Increased expression of TREM2 in peripheral blood of Alzheimer's disease patients

Journal of Alzheimer's Disease

Volumn 38, Issue 3, 2014, Pages 497-501

  Hu, Nan ^a   Tan, Meng Shan ^b   Yu, Jin Tai ^a,b,c   Sun, Lei ^a   Tan, Lin ^a   Wang, Ying Li ^a   Jiang, Teng ^c   Tan, Lan ^a,b,c  

^a QINGDAO UNIVERSITY   (China)

^b OCEAN UNIVERSITY OF CHINA   (China)

^c NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Alzheimer's disease; biomarker; blood; diagnosis; mRNA; plasma; protein; TREM2

Indexed keywords

MESSENGER RNA; PEPTIDES AND PROTEINS; PROTEIN TREM2; UNCLASSIFIED DRUG;

AGED; ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; MONOCYTE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY;

ALZHEIMER'S DISEASE; BIOMARKER; BLOOD; DIAGNOSIS; MRNA; PLASMA; PROTEIN; TREM2;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; CASE-CONTROL STUDIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MENTAL STATUS SCHEDULE; RECEPTORS, IMMUNOLOGIC; RNA, MESSENGER; ROC CURVE;

EID: 84889650344     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-130854     Document Type: Article

References (26)

1. Castellani RJ, Rolston RK, Smith MA (2010) Alzheimer disease. Dis Mon 56, 484-546.
2. Jiang T, Yu JT, Tan L (2012) Novel disease-modifying therapies for Alzheimer's disease. J Alzheimers Dis 31, 475-492.
3. Hampel H, Wilcock G, Andrieu S, Aisen P, Blennow K, Broich K, Carrillo M, Fox NC, Frisoni GB, Isaac M, Lovestone S, Nordberg A, Prvulovic D, Sampaio C, Scheltens P, Weiner M,Winblad B, Coley N, Vellas B (2011) Biomarkers for Alzheimer's disease therapeutic trials. Prog Neurobiol 95, 579-593.
4. Xing YY, Yu JT, Cui WZ, Zhong XL,Wu ZC, Zhang Q, Tan L (2012) Blood clusterin levels, rs9331888 polymorphism, and the risk of Alzheimer's disease. J Alzheimers Dis 29, 515-519.
5. Guerreiro R, Wojtas A, Bras J, Carrasquillo M, Rogaeva E, Majounie E, Cruchaga C, Sassi C, Kauwe JS, Younkin S, Hazrati L, Collinge J, Pocock J, Lashley T, Williams J, Lambert JC, Amouyel P, Goate A, Rademakers R, Morgan K, Powell J, St George-Hyslop P, Singleton A, Hardy J (2013) TREM2 variants in Alzheimer's disease. N Engl J Med 368, 117-127.
6. Jonsson T, Stefansson H, Steinberg S, Jonsdottir I, Jonsson PV, Snaedal J, Bjornsson S, Huttenlocher J, Levey AI, Lah JJ, Rujescu D, Hampel H, Giegling I, Andreassen OA, Engedal K, Ulstein I, Djurovic S, Ibrahim-Verbaas C, Hofman A, Ikram MA, van Duijn CM, Thorsteinsdottir U, Kong A, Stefansson K (2013) Variant of TREM2 associated with the risk of Alzheimer's disease. N Engl J Med 368, 107-116.
7. Pottier C,Wallon D, Rousseau S, Rovelet-Lecrux A, Richard AC, Rollin-Sillaire A, Frebourg T, Campion D, Hannequin D (2013) TREM2 R47H variant as a risk factor for early-onset Alzheimer's disease. J Alzheimers Dis 35, 45-49.
8. ColonnaM(2003) TREMs in the immune system and beyond. Nat Rev Immunol 3, 445-453.
9. Jiang T, Yu JT, Zhu XC, Tan L (2013) TREM2 in Alzheimer's disease. Mol Neurobiol 48, 180-185.
10. Bajramovic JJ (2011) Regulation of innate immune responses in the central nervous system. CNS Neurol Disord Drug Targets 10, 4-24.
11. Hsieh CL, Koike M, Spusta SC, Niemi EC, Yenari M, Nakamura MC, Seaman WE (2009) A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia. J Neurochem 109, 1144-1156.
12. Schmid CD, Sautkulis LN, Danielson PE, Cooper J, Hasel KW, Hilbush BS, Sutcliffe JG, Carson MJ (2002) Heterogeneous expression of the triggering receptor expressed on myeloid cells-2 on adult murine microglia. J Neurochem 83, 1309-1320.
13. Frank S, Burbach GJ, BoninM,WalterM,StreitW, Bechmann I, Deller T (2008) TREM2 is upregulated in amyloid plaqueassociated microglia in aged APP23 transgenic mice. Glia 56, 1438-1447.
14. Melchior B, Garcia AE, Hsiung BK, Lo KM, Doose JM, Thrash JC, Stalder AK, Staufenbiel M, Neumann H, Carson MJ (2010) Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: Implications for vaccine-based therapies for Alzheimer's disease. ASN Neuro 2, e00037.
15. Cruchaga C, Kauwe JS, Harari O, Jin SC, Cai Y, Karch CM, Benitez BA, Jeng AT, Skorupa T, Carrell D, Bertelsen S, Bailey M, McKean D, Shulman JM, De Jager PL, Chibnik L, Bennett DA, Arnold SE, Harold D, Sims R, Gerrish A, Williams J, Van Deerlin VM, Lee VM, Shaw LM, Trojanowski JQ, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD, Peskind ER, Galasko D, Fagan AM, Holtzman DM, Morris JC, Goate AM (2013) GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease. Neuron 78, 256-268.
16. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDAWork Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34, 939-944.
17. Bustin SA, Benes V, Garson JA, Hellemans J, Huggett J, Kubista M, Mueller R, Nolan T, Pfaffl MW, Shipley GL, Vandesompele J, Wittwer CT (2009) The MIQE guidelines: Minimum information for publication of quantitative realtime PCR experiments. Clin Chem 55, 611-622.
18. Sun L, TanMS, Hu N,Yu JT, Tan L (2013) Exploring the value of plasma BIN1 as a potential biomarker for Alzheimer's disease. J Alzheimers Dis 37(2), 291-295. doi: 10.3233/JAD-130392
19. Lacombe F, Durrieu F, Briais A, Dumain P, Belloc F, Bascans E, Reiffers J, Boisseau MR, Bernard P (1997) Flow cytometry CD45 gating for immunophenotyping of acute myeloid leukemia. Leukemia 11, 1878-1886.
20. Zhang W, Wang LZ, Yu JT, Chi ZF, Tan L (2012) Increased expressions of TLR2 and TLR4 on peripheral blood mononuclear cells from patients with Alzheimer's disease. J Neurol Sci 315, 67-71.
21. Piccio L, Buonsanti C, Cella M, Tassi I, Schmidt RE, Fenoglio C, Rinker J, 2nd, NaismithRT, Panina-Bordignon P, Passini N, Galimberti D, Scarpini E, Colonna M, Cross AH (2008) Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation. Brain 131, 3081-3091.
22. Neumann H, Takahashi K (2007) Essential role of the microglial triggering receptor expressed on myeloid cells-2 (TREM2) for central nervous tissue immune homeostasis. J Neuroimmunol 184, 92-99.
23. Piccio L, Buonsanti C, Mariani M, Cella M, Gilfillan S, Cross AH, Colonna M, Panina-Bordignon P (2007) Blockade of TREM-2 exacerbates experimental autoimmune encephalomyelitis. Eur J Immunol 37, 1290-1301.
24. Takahashi K, Prinz M, Stagi M, Chechneva O, Neumann H (2007) TREM2-Transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis. PLoS Med 4, e124.
25. Hamerman JA, Jarjoura JR, Humphrey MB, Nakamura MC, Seaman WE, Lanier LL (2006) Cutting edge: Inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12. J Immunol 177, 2051-2055.
26. Takahashi K, Rochford CD, Neumann H (2005) Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2. J Exp Med 201, 647-657.