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Volumn 27, Issue 2, 2015, Pages 163-175

Emerging Strategies for Treating Brain Metastases from Breast Cancer

Author keywords

[No Author keywords available]

Indexed keywords

ABEMACICLIB; BEVACIZUMAB; BUPARLISIB; CABAZITAXEL; CABOZANTINIB; CAPECITABINE; CARBOPLATIN; CISPLATIN; CPG OLIGODEOXYNUCLEOTIDE; EPOTHILONE B; ETOPOSIDE; EVEROLIMUS; INIPARIB; IRBINITINIB; IRINOTECAN; LAPATINIB; NAVELBINE; NERATINIB; PACLITAXEL; PAZOPANIB; SARACATINIB; SHORT HAIRPIN RNA; SORAFENIB; TEMOZOLOMIDE; TRASTUZUMAB; TRASTUZUMAB EMTANSINE; TREBANANIB; UNINDEXED DRUG; VARDENAFIL; VORINOSTAT; EPIDERMAL GROWTH FACTOR RECEPTOR 2;

EID: 84922782200     PISSN: 15356108     EISSN: 18783686     Source Type: Journal    
DOI: 10.1016/j.ccell.2015.01.001     Document Type: Review
Times cited : (120)

References (98)
  • 2
    • 79961230399 scopus 로고    scopus 로고
    • Pericytes: developmental, physiological, and pathological perspectives, problems, and promises
    • Armulik A., Genové G., Betsholtz C. Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. Dev. Cell 2011, 21:193-215.
    • (2011) Dev. Cell , vol.21 , pp. 193-215
    • Armulik, A.1    Genové, G.2    Betsholtz, C.3
  • 4
    • 84892381025 scopus 로고    scopus 로고
    • Angiopoietin-2 mediates blood-brain barrier impairment and colonization of triple-negative breast cancer cells in brain
    • Avraham H.K., Jiang S., Fu Y., Nakshatri H., Ovadia H., Avraham S. Angiopoietin-2 mediates blood-brain barrier impairment and colonization of triple-negative breast cancer cells in brain. J.Pathol. 2014, 232:369-381.
    • (2014) J.Pathol. , vol.232 , pp. 369-381
    • Avraham, H.K.1    Jiang, S.2    Fu, Y.3    Nakshatri, H.4    Ovadia, H.5    Avraham, S.6
  • 5
    • 84871722407 scopus 로고    scopus 로고
    • Lapatinib plus capecitabine in patients with previously untreated brain metastases from HER2-positive metastatic breast cancer (LANDSCAPE): a single-group phase 2 study
    • Bachelot T., Romieu G., Campone M., Diéras V., Cropet C., Dalenc F., Jimenez M., Le Rhun E., Pierga J.Y., Gonçalves A., et al. Lapatinib plus capecitabine in patients with previously untreated brain metastases from HER2-positive metastatic breast cancer (LANDSCAPE): a single-group phase 2 study. Lancet Oncol. 2013, 14:64-71.
    • (2013) Lancet Oncol. , vol.14 , pp. 64-71
    • Bachelot, T.1    Romieu, G.2    Campone, M.3    Diéras, V.4    Cropet, C.5    Dalenc, F.6    Jimenez, M.7    Le Rhun, E.8    Pierga, J.Y.9    Gonçalves, A.10
  • 7
    • 84891754753 scopus 로고    scopus 로고
    • Breast cancer brain metastases responding to primary systemic therapy with T-DM1
    • Bartsch R., Berghoff A.S., Preusser M. Breast cancer brain metastases responding to primary systemic therapy with T-DM1. J.Neurooncol. 2014, 116:205-206.
    • (2014) J.Neurooncol. , vol.116 , pp. 205-206
    • Bartsch, R.1    Berghoff, A.S.2    Preusser, M.3
  • 9
    • 78049279739 scopus 로고    scopus 로고
    • Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging
    • Bell R.D., Winkler E.A., Sagare A.P., Singh I., LaRue B., Deane R., Zlokovic B.V. Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging. Neuron 2010, 68:409-427.
    • (2010) Neuron , vol.68 , pp. 409-427
    • Bell, R.D.1    Winkler, E.A.2    Sagare, A.P.3    Singh, I.4    LaRue, B.5    Deane, R.6    Zlokovic, B.V.7
  • 13
    • 81155123190 scopus 로고    scopus 로고
    • RIBBON-2: a randomized, double-blind, placebo-controlled, phase III trial evaluating the efficacy and safety of bevacizumab in combination with chemotherapy for second-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer
    • Brufsky A.M., Hurvitz S., Perez E., Swamy R., Valero V., O'Neill V., Rugo H.S. RIBBON-2: a randomized, double-blind, placebo-controlled, phase III trial evaluating the efficacy and safety of bevacizumab in combination with chemotherapy for second-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer. J.Clin. Oncol. 2011, 29:4286-4293.
    • (2011) J.Clin. Oncol. , vol.29 , pp. 4286-4293
    • Brufsky, A.M.1    Hurvitz, S.2    Perez, E.3    Swamy, R.4    Valero, V.5    O'Neill, V.6    Rugo, H.S.7
  • 14
    • 79960429096 scopus 로고    scopus 로고
    • Central nervous system metastases in patients with HER2-positive metastatic breast cancer: incidence, treatment, and survival in patients from registHER
    • Brufsky A.M., Mayer M., Rugo H.S., Kaufman P.A., Tan-Chiu E., Tripathy D., Tudor I.C., Wang L.I., Brammer M.G., Shing M., et al. Central nervous system metastases in patients with HER2-positive metastatic breast cancer: incidence, treatment, and survival in patients from registHER. Clin. Cancer Res. 2011, 17:4834-4843.
    • (2011) Clin. Cancer Res. , vol.17 , pp. 4834-4843
    • Brufsky, A.M.1    Mayer, M.2    Rugo, H.S.3    Kaufman, P.A.4    Tan-Chiu, E.5    Tripathy, D.6    Tudor, I.C.7    Wang, L.I.8    Brammer, M.G.9    Shing, M.10
  • 15
    • 56549113680 scopus 로고    scopus 로고
    • A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: updated efficacy and biomarker analyses
    • Cameron D., Casey M., Press M., Lindquist D., Pienkowski T., Romieu C.G., Chan S., Jagiello-Gruszfeld A., Kaufman B., Crown J., et al. A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: updated efficacy and biomarker analyses. Breast Cancer Res. Treat. 2008, 112:533-543.
    • (2008) Breast Cancer Res. Treat. , vol.112 , pp. 533-543
    • Cameron, D.1    Casey, M.2    Press, M.3    Lindquist, D.4    Pienkowski, T.5    Romieu, C.G.6    Chan, S.7    Jagiello-Gruszfeld, A.8    Kaufman, B.9    Crown, J.10
  • 17
    • 84875755046 scopus 로고    scopus 로고
    • Glioblastoma stem cells generate vascular pericytes to support vessel function and tumor growth
    • Cheng L., Huang Z., Zhou W., Wu Q., Donnola S., Liu J.K., Fang X., Sloan A.E., Mao Y., Lathia J.D., et al. Glioblastoma stem cells generate vascular pericytes to support vessel function and tumor growth. Cell 2013, 153:139-152.
    • (2013) Cell , vol.153 , pp. 139-152
    • Cheng, L.1    Huang, Z.2    Zhou, W.3    Wu, Q.4    Donnola, S.5    Liu, J.K.6    Fang, X.7    Sloan, A.E.8    Mao, Y.9    Lathia, J.D.10
  • 18
    • 79960393173 scopus 로고    scopus 로고
    • Caveolin-1 upregulation mediates suppression of primary breast tumor growth and brain metastases by stat3 inhibition
    • Chiu W.T., Lee H.T., Huang F.J., Aldape K.D., Yao J., Steeg P.S., Chou C.Y., Lu Z., Xie K., Huang S. Caveolin-1 upregulation mediates suppression of primary breast tumor growth and brain metastases by stat3 inhibition. Cancer Res. 2011, 71:4932-4943.
    • (2011) Cancer Res. , vol.71 , pp. 4932-4943
    • Chiu, W.T.1    Lee, H.T.2    Huang, F.J.3    Aldape, K.D.4    Yao, J.5    Steeg, P.S.6    Chou, C.Y.7    Lu, Z.8    Xie, K.9    Huang, S.10
  • 19
    • 84881237946 scopus 로고    scopus 로고
    • Optimally tolerated dose of lapatinib in combination with docetaxel plus trastuzumab in first-line treatment of HER2-positive metastatic breast cancer
    • Crown J., Kennedy M.J., Tresca P., Marty M., Espie M., Burris H.A., DeSilvio M., Lau M.R., Kothari D., Koch K.M., Diéras V. Optimally tolerated dose of lapatinib in combination with docetaxel plus trastuzumab in first-line treatment of HER2-positive metastatic breast cancer. Ann. Oncol. 2013, 24:2005-2011.
    • (2013) Ann. Oncol. , vol.24 , pp. 2005-2011
    • Crown, J.1    Kennedy, M.J.2    Tresca, P.3    Marty, M.4    Espie, M.5    Burris, H.A.6    DeSilvio, M.7    Lau, M.R.8    Kothari, D.9    Koch, K.M.10    Diéras, V.11
  • 21
    • 34250177984 scopus 로고    scopus 로고
    • The blood-brain barrier and cancer: transporters, treatment, and Trojan horses
    • Deeken J.F., Löscher W. The blood-brain barrier and cancer: transporters, treatment, and Trojan horses. Clin. Cancer Res. 2007, 13:1663-1674.
    • (2007) Clin. Cancer Res. , vol.13 , pp. 1663-1674
    • Deeken, J.F.1    Löscher, W.2
  • 23
    • 58749089099 scopus 로고    scopus 로고
    • Clinical patterns and biological correlates of cognitive dysfunction associated with cancer therapy
    • Dietrich J., Monje M., Wefel J., Meyers C. Clinical patterns and biological correlates of cognitive dysfunction associated with cancer therapy. Oncologist 2008, 13:1285-1295.
    • (2008) Oncologist , vol.13 , pp. 1285-1295
    • Dietrich, J.1    Monje, M.2    Wefel, J.3    Meyers, C.4
  • 26
    • 84888816383 scopus 로고    scopus 로고
    • Dual HER2 inhibition in combination with anti-VEGF treatment is active in heavily pretreated HER2-positive breast cancer
    • Falchook G.S., Moulder S.L., Wheler J.J., Jiang Y., Bastida C.C., Kurzrock R. Dual HER2 inhibition in combination with anti-VEGF treatment is active in heavily pretreated HER2-positive breast cancer. Ann. Oncol. 2013, 24:3004-3011.
    • (2013) Ann. Oncol. , vol.24 , pp. 3004-3011
    • Falchook, G.S.1    Moulder, S.L.2    Wheler, J.J.3    Jiang, Y.4    Bastida, C.C.5    Kurzrock, R.6
  • 28
  • 29
    • 34250221510 scopus 로고    scopus 로고
    • Increased permeability of the blood-brain barrier to chemotherapy in metastatic brain tumors: establishing a treatment paradigm
    • Gerstner E.R., Fine R.L. Increased permeability of the blood-brain barrier to chemotherapy in metastatic brain tumors: establishing a treatment paradigm. J.Clin. Oncol. 2007, 25:2306-2312.
    • (2007) J.Clin. Oncol. , vol.25 , pp. 2306-2312
    • Gerstner, E.R.1    Fine, R.L.2
  • 31
    • 84879477431 scopus 로고    scopus 로고
    • AVEREL: a randomized phase III Trial evaluating bevacizumab in combination with docetaxel and trastuzumab as first-line therapy for HER2-positive locally recurrent/metastatic breast cancer
    • Gianni L., Romieu G.H., Lichinitser M., Serrano S.V., Mansutti M., Pivot X., Mariani P., Andre F., Chan A., Lipatov O., et al. AVEREL: a randomized phase III Trial evaluating bevacizumab in combination with docetaxel and trastuzumab as first-line therapy for HER2-positive locally recurrent/metastatic breast cancer. J.Clin. Oncol. 2013, 31:1719-1725.
    • (2013) J.Clin. Oncol. , vol.31 , pp. 1719-1725
    • Gianni, L.1    Romieu, G.H.2    Lichinitser, M.3    Serrano, S.V.4    Mansutti, M.5    Pivot, X.6    Mariani, P.7    Andre, F.8    Chan, A.9    Lipatov, O.10
  • 38
    • 0037149539 scopus 로고    scopus 로고
    • Tumour biology: Herceptin acts as an anti-angiogenic cocktail
    • Izumi Y., Xu L., di Tomaso E., Fukumura D., Jain R.K. Tumour biology: Herceptin acts as an anti-angiogenic cocktail. Nature 2002, 416:279-280.
    • (2002) Nature , vol.416 , pp. 279-280
    • Izumi, Y.1    Xu, L.2    di Tomaso, E.3    Fukumura, D.4    Jain, R.K.5
  • 39
    • 84912096468 scopus 로고    scopus 로고
    • Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia
    • Jain R.K. Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia. Cancer Cell 2014, 26:605-622.
    • (2014) Cancer Cell , vol.26 , pp. 605-622
    • Jain, R.K.1
  • 43
    • 3342959040 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression promotes the growth of breast cancer brain metastases in nude mice
    • Kim L.S., Huang S., Lu W., Lev D.C., Price J.E. Vascular endothelial growth factor expression promotes the growth of breast cancer brain metastases in nude mice. Clin. Exp. Metastasis 2004, 21:107-118.
    • (2004) Clin. Exp. Metastasis , vol.21 , pp. 107-118
    • Kim, L.S.1    Huang, S.2    Lu, W.3    Lev, D.C.4    Price, J.E.5
  • 45
    • 84922762369 scopus 로고    scopus 로고
    • Role of the endothelin axis in astrocyte- and endothelial cell-mediated chemoprotection of cancer cells
    • Kim S.W., Choi H.J., Lee H.J., He J., Wu Q., Langley R.R., Fidler I.J., Kim S.J. Role of the endothelin axis in astrocyte- and endothelial cell-mediated chemoprotection of cancer cells. Neuro. Oncol. 2014, 16:1585-1598.
    • (2014) Neuro. Oncol. , vol.16 , pp. 1585-1598
    • Kim, S.W.1    Choi, H.J.2    Lee, H.J.3    He, J.4    Wu, Q.5    Langley, R.R.6    Fidler, I.J.7    Kim, S.J.8
  • 46
    • 79951966253 scopus 로고    scopus 로고
    • Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: results of the EORTC 22952-26001 study
    • Kocher M., Soffietti R., Abacioglu U., Villà S., Fauchon F., Baumert B.G., Fariselli L., Tzuk-Shina T., Kortmann R.D., Carrie C., et al. Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: results of the EORTC 22952-26001 study. J.Clin. Oncol. 2011, 29:134-141.
    • (2011) J.Clin. Oncol. , vol.29 , pp. 134-141
    • Kocher, M.1    Soffietti, R.2    Abacioglu, U.3    Villà, S.4    Fauchon, F.5    Baumert, B.G.6    Fariselli, L.7    Tzuk-Shina, T.8    Kortmann, R.D.9    Carrie, C.10
  • 48
    • 84901639476 scopus 로고    scopus 로고
    • Trastuzumab emtansine versus treatment of physician's choice for pretreated HER2-positive advanced breast cancer (TH3RESA): a randomised, open-label, phase 3 trial
    • Krop I.E., Kim S.B., González-Martín A., LoRusso P.M., Ferrero J.M., Smitt M., Yu R., Leung A.C., Wildiers H. Trastuzumab emtansine versus treatment of physician's choice for pretreated HER2-positive advanced breast cancer (TH3RESA): a randomised, open-label, phase 3 trial. Lancet Oncol. 2014, 15:689-699. TH3RESA Study Collaborators.
    • (2014) Lancet Oncol. , vol.15 , pp. 689-699
    • Krop, I.E.1    Kim, S.B.2    González-Martín, A.3    LoRusso, P.M.4    Ferrero, J.M.5    Smitt, M.6    Yu, R.7    Leung, A.C.8    Wildiers, H.9
  • 49
    • 79952726291 scopus 로고    scopus 로고
    • Monoclonal antibodies in neuro-oncology: getting past the blood-brain barrier
    • Lampson L.A. Monoclonal antibodies in neuro-oncology: getting past the blood-brain barrier. MAbs 2011, 3:153-160.
    • (2011) MAbs , vol.3 , pp. 153-160
    • Lampson, L.A.1
  • 50
    • 79955494691 scopus 로고    scopus 로고
    • Clinical neurological outcome and quality of life among patients with limited small-cell cancer treated with two different doses of prophylactic cranial irradiation in the intergroup phase III trial (PCI99-01, EORTC 22003-08004, RTOG 0212 and IFCT 99-01)
    • Le Péchoux C., Laplanche A., Faivre-Finn C., Ciuleanu T., Wanders R., Lerouge D., Keus R., Hatton M., Videtic G.M., Senan S., et al. Clinical neurological outcome and quality of life among patients with limited small-cell cancer treated with two different doses of prophylactic cranial irradiation in the intergroup phase III trial (PCI99-01, EORTC 22003-08004, RTOG 0212 and IFCT 99-01). Ann. Oncol. 2011, 22:1154-1163.
    • (2011) Ann. Oncol. , vol.22 , pp. 1154-1163
    • Le Péchoux, C.1    Laplanche, A.2    Faivre-Finn, C.3    Ciuleanu, T.4    Wanders, R.5    Lerouge, D.6    Keus, R.7    Hatton, M.8    Videtic, G.M.9    Senan, S.10
  • 55
    • 84904736573 scopus 로고    scopus 로고
    • Systemic treatments for brain metastases from breast cancer, non-small cell lung cancer, melanoma and renal cell carcinoma: an overview of the literature
    • Lombardi G., Di Stefano A.L., Farina P., Zagonel V., Tabouret E. Systemic treatments for brain metastases from breast cancer, non-small cell lung cancer, melanoma and renal cell carcinoma: an overview of the literature. Cancer Treat. Rev. 2014, 40:951-959.
    • (2014) Cancer Treat. Rev. , vol.40 , pp. 951-959
    • Lombardi, G.1    Di Stefano, A.L.2    Farina, P.3    Zagonel, V.4    Tabouret, E.5
  • 56
    • 77953215400 scopus 로고    scopus 로고
    • Capturing changes in the brain microenvironment during initial steps of breast cancer brain metastasis
    • Lorger M., Felding-Habermann B. Capturing changes in the brain microenvironment during initial steps of breast cancer brain metastasis. Am. J. Pathol. 2010, 176:2958-2971.
    • (2010) Am. J. Pathol. , vol.176 , pp. 2958-2971
    • Lorger, M.1    Felding-Habermann, B.2
  • 57
    • 67649811051 scopus 로고    scopus 로고
    • Activation of tumor cell integrin alphavbeta3 controls angiogenesis and metastatic growth in the brain
    • Lorger M., Krueger J.S., O'Neal M., Staflin K., Felding-Habermann B. Activation of tumor cell integrin alphavbeta3 controls angiogenesis and metastatic growth in the brain. Proc. Natl. Acad. Sci. USA 2009, 106:10666-10671.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 10666-10671
    • Lorger, M.1    Krueger, J.S.2    O'Neal, M.3    Staflin, K.4    Felding-Habermann, B.5
  • 58
    • 84883487600 scopus 로고    scopus 로고
    • Neurotrophin-3 modulates breast cancer cells and the microenvironment to promote the growth of breast cancer brain metastasis
    • Louie E., Chen X.F., Coomes A., Ji K., Tsirka S., Chen E.I. Neurotrophin-3 modulates breast cancer cells and the microenvironment to promote the growth of breast cancer brain metastasis. Oncogene 2013, 32:4064-4077.
    • (2013) Oncogene , vol.32 , pp. 4064-4077
    • Louie, E.1    Chen, X.F.2    Coomes, A.3    Ji, K.4    Tsirka, S.5    Chen, E.I.6
  • 62
    • 34547183458 scopus 로고    scopus 로고
    • MMP2 role in breast cancer brain metastasis development and its regulation by TIMP2 and ERK1/2
    • Mendes O., Kim H.T., Lungu G., Stoica G. MMP2 role in breast cancer brain metastasis development and its regulation by TIMP2 and ERK1/2. Clin. Exp. Metastasis 2007, 24:341-351.
    • (2007) Clin. Exp. Metastasis , vol.24 , pp. 341-351
    • Mendes, O.1    Kim, H.T.2    Lungu, G.3    Stoica, G.4
  • 64
    • 0036554830 scopus 로고    scopus 로고
    • Role of host microenvironment in angiogenesis and microvascular functions in human breast cancer xenografts: mammary fat pad versus cranial tumors
    • Monsky W.L., Mouta Carreira C., Tsuzuki Y., Gohongi T., Fukumura D., Jain R.K. Role of host microenvironment in angiogenesis and microvascular functions in human breast cancer xenografts: mammary fat pad versus cranial tumors. Clin. Cancer Res. 2002, 8:1008-1013.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 1008-1013
    • Monsky, W.L.1    Mouta Carreira, C.2    Tsuzuki, Y.3    Gohongi, T.4    Fukumura, D.5    Jain, R.K.6
  • 66
    • 84891882638 scopus 로고    scopus 로고
    • Brain metastases from breast cancer: lessons from experimental magnetic resonance imaging studies and clinical implications
    • Murrell D.H., Foster P.J., Chambers A.F. Brain metastases from breast cancer: lessons from experimental magnetic resonance imaging studies and clinical implications. J.Mol. Med. 2014, 92:5-12.
    • (2014) J.Mol. Med. , vol.92 , pp. 5-12
    • Murrell, D.H.1    Foster, P.J.2    Chambers, A.F.3
  • 67
    • 84883045013 scopus 로고    scopus 로고
    • Antitumor activity of TAK-285, an investigational, non-pgp substrate HER2/EGFR kinase inhibitor, in cultured tumor cells, mouse and rat xenograft tumors, and in an HER2-positive brain metastasis model
    • Nakayama A., Takagi S., Yusa T., Yaguchi M., Hayashi A., Tamura T., Kawakita Y., Ishikawa T., Ohta Y. Antitumor activity of TAK-285, an investigational, non-pgp substrate HER2/EGFR kinase inhibitor, in cultured tumor cells, mouse and rat xenograft tumors, and in an HER2-positive brain metastasis model. J.Cancer 2013, 4:557-565.
    • (2013) J.Cancer , vol.4 , pp. 557-565
    • Nakayama, A.1    Takagi, S.2    Yusa, T.3    Yaguchi, M.4    Hayashi, A.5    Tamura, T.6    Kawakita, Y.7    Ishikawa, T.8    Ohta, Y.9
  • 72
    • 84878430061 scopus 로고    scopus 로고
    • Incidence and risk of central nervous system metastases as site of first recurrence in patients with HER2-positive breast cancer treated with adjuvant trastuzumab
    • Olson E.M., Abdel-Rasoul M., Maly J., Wu C.S., Lin N.U., Shapiro C.L. Incidence and risk of central nervous system metastases as site of first recurrence in patients with HER2-positive breast cancer treated with adjuvant trastuzumab. Ann. Oncol. 2013, 24:1526-1533.
    • (2013) Ann. Oncol. , vol.24 , pp. 1526-1533
    • Olson, E.M.1    Abdel-Rasoul, M.2    Maly, J.3    Wu, C.S.4    Lin, N.U.5    Shapiro, C.L.6
  • 73
    • 84864464545 scopus 로고    scopus 로고
    • Immune surveillance in the central nervous system
    • Ousman S.S., Kubes P. Immune surveillance in the central nervous system. Nat. Neurosci. 2012, 15:1096-1101.
    • (2012) Nat. Neurosci. , vol.15 , pp. 1096-1101
    • Ousman, S.S.1    Kubes, P.2
  • 78
    • 79953874259 scopus 로고    scopus 로고
    • RIBBON-1: randomized, double-blind, placebo-controlled, phase III trial of chemotherapy with or without bevacizumab for first-line treatment of human epidermal growth factor receptor 2-negative, locally recurrent or metastatic breast cancer
    • Robert N.J., Diéras V., Glaspy J., Brufsky A.M., Bondarenko I., Lipatov O.N., Perez E.A., Yardley D.A., Chan S.Y., Zhou X., et al. RIBBON-1: randomized, double-blind, placebo-controlled, phase III trial of chemotherapy with or without bevacizumab for first-line treatment of human epidermal growth factor receptor 2-negative, locally recurrent or metastatic breast cancer. J.Clin. Oncol. 2011, 29:1252-1260.
    • (2011) J.Clin. Oncol. , vol.29 , pp. 1252-1260
    • Robert, N.J.1    Diéras, V.2    Glaspy, J.3    Brufsky, A.M.4    Bondarenko, I.5    Lipatov, O.N.6    Perez, E.A.7    Yardley, D.A.8    Chan, S.Y.9    Zhou, X.10
  • 79
    • 0022530993 scopus 로고
    • Chemotherapy induces regression of brain metastases in breast carcinoma
    • Rosner D., Nemoto T., Lane W.W. Chemotherapy induces regression of brain metastases in breast carcinoma. Cancer 1986, 58:832-839.
    • (1986) Cancer , vol.58 , pp. 832-839
    • Rosner, D.1    Nemoto, T.2    Lane, W.W.3
  • 82
    • 84863020427 scopus 로고    scopus 로고
    • Summary report on the graded prognostic assessment: an accurate and facile diagnosis-specific tool to estimate survival for patients with brain metastases
    • Sperduto P.W., Kased N., Roberge D., Xu Z., Shanley R., Luo X., Sneed P.K., Chao S.T., Weil R.J., Suh J., et al. Summary report on the graded prognostic assessment: an accurate and facile diagnosis-specific tool to estimate survival for patients with brain metastases. J.Clin. Oncol. 2012, 30:419-425.
    • (2012) J.Clin. Oncol. , vol.30 , pp. 419-425
    • Sperduto, P.W.1    Kased, N.2    Roberge, D.3    Xu, Z.4    Shanley, R.5    Luo, X.6    Sneed, P.K.7    Chao, S.T.8    Weil, R.J.9    Suh, J.10
  • 83
    • 84885058143 scopus 로고    scopus 로고
    • The effect of tumor subtype on the time from primary diagnosis to development of brain metastases and survival in patients with breast cancer
    • Sperduto P.W., Kased N., Roberge D., Chao S.T., Shanley R., Luo X., Sneed P.K., Suh J., Weil R.J., Jensen A.W., et al. The effect of tumor subtype on the time from primary diagnosis to development of brain metastases and survival in patients with breast cancer. J.Neurooncol. 2013, 112:467-472.
    • (2013) J.Neurooncol. , vol.112 , pp. 467-472
    • Sperduto, P.W.1    Kased, N.2    Roberge, D.3    Chao, S.T.4    Shanley, R.5    Luo, X.6    Sneed, P.K.7    Suh, J.8    Weil, R.J.9    Jensen, A.W.10
  • 84
    • 48749122073 scopus 로고    scopus 로고
    • Central nervous system metastases in HER-2-overexpressing metastatic breast cancer: a treatment challenge
    • Stemmler H.J., Heinemann V. Central nervous system metastases in HER-2-overexpressing metastatic breast cancer: a treatment challenge. Oncologist 2008, 13:739-750.
    • (2008) Oncologist , vol.13 , pp. 739-750
    • Stemmler, H.J.1    Heinemann, V.2
  • 85
    • 33845599378 scopus 로고    scopus 로고
    • Ratio of trastuzumab levels in serum and cerebrospinal fluid is altered in HER2-positive breast cancer patients with brain metastases and impairment of blood-brain barrier
    • Stemmler H.J., Schmitt M., Willems A., Bernhard H., Harbeck N., Heinemann V. Ratio of trastuzumab levels in serum and cerebrospinal fluid is altered in HER2-positive breast cancer patients with brain metastases and impairment of blood-brain barrier. Anticancer Drugs 2007, 18:23-28.
    • (2007) Anticancer Drugs , vol.18 , pp. 23-28
    • Stemmler, H.J.1    Schmitt, M.2    Willems, A.3    Bernhard, H.4    Harbeck, N.5    Heinemann, V.6
  • 91
    • 19944422751 scopus 로고    scopus 로고
    • Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases
    • Winkler F., Kozin S.V., Tong R.T., Chae S.S., Booth M.F., Garkavtsev I., Xu L., Hicklin D.J., Fukumura D., di Tomaso E., et al. Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases. Cancer Cell 2004, 6:553-563.
    • (2004) Cancer Cell , vol.6 , pp. 553-563
    • Winkler, F.1    Kozin, S.V.2    Tong, R.T.3    Chae, S.S.4    Booth, M.F.5    Garkavtsev, I.6    Xu, L.7    Hicklin, D.J.8    Fukumura, D.9    di Tomaso, E.10
  • 92
    • 53049095387 scopus 로고    scopus 로고
    • Effective CpG immunotherapy of breast carcinoma prevents but fails to eradicate established brain metastasis
    • Xiong Z., Gharagozlou S., Vengco I., Chen W., Ohlfest J.R. Effective CpG immunotherapy of breast carcinoma prevents but fails to eradicate established brain metastasis. Clin. Cancer Res. 2008, 14:5484-5493.
    • (2008) Clin. Cancer Res. , vol.14 , pp. 5484-5493
    • Xiong, Z.1    Gharagozlou, S.2    Vengco, I.3    Chen, W.4    Ohlfest, J.R.5
  • 93
    • 84873929747 scopus 로고    scopus 로고
    • Bevacizumab in the treatment of five patients with breast cancer and brain metastases: Japan Breast Cancer Research Network-07 trial
    • Yamamoto D., Iwase S., Tsubota Y., Sueoka N., Yamamoto C., Kitamura K., Odagiri H., Nagumo Y. Bevacizumab in the treatment of five patients with breast cancer and brain metastases: Japan Breast Cancer Research Network-07 trial. Onco Targets Ther. 2012, 5:185-189.
    • (2012) Onco Targets Ther. , vol.5 , pp. 185-189
    • Yamamoto, D.1    Iwase, S.2    Tsubota, Y.3    Sueoka, N.4    Yamamoto, C.5    Kitamura, K.6    Odagiri, H.7    Nagumo, Y.8
  • 94
    • 77957585027 scopus 로고    scopus 로고
    • Phase I trial of the irreversible EGFR and HER2 kinase inhibitor BIBW 2992 in patients with advanced solid tumors
    • Yap T.A., Vidal L., Adam J., Stephens P., Spicer J., Shaw H., Ang J., Temple G., Bell S., Shahidi M., et al. Phase I trial of the irreversible EGFR and HER2 kinase inhibitor BIBW 2992 in patients with advanced solid tumors. J.Clin. Oncol. 2010, 28:3965-3972.
    • (2010) J.Clin. Oncol. , vol.28 , pp. 3965-3972
    • Yap, T.A.1    Vidal, L.2    Adam, J.3    Stephens, P.4    Spicer, J.5    Shaw, H.6    Ang, J.7    Temple, G.8    Bell, S.9    Shahidi, M.10
  • 95
    • 75649093779 scopus 로고    scopus 로고
    • Disruption of the blood brain barrier by brain metastases of triple-negative and basal-type breast cancer but not HER2/neu-positive breast cancer
    • Yonemori K., Tsuta K., Ono M., Shimizu C., Hirakawa A., Hasegawa T., Hatanaka Y., Narita Y., Shibui S., Fujiwara Y. Disruption of the blood brain barrier by brain metastases of triple-negative and basal-type breast cancer but not HER2/neu-positive breast cancer. Cancer 2010, 116:302-308.
    • (2010) Cancer , vol.116 , pp. 302-308
    • Yonemori, K.1    Tsuta, K.2    Ono, M.3    Shimizu, C.4    Hirakawa, A.5    Hasegawa, T.6    Hatanaka, Y.7    Narita, Y.8    Shibui, S.9    Fujiwara, Y.10
  • 96
    • 0028856184 scopus 로고
    • Reactions of astrocytes and microglial cells around hematogenous metastases of the human brain. Expression of endothelin-like immunoreactivity in reactive astrocytes and activation of microglial cells
    • Zhang M., Olsson Y. Reactions of astrocytes and microglial cells around hematogenous metastases of the human brain. Expression of endothelin-like immunoreactivity in reactive astrocytes and activation of microglial cells. J.Neurol. Sci. 1995, 134:26-32.
    • (1995) J.Neurol. Sci. , vol.134 , pp. 26-32
    • Zhang, M.1    Olsson, Y.2
  • 97
    • 79551514024 scopus 로고    scopus 로고
    • MicroRNA-1258 suppresses breast cancer brain metastasis by targeting heparanase
    • Zhang L., Sullivan P.S., Goodman J.C., Gunaratne P.H., Marchetti D. MicroRNA-1258 suppresses breast cancer brain metastasis by targeting heparanase. Cancer Res. 2011, 71:645-654.
    • (2011) Cancer Res. , vol.71 , pp. 645-654
    • Zhang, L.1    Sullivan, P.S.2    Goodman, J.C.3    Gunaratne, P.H.4    Marchetti, D.5


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