
    • (2008) Blood (ASH Annual Meeting Abstracts) , vol.112
    • Hallek, M.1    Fingerle-Rowson, G.2    Fink, A.M.3
  • 38
    • 0034667537 scopus 로고    scopus 로고
    • Cladribine with prednisone versus chlorambucil with prednisone as first-line therapy in chronic lymphocytic leukemia: Report of a prospective, randomized, multicenter trial
    • 11023504 1:CAS:528:DC%2BD3cXnt12gsb0%3D
    • T Robak J Blonski M Kasznicki, et al. 2000 Cladribine with prednisone versus chlorambucil with prednisone as first-line therapy in chronic lymphocytic leukemia: report of a prospective, randomized, multicenter trial Blood 96 2723 2729 11023504 1:CAS:528:DC%2BD3cXnt12gsb0%3D
    • (2000) Blood , vol.96 , pp. 2723-2729
    • Robak, T.1    Blonski, J.2    Kasznicki, M.3
  • 39
    • 76649123621 scopus 로고    scopus 로고
    • Comparison of cladribine plus cyclophosphamide or fludarabine plus cyclophosphamide in different age groups in previously untreated patients with chronic lymphocytic leukemia (PALG-CLL3 study) [abstract 0407]
    • T Robak JZ Blonski J Gora-Tybor, et al. 2008 Comparison of cladribine plus cyclophosphamide or fludarabine plus cyclophosphamide in different age groups in previously untreated patients with chronic lymphocytic leukemia (PALG-CLL3 study) [abstract 0407] Haematologica 93 suppl 1 162
    • (2008) Haematologica , vol.93 , Issue.SUPPL 1 , pp. 162
    • Robak, T.1    Blonski, J.Z.2    Gora-Tybor, J.3
  • 43
    • 34249042684 scopus 로고    scopus 로고
    • Pentostatin, cyclophosphamide, and rituximab regimen in older patients with chronic lymphocytic leukemia
    • DOI 10.1002/cncr.22662
    • TD Shanafelt T Lin SM Geyer, et al. 2007 Pentostatin, cyclophosphamide, and rituximab regimen in older patients with chronic lymphocytic leukemia Cancer 109 2291 2298 10.1002/cncr.22662 17514743 1:CAS:528:DC%2BD2sXmvVKjsLc%3D This study confirmed that the "PCR" regimen is active and tolerable in patients older than 65 years of age (Pubitemid 46801560)
    • (2007) Cancer , vol.109 , Issue.11 , pp. 2291-2298
    • Shanafelt, T.D.1    Lin, T.2    Geyer, S.M.3    Zent, C.S.4    Leung, N.5    Kabat, B.6    Bowen, D.7    Grever, M.R.8    Byrd, J.C.9    Kay, N.E.10
  • 44
    • 70349330220 scopus 로고    scopus 로고
    • Phase III randomized study of bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukemia
    • 10.1200/JCO.2008.20.8389 19652068 1:CAS:528:DC%2BD1MXht1WisbnO
    • WU Knauf T Lissichkov A Aldaoud, et al. 2009 Phase III randomized study of bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukemia J Clin Oncol 27 4378 4384 10.1200/JCO.2008.20.8389 19652068 1:CAS:528:DC%2BD1MXht1WisbnO
    • (2009) J Clin Oncol , vol.27 , pp. 4378-4384
    • Knauf, W.U.1    Lissichkov, T.2    Aldaoud, A.3
  • 46
    • 0036683449 scopus 로고    scopus 로고
    • Phase II trial of subcutaneous anti-CD52 monoclonal antibody alemtuzumab (Campath-1H) as first-line treatment for patients with B-cell chronic lymphocytic leukemia (B-CLL)
    • DOI 10.1182/blood-2002-01-0159
    • J Lundin E Kimby M Bjorkholm, et al. 2002 A phase II trial of subcutaneous anti-CD52 monoclonal antibody alemtuzumab (Campath-1H) as first-line treatment for patients with B-cell chronic lymphocytic leukemia (B-CLL) Blood 100 768 773 10.1182/blood-2002-01-0159 12130484 1:CAS:528:DC%2BD38XlvVCltrg%3D (Pubitemid 34832599)
    • (2002) Blood , vol.100 , Issue.3 , pp. 768-773
    • Lundin, J.1    Kimby, E.2    Bjorkholm, M.3    Broliden, P.-A.4    Celsing, F.5    Hjalmar, V.6    Mollgard, L.7    Rebello, P.8    Hale, G.9    Waldmann, H.10    Mellstedt, H.11    Osterborg, A.12
  • 47
    • 37649004407 scopus 로고    scopus 로고
    • Alemtuzumab compared with chlorambucil as first-line therapy for chronic lymphocytic leukemia
    • 10.1200/JCO.2007.12.9098 1:CAS:528:DC%2BD1cXmsFKltQ%3D%3D
    • P Hillmen AB Skotnick T Robak, et al. 2007 Alemtuzumab compared with chlorambucil as first-line therapy for chronic lymphocytic leukemia J Clin Oncol 25 5615 5623 10.1200/JCO.2007.12.9098 1:CAS:528:DC%2BD1cXmsFKltQ%3D%3D
    • (2007) J Clin Oncol , vol.25 , pp. 5615-5623
    • Hillmen, P.1    Skotnick, A.B.2    Robak, T.3
  • 49
    • 0037860441 scopus 로고    scopus 로고
    • A phase II trial of fludarabine followed by alemtuzumab (Campath-1H) in previously untreated chronic lymphocytic leukemia patients with active disease: Cancer and Leukemia Group B (CALGB) Study 19901 [abstract]
    • K Rai J Byrd BL Peterson RA Larson 2002 A phase II trial of fludarabine followed by alemtuzumab (Campath-1H) in previously untreated chronic lymphocytic leukemia patients with active disease: Cancer and Leukemia Group B (CALGB) Study 19901 [abstract] Blood 100 205a
    • (2002) Blood , vol.100
    • Rai, K.1    Byrd, J.2    Peterson, B.L.3    Larson, R.A.4
  • 51
    • 55249095945 scopus 로고    scopus 로고
    • Alemtuzumab increases serious infections in patients with previously untreated chronic lymphocytic leukemia receiving fludarabine-based therapy: A comparative analysis of 3 Cancer and Leukemia Group B Studies (CALGB 9011, 9712, 19901)
    • [abstract] Abstract 756
    • Morrison VA, Peterson FL, Rai KR, et al.: Alemtuzumab increases serious infections in patients with previously untreated chronic lymphocytic leukemia receiving fludarabine-based therapy: A comparative analysis of 3 Cancer and Leukemia Group B Studies (CALGB 9011, 9712, 19901) [abstract]. Blood (ASH Annual Meeting Abstracts) 2007, 110:Abstract 756.
    • (2007) Blood (ASH Annual Meeting Abstracts) , vol.110
    • Morrison, V.A.1    Peterson, F.L.2    Rai, K.R.3
  • 52
    • 51249108295 scopus 로고    scopus 로고
    • Consolidation therapy with subcutaneous alemtuzumab results in severe infectious toxicity in previously untreated CLL patients who achieve a complete response (CR) after fludarabine and rituximab induction therapy: Interim safety analysis of CALGB 10101
    • [abstract] Abstract 755
    • Lin TS, Donohue KA, Lucas MS, et al.: Consolidation therapy with subcutaneous alemtuzumab results in severe infectious toxicity in previously untreated CLL patients who achieve a complete response (CR) after fludarabine and rituximab induction therapy: Interim safety analysis of CALGB 10101 [abstract]. Blood (ASH Annual Meeting Abstracts) 2007, 110:Abstract 755.
    • (2007) Blood (ASH Annual Meeting Abstracts) , vol.110
    • Lin, T.S.1    Donohue, K.A.2    Lucas, M.S.3
  • 53
    • 66749113746 scopus 로고    scopus 로고
    • A phase II study of lenalidomide in previously untreated, symptomatic chronic lymphocytic leukemia (CLL)
    • [abstract] Abstract 44
    • Chen C, Paul H, Xu W, et al.: A phase II study of lenalidomide in previously untreated, symptomatic chronic lymphocytic leukemia (CLL) [abstract]. Blood (ASH Annual Meeting Abstracts) 2008, 112:Abstract 44.
    • (2008) Blood (ASH Annual Meeting Abstracts) , vol.112
    • Chen, C.1    Paul, H.2    Xu, W.3
  • 54
    • 69049084353 scopus 로고    scopus 로고
    • Lenalidomide as initial treatment of elderly patients with chronic lymphocytic leukemia (CLL)
    • [abstract] abstract 45
    • Ferrajoli A, O'Brien S, Wierda W, et al.: Lenalidomide as initial treatment of elderly patients with chronic lymphocytic leukemia (CLL) [abstract]. Blood (ASH Annual Meeting Abstracts) 2008, 112:abstract 45.
    • (2008) Blood (ASH Annual Meeting Abstracts) , vol.112
    • Ferrajoli, A.1    O'Brien, S.2    Wierda, W.3
  • 55
    • 84870039427 scopus 로고    scopus 로고
    • Surveillance, Epidemiology, and End Results Program: Median age of cancer patients at diagnosis, 2002-2006 by primary cancer site, race and sex. Bethesda, MD: National Cancer Institute Available at
    • Surveillance, Epidemiology, and End Results Program: Median age of cancer patients at diagnosis, 2002-2006 by primary cancer site, race and sex. Bethesda, MD: National Cancer Institute; 2006. Available at http://seer.cancer. gov/csr/1975-2006/results-single/sect-01-table.11-2pgs.pdf. Accessed October 19, 2009.
    • (2006)
  • 56
    • 34249092894 scopus 로고    scopus 로고
    • Treatment of patients with CLL 70 years old and older: A single center experience of 142 patients
    • A Ferrajoli S O'Brien W Wierda, et al. 2005 Treatment of patients with CLL 70 years old and older: a single center experience of 142 patients Leuk Lymphoma 46 suppl 1 S86
    • (2005) Leuk Lymphoma , vol.46 , Issue.SUPPL 1 , pp. 86
    • Ferrajoli, A.1    O'Brien, S.2    Wierda, W.3
  • 57
    • 70350720141 scopus 로고    scopus 로고
    • First line therapy with fludarabine compared to chlorambucil does not result in a major benefit for elderly patients with advanced chronic lymphocytic leukemia
    • 10.1182/blood-2009-02-206185 19605849 1:CAS:528:DC%2BD1MXhtlensb7N This important paper confirms that fludarabine does not result in a major clinical benefit in patients older than 65 years of age, versus treatment with chlorambucil
    • BF Eichhorst R Busch S Stilgenbauer, et al. 2009 First line therapy with fludarabine compared to chlorambucil does not result in a major benefit for elderly patients with advanced chronic lymphocytic leukemia Blood 114 3382 3391 10.1182/blood-2009-02-206185 19605849 1:CAS:528:DC%2BD1MXhtlensb7N This important paper confirms that fludarabine does not result in a major clinical benefit in patients older than 65 years of age, versus treatment with chlorambucil
    • (2009) Blood , vol.114 , pp. 3382-3391
    • Eichhorst, B.F.1    Busch, R.2    Stilgenbauer, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.