The E–Id protein axis modulates the activities of the PI3K–AKT–mTORC1–Hif1a and c-myc/p19arf pathways to suppress innate variant TFH cell development, thymocyte expansion, and lymphomagenesis

Genes and Development

Volumn 29, Issue 4, 2015, Pages 409-425

  Miyazaki, Masaki ^a   Miyazaki, Kazuko ^a   Chen, Shuwen ^a   Chandra, Vivek ^a   Wagatsuma, Keisuke ^b   Agata, Yasutoshi ^b   Rodewald, Hans Reimer ^c   Saito, Rintaro ^a   Chang, Aaron N ^a   Varki, Nissi ^a   Kawamoto, Hiroshi ^d   Murre, Cornelis ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^d KYOTO UNIVERSITY   (Japan)

Author keywords

C Myc p19Arf ; FOXO mTORC1 pathway; Id proteins; T cell lymphoma; T cell quiescence; Tumor suppressor

Indexed keywords

E PROTEIN; GAMMA INTERFERON; IMMUNOGLOBULIN D; IMMUNOGLOBULIN G1; INHIBITOR OF DIFFERENTIATION 2; INHIBITOR OF DIFFERENTIATION 3; INHIBITOR OF DIFFERENTIATION PROTEIN; INTERLEUKIN 4; LYMPHOCYTE ANTIGEN RECEPTOR; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MYC PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REGULATOR PROTEIN; TRANSCRIPTION FACTOR E2A; TRANSCRIPTION FACTOR FKHR; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX LEUCINE ZIPPER TRANSCRIPTION FACTOR; CDKN2A PROTEIN, MOUSE; CYCLIN DEPENDENT KINASE INHIBITOR 2A; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; MYC PROTEIN, MOUSE; ONCOPROTEIN; STAT1 PROTEIN; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; BURKITT LYMPHOMA; CD4+ T LYMPHOCYTE; CELL EXPANSION; CELL FATE; CELL MATURATION; COLITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; FOLLICULAR HELPER T CELL; GERMINAL CENTER; LYMPHOCYTE MIGRATION; LYMPHOCYTE PROLIFERATION; LYMPHOMAGENESIS; MOUSE; NATURAL KILLER T CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T CELL LYMPHOMA; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; THYMOCYTE; TRANSCRIPTION INITIATION; ANIMAL; CELL DIFFERENTIATION; CELL PROLIFERATION; CYTOLOGY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; HELPER CELL; LYMPHOID TISSUE; LYMPHOMA; METABOLISM; PATHOPHYSIOLOGY;

MUS;

ANIMALS; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; CELL DIFFERENTIATION; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P16; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INHIBITOR OF DIFFERENTIATION PROTEINS; LYMPHOID TISSUE; LYMPHOMA; MICE; MULTIPROTEIN COMPLEXES; ONCOGENE PROTEIN V-AKT; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-MYC; STAT1 TRANSCRIPTION FACTOR; T-LYMPHOCYTES, HELPER-INDUCER; THYMOCYTES; TOR SERINE-THREONINE KINASES;

EID: 84923006671     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.255331.114     Document Type: Article

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