Effects of ivabradine and ranolazine in patients with microvascular angina pectoris

American Journal of Cardiology

Volumn 112, Issue 1, 2013, Pages 8-13

  Villano, Angelo ^a   Di Franco, Antonino ^a   Nerla, Roberto ^a   Sestito, Alfonso ^a   Tarzia, Pierpaolo ^a   Lamendola, Priscilla ^a   Di Monaco, Antonio ^a   Sarullo, Filippo Maria ^b   Lanza, Gaetano Antonio ^a   Crea, Filippo ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b Buccheri La Ferla Fatebenefratelli Hospital   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM ANTAGONIST; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IVABRADINE; NITRATE; PLACEBO; RANOLAZINE;

ADULT; ANGINA PECTORIS; ANGIOCARDIOGRAPHY; BLOOD VESSEL FUNCTION; CARDIOPULMONARY EXERCISE TEST; CLINICAL ARTICLE; COLD PRESSOR TEST; CONFERENCE PAPER; CONTROLLED STUDY; CORONARY ARTERY DILATATION; CORONARY FLOW RESERVE; DRUG EFFECT; EUROQOL SCALE; FEMALE; FOLLOW UP; HUMAN; MALE; MICROANGIOPATHY; MICROVASCULAR ANGINA PECTORIS; MICROVASCULAR ISCHEMIA; PRIORITY JOURNAL; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; SEATTLE ANGINA QUESTIONNAIRE; TREATMENT RESPONSE; VASCULAR ENDOTHELIUM;

ACETANILIDES; ANALYSIS OF VARIANCE; ANGINA PECTORIS; BENZAZEPINES; CHI-SQUARE DISTRIBUTION; CORONARY ANGIOGRAPHY; ENZYME INHIBITORS; EXERCISE TEST; FEMALE; HUMANS; MALE; MIDDLE AGED; PIPERAZINES; PLACEBOS; QUALITY OF LIFE; QUESTIONNAIRES; TREATMENT OUTCOME;

EID: 84879115445     PISSN: 00029149     EISSN: 18791913     Source Type: Journal    
DOI: 10.1016/j.amjcard.2013.02.045     Document Type: Conference Paper

References (30)

1. G.A. Lanza, and F. Crea Primary coronary microvascular dysfunction: clinical presentation, pathophysiology and management Circulation 121 2010 2317 2325
2. P. Lamendola, G.A. Lanza, A. Spinelli, G.A. Sgueglia, A. Di Monaco, L. Barone, A. Sestito, and F. Crea Long-term prognosis of patients with cardiac syndrome X Int J Cardiol 140 2010 197 199
3. J.C. Kaski, G. Rosano, S. Gavrielides, and L. Chen Effects of angiotensin-converting enzyme inhibition on exercise-induced angina and ST segment depression in patients with microvascular angina J Am Coll Cardiol 23 1994 652 657
4. M. Kayikcioglu, S. Payzin, O. Yavuzgil, H. Kultursay, L.H. Can, and I. Soydan Benefits of statin treatment in cardiac syndrome-X1 Eur Heart J 24 2003 1999 2005
5. P.M. Elliott, K. Krzyzowska-Dickinson, R. Calvino, C. Hann, and J.C. Kaski Effect of oral aminophylline in patients with angina and normal coronary arteriograms (cardiac syndrome X) Heart 77 1997 523 526
6. P. Collins, G.M. Rosano, P.M. Sarrel, L. Ulrich, S. Adamopoulos, C.M. Beale, J.G. McNeill, and P.A. Poole-Wilson 17 beta-estradiol attenuates acetylcholine-induced coronary arterial constriction in women but not men with coronary heart disease Circulation 92 1995 24 30
7. G.A. Sgueglia, A. Sestito, A. Spinelli, B. Cioni, F. Infusino, F. Papacci, F. Bellocci, M. Meglio, F. Crea, and G.A. Lanza Long-term follow-up of patients with cardiac syndrome X treated by spinal cord stimulation Heart 93 2007 591 597
8. f inhibitor, in stable angina. A randomized, double blind, multicentered, placebo-controlled trial Circulation 107 2003 817 823
9. J.C. Tardif, I. Ford, M. Tendera, M.G. Bourassa, K. Fox, and INITIATIVE Investigators Efficacy of ivabradine, a new selective I(f) inhibitor, compared with atenolol in patients with chronic stable angina Eur Heart J 26 2005 2529 2536
10. B.R. Chaitman, C.J. Pepine, J.O. Parker, J. Skopal, G. Chumakova, J. Kuch, W. Wang, S.L. Skettino, A.A. Wolff, and Combination Assessment of Ranolazine In Stable Angina (CARISA) Investigators Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: a randomized controlled trial JAMA 291 2004 309 316
11. B.R. Chaitman, S.L. Skettino, J.O. Parker, P. Hanley, J. Meluzin, J. Kuch, C.J. Pepine, W. Wang, J.J. Nelson, D.A. Hebert, A.A. Wolff, and MARISA Investigators Anti-ischemic effects and long-term survival during ranolazine monotherapy in patients with chronic severe angina J Am Coll Cardiol 43 2004 1375 1382
12. P.H. Stone, N.A. Gratsiansky, A. Blokhin, I.Z. Huang, L. Meng, and ERICA Investigators Antianginal efficacy of ranolazine when added to treatment with amlodipine: the ERICA (Efficacy of Ranolazine in Chronic Angina) trial J Am Coll Cardiol 48 2006 566 575
13. D. Di Francesco, and A.J. Camm Heart rate lowering by specific and selective If current inhibition with ivabradine. A new therapeutic perspective in cardiovascular disease Drugs 64 2004 1757 1765
14. L. Belardinelli, C. Antzelevitch, and H. Fraser Inhibition of late (sustained/persistent) sodium current: a potential drug target to reduce intracellular sodium-dependent calcium overload and its detrimental effects on cardiomyocyte function Eur Heart J 6 2004 I3 I7
15. W. Hayashida, C. van Eyll, M.F. Rousseau, and H. Pouleur Effects of ranolazine on left ventricular regional diastolic function in patients with ischemic heart disease Cardiovasc Drugs Ther 8 1994 741 747
16. P.K. Mehta, P. Goykhman, L.E. Thomson, C. Shufelt, J. Wei, Y. Yang, E. Gill, M. Minissian, L.J. Shaw, P.J. Slomka, M. Slivka, D.S. Berman, and C.N. Bairey Merz Ranolazine improves angina in women with evidence of myocardial ischemia but no obstructive coronary artery disease J Am Coll Cardiol Imag 4 2011 514 522
17. E.M. Geltman, C.G. Henes, M.J. Senneff, B.E. Sobel, and S.R. Bergmann Increased myocardial perfusion at rest and diminished perfusion reserve in patients with angina and angiographically normal coronary arteries J Am Coll Cardiol 16 1990 586 595
18. H.E. Bøtker, H.S. Sonne, J.P. Bagger, and T.T. Nielsen Impact of impaired coronary flow reserve and insulin resistance on myocardial energy metabolism in patients with syndrome X Am J Cardiol 79 1997 1615 1622
19. J.A. Spertus, J.A. Winder, T.A. Dewhurst, R.A. Deyo, J. Prodzinski, M. McDonell, and S.D. Fihn Development and evaluation of the Seattle Angina Questionnaire: a new functional status measure for coronary artery disease J Am Coll Cardiol 25 1995 333 341
20. A. Stewart Conceptual and methodologic issues in defining quality of life: state of the art Prog Cardiovasc Nurs 7 1992 3 11
21. EuroQol Group EuroQol - A new facility for the measurement of health-related quality of life Health Policy 16 1990 199 208
22. R.F. Wilson, K. Wyche, B.V. Christensen, S. Zimmer, and D.D. Laxson Effects of adenosine on human coronary arterial circulation Circulation 82 1990 1595 1606
23. J.O. Prior, T.H. Schindler, A.D. Facta, M. Hernandez-Pampaloni, R. Campisi, M. Dahlbom, and H.R. Schelbert Determinants of myocardial blood flow response to cold pressor testing and pharmacologic vasodilation in healthy humans Eur J Nucl Med Mol Imaging 34 2007 20 27
24. A. Sestito, G.A. Lanza, A. Di Monaco, P. Lamendola, G. Careri, P. Tarzia, G. Pinnacchio, I. Battipaglia, and F. Crea Relation between cardiovascular risk factors and coronary microvascular dysfunction in cardiac syndrome X J Cardiovasc Med (Hagerstown) 12 2011 322 327
25. R. Nerla, A. Di Monaco, A. Sestito, P. Lamendola, E. Di Stasio, F. Romitelli, G.A. Lanza, and F. Crea Transient endothelial dysfunction following flow mediated dilation assessment Heart Vessels 26 2011 524 529
26. L. Ghiadoni, F. Faita, M. Salvetti, C. Cordiano, A. Biggi, M. Puato, A. Di Monaco, L. De Siati, M. Volpe, G. Ambrosio, V. Gemignani, M.L. Muiesan, S. Taddei, G.A. Lanza, and F. Cosentino Assessment of flow-mediated dilation reproducibility: a nationwide multicenter study J Hypertens 30 2012 1399 1405
27. B. Clarke, K.M. Wyatt, and J.G. McCormack Ranolazine increases active pyruvate dehydrogenase in perfused normoxic rat hearts: evidence for an indirect mechanism J Mol Cell Cardiol 28 1996 341 350
28. S.H. Deshmukh, S.R. Patel, E. Pinassi, C. Mindrescu, E.V. Hermance, M.N. Infantino, J.T. Coppola, and C.S. Staniloae Ranolazine improves endothelial function in patients with stable coronary artery disease Coron Artery Dis 20 2009 343 347
29. P. Lamendola, R. Nerla, D. Pitocco, A. Villano, G. Scavone, A. Stazi, G. Russo, A. Di Franco, A. Sestito, G. Ghirlanda, G.A. Lanza, and F. Crea Effect of ranolazine on arterial endothelial function in patients with type 2 diabetes mellitus Atherosclerosis 226 2013 157 160
30. M. Aldakkak, A.K. Camara, J.S. Heisner, M. Yang, and D.F. Stowe Ranolazine reduces Ca2+ overload and oxidative stress and improves mitochondrial integrity to protect against ischemia reperfusion injury in isolated hearts Pharmacol Res 64 2011 381 392