αb-crystallin: A novel regulator of breast cancer metastasis to the Brain

Clinical Cancer Research

Volumn 20, Issue 1, 2014, Pages 56-67

  Malin, Dmitry ^a   Strekalova, Elena ^a   Petrovic, Vladimir ^a   Deal, Allison M ^c   Al Ahmad, Abraham ^b   Adamo, Barbara ^d   Miller, C Ryan ^c   Ugolkov, Andrey ^e   Livasy, Chad ^f   Fritchie, Karen ^g   Hamilton, Erika ^h   Blackwell, Kimberly ^h   Geradts, Joseph ^h   Ewend, Matt ^c   Carey, Lisa ^c   Shusta, Eric V ^b   Anders, Carey K ^c   Cryns, Vincent L ^a  

^a UNIVERSITY OF WISCONSIN   (United States)

^b University of Wisconsin Madison   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

^d VALL D HEBRON UNIVERSITY HOSPITAL   (Spain)

^e NORTHWESTERN UNIVERSITY   (United States)

^f CAROLINAS MEDICAL CENTER   (United States)

^g MAYO CLINIC   (United States)

^h DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CRYSTALLIN; ALPHAB CRYSTALLIN; SCLEROPROTEIN; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN METASTASIS; CANCER CELL; CELL ADHESION; CONTROLLED STUDY; FEMALE; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MAJOR CLINICAL STUDY; MICROVASCULAR ENDOTHELIAL CELL; MOUSE; NONHUMAN; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSENDOTHELIAL AND TRANSEPITHELIAL MIGRATION; TRIPLE NEGATIVE BREAST CANCER; ANIMAL; BRAIN TUMOR; CANCER TRANSPLANTATION; GENE EXPRESSION; KAPLAN MEIER METHOD; KNOCKOUT MOUSE; METABOLISM; METASTASIS; MORTALITY; NONOBESE DIABETIC MOUSE; PATHOLOGY; PHYSIOLOGY; SCID MOUSE; TUMOR CELL LINE; VASCULAR ENDOTHELIUM;

ALPHA-CRYSTALLIN B CHAIN; ANIMALS; BLOOD-BRAIN BARRIER; BRAIN NEOPLASMS; CELL ADHESION; CELL LINE, TUMOR; ENDOTHELIUM, VASCULAR; FEMALE; GENE EXPRESSION; GENE KNOCKDOWN TECHNIQUES; HUMANS; KAPLAN-MEIER ESTIMATE; MICE, INBRED NOD; MICE, KNOCKOUT; MICE, SCID; NEOPLASM TRANSPLANTATION; TRANSENDOTHELIAL AND TRANSEPITHELIAL MIGRATION; TRIPLE NEGATIVE BREAST NEOPLASMS;

EID: 84892176637     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-13-1255     Document Type: Article

References (44)

1. Lin NU, Bellon JR, Winer EP. CNS metastases in breast cancer. J Clin Oncol 2004;22:3608-17.
2. Arshad F, Wang L, Sy C, Avraham S, Avraham HK. Blood-brain barrier integrity and breast cancer metastasis to the brain. Patholog Res Int 2010;2011:920509.
3. Steeg PS, Camphausen KA, Smith QR. Brain metastases as preventive and therapeutic targets. Nat Rev Cancer 2011;11:352-63.
4. Kienast Y, von Baumgarten L, Fuhrmann M, Klinkert WE, Goldbrunner R, Herms J, et al. Real-time imaging reveals the single steps of brain metastasis formation. Nat Med 2010;16:116-22.
5. Lorger M, Felding-Habermann B. Capturing changes in the brain microenvironment during initial steps of breast cancer brain metastasis. Am J Pathol 2010;176:2958-71.
6. Carbonell WS, Ansorge O, Sibson N, Muschel R. The vascular basement membrane as "soil" in brain metastasis. PLoS One 2009; 4:e5857.
7. Gaedcke J, Traub F, Milde S, Wilkens L, Stan A, Ostertag H, et al. Predominance of the basal type and HER-2/neu type in brain metastasis from breast cancer. Mod Pathol 2007;20:864-70.
8. Smid M, Wang Y, Zhang Y, Sieuwerts AM, Yu J, Klijn JG, et al. Subtypes of breast cancer show preferential site of relapse. Cancer Res 2008;68:3108-14.
9. Toft DJ, Cryns VL. Minireview: Basal-like breast cancer: from molecular profiles to targeted therapies. Mol Endocrinol 2011;25:199-211.
10. Lin NU, Claus E, Sohl J, Razzak AR, Arnaout A, Winer EP. Sites of distant recurrence and clinical outcomes in patients with metastatic triple-negative breast cancer: high incidence of central nervous system metastases. Cancer 2008;113:2638-45.
11. Dawood S, Lei X, Litton JK, Buchholz TA, Hortobagyi GN, Gonzalez- Angulo AM. Incidence of brain metastases as a first site of recurrence among women with triple receptor-negative breast cancer. Cancer 2012;118:4652-9.
12. Bos PD, Zhang XH, Nadal C, Shu W, Gomis RR, Nguyen DX, et al. Genes that mediate breast cancer metastasis to the brain. Nature 2009;459:1005-9.
13. Moyano JV, Evans JR, Chen F, Lu M, Werner ME, Yehiely F, et al. αBcrystallin is a novel oncoprotein that predicts poor clinical outcome in breast cancer. J Clin Invest 2006;116:261-70.
14. Sitterding SM, Wiseman WR, Schiller CL, Luan C, Chen F, Moyano JV, et al. αB-crystallin: a novel marker of invasive basal-like and metaplastic breast carcinomas. Ann Diagn Pathol 2008;12:33-40.
15. Kim HS, Lee Y, Lim YA, Kang HJ, Kim LS. αB-crystallin is a novel oncoprotein associated with poor prognosis in breast cancer. J Breast Cancer 2011;14:14-19.
16. Kamradt MC, Chen F, Cryns VL. The small heat shock protein αBcrystallin negatively regulates cytochrome c- and caspase-8-dependent activation of caspase-3 by inhibiting its autoproteolytic maturation. J Biol Chem 2001;276:16059-63.
17. Kamradt MC, Chen F, Sam S, Cryns VL. The small heat shock protein αB-crystallin negatively regulates apoptosis during myogenic differentiation by inhibiting caspase-3 activation. J Biol Chem 2002;277:38731-6.
18. Petrovic V, Malin D, Cryns VL. αB-Crystallin promotes oncogenic transformation and inhibits caspase activation in cells primed for apoptosis by Rb inactivation. Breast Cancer Res Treat 2013;138:415-25.
19. Stegh AH, Kesari S, Mahoney JE, Jenq HT, Forloney KL, Protopopov A, et al. Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma. Proc Natl Acad Sci U S A 2008;105:10703-8.
20. Ho PY, Chueh SC, Chiou SH, Wang SM, Lin WC, Lee IL, et al. αBcrystallin in clear cell renal cell carcinoma: tumor progression and prognostic significance. Urol Oncol 2013;31:1367-77.
21. van de Schootbrugge C, Bussink J, Span P, Sweep F, Gréenman R, Stegeman H, et al. αB-crystallin stimulates VEGF secretion and tumor cell migration and correlates with enhanced distant metastasis in head and neck squamous cell carcinoma. BMC Cancer 2012;13:128.
22. Goplen D, Bougnaud S, Rajcevic U, Boe SO, Skaftnesmo KO, Voges J, et al. αB-crystallin is elevated in highly infiltrative apoptosis-resistant glioblastoma cells. Am J Pathol 2010;177:1618-28.
23. Perng MD, Cairns L, van den IP, Prescott A, Hutcheson AM, Quinlan RA. Intermediate filament interactions can be altered by HSP27 and αB-crystallin. J Cell Sci 1999;112:2099-112.
24. Singh BN, Rao KS, Ramakrishna T, Rangaraj N, Rao Ch M. Association of αB-crystallin, a small heat shock protein, with actin: role in modulating actin filament dynamics in vivo. J Mol Biol 2007;366:756-67.
25. Chelouche-Lev D, Kluger HM, Berger AJ, Rimm DL, Price JE. αBcrystallin as a marker of lymph node involvement in breast carcinoma. Cancer 2004;100:2543-8.
26. Allred DC, Harvey JM, Berardo M, Clark GM. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod Pathol 1998;11:155-68.
27. Wolff AC, Hammond ME, Schwartz JN, Hagerty KL, Allred DC, Cote RJ, et al. American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer. J Clin Oncol 2007;25:118-45.
28. Malin D, Chen F, Schiller C, Koblinski J, Cryns VL. Enhanced metastasis suppression by targeting TRAIL receptor 2 in a murine model of triple-negative breast cancer. Clin Cancer Res 2011;17:5005-15.
29. Pear WS, Nolan GP, Scott ML, Baltimore D. Production of high-titer helper-free retroviruses by transient transfection. Proc Natl Acad Sci U S A 1993;90:8392-6.
30. Chatterjee S, Wei H. Roles of glycosphingolipids in cell signaling: adhesion, migration, and proliferation. Methods Enzymol 2003;363:300-312.
31. Eugenin EA, Berman JW. Chemokine-dependent mechanisms of leukocyte trafficking across a model of the blood-brain barrier. Methods 2003;29:351-61.
32. Lu M, Strohecker A, Chen F, Kwan T, Bosman J, Jordan VC, et al. Aspirin sensitizes cancer cells to TRAIL-induced apoptosis by reducing survivin levels. Clin Cancer Res 2008;14:3168-76.
33. Price EA, Coombe DR, Murray JC. Beta-1 integrins mediate tumour cell adhesion to quiescent endothelial cells in vitro. Br J Cancer 1996; 74:1762-6.
34. Fujisaki T, Tanaka Y, Fujii K, Mine S, Saito K, Yamada S, et al. CD44 stimulation induces integrin-mediated adhesion of colon cancer cell lines to endothelial cells by up-regulation of integrins and c-Met and activation of integrins. Cancer Res 1999;59:4427-4434.
35. Reymond N, Im JH, Garg R, Vega FM, Borda d'Agua B, Riou P, et al. Cdc42 promotes transendothelial migration of cancer cells through b1 integrin. J Cell Biol 2012;199:653-68.
36. Wang H, Fu W, Im JH, Zhou Z, Santoro SA, Iyer V, et al. Tumor cell a3b1 integrin and vascular laminin-5 mediate pulmonary arrest and metastasis. J Cell Biol 2004;164:935-41.
37. Gril B, Evans L, Palmieri D, Steeg PS. Translational research in brain metastasis is identifying molecular pathways that may lead to the development of new therapeutic strategies. Eur J Cancer 2010;46:1204-10.
38. Cruz-Munoz W, Kerbel RS. Preclinical approaches to study the biology and treatment of brain metastases. Semin Cancer Biol 2011;21:123-30.
39. Huang XY, Ke AW, Shi GM, Zhang X, Zhang C, Shi YH, et al. αBCrystallin complexes with 14-3-3z to induce epithelial-mesenchymal transition and resistance to sorafenib in hepatocellular carcinoma. Hepatology 2013;57:2235-47.
40. Shintani Y, Higashiyama S, Ohta M, Hirabayashi H, Yamamoto S, Yoshimasu T, et al. Overexpression of ADAM9 in non-small cell lung cancer correlates with brain metastasis. Cancer Res 2004;64:4190-6.
41. Yoshimasu T, Sakurai T, Oura S, Hirai I, Tanino H, Kokawa Y, et al. Increased expression of integrin a3b1 in highly brain metastatic subclone of a human non-small cell lung cancer cell line. Cancer Sci 2004;95:142-8.
42. Huck L, Pontier SM, Zuo DM, Muller WJ. b1-integrin is dispensable for the induction of Erb B2 mammary tumors but plays a critical role in the metastatic phase of tumor progression. Proc Natl Acad Sci U S A 2010;107:15559-64.
43. Kamradt MC, Lu M, Werner ME, Kwan T, Chen F, Strohecker A, et al. The small heat shock protein αB-crystallin is a novel inhibitor of TRAIL induced apoptosis that suppresses the activation of caspase-3. J Biol Chem 2005;280:11059-66.
44. Kato H, Liao Z, Mitsios JV, Wang HY, Deryugina EI, Varner JA, et al. The primacy of b1 integrin activation in the metastatic cascade. PLoS One 2012;7:e46576.