KRAS mutation and microsatellite instability: Two genetic markers of early tumor development that influence the prognosis of colorectal cancer

Annals of Surgical Oncology

Volumn 17, Issue 2, 2010, Pages 416-424

  Nash, Garrett M ^a   Gimbel, Mark ^a   Cohen, Alfred M ^b   Zeng, Zhao Shi ^a   Ndubuisi, MacKevin I ^a   Nathanson, Daniel R ^a   Ott, Jurg ^c   Barany, Francis ^d   Paty, Philip B ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c ROCKEFELLER UNIVERSITY   (United States)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOCARCINOMA; ADULT; AGED; ARTICLE; CANCER ADJUVANT THERAPY; CANCER GROWTH; CANCER MORTALITY; CANCER STAGING; CANCER SURVIVAL; CARCINOGENESIS; COLON RESECTION; COLORECTAL CANCER; CONTROLLED STUDY; EARLY CANCER; FEMALE; FOLLOW UP; GENE MUTATION; GENETIC MARKER; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; ONCOGENE K RAS; PROGNOSIS; PROTO ONCOGENE; SURVIVAL RATE; SURVIVAL TIME;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; COLON; COLORECTAL NEOPLASMS; DISEASE PROGRESSION; FEMALE; FOLLOW-UP STUDIES; GENETIC MARKERS; HUMANS; MALE; MICROSATELLITE INSTABILITY; MIDDLE AGED; MUTATION; PROTO-ONCOGENE PROTEINS; RAS PROTEINS; RECTUM; SURVIVAL RATE; TREATMENT OUTCOME; YOUNG ADULT;

EID: 77149176231     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/s10434-009-0713-0     Document Type: Article

References (53)

1. Skibber J, Minsky B, Hoff P. Cancer of the colon. In: DeVita VT, Rosenberg SA, editors. Principles and practice of oncology. Philadelphia: Lippincott Williams & Wilkins; 2001.
2. PH Chapuis R Fisher OF Dent RC Newland MT Pheils 1985 The relationship between different staging methods and survival in colorectal carcinoma Dis Colon Rectum 28 158 161 10.1007/BF02554232 1:STN:280:DyaL2M7is1egug%3D%3D 3971820 (Pubitemid 15136582)
3. P Barillari R de Angelis S Valabrega M Indinnimeo P Gozzo G Ramacciato, et al. 1989 Relationship of symptom duration and survival in patients with colorectal carcinoma Eur J Surg Oncol 15 441 445 1:STN:280: DyaK3c%2Fgs1Sgtw%3D%3D 2551743
4. M Robinson J Hardcastle 1998 Should we be screening for colorectal cancer? Br Med Bull 54 807 821 1:STN:280:DyaK1M3psFCqsA%3D%3D 10367416
5. Culliford A, Paty P. Surgery of colon cancer. In: Saltz L, editor. Colorectal cancer: multimodality management. Oxford, UK: Blackwell; 2002.
6. CB Diep L Thorstensen GI Meling E Skovlund TO Rognum RA Lothe 2003 Genetic tumor markers with prognostic impact in Dukes' stages B and C colorectal cancer patients J Clin Oncol 21 820 829 10.1200/JCO.2003.05.190 12610180 (Pubitemid 46606441)
7. H Elsaleh B Powell K McCaul F Grieu R Grant D Joseph, et al. 2001 P53 alteration and microsatellite instability have predictive value for survival benefit from chemotherapy in stage III colorectal carcinoma Clin Cancer Res 7 1343 1349 1:CAS:528:DC%2BD3MXktlelsrc%3D 11350904
8. R Gryfe H Kim ET Hsieh MD Aronson EJ Holowaty SB Bull, et al. 2000 Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer N Engl J Med 342 69 77 10.1056/NEJM200001133420201 1:STN:280:DC%2BD3c%2FotVeitA%3D%3D 10631274 (Pubitemid 30036597)
9. KC Halling AJ French SK McDonnell LJ Burgart DJ Schaid BJ Peterson, et al. 1999 Microsatellite instability and 8p allelic imbalance in stage B2 and C colorectal cancers J Natl Cancer Inst 91 1295 1303 10.1093/jnci/91.15.1295 1:CAS:528:DyaK1MXlsFyltbc%3D 10433618
10. P Peltomäki RA Lothe LA Aaltonen L Pylkkänen M Nyström-Lahti R Seruca, et al. 1993 Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome Cancer Res 53 5853 5855 8261393
11. ML Slattery K Curtin D Schaffer K Anderson W Samowitz 2002 Associations between family history of colorectal cancer and genetic alterations in tumors Int J Cancer 97 823 827 10.1002/ijc.10148 1:CAS:528:DC%2BD38XhtVShs7k%3D 11857362 (Pubitemid 34106339)
12. T Watanabe TT Wu PJ Catalano T Ueki R Satriano DG Haller, et al. 2001 Molecular predictors of survival after adjuvant chemotherapy for colon cancer N Engl J Med 344 1196 1206 10.1056/NEJM200104193441603 1:CAS:528: DC%2BD3MXjsV2ms74%3D 11309634 (Pubitemid 32319494)
13. A Lièvre JB Bachet V Boige A Cayre D Le Corre E Buc, et al. 2008 KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab J Clin Oncol 26 374 379 10.1200/JCO.2007.12.5906 18202412 (Pubitemid 351171687)
14. HJ Andreyev AR Norman D Cunningham J Oates BR Dix BJ Iacopetta, et al. 2001 Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study Br J Cancer 85 692 696 10.1054/bjoc.2001.1964 1:CAS:528: DC%2BD3MXns1yktr8%3D 11531254 (Pubitemid 32929467)
15. HJ Andreyev AR Norman D Cunningham JR Oates PA Clarke 1998 Kirsten ras mutations in patients with colorectal cancer: the multicenter "RASCAL" study J Natl Cancer Inst 90 675 684 10.1093/jnci/90.9.675 1:CAS:528: DyaK1cXjtlSiu7s%3D 9586664
16. B Klump O Hehls T Okech CJ Hsieh V Gaco FS Gittinger, et al. 2004 Molecular lesions in colorectal cancer: impact on prognosis? Original data and review of the literature Int J Colorectal Dis 19 23 42 10.1007/s00384-003-0499-7 1:STN:280:DC%2BD3srmsl2gtQ%3D%3D 12827409 (Pubitemid 38088282)
17. MJ Duffy A van Dalen C Haglund L Hansson E Holinski-Feder R Klapdor, et al. 2007 Tumour markers in colorectal cancer: European Group on Tumour Markers (EGTM) guidelines for clinical use Eur J Cancer 43 1348 1360 10.1016/j.ejca.2007.03.021 1:CAS:528:DC%2BD2sXmtlags7c%3D 17512720 (Pubitemid 46874070)
18. MJ Duffy A van Dalen C Haglund L Hansson R Klapdor R Lamerz, et al. 2003 Clinical utility of biochemical markers in colorectal cancer: European Group on Tumour Markers (EGTM) guidelines Eur J Cancer 39 718 727 10.1016/S0959-8049(02) 00811-0 1:CAS:528:DC%2BD3sXitVKgur8%3D 12651195 (Pubitemid 36315986)
19. F Graziano S Cascinu 2003 Prognostic molecular markers for planning adjuvant chemotherapy trials in Dukes' B colorectal cancer patients: how much evidence is enough? Ann Oncol 14 1026 1038 10.1093/annonc/mdg284 1:STN:280:DC%2BD3szitlCkug%3D%3D 12853343 (Pubitemid 36950166)
20. Y Ionov MA Peinado S Malkhosyan D Shibata M Perucho 1993 Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis Nature 363 558 561 10.1038/363558a0 1:CAS:528: DyaK3sXks12hu7c%3D 8505985 (Pubitemid 23186645)
21. RD Kolodner GT Marsischky 1999 Eukaryotic DNA mismatch repair Curr Opin Genet Dev 9 89 96 10.1016/S0959-437X(99)80013-6 1:CAS:528:DyaK1MXhsFSntLY%3D 10072354 (Pubitemid 29080392)
22. M Pedroni E Sala A Scarselli F Borghi M Menigatti P Benatti, et al. 2001 Microsatellite instability and mismatch-repair protein expression in hereditary and sporadic colorectal carcinogenesis Cancer Res 61 896 899 1:CAS:528:DC%2BD3MXhsFSrtbg%3D 11221877
23. H Rajagopalan MA Nowak B Vogelstein C Lengauer 2003 The significance of unstable chromosomes in colorectal cancer Nat Rev Cancer 3 695 701 10.1038/nrc1165 1:CAS:528:DC%2BD3sXmvVWlu78%3D 12951588
24. K Yamashita T Dai Y Dai F Yamamoto M Perucho 2003 Genetics supersedes epigenetics in colon cancer phenotype Cancer Cell 4 121 131 10.1016/S1535- 6108(03)00190-9 1:CAS:528:DC%2BD3sXntFegtbs%3D 12957287 (Pubitemid 37040828)
25. WS Samowitz K Curtin KN Ma D Schaffer LW Coleman M Leppert, et al. 2001 Microsatellite instability in sporadic colon cancer is associated with an improved prognosis at the population level Cancer Epidemiol Biomarkers Prev 10 917 923 1:CAS:528:DC%2BD3MXnt1Gis78%3D 11535541
26. GM Nash M Gimbel J Shia AT Culliford DR Nathanson M Ndubuisi, et al. 2003 Automated, multiplex assay for high-frequency microsatellite instability in colorectal cancer J Clin Oncol 21 3105 3112 10.1200/JCO.2003.11.133 1:CAS:528:DC%2BD2cXpsVWqtLc%3D 12915601 (Pubitemid 46606291)
27. N Suraweera A Duval M Reperant C Vaury D Furlan K Leroy, et al. 2002 Evaluation of tumor microsatellite instability using five quasimonomorphic mononucleotide repeats and pentaplex PCR Gastroenterology 123 1804 1811 10.1053/gast.2002.37070 1:CAS:528:DC%2BD38Xps1yktb8%3D 12454837 (Pubitemid 35408304)
28. RM Xicola X Llor E Pons A Castells C Alenda V Piñol, et al. 2007 Performance of different microsatellite marker panels for detection of mismatch repair-deficient colorectal tumors J Natl Cancer Inst 99 244 252 10.1093/jnci/djk033 1:CAS:528:DC%2BD2sXis1ShtbY%3D 17284719
29. A Umar CR Boland JP Terdiman S Syngal A de la Chapelle J Rüschoff, et al. 2004 Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability J Natl Cancer Inst 96 261 268 1:CAS:528:DC%2BD2cXhsV2qtLk%3D 14970275 (Pubitemid 38256271)
30. AD Cox CJ Der 2002 Ras family signaling: therapeutic targeting Cancer Biol Ther 1 599 606 1:CAS:528:DC%2BD3sXntVSlsLw%3D 12642680
31. E Sahai MF Olson CJ Marshall 2001 Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility EMBO J 20 755 766 10.1093/emboj/20.4.755 1:CAS:528:DC%2BD3MXhsVyht7Y%3D 11179220 (Pubitemid 32167640)
32. M Porta D Ayude J Alguacil M Jariod 2003 Exploring environmental causes of altered ras effects: fragmentation plus integration? Mol Carcinog 36 45 52 10.1002/mc.10093 1:CAS:528:DC%2BD3sXhtF2lu7g%3D 12557259 (Pubitemid 36187430)
33. L Cheng MD Lai 2003 Aberrant crypt foci as microscopic precursors of colorectal cancer World J Gastroenterol 9 2642 2649 1:CAS:528: DC%2BD2cXmt1Cmsw%3D%3D 14669304
34. D Shibata J Schaeffer ZH Li G Capella M Perucho 1993 Genetic heterogeneity of the c-K-ras locus in colorectal adenomas but not in adenocarcinomas J Natl Cancer Inst 85 1058 1063 10.1093/jnci/85.13.1058 1:STN:280:DyaK3s3psVyrtQ%3D%3D 8515492
35. Y Kondo JP Issa 2004 Epigenetic changes in colorectal cancer Cancer Metastasis Rev 23 29 39 10.1023/A:1025806911782 1:CAS:528:DC%2BD3sXnsFansr0%3D 15000147 (Pubitemid 38221595)
36. DJ Ahnen P Feigl G Quan C Fenoglio-Preiser LC Lovato PA Bunn Jr, et al. 1998 Ki-ras mutation and p53 overexpression predict the clinical behavior of colorectal cancer: a Southwest Oncology Group study Cancer Res 58 1149 1158 1:CAS:528:DyaK1cXhvV2rsro%3D 9515799
37. WS Samowitz K Curtin D Schaffer M Robertson M Leppert ML Slattery 2000 Relationship of Ki-ras mutations in colon cancers to tumor location, stage, and survival: a population-based study Cancer Epidemiol Biomarkers Prev 9 1193 1197 1:CAS:528:DC%2BD3cXos12isb4%3D 11097226
38. N Umetani S Sasaki T Watanabe H Ishigami E Ueda H Nagawa 2000 Diagnostic primer sets for microsatellite instability optimized for a minimal amount of damaged DNA from colorectal tissue samples Ann Surg Oncol 7 276 280 10.1007/s10434-000-0276-6 1:STN:280:DC%2BD3c3nslGiug%3D%3D 10819367
39. M Khanna P Park M Zirvi W Cao A Picon J Day, et al. 1999 Multiplex PCR/LDR for detection of K-ras mutations in primary colon tumors Oncogene 18 27 38 10.1038/sj.onc.1202291 1:CAS:528:DyaK1MXhtVCnu74%3D 9926917 (Pubitemid 29060576)
40. SJ Alrawi M Schiff RE Carroll M Dayton JF Gibbs M Kulavlat, et al. 2006 Aberrant crypt foci Anticancer Res 26 107 119 1:CAS:528:DC%2BD28Xhs1ahtr8%3D 16475686
41. TP Pretlow TA Brasitus NC Fulton C Cheyer EL Kaplan 1993 K-ras mutations in putative preneoplastic lesions in human colon J Natl Cancer Inst 85 2004 2007 10.1093/jnci/85.24.2004 1:CAS:528:DyaK2cXlsFCnsbk%3D 8246286
42. D Shibata MA Peinado Y Ionov S Malkhosyan M Perucho 1994 Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation Nat Genet 6 273 281 10.1038/ng0394-273 1:CAS:528:DyaK2cXivFGgtLg%3D 8012390 (Pubitemid 24188625)
43. L Losi J Benhattar J Costa 1992 Stability of K-ras mutations throughout the natural history of human colorectal cancer Eur J Cancer 28A 1115 1120 10.1016/0959-8049(92)90468-H 1:CAS:528:DyaK38XmtlWhtr0%3D 1627381
44. SD Finkelstein R Sayegh S Christensen PA Swalsky 1993 Genotypic classification of colorectal adenocarcinoma. Biologic behavior correlates with K-ras-2 mutation type Cancer 71 3827 3838 10.1002/1097-0142(19930615)71: 12<3827::AID-CNCR2820711207>3.0.CO;2-N 1:STN:280:DyaK3s3osVCqsA%3D%3D 8508351
45. B Vogelstein ER Fearon SE Kern SR Hamilton AC Preisinger Y Nakamura, et al. 1989 Allelotype of colorectal carcinomas Science 244 207 211 10.1126/science.2565047 1:STN:280:DyaL1M3gtlalsg%3D%3D 2565047
46. B Curran K Lenehan H Mulcahy O Tighe MA Bennett EW Kay, et al. 2000 Replication error phenotype, clinicopathological variables, and patient outcome in Dukes' B stage II (T3, N0, M0) colorectal cancer Gut 46 200 204 10.1136/gut.46.2.200 1:STN:280:DC%2BD3c7htFWguw%3D%3D 10644313 (Pubitemid 30305845)
47. G Gnanasampanthan H Elsaleh K McCaul B Iacopetta 2001 Ki-ras mutation type and the survival benefit from adjuvant chemotherapy in Dukes' C colorectal cancer J Pathol 195 543 548 10.1002/path.990 1:CAS:528:DC%2BD38XjvVemtA%3D%3D 11745689 (Pubitemid 34030791)
48. C Wang M van Rijnsoever F Grieu S Bydder H Elsaleh D Joseph, et al. 2003 Prognostic significance of microsatellite instability and Ki-ras mutation type in stage II colorectal cancer Oncology 64 259 265 10.1159/000069311 1:CAS:528:DC%2BD3sXivFOhtrc%3D 12697967 (Pubitemid 36438811)
49. R Rodriguez LT Hansen G Phear J Scorah M Spang-Thomsen A Cox, et al. 2008 Thymidine selectively enhances growth suppressive effects of camptothecin/irinotecan in MSI+ cells and tumors containing a mutation of MRE11 Clin Cancer Res 14 5476 5483 10.1158/1078-0432.CCR-08-0274 1:CAS:528: DC%2BD1cXhtVKmsbjL 18765539
50. D Fink S Aebi SB Howell 1998 The role of DNA mismatch repair in drug resistance Clin Cancer Res 4 1 6 1:CAS:528:DyaK1cXmtFSnuw%3D%3D 9516945
51. A Lièvre JB Bachet D Le Corre V Boige B Landi JF Emile, et al. 2006 KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer Cancer Res 66 3992 3995 10.1158/0008-5472.CAN-06-0191 16618717
52. D Fallik F Borrini V Boige J Viguier S Jacob C Miquel, et al. 2003 Microsatellite instability is a predictive factor of the tumor response to irinotecan in patients with advanced colorectal cancer Cancer Res 63 5738 5744 1:CAS:528:DC%2BD3sXnvVSjtLo%3D 14522894
53. CQ Zhu G da Cunha Santos K Ding A Sakurada JC Cutz N Liu, et al. 2008 Role of KRAS and EGFR as biomarkers of response to erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR 21 J Clin Oncol 26 4268 4275 10.1200/JCO.2007.14.8924 1:CAS:528:DC%2BD1cXhtF2it7bF 18626007