Hepatitis B virus X protein enhances cisplatin-induced hepatotoxicity via a mechanism involving degradation of Mcl-1

Journal of Virology

Volumn 85, Issue 7, 2011, Pages 3214-3228

  Hu, Liang ^a   Chen, Lei ^a   Li, Liang ^a   Sun, HanYong ^a   Yang, GuangZhen ^a   Chang, YanXin ^a   Tu, QianQian ^a   Wu, MengChao ^a   Wang, HongYang ^a,b  

^a EASTERN HEPATOBILIARY SURGERY HOSPITAL   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; CASPASE 3; CISPLATIN; HEPATITIS B VIRUS X PROTEIN; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN MCL 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG SENSITIZATION; ENZYME ACTIVATION; ENZYME INHIBITION; GENE REPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; LIVER CELL CARCINOMA; LIVER TOXICITY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SINGLE DRUG DOSE;

ANIMALS; APOPTOSIS; CASPASE 3; CELLS, CULTURED; CISPLATIN; HEPATITIS B VIRUS; HEPATOCYTES; HUMANS; LIVER; MICE; MICE, NUDE; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; TRANS-ACTIVATORS; VIRULENCE FACTORS;

HEPATITIS B VIRUS;

EID: 79952596359     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01841-10     Document Type: Article

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