Association between molecular subtypes of colorectal cancer and patient survival

Gastroenterology

Volumn 148, Issue 1, 2015, Pages 77-87.e2

  Phipps, Amanda I ^a,b   Limburg, Paul J ^c   Baron, John A ^d   Burnett Hartman, Andrea N ^a,b   Weisenberger, Daniel J ^e   Laird, Peter W ^e   Sinicrope, Frank A ^c   Rosty, Christophe ^f,g   Buchanan, Daniel D ^f   Potter, John D ^a,b,h   Newcomb, Polly A ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

^c MAYO CLINIC   (United States)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^f QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^g UNIVERSITY OF QUEENSLAND   (Australia)

^h MASSEY UNIVERSITY   (New Zealand)

Author keywords

Methylation; Oncogene; Prognostic Factor; Serrated Colorectal Cancer

Indexed keywords

B RAF KINASE; K RAS PROTEIN; TUMOR MARKER; BRAF PROTEIN, HUMAN; KRAS PROTEIN, HUMAN; ONCOPROTEIN; RAS PROTEIN;

ADULT; AGED; ARTICLE; CANCER CLASSIFICATION; CANCER MORTALITY; CANCER REGISTRY; CANCER SURVIVAL; COLORECTAL CANCER; CONTROLLED STUDY; CPG ISLAND; DISEASE ASSOCIATION; FEMALE; GENE MUTATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; MIDDLE AGED; OVERALL SURVIVAL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; COLORECTAL NEOPLASMS; DISEASE FREE SURVIVAL; DNA METHYLATION; DNA MUTATIONAL ANALYSIS; GENETIC PREDISPOSITION; GENETICS; KAPLAN MEIER METHOD; MORTALITY; MUTATION; PATHOLOGY; PROPORTIONAL HAZARDS MODEL; REGISTER; RISK FACTOR; TIME FACTOR; TREATMENT OUTCOME; WASHINGTON; YOUNG ADULT;

ADULT; AGED; BIOMARKERS, TUMOR; COLORECTAL NEOPLASMS; CPG ISLANDS; DISEASE-FREE SURVIVAL; DNA METHYLATION; DNA MUTATIONAL ANALYSIS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MICROSATELLITE INSTABILITY; MIDDLE AGED; MUTATION; PHENOTYPE; PROPORTIONAL HAZARDS MODELS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS B-RAF; RAS PROTEINS; REGISTRIES; RISK FACTORS; TIME FACTORS; TREATMENT OUTCOME; WASHINGTON; YOUNG ADULT;

EID: 84922879141     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2014.09.038     Document Type: Article

References (51)

1. J.R. Jass Classification of colorectal cancer based on correlation of clinical, morphological and molecular features Histopathology 50 2007 113 130
2. B. Leggett, and V. Whitehall Role of the serrated pathway in colorectal cancer pathogenesis Gastroenterology 138 2010 2088 2100
3. N.J. Samadder, R.A. Vierkant, and L.S. Tillmans Associations between colorectal cancer molecular markers and pathways with clinicopathologic features in older women Gastroenterology 145 2013 348 356
4. W.S. Samowitz, K. Curtin, and D. Schaffer Relationship of Ki-ras mutations in colon cancers to tumor location, stage, and survival: a population-based study Cancer Epidemiol Biomarkers Prev 9 2000 1193 1197
5. H.J. Andreyev, A.R. Norman, and D. Cunningham Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study Br J Cancer 85 2001 692 696
6. S. Ogino, J.A. Meyerhardt, and N. Irahara KRAS mutation in stage III colon cancer and clinical outcome following intergroup trial CALGB 89803 Clin Cancer Res 15 2009 7322 7329
7. Y. Imamura, T. Morikawa, X. Liao, and P. Lochhead Specific mutations in KRAS codons 12 and 13, and patient prognosis in 1075 BRAF-wild-type colorectal cancers Clin Cancer Res 18 2012 4753 4763
8. A.I. Phipps, D.D. Buchanan, and K.W. Makar KRAS-mutation status in relation to colorectal cancer survival: the joint impact of correlated tumour markers Br J Cancer 108 2013 1757 1764
9. A.I. Phipps, D.D. Buchanan, and K.W. Makar BRAF mutation status and survival after colorectal cancer diagnosis according to patient and tumor characteristics Cancer Epidemiol Biomarkers Prev 21 2012 1792 1798
10. W. De Roock, B. Claes, and D. Bernasconi Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis Lancet Oncol 11 2010 753 762
11. A.D. Roth, S. Tejpar, and M. Delorenzi Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: results of the translational study on the PETACC-3, EORTC 40993, SAKK 60-00 trial J Clin Oncol 28 2010 466 474
12. A. Farina-Sarasqueta, G. van Lijnschoten, and E. Moerland The BRAF V600E mutation is an independent prognostic factor for survival in stage II and stage III colon cancer patients Ann Oncol 21 2010 2396 2402
13. M.F. Kalady, K.L. Dejulius, and J.A. Sanchez BRAF mutations in colorectal cancer are associated with distinct clinical characteristics and worse prognosis Dis Colon Rectum 55 2012 128 133
14. S. Ogino, K. Shima, and J.A. Meyerhardt Predictive and prognostic roles of BRAF mutation in stage III colon cancer: results from intergroup trial CALGB 89803 Clin Cancer Res 18 2012 890 900
15. C. Guastadisegni, M. Colafranceschi, and L. Ottini Microsatellite instability as a marker of prognosis and response to therapy: a meta-analysis of colorectal cancer survival data Eur J Cancer 46 2010 2788 2798
16. C. Wang, M. van Rijnsoever, and F. Grieu Prognostic significance of microsatellite instability and Ki-ras mutation type in stage II colorectal cancer Oncology 64 2003 259 265
17. A.J. French, D.J. Sargent, and L.J. Burgart Prognostic significance of defective mismatch repair and BRAF V600E in patients with colon cancer Clin Cancer Res 14 2008 3408 3415
18. W.S. Samowitz, C. Sweeney, and J. Herrick Poor survival associated with the BRAF V600E mutation in microsatellite-stable colon cancers Cancer Res 65 2005 6063 6069
19. S. Ogino, K. Nosho, and G.J. Kirkner CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer Gut 58 2009 90 96
20. S. Lee, N.Y. Cho, and M. Choi Clinicopathological features of CpG island methylator phenotype-positive colorectal cancer and its adverse prognosis in relation to KRAS/BRAF mutation Pathol Int 58 2008 104 113
21. G. Hutchins, K. Southward, and K. Handley Value of mismatch repair, KRAS, and BRAF mutations in predicting recurrence and benefits from chemotherapy in colorectal cancer J Clin Oncol 29 2011 1261 1270
22. G.M. Nash, M. Gimbel, and A.M. Cohen KRAS mutation and microsatellite instability: two genetic markers of early tumor development that influence the prognosis of colorectal cancer Ann Surg Oncol 17 2010 416 424
23. I. Zlobec, M.P. Bihl, and A. Foerster Stratification and prognostic relevance of Jass's molecular classification of colorectal cancer Front Oncol 2 2012 7
24. P.A. Newcomb, J. Baron, and M. Cotterchio Colon Cancer Family Registry: an international resource for studies of the genetic epidemiology of colon cancer Cancer Epidemiol Biomarkers Prev 16 2007 2331 2343
25. P.A. Newcomb, Y. Zheng, and V.M. Chia Estrogen plus progestin use, microsatellite instability, and the risk of colorectal cancer in women Cancer Res 67 2007 7534 7539
26. C.R. Boland, S.N. Thibodeau, and S.R. Hamilton A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer Cancer Res 58 1998 5248 5257
27. N.M. Lindor, L.J. Burgart, and O. Leontovich Immunohistochemistry versus microsatellite instability testing in phenotyping colorectal tumors J Clin Oncol 20 2002 1043 1048
28. J. Shia Immunohistochemistry versus microsatellite instability testing for screening colorectal cancer patients at risk for hereditary nonpolyposis colorectal cancer syndrome. Part I. The utility of immunohistochemistry J Mol Diagn 10 2008 293 300
29. D.D. Buchanan, K. Sweet, and M. Drini Risk factors for colorectal cancer in patients with multiple serrated polyps: a cross-sectional case series from genetics clinics PLoS One 5 2010 e11636
30. H. Davies, G.R. Bignell, and C. Cox Mutations of the BRAF gene in human cancer Nature 417 2002 949 954
31. K. Alsop, L. Mead, and L.D. Smith Low somatic K-ras mutation frequency in colorectal cancer diagnosed under the age of 45 years Eur J Cancer 42 2006 1357 1361
32. The Cancer Genome Atlas. cBioPortal for Cancer Genomics. http://www.cbioportal.org/public-portal/index.do. Computational Biology Center, Memorial Sloan-Kettering Cancer Center, 2013.
33. Y. Imamura, P. Lochhead, M. Yamauchi, A. Kuchiba, Z.R. Qian, X. Liao, R. Nishihara, S. Jung, K. Wu, K. Nosho, Y.E. Wang, S. Peng, A.J. Bass, K.M. Haigis, J. Meyerhardt, A.T. Chan, C.S. Fuchs, and S. Ogino Analyses of clinicopathological, molecular, and prognostic associations of KRAS codon 61 and codon 146 mutations in colorectal cancer: cohort study and literature review Mol Cancer 13 2014 135
34. D.J. Weisenberger, K.D. Siegmund, and M. Campan CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer Nat Genet 38 2006 787 793
35. S. Ogino, M. Cantor, and T. Kawasaki CpG island methylator phenotype (CIMP) of colorectal cancer is best characterised by quantitative DNA methylation analysis and prospective cohort studies Gut 55 2006 1000 1006
36. T. Hinoue, D.J. Weisenberger, and C.P. Lange Genome-scale analysis of aberrant DNA methylation in colorectal cancer Genome Res 22 2012 271 282
37. G.J.M.G. van der Heijden, A.R.T. Donders, and T. Stijnen Imputation of missing values is superior to complete case analysis and the missing-indicator method in multivariable diagnostic research: a clinical example J Clin Epidemiol 59 2006 1102 1109
38. M.J. Azur, E.A. Stuart, and C. Frangakis Multiple imputation by chained equations: what is it and how does it work? Int J Methods Psychiatr Res 20 2011 40 49
39. World Health Organization International Classification of Diseases 2007 WHO Geneva
40. T.M. Therneau, and P.M. Grambsch Modeling survival data: extending the Cox model 2000 Springer New York
41. A. Farcomeni A review of modern multiple hypothesis testing, with particular attention to the false discovery proportion Stat Methods Med Res 17 2008 347 388
42. S. Popat, R. Hubner, and R.S. Houlston Systematic review of microsatellite instability and colorectal cancer prognosis J Clin Oncol 23 2005 609 618
43. P. Lochhead, A. Kuchiba, and Y. Imamura Microsatellite instability and BRAF mutation testing in colorectal cancer prognostication J Natl Cancer Inst 105 2013 1151 1156
44. R.L. Ward, K. Cheong, and S.L. Ku Adverse prognostic effect of methylation in colorectal cancer is reversed by microsatellite instability J Clin Oncol 21 2003 3729 3736
45. J.A. Sanchez, L. Krumroy, and S. Plummer Genetic and epigenetic classifications define clinical phenotypes and determine patient outcomes in colorectal cancer Br J Surg 96 2009 1196 1204
46. M.M. Bertagnolli, D. Niedzwiecki, and C.C. Compton Microsatellite instability predicts improved response to adjuvant therapy with irinotecan, fluorouracil, and leucovorin in stage III colon cancer: Cancer and Leukemia Group B Protocol 89803 J Clin Oncol 27 2009 1814 1821
47. D.J. Sargent, S. Marsoni, and G. Monges Defective mismatch repair as a predictive marker for lack of efficacy of fluorouracil-based adjuvant therapy in colon cancer J Clin Oncol 28 2010 3219 3226
48. R. Jover, T.P. Nguyen, and L. Perez-Carbonell 5-Fluorouracil adjuvant chemotherapy does not increase survival in patients with CpG island methylator phenotype colorectal cancer Gastroenterology 140 2011 1174 1181
49. A.Y. Lin, N.S. Buckley, and A.T. Lu Effect of KRAS mutational status in advanced colorectal cancer on the outcomes of anti-epidermal growth factor receptor monoclonal antibody therapy: a systematic review and meta-analysis Clin Colorectal Cancer 10 2011 63 69
50. C. Bokemeyer, E. van Cutsem, and P. Rougier Addition of cetuximab to chemotherapy as first-line treatment for KRAS wild-type metastatic colorectal cancer: pooled analysis of the CRYSTAL and OPUS randomised clinical trials Eur J Cancer 48 2012 1466 1475
51. Surveillance Epidemiology and End Results (SEER) Program. SEER∗Stat Database. Incidence - SEER 13 Regs Research Data, Nov 2011 Sub, Vintage 2009 Pops (1992-2009) - Linked To County Attributes - Total US, 1969-2010 Counties. In: National Cancer Institute D, Surveillance Research Program, Cancer Statistics Branch, released April 2012, based on the November 2011 submission. Available at www.seer.cancer.gov. Accessed March 10, 2014.