A new series of HAPs as anti-HBV agents targeting at capsid assembly

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 17, 2014, Pages 4247-4249

  Yang, Xiu Yan ^a,b   Xu, Xiao Qian ^a,b   Guan, Hua ^c   Wang, Li Li ^b   Wu, Qin ^d   Zhao, Guo Ming ^b   Li, Song ^a,b  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

^c BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

^d BEIJING 302 HOSPITAL   (China)

Author keywords

Anti HBV; Capsid; HAPs; SEC

Indexed keywords

ANTIVIRUS AGENT; CYTOTOXIC AGENT; HETEROARYLDIHYDROPYRIMIDINE; LAMIVUDINE; UNCLASSIFIED DRUG; PYRIMIDINE DERIVATIVE; VIRUS DNA;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DNA REPLICATION; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; VIRUS CAPSID; VIRUS INHIBITION; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; HEPG2 CELL LINE; METABOLISM; MICROBIAL SENSITIVITY TEST; STRUCTURE ACTIVITY RELATION; SYNTHESIS; VIRUS REPLICATION;

HEPATITIS B VIRUS; MIRIDAE;

ANTIVIRAL AGENTS; CAPSID; CELL SURVIVAL; DNA, VIRAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HEP G2 CELLS; HEPATITIS B VIRUS; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

EID: 84906934387     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.07.032     Document Type: Article

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