Coronary microvascular dysfunction, microvascular angina, and treatment strategies

JACC: Cardiovascular Imaging

Volumn 8, Issue 2, 2015, Pages 210-220

  Marinescu, Mark A ^a   Löffler, Adrián I ^a   Ouellette, Michelle ^a   Smith, Lavone ^a   Kramer, Christopher M ^a   Bourque, Jamieson M ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

cardiac syndrome X; coronary flow reserve; coronary microvascular dysfunction; microvascular angina; myocardial perfusion reserve

Indexed keywords

ARGININE; DILTIAZEM; DOXAZOSIN; ESTROGEN; PRAVASTATIN; QUINAPRIL; SILDENAFIL;

CARDIOVASCULAR MAGNETIC RESONANCE; CORONARY FLOW RESERVE; CORONARY MICROVASCULAR DYSFUNCTION; HEART DISEASE; HEART MUSCLE PERFUSION; HUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; SYNDROME X; SYSTEMATIC REVIEW; THORAX PAIN; TRANSCUTANEOUS NERVE STIMULATION; ANGIOCARDIOGRAPHY; BLOOD FLOW; CORONARY ARTERY BLOOD FLOW; DIFFERENTIAL DIAGNOSIS; HEART MUSCLE REVASCULARIZATION; MICROCIRCULATION; MICROVASCULAR ANGINA; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PHYSIOLOGY; PRACTICE GUIDELINE; PROCEDURES;

CORONARY ANGIOGRAPHY; CORONARY CIRCULATION; DIAGNOSIS, DIFFERENTIAL; HUMANS; MAGNETIC RESONANCE IMAGING, CINE; MICROCIRCULATION; MICROVASCULAR ANGINA; MYOCARDIAL REVASCULARIZATION; POSITRON-EMISSION TOMOGRAPHY; PRACTICE GUIDELINES AS TOPIC; REGIONAL BLOOD FLOW;

EID: 84923070278     PISSN: 1936878X     EISSN: 18767591     Source Type: Journal    
DOI: 10.1016/j.jcmg.2014.12.008     Document Type: Review

References (78)

1. L.J. Shaw, C.N.B. Merz, and C.J. Pepine The economic burden of angina in women with suspected ischemic heart disease: results from the National Institutes of Health-National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation Circulation 114 2006 894 904
2. C.J. Pepine, R.D. Anderson, and B.L. Sharaf Coronary microvascular reactivity to adenosine predicts adverse outcome in women evaluated for suspected ischemia J Am Coll Cardiol 55 2010 2825 2832
3. P.M. Farrehi, S.J. Bernstein, and M. Rasak Frequency of negative coronary arteriographic findings in patients with chest pain is related to community practice patterns Am J Manag Care 8 2002 643 648
4. S.M. Bradley, T.M. Maddox, and M.A. Stanislawski Normal coronary rates for elective angiography in the Veterans Affairs Healthcare System: insights from the VA CART program (Veterans Affairs Clinical Assessment Reporting and Tracking) J Am Coll Cardiol 63 2014 417 426
5. S.E. Reis, R. Holubkov, and J.S. Lee Coronary flow velocity response to adenosine characterizes coronary microvascular function in women with chest pain and no obstructive coronary disease. Results from the pilot phase of the Women's Ischemia Syndrome Evaluation (WISE) study J Am Coll Cardiol 33 1999 1469 1475
6. E.M. Geltman, C.G. Henes, M.J. Senneff, B.E. Sobel, and S.R. Bergmann Increased myocardial perfusion at rest and diminished perfusion reserve in patients with angina and angiographically normal coronary arteries J Am Coll Cardiol 16 1990 586 595
7. S. Graf, A. Khorsand, and M. Gwechenberger Typical chest pain and normal coronary angiogram: cardiac risk factor analysis versus PET for detection of microvascular disease J Nucl Med 48 2007 175 181
8. V.L. Murthy, M. Naya, and C.R. Foster Improved cardiac risk assessment with noninvasive measures of coronary flow reserve Circulation 124 2011 2215 2224
9. M.B. Britten, A.M. Zeiher, and V. Schächinger Microvascular dysfunction in angiographically normal or mildly diseased coronary arteries predicts adverse cardiovascular long-term outcome Coron Artery Dis 15 2004 259 264
10. B.A. Herzog, L. Husmann, and I. Valenta Long-term prognostic value of 13N-ammonia myocardial perfusion positron emission tomography J Am Coll Cardiol 54 2009 150 156
11. K. Fukushima, M.S. Javadi, and T. Higuchi Prediction of short-term cardiovascular events using quantification of global myocardial flow reserve in patients referred for clinical 82Rb PET perfusion imaging J Nucl Med 52 2011 726 732
12. H.G. Kemp, P.S. Vokonas, P.F. Cohn, and R. Gorlin The anginal syndrome associated with normal coronary arteriograms. Report of a six year experience Am J Med 54 1973 735 742
13. R. Bugiardini, and C.N. Bairey Merz Angina with "normal" coronary arteries: a changing philosophy JAMA 293 2005 477 484
14. F. Crea, P.G. Camici, and C.N. Bairey Merz Coronary microvascular dysfunction: an update Eur Heart J 35 2014 1101 1111
15. I.A.C. Vermeltfoort, P.G.H.M. Raijmakers, and I.I. Riphagen Definitions and incidence of cardiac syndrome X: review and analysis of clinical data Clin Res Cardiol 99 2010 475 481
16. T.D. Karamitsos, J.R. Arnold, and T.J. Pegg Patients with syndrome X have normal transmural myocardial perfusion and oxygenation: a 3-T cardiovascular magnetic resonance imaging study Circ Cardiovasc Imaging 5 2012 194 200
17. G.A. Lanza, A. Buffon, and A. Sestito Relation between stress-induced myocardial perfusion defects on cardiovascular magnetic resonance and coronary microvascular dysfunction in patients with cardiac syndrome X J Am Coll Cardiol 51 2008 466 472
18. J. Herrmann, J.C. Kaski, and A. Lerman Coronary microvascular dysfunction in the clinical setting: from mystery to reality Eur Heart J 33 2012 2771 2782b
19. E. Jones, W. Eteiba, and N.B. Merz Cardiac syndrome X and microvascular coronary dysfunction Trends Cardiovasc Med 22 2012 161 168
20. B.L. Gerber Quantification of myocardial perfusion and myocardial perfusion reserve by positron emission tomography and cardiovascular magnetic resonance imaging J Am Coll Cardiol 60 2012 1556 1557
21. P.W. Serruys, C. Di Mario, and J. Piek Prognostic value of intracoronary flow velocity and diameter stenosis in assessing the short- and long-term outcomes of coronary balloon angioplasty: the DEBATE Study (Doppler Endpoints Balloon Angioplasty Trial Europe) Circulation 96 1997 3369 3377
22. J.A. Suwaidi, S. Hamasaki, S.T. Higano, R.A. Nishimura, D.R. Holmes, and A. Lerman Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction Circulation 101 2000 948 954
23. P. Knaapen, P.G. Camici, and K.M. Marques Coronary microvascular resistance: methods for its quantification in humans Basic Res Cardiol 104 2009 485 498
24. J. Wei, P.K. Mehta, and B.D. Johnson Safety of coronary reactivity testing in women with no obstructive coronary artery disease J Am Coll Cardiol Intv 5 2012 646 653
25. A. Saraste, S. Kajander, C. Han, S.V. Nesterov, and J. Knuuti PET: is myocardial flow quantification a clinical reality? J Nucl Cardiol 19 2012 1044 1059
26. 2O PET imaging J Am Coll Cardiol 64 2014 1464 1475
27. V.L. Murthy, B.C. Lee, and A. Sitek Comparison and prognostic validation of multiple methods of quantification of myocardial blood flow with 82Rb PET J Nucl Med 55 2014 1952 1958
28. J.P. Pärkkä, P. Niemi, and A. Saraste Comparison of MRI and positron emission tomography for measuring myocardial perfusion reserve in healthy humans Magn Reson Med 55 2006 772 779
29. G. Morton, A. Chiribiri, and M. Ishida Quantification of absolute myocardial perfusion in patients with coronary artery disease: comparison between cardiovascular magnetic resonance and positron emission tomography J Am Coll Cardiol 60 2012 1546 1555
30. A.G. Elkington, P.D. Gatehouse, N.A. Ablitt, G.-Z. Yang, D.N. Firmin, and D.J. Pennell Interstudy reproducibility of quantitative perfusion cardiovascular magnetic resonance J Cardiovasc Magn Reson 7 2005 815 822
31. A.R. Patel, P.F. Antkowiak, and K.R. Nandalur Assessment of advanced coronary artery disease: advantages of quantitative cardiac magnetic resonance perfusion analysis J Am Coll Cardiol 56 2010 561 569
32. M. Salerno, and C.M. Kramer Advances in parametric mapping with CMR imaging J Am Coll Cardiol Img 6 2013 806 822
33. K. Bratis, I. Mahmoud, A. Chiribiri, and E. Nagel Quantitative myocardial perfusion imaging by cardiovascular magnetic resonance and positron emission tomography J Nucl Cardiol 20 2013 857 871
34. M. Salerno, and G.A. Beller Noninvasive assessment of myocardial perfusion Circ Cardiovasc Imaging 2 2009 412 424
35. R. Vogel, A. Indermühle, and J. Reinhardt The quantification of absolute myocardial perfusion in humans by contrast echocardiography: algorithm and validation J Am Coll Cardiol 45 2005 754 762
36. H.-J. Youn, and E. Foster Demonstration of coronary artery flow using transthoracic Doppler echocardiography J Am Soc Echocardiogr 17 2004 178 185
37. M. Takeuchi, J.A. Lodato, K.T. Furlong, R.M. Lang, and J. Yoshikawa Feasibility of measuring coronary flow velocity and reserve in the left anterior descending coronary artery by transthoracic Doppler echocardiography in a relatively obese American population Echocardiography 22 2005 225 232
38. B.L. Sharaf, C.J. Pepine, and R.A. Kerensky Detailed angiographic analysis of women with suspected ischemic chest pain (pilot phase data from the NHLBI-sponsored Women's Ischemia Syndrome Evaluation [WISE] Study Angiographic Core Laboratory) Am J Cardiol 87 2001 937 941 A3
39. K.L. Gould, and K. Lipscomb Effects of coronary stenoses on coronary flow reserve and resistance Am J Cardiol 34 1974 48 55
40. J.C. Kaski, and G. Russo Cardiac syndrome X: an overview Hosp Pract (1995) 35 2000 75 76 79-82, 85-88, 91-94
41. D.F. Pauly, B.D. Johnson, and R.D. Anderson In women with symptoms of cardiac ischemia, nonobstructive coronary arteries, and microvascular dysfunction, angiotensin-converting enzyme inhibition is associated with improved microvascular function: a double-blind randomized study from the National Heart, Lung and Blood Institute Women's Ischemia Syndrome Evaluation (WISE) Am Heart J 162 2011 678 684
42. J.C. Kaski, G. Rosano, S. Gavrielides, and L. Chen Effects of angiotensin-converting enzyme inhibition on exercise-induced angina and ST segment depression in patients with microvascular angina J Am Coll Cardiol 23 1994 652 657
43. W. Motz, and B.E. Strauer Improvement of coronary flow reserve after long-term therapy with enalapril Hypertension 27 1996 1031 1038
44. A.A. Bavry, E.M. Handberg, and T. Huo Aldosterone inhibition and coronary endothelial function in women without obstructive coronary artery disease: An ancillary study of the National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation Am Heart J 167 2014 826 832
45. M.E. McIvor, C. Undemir, J. Lawson, and J. Reddinger Clinical effects and utility of intracoronary diltiazem Cathet Cardiovasc Diagn 35 1995 287 293
46. G. Sutsch, E. Oechslin, I. Mayer, and O.M. Hess Effect of diltiazem on coronary flow reserve in patients with microvascular angina Int J Cardiol 52 1995 135 143
47. R.O. Cannon, R.M. Watson, D.R. Rosing, and S.E. Epstein Efficacy of calcium channel blocker therapy for angina pectoris resulting from small-vessel coronary artery disease and abnormal vasodilator reserve Am J Cardiol 56 1985 242 246
48. R.O. Cannon, J.E. Brush, W.H. Schenke, C.M. Tracy, and S.E. Epstein Beneficial and detrimental effects of lidoflazine in microvascular angina Am J Cardiol 66 1990 37 41
49. J.L. Houghton, T.A. Pearson, and R.G. Reed Cholesterol lowering with pravastatin improves resistance artery endothelial function: report of six subjects with normal coronary arteriograms Chest 118 2000 756 760
50. X. Zhang, Q. Li, and J. Zhao Effects of combination of statin and calcium channel blocker in patients with cardiac syndrome X Coron Artery Dis 25 2014 40 44
51. P. Eshtehardi, M.C. McDaniel, and S.S. Dhawan Effect of intensive atorvastatin therapy on coronary atherosclerosis progression, composition, arterial remodeling, and microvascular function J Invasive Cardiol 24 2012 522 529
52. M. Caliskan, D. Erdogan, and H. Gullu Effects of atorvastatin on coronary flow reserve in patients with slow coronary flow Clin Cardiol 30 2007 475 479
53. A. Nemes, T. Forster, N. Gruber, and M. Csanady Coronary flow velocity reserve and indices describing aortic distensibility in patients after coronary angiography Int J Cardiol 96 2004 29 33
54. J.O. Lundberg, E. Weitzberg, and M.T. Gladwin The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics Nat Rev Drug Discov 7 2008 156 167
55. S.J. Denardo, X. Wen, and E.M. Handberg Effect of phosphodiesterase type 5 inhibition on microvascular coronary dysfunction in women: a Women's Ischemia Syndrome Evaluation (WISE) ancillary study Clin Cardiol 34 2011 483 487
56. M. Bøttcher, H.E. Bøtker, H. Sonne, T.T. Nielsen, and J. Czernin Endothelium-dependent and -independent perfusion reserve and the effect of L-arginine on myocardial perfusion in patients with syndrome X Circulation 99 1999 1795 1801
57. K. Egashira, Y. Hirooka, T. Kuga, M. Mohri, and A. Takeshita Effects of L-arginine supplementation on endothelium-dependent coronary vasodilation in patients with angina pectoris and normal coronary arteriograms Circulation 94 1996 130 134
58. J. Gellman, J.M. Hare, and C.J. Lowenstein L-arginine ameliorates the abnormal sympathetic response of the dysfunctional human coronary microvasculature Angiology 55 2004 1 8
59. A. Lerman, J.C. Burnett, S.T. Higano, L.J. McKinley, and D.R. Holmes Long-term L-arginine supplementation improves small-vessel coronary endothelial function in humans Circulation 97 1998 2123 2128
60. H.E. Bøtker, H.S. Sonne, O. Schmitz, and T.T. Nielsen Effects of doxazosin on exercise-induced angina pectoris, ST-segment depression, and insulin sensitivity in patients with syndrome X Am J Cardiol 82 1998 1352 1356
61. S.D. Rosen, R. Lorenzoni, J.C. Kaski, R.A. Foale, and P.G. Camici Effect of alpha1-adrenoceptor blockade on coronary vasodilator reserve in cardiac syndrome X J Cardiovasc Pharmacol 34 1999 554 560
62. C.N. Bairey Merz, M.B. Olson, and C. McClure A randomized controlled trial of low-dose hormone therapy on myocardial ischemia in postmenopausal women with no obstructive coronary artery disease: results from the National Institutes of Health/National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation (WISE) Am Heart J 159 2010 987.e1 987.e7
63. J. Knuuti, R. Kalliokoski, and T. Janatuinen Effect of estradiol-drospirenone hormone treatment on myocardial perfusion reserve in postmenopausal women with angina pectoris Am J Cardiol 99 2007 1648 1652
64. G.A.J. Jessurun, R.W.M. Hautvast, R.A. Tio, and M.J.L. DeJongste Electrical neuromodulation improves myocardial perfusion and ameliorates refractory angina pectoris in patients with syndrome X: fad or future? Eur J Pain 7 2003 507 512
65. C. Luo, D. Liu, and G. Wu Effect of enhanced external counterpulsation on coronary slow flow and its relation with endothelial function and inflammation: a mid-term follow-up study Cardiology 122 2012 260 268
66. J.E. Sanderson, K.S. Woo, H.K. Chung, W.W. Chan, L.K. Tse, and H.D. White The effect of transcutaneous electrical nerve stimulation on coronary and systemic haemodynamics in syndrome X Coron Artery Dis 7 1996 547 552
67. P.K. Mehta, P. Goykhman, and L.E.J. Thomson Ranolazine improves angina in women with evidence of myocardial ischemia but no obstructive coronary artery disease J Am Coll Cardiol Img 4 2011 514 522
68. A. Villano, A. Di Franco, and R. Nerla Effects of ivabradine and ranolazine in patients with microvascular angina pectoris Am J Cardiol 112 2013 8 13
69. G. Russo, A. Di Franco, and P. Lamendola Lack of effect of nitrates on exercise stress test results in patients with microvascular angina Cardiovasc Drugs Ther 27 2013 229 234
70. R. Bugiardini, A. Borghi, A. Pozzati, F. Ottani, G.L. Morgagni, and P. Puddu The paradox of nitrates in patients with angina pectoris and angiographically normal coronary arteries Am J Cardiol 72 1993 343 347
71. J. Czernin, R.J. Barnard, and K.T. Sun Effect of short-term cardiovascular conditioning and low-fat diet on myocardial blood flow and flow reserve Circulation 92 1995 197 204
72. R. Nerla, P. Tarzia, and A. Sestito Effect of bariatric surgery on peripheral flow-mediated dilation and coronary microvascular function Nutr Metab Cardiovasc Dis 22 2012 626 634
73. P.G. Camici, and F. Crea Coronary microvascular dysfunction N Engl J Med 356 2007 830 840
74. K. Iino, H. Watanabe, and T. Iino Candesartan improves impaired endothelial function in the human coronary artery Coron Artery Dis 23 2012 278 283
75. J.-W. Chen, N.-W. Hsu, T.-C. Wu, S.-J. Lin, and M.-S. Chang Long-term angiotensin-converting enzyme inhibition reduces plasma asymmetric dimethylarginine and improves endothelial nitric oxide bioavailability and coronary microvascular function in patients with syndrome X Am J Cardiol 90 2002 974 982
76. S. Setoguchi, M. Mohri, H. Shimokawa, and A. Takeshita Tetrahydrobiopterin improves endothelial dysfunction in coronary microcirculation in patients without epicardial coronary artery disease J Am Coll Cardiol 38 2001 493 498
77. T.O. Kiviniemi, A. Saraste, and J.O. Toikka Effects of cognac on coronary flow reserve and plasma antioxidant status in healthy young men Cardiovasc Ultrasound 6 2008 25
78. P.A. Kaufmann, T. Gnecchi-Ruscone, M. di Terlizzi, K.P. Schäfers, T.F. Luscher, and P.G. Camici Coronary heart disease in smokers: vitamin C restores coronary microcirculatory function Circulation 102 2000 1233 1238