Syntheses and antituberculosis activity of 1,3-benzothiazinone sulfoxide and sulfone derived from BTZ043

ACS Medicinal Chemistry Letters

Volumn 6, Issue 2, 2015, Pages 128-133

  Tiwari, Rohit ^a   Miller, Patricia A ^a   Cho, Sanghyun ^b   Franzblau, Scott G ^b   Miller, Marvin J ^a  

^a UNIVERSITY OF NOTRE DAME   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

BTZ043; DprE1; oxidation; sulfone; sulfoxide; tuberculosis

Indexed keywords

1,3 BENZOTHIAZINONE SULFONE DERIVATIVE; 1,3 BENZOTHIAZINONE SULFOXIDE DERIVATIVE; ACETIC ACID; BTZ 043; DELAMANID; HYDROXYLAMINE; PRETOMANID; SULFONE DERIVATIVE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ACINETOBACTER BAUMANNII; AEROBIC METABOLISM; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL CELL WALL; BACTERIAL GROWTH; BACTERIAL STRAIN; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYCLOADDITION; DRUG BINDING; DRUG CONFORMATION; DRUG POTENCY; DRUG SYNTHESIS; ELECTROPHILICITY; ENZYME ACTIVE SITE; HUMAN; IN VITRO STUDY; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MASS SPECTROMETRY; MICROCOCCUS LUTEUS; MOLECULAR DOCKING; MOUSE; MYCOBACTERIUM AURUM; MYCOBACTERIUM VACCAE; NONHUMAN; NUCLEOPHILICITY; OXIDATION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS AERUGINOSA; ROOM TEMPERATURE; STAPHYLOCOCCUS AUREUS; TUBERCULOSIS;

EID: 84922921459     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml5003458     Document Type: Article

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