Structure-activity relationship for FDA approved drugs as inhibitors of the human sodium taurocholate cotransporting polypeptide (NTCP)

Molecular Pharmaceutics

Volumn 10, Issue 3, 2013, Pages 1008-1019

  Dong, Zhongqi ^a   Ekins, Sean ^a,b   Polli, James E ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^b Collaborations in Chemistry ^*  (United States)

Author keywords

apical sodium dependent bile acid transporter (ASBT); Bayesian; pharmacophore; sodium taurocholate cotransporting polypeptide (NTCP); transporter

Indexed keywords

ABACAVIR; ACARBOSE; APICAL SODIUM DEPENDENT BILE ACID TRANSPORTER; AZTREONAM; BENDROFLUMETHIAZIDE; BILE ACID; CHLOROQUINE; DILTIAZEM; ETHOSUXIMIDE; EZETIMIBE; INDOMETACIN; IRBESARTAN; KETOPROFEN; METHYLPREDNISOLONE; NEFAZODONE; NIFEDIPINE; NITRENDIPINE; OMEPRAZOLE; POLYPEPTIDE; PROBENECID; PROCHLORPERAZINE; PROPAFENONE; QUININE; ROSUVASTATIN; SIMVASTATIN; SODIUM TAUROCHOLATE COTRANSPORTING POLYPEPTIDE; TIOCONAZOLE; TIOTIXENE; UNCLASSIFIED DRUG; UNINDEXED DRUG; YOHIMBINE;

ARTICLE; BAYES THEOREM; CONTROLLED STUDY; CYTOTOXICITY; DRUG INHIBITION; DRUG SCREENING; FOOD AND DRUG ADMINISTRATION; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROPHOBICITY; IN VITRO STUDY; PHARMACOPHORE; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

EID: 84874588814     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300453k     Document Type: Article

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