Interaction of digitalis-like compounds with liver uptake transporters NTCP, OATP1B1, and OATP1B3

Molecular Pharmaceutics

Volumn 11, Issue 6, 2014, Pages 1844-1855

  Gozalpour, Elnaz ^a   Greupink, Rick ^a   Wortelboer, Heleen M ^b   Bilos, Albert ^a   Schreurs, Marieke ^a   Russel, Frans G M ^a   Koenderink, Jan B ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b TNO   (Netherlands)

Author keywords

bufadienolides; cardenolides; cell transport; convallatoxin; digitalis like compounds; dihydroouabain; drug induced toxicity; NTCP; OATP1B1; OATP1B3; ouabagenin; ouabain

Indexed keywords

CARDIAC GLYCOSIDE; CONVALLATOXIN; CYMARIN; DEHYDROOUABAIN; DIGITOXIGENIN; DIGITOXIN; DIGOXIGENIN; DIGOXIN; DIHYDROOUABAIN; ESTRADIOL 17 GLUCURONIDE; GITOXIGENIN; HYDROXYL GROUP; OUABAGENIN; OUABAIN; PERUVOSIDE; PLANT GLYCOSIDE; PROSCILLARIDIN; SODIUM BILE ACID COTRANSPORTER; SOLUTE CARRIER ORGANIC ANION TRANSPORTER 1B1; SOLUTE CARRIER ORGANIC ANION TRANSPORTER 1B3; STROPHANTHIDIN; STROPHANTHIDOL; SUGAR; TAUROCHOLIC ACID; UNCLASSIFIED DRUG; CARRIER PROTEIN; COTRANSPORTER; DIGITALIS; ORGANIC ANION TRANSPORTER; SLCO1B1 PROTEIN, HUMAN; SLCO1B3 PROTEIN, HUMAN; SODIUM-BILE ACID COTRANSPORTER;

ANIMAL CELL; ARTICLE; CHEMICAL STRUCTURE; CHO CELL LINE; CONTROLLED STUDY; DRUG INTERACTION; DRUG UPTAKE; EMBRYO; HUMAN; HUMAN CELL; IC 50; KIDNEY CELL; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; ANIMAL; CELL LINE; CRICETULUS; HAMSTER; HEK293 CELL LINE; LIVER; METABOLISM; PHYSIOLOGY; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; CELL LINE; CHO CELLS; CRICETINAE; CRICETULUS; DIGITALIS; HEK293 CELLS; HUMANS; LIVER; MEMBRANE TRANSPORT PROTEINS; ORGANIC ANION TRANSPORTERS; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; SYMPORTERS;

EID: 84901814488     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp400699p     Document Type: Article

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