Transcriptomics and mechanistic elucidation of Alzheimer's disease risk genes in the brain and invitro models

Neurobiology of Aging

Volumn 36, Issue 2, 2015, Pages 1221.e15-1221.e28

  Martiskainen, Henna ^a,b   Viswanathan, Jayashree ^a,b   Nykänen, Niko Petteri ^c   Kurki, Mitja ^a,b   Helisalmi, Seppo ^a,b   Natunen, Teemu ^a,b   Sarajärvi, Timo ^a,b   Kurkinen, Kaisa M A ^a,b   Pursiheimo, Juha Pekka ^d   Rauramaa, Tuomas ^a,b   Alafuzoff, Irina ^e   Jääskeläinen, Juha E ^a,b   Leinonen, Ville ^a,b   Soininen, Hilkka ^a,b   Haapasalo, Annakaisa ^a,b   Huttunen, Henri J ^c   Hiltunen, Mikko ^a,b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

^d UNIVERSITY OF TURKU   (Finland)

^e UPPSALA UNIVERSITY   (Sweden)

Author keywords

Alzheimer's disease; Neurofibrillary pathology; Pathway analysis; Risk genes; Transcriptomics

Indexed keywords

ALPHA SECRETASE; AMYLOID BETA PROTEIN[1-42]; BETA SECRETASE; GAMMA SECRETASE; TAU PROTEIN; AMYLOID BETA PROTEIN; BIN1 PROTEIN, HUMAN; FERM DOMAIN-CONTAINING PROTEIN 4A, HUMAN; IMMUNOGLOBULIN RECEPTOR; MEMBRANE PROTEIN; MS4A6A PROTEIN, HUMAN; NUCLEAR PROTEIN; SECRETASE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TRANSCRIPTOME; TREM2 PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN;

AGED; ALLELE; ALZHEIMER DISEASE; ARTICLE; BIN1 GENE; BRAIN BIOPSY; CLU GENE; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ACTIVITY; ENZYME REGULATION; ENZYME SYNTHESIS; EXON; FEMALE; FRMD4A GENE; GENE; GENE CONTROL; GENE EXPRESSION; GENETIC CORRELATION; GENETIC RISK; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; MS4A6A GENE; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; QUANTITATIVE TRAIT LOCUS; RNA SPLICING; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSCRIPTOMICS; TREM2 GENE; BRAIN; GENE EXPRESSION PROFILING; GENETIC PREDISPOSITION; GENETICS; METABOLISM; NEUROFILAMENT; PATHOLOGY; PHOSPHORYLATION; RISK; VERY ELDERLY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; BRAIN; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IN VITRO TECHNIQUES; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; NEUROFIBRILS; NUCLEAR PROTEINS; PHOSPHORYLATION; RECEPTORS, IMMUNOLOGIC; RISK; TAU PROTEINS; TRANSCRIPTOME; TUMOR SUPPRESSOR PROTEINS;

EID: 84922881812     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2014.09.003     Document Type: Article

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