Coronary heart desease in smokers: Vitamin C restores coronary microcirculatory function

Circulation

Volumn 102, Issue 11, 2000, Pages 1233-1238

  Kaufmann, Philipp A ^a,b   Gnecchi Ruscone, Tomaso ^a   Di Terlizzi, Marco ^a   Schäfers, Klaus P ^a,c   Lüscher, Thomas F ^b   Camici, Paolo G ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Blood flow; Circulation; Coronary arteries; Smoking; Tomography; Vitamins

Indexed keywords

ASCORBIC ACID; ANTIOXIDANT;

ADULT; ARTICLE; BLOOD VESSEL TONE; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DRUG EFFECT; HUMAN; ISCHEMIC HEART DISEASE; MALE; MICROCIRCULATION; OXIDATIVE STRESS; PRIORITY JOURNAL; SMOKING; BLOOD FLOW; BLOOD PRESSURE; CLINICAL TRIAL; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CORONARY BLOOD VESSEL; DOSE RESPONSE; ELECTROCARDIOGRAPHY; HEART RATE; MIDDLE AGED; PERICARDIUM; PHYSIOLOGY; VASCULAR RESISTANCE;

ADULT; ANTIOXIDANTS; ASCORBIC ACID; BLOOD PRESSURE; CORONARY VESSELS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROCARDIOGRAPHY; HEART RATE; HUMANS; MALE; MICROCIRCULATION; MIDDLE AGED; OXIDATIVE STRESS; PERICARDIUM; REGIONAL BLOOD FLOW; SMOKING; TOMOGRAPHY, EMISSION-COMPUTED; VASCULAR RESISTANCE;

EID: 0034641618     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.102.11.1233     Document Type: Article

References (59)

1. Relation between aortic atherosclerosis and the use of cigarettes and alcohol: An autopsy study
2. Statement on smoking and cardiovascular disease for health care professionals
3. Free radical chemistry of cigarette smoke and its toxicological implications
4. Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults
5. Long-term cigarette smoking impairs endothelium-dependent coronary arterial vasodilator function
6. Passive smoking and impaired endothelium-dependent arterial dilation in healthy young adults
7. Does passive smoking impair endothelium-dependent coronary artery dilation in women?
8. Ascorbate is an outstanding antioxidant in human blood plasma
9. The antioxidant role of vitamin C
10. The influence of smoking on vitamin C status in adults
11. Vitamins E and C and lipid peroxidation in plasma and arterial tissue of smokers and nonsmokers
12. Antioxidant vitamin C improves endothelial dysfunction in chronic smokers
13. Vitamin C improves endothelial dysfunction of epicardial coronary arteries in hypertensive patients
14. Analysis of probability as an aid in the clinical diagnosis of coronary artery disease
15. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia
16. Physical performance of the latest generation of commercial positron scanner
17. Measurement of myocardial blood flow with oxygen-15 labelled water: Comparison of different administration protocols
18. 15O blood pool scan
19. Relation between myocardial blood flow and the severity of coronary artery stenosis
20. Safety profile of adenosine stress perfusion imaging: Results from the Adenoscan Multicenter Trial Registry
21. Guidelines for clinical use of cardiac radionuclide imaging. A report of the American Heart Association/American College of Cardiology Task Force on Assessment of Diagnostic and Therapeutic Cardiovascular Procedures, Committee on Radionuclide Imaging, developed in collaboration with the American Society of Nuclear Cardiology
22. Effects of adenosine on human coronary circulation
23. 15-labeled water and PET
24. Early detection of abnormal coronary flow reserve in asymptomatic men at high risk for coronary artery disease using positron emission tomography
25. Noninvasive quantification of regional myocardial flow reserve in patients with coronary atherosclerosis using nitrogen- 13 ammonia positron emission tomography: Determination of extent of altered vascular reactivity
26. Delayed response of myocardial flow reserve to lipid-lowering therapy with fluvastatin
27. Coronary hemodynamics and myocardial metabolism during and after pacing stress in normal humans
28. Reproducibility of measurements of regional resting and hyperemic myocardial blood flow assessed with PET
29. Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension
30. Physiologic basis for assessing critical coronary stenosis
31. Role of positron emission tomography in the investigation of human coronary circulatory function
32. 'Structural factor' in primary and secondary hypertension
33. Microcirculation: What is the role of calcium antagonists?
34. Influence of serum cholesterol and other coronary risk factors on vasomotion of angiographically normal coronary arteries
35. Normalization of abnormal coronary vasomotion by calcium antagonists in patients with hypertension
36. Impairment of coronary vascular reserve and ACh-induced coronary vasodilation in diabetic patients with angiographically normal coronary arteries and normal left ventricular systolic function
37. Endothelium-dependent dilation of the coronary microvasculature is impaired in dilated cardiomyopathy
38. Endothelium-dependent and -independent relaxations to adenosine in guinea pig aorta
39. Coronary vasodilation to acetylcholine, adenosine and bradykinin in dogs: Effects of inhibition of NO-synthesis and captopril
40. Endothelial release of nitric oxide contributes to the vasodilator effect of adenosine in humans
41. The adenosine hypothesis of metabolic regulation of coronary flow in the light of newly recognized properties of the coronary endothelium
42. Coronary flow velocity response to adenosine characterizes coronary microvascular function in women with chest pain and no obstructive coronary disease
43. Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation: Contribution to alterations of vasomotor tone
44. Effect of chronic oral consumption of nicotine on the rabbit aortic endothelium
45. Intimal ultrastructure of human umbilical arteries: Observation on arteries from newborn children of smoking and nonsmoking mothers
46. Oxidized low density lipoproteins cause contraction and inhibit relaxation in the pig coronary artery
47. LDLs impair vasomotor function of the coronary microcirculation: Role of superoxide anions
48. L-Arginine normalizes coronary vasomotion in long-term smoker
49. Intracoronary infusion of reduced glutathione improves endothelial vasomotor response to acetylcholine in human coronary circulation
50. Vitamin C attenuates abnormal vasomotor reactivity in spasm coronary arteries in patients with coronary spastic angina
51. Noninvasive quantification of regional blood flow in the human heart using N-13 ammonia and dynamic positron emission tomographic imaging
52. 15O]water techniques
53. Validation of nitrogen-13-ammonia tracer kinetic model for quantification of myocardial blood flow using PET
54. Mediterranean dietary pattern in a randomized trial: Prolonged survival and possible reduced cancer rate
55. Serum total cholesterol and long-term coronary heart disease mortality in different cultures: Twenty-five-year follow-up of the Seven Countries Study
56. Classical risk factors and emerging elements in the risk profile for coronary artery disease
57. Vitamin exhibits prooxidant properties
58. Dietary antioxidants and carotid artery wall thickness. The ARIC Study. Atherosclerosis Risk In Communities Study
59. Smoking, antioxidants, essential fatty acids and coronary heart disease