Protein-bearing cubosomes prepared by liquid precursor dilution: Inner ear delivery and pharmacokinetic study following intratympanic administration

Journal of Biomedical Nanotechnology

Volumn 9, Issue 10, 2013, Pages 1784-1793

  Liu, Hongzhuo ^a   Wang, Yan ^a   Wang, Qifang ^a   Li, Zhen ^a   Zhou, Yanyan ^a   Zhang, Yusheng ^a   Li, Sanming ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Bottom up; Cubosomes; Earthworm fibrinolytic enzyme; Hydration; Intratympanic delivery; SAXS

Indexed keywords

BIOCHEMISTRY; CHLORINE COMPOUNDS; CRYSTALLINE MATERIALS; DRUG DELIVERY; ENZYMES; HYDRATION; NANOPARTICLES; PROPYLENE; PROTEINS; X RAY SCATTERING;

BOTTOM UP; CUBOSOMES; EARTHWORM FIBRINOLYTIC ENZYME; INTRATYMPANIC; SAXS;

LIQUIDS;

CUBOSOME; EARTHWORM FIBRINOLYTIC ENZYME; GLYCEROL OLEATE; HYDROTROPE; NANOPARTICLE; PLASMIN; PROPYLENE GLYCOL; RHODAMINE B; STABILIZING AGENT; UNCLASSIFIED DRUG; LUMBROKINASE; NANOCAPSULE; PROTEINASE; SOLUTION AND SOLUBILITY;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BODY FLUID; CELL VIABILITY; COCHLEA; CONTROLLED STUDY; CYTOTOXICITY; DILUTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; IN VITRO STUDY; INNER EAR; MALE; MEMBRANE PERMEABILITY; MICROEMULSION; NANOENCAPSULATION; NONHUMAN; PARTICLE SIZE; PHASE TRANSITION; PHYSICAL CHEMISTRY; PLASMA CONCENTRATION-TIME CURVE; PRECURSOR; SCALA TYMPANI; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE; X RAY CRYSTALLOGRAPHY; ZETA POTENTIAL; ANIMAL; CHEMISTRY; DRUG EFFECTS; EARDRUM; GUINEA PIG; LIQUID CRYSTAL; METABOLISM; SOLUTION AND SOLUBILITY;

ANIMALS; COCHLEA; ENDOPEPTIDASES; GUINEA PIGS; LIQUID CRYSTALS; NANOCAPSULES; PARTICLE SIZE; SOLUTIONS; TYMPANIC MEMBRANE;

EID: 84922794130     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2013.1685     Document Type: Article

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