Hepatocyte free cholesterol lipotoxicity results from JNK1-mediated mitochondrial injury and is HMGB1 and TLR4-dependent

Journal of Hepatology

Volumn 61, Issue 6, 2014, Pages 1376-1384

  Gan, Lay T ^a   Van Rooyen, Derrick M ^a   Koina, Mark E ^b   McCuskey, Robert S ^c   Teoh, Narcissus C ^a   Farrell, Geoffrey C ^a  

^a AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^b CANBERRA HOSPITAL   (Australia)

^c UNIVERSITY OF ARIZONA   (United States)

Author keywords

Electron microscopy; Endoplasmic reticulum stress; Membrane pore transition; Mitochondrial oxidative stress; Plasma membrane

Indexed keywords

4 PHENYLBUTYRIC ACID; ADENOSINE TRIPHOSPHATE; CASPASE 3 INHIBITOR; CHOLESTEROL; CYCLOSPORIN A; CYTOCHROME C; FREE CHOLESTEROL; GLUTATHIONE; GLUTATHIONE DISULFIDE; HIGH MOBILITY GROUP B1 PROTEIN; LACTATE DEHYDROGENASE; LOW DENSITY LIPOPROTEIN; STRESS ACTIVATED PROTEIN KINASE 1; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG; HMGB1 PROTEIN, MOUSE; MITOGEN ACTIVATED PROTEIN KINASE 9; TLR4 PROTEIN, MOUSE;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DEATH; CELL MEMBRANE; CONTROLLED STUDY; CULTURE MEDIUM; DIABETES MELLITUS; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ELECTRON MICROSCOPY; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FEMALE; FLUORESCENCE; INCUBATION TIME; LIPOTOXICITY; LIVER CELL; LIVER CELL DAMAGE; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; MITOCHONDRION SWELLING; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; OBESITY; OXIDATIVE STRESS; PRIORITY JOURNAL; SINGLE BLIND PROCEDURE; WILD TYPE; ANIMAL; C57BL MOUSE; CELL CULTURE; DEFICIENCY; DISEASE MODEL; GENETICS; KNOCKOUT MOUSE; LIVER MITOCHONDRION; METABOLISM; MUTANT MOUSE STRAIN; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; CELLS, CULTURED; CHOLESTEROL; CYTOCHROMES C; DISEASE MODELS, ANIMAL; FEMALE; HEPATOCYTES; HMGB1 PROTEIN; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, MUTANT STRAINS; MITOCHONDRIA, LIVER; MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASE 9; NON-ALCOHOLIC FATTY LIVER DISEASE; OXIDATIVE STRESS; TOLL-LIKE RECEPTOR 4;

EID: 84922735187     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2014.07.024     Document Type: Article

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