Vitamins C and E for asthma and exercise-induced bronchoconstriction

Cochrane Database of Systematic Reviews

Volumn 2014, Issue 6, 2014, Pages

  Wilkinson, Mark ^a   Hart, Anna ^b   Milan, Stephen J ^c   Sugumar, Karnam ^d  

^a UNIVERSITY HOSPITALS OF MORECAMBE BAY NHS FOUNDATION TRUST   (United Kingdom)

^b LANCASTER UNIVERSITY   (United Kingdom)

^c LANCASTER UNIVERSITY   (United Kingdom)

^d ROYAL PRESTON HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; PLACEBO; ANTIOXIDANT; VITAMIN;

ADULT; BRONCHOCONSTRICTION; DISEASE EXACERBATION; DRUG EFFICACY; DRUG SAFETY; EVIDENCE BASED MEDICINE; EXERCISE INDUCED ASTHMA; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SYSTEMATIC REVIEW; VITAMIN SUPPLEMENTATION; ASTHMA; ASTHMA, EXERCISE-INDUCED; CHILD; CHRONIC DISEASE; DRUG EFFECTS; EXERCISE;

ADULT; ANTIOXIDANTS; ASCORBIC ACID; ASTHMA; ASTHMA, EXERCISE-INDUCED; BRONCHOCONSTRICTION; CHILD; CHRONIC DISEASE; EXERCISE; HUMANS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; VITAMINS;

EID: 84922733429     PISSN: None     EISSN: 1469493X     Source Type: Journal    
DOI: 10.1002/14651858.CD010749.pub2     Document Type: Review

References (159)

1. Hernandez M, Zhou H, Zhou B, Robinette C, Crissman K, Hatch G, et al. Combination treatment with high-dose vitamin C and alpha-tocopherol does not enhance respiratory-tract lining fluid vitamin C levels in asthmatics. Inhalation Toxicology 2009;21(3):173-81. [CRS-ID: 4900100000023507]
2. NCT00142610. The role of vitamins E and C in maintaining lung health in people with asthma. http://clinicaltrials.gov/show/NCT00142610 (accessed 27 January 2014). [CRS-ID: 4900100000020473]
3. Kiss A, Horvath IM, Chung KF, Barnes PJ, Horvath I M, Chung KF. Vitamin C and E supplementation in mild asthma - assessment by non-invasive methods. European Respiratory Journal 2000;16(Supplement 31):40s. [CRS-ID: 4900100000013940]
4. Murphy JD, Ferguson CS, Brown KR, Harms CA. The effect of dietary antioxidants on lung function in exercise induced asthmatics [Abstract]. Medicine and Science in Sports and Exercise 2002;34(5 Suppl 1):S155. [CRS-ID: 4900100000022714]
5. Ramirez M, Morena H, Sienra JJ, Reyes N, Del Rio BE, Hatch G, et al. Modulation of air pollution impact on peak expiratory flow by serum levels of a-tocopherol and ascorbic acid among asthmatic children in Mexico City [abstract]. American Thoracic Society 99th International Conference; May 16-21; Seattle. 2003:B091 Poster 917. [CRS-ID: 4900100000015550;: 4900100000015550]
6. Romieu I, Sienra JJ, Ramirez M, Moreno H, Del Rio BE, Hatch G, et al. Antioxidant supplementation and inflammatory responses among young asthmatics exposed to high levels of air pollutants [Abstract]. European Respiratory Journal 2004;24(Suppl 48):623s. [CRS-ID: 4900100000018388]
7. Romieu I, Sienra JJ, Ramirez M, Moreno H, Reyes NI, Del Rio BE, et al. Antioxidant supplementation and generic susceptibility to ozone: a randomized controlled trial of children with asthma [abstract]. American Thoracic Society 99th International Conference; May 16-21; Seattle. 2003:C014. [CRS-ID: 4900100000015561;: 4900100000015561]
8. Romieu I, Sienra Monge JJ, Ramirez M, Reyes Ruiz NI, del Rio Navarro BE, Ruiz Navarro MX, et al. Impact of antioxidant supplementation on the respiratory health of asthmatic children exposed to high levels of particulate and ozone in Mexico City. American Journal of Respiratory and Critical Care Medicine 2001;163(5 Suppl):A40. [CRS-ID: 4900100000012741]
9. Romieu I, Sienra-Monge J, Ramirez M, Moreno-Macias H, del Rio-Navarro B, Ruiz-Navarro M, et al. Impact of antioxidant supplementation in the inflammatory response in asthmatic children exposed to high levels of ozone in Mexico City [abstract]. American Journal of Respiratory and Critical Care Medicine 2002;165(8 Suppl):A437. [CRS-ID: 4900100000021202;: 4900100000021202]
10. Romieu I, Sienra-Monge JJ, Ramirez-Aguilar M, Moreno-Macias H, Reyes-Ruiz NI, Del Rio-Navarro BE. Incidence of wheezing and genetic polymorphism of GSTM1 among asthmatic children supplemented with antioxidants in Mexico City [Abstract]. American Thoracic Society 100th International Conference; May 21-26; Orlando. 2004:C24 Poster 701. [CRS-ID: 4900100000017543]
11. Romieu I, Sienra-Monge JJ, Ramirez-Aguilar M, Moreno-Macias H, Reyes-Ruiz NI, Estela del Río-Navarro B, et al. Genetic polymorphism of GSTM1 and antioxidant supplementation influence lung function in relation to ozone exposure in asthmatic children in Mexico City.[see comment]. Thorax 2004;59(1):8-10. [CRS-ID: 4900100000015916]
12. Romieu I, Sienra-Monge JJ, Ramírez-Aguilar M, Téllez-Rojo MM, Moreno-Macías H, Reyes-Ruiz NI, et al. Antioxidant supplementation and lung functions among children with asthma exposed to high levels of air pollutants. American Journal of Respiratory and Critical Care Medicine 2002;166(5):703-9. [CRS-ID: 4900100000013590]
13. Sienra-Monge JJ, Ramirez-Aguilar M, Moreno-Macias H, Reyes-Ruiz NI, Del Río-Navarro BE, Ruiz-Navarro MX, et al. Antioxidant supplementation and nasal inflammatory responses among young asthmatics exposed to high levels of ozone. Clinical and Experimental Immunology 2004;138(2):317-22. [CRS-ID: 4900100000017232]
14. Trenga CA, Koenig JQ, Williams PV. Dietary antioxidants and ozone-induced bronchial hyperresponsiveness in adults with asthma. Archives of Environmental Health 2001;56(3):242-9. [CRS-ID: 4900100000010633]
15. Retraction. Omega-3 fatty acids, vitamin C and Zn supplementation in asthmatic children: a randomized self-controlled study. Acta Paediatrica 2012;8:891.
16. Al-Biltagi MA, Baset AA, Bassiouny M, Kasrawi MA, Attia M. Omega-3 fatty acids, vitamin C and Zn supplementation in asthmatic children: a randomized self-controlled study. Acta Paediatrica 2009;98(4):737-42. [CRS-ID: 4900100000024026]
17. Aliyali M, Poorhasan Amiri A, Sharifpoor A, Zalli F, Amiri AP. Effects of N-acetylcysteine on asthma exacerbation. Iranian Journal of Allergy, Asthma, and Immunology 2010;9(2):103-9. [CRS-ID: 4900100000025774]
18. Anah CO, Jarike LN, Baig HA. High dose ascorbic acid in Nigerian asthmatics. Tropical and Geographical Medicine 1980;32(2):132-7. [CRS-ID: 4900100000001041]
19. Anderson R, Hay I, van Wyk HA, Theron A. Ascorbic acid in bronchial asthma. South African Medical Journal 1983;63(17):649-52. [CRS-ID: 4900100000007725]
20. Bagnato GF, Gulli S, De Pasquale R, Giacobbe O, Spatari G, Purello d'Ambrosio F. Effect of inhaled glutathione on airway response to 'fog' challenge in asthmatic patients [English]. Respiration 1999;66(6):518-21. [CRS-ID: 4900100000008282]
21. Baumann JM, Rundell KW, Evans TM, Levine AM. Effects of cysteine donor supplementation on exercise-induced bronchoconstriction. Medicine and Science in Sports and Exercise 2005;37(9):1468-73. [CRS-ID: 4900100000019033]
22. Bede O, Nagy D, Suranyi A, Horvath I, Szlavik M, Gyurkovits K. Effects of magnesium supplementation on the glutathione redox system in atopic asthmatic children. Inflammation Research 2008;57(6):279-86. [CRS-ID: 4900100000022810]
23. Belousova CG, Geppe NA, Bolevich SB, Soodaeva SK, Climanov IA, Kolosova NG. Free radical status and antioxidant defense in children with asthma treated by inhaled corticosteroids combined with prolonged b2-agonist [Abstract]. European Respiratory Journal 2006;28(Suppl 50):483s [P2790]. [CRS-ID: 4900100000021733]
24. Bensenor IM, Cook NR, Lee IM, Chown MJ, Hennekens CH, Buring JE, et al. Active and passive smoking and risk of colds in women. Annals of Epidemiology 2001;11(4):225-31. [CRS-ID: 4900100000010411]
25. Bernorio S, Pecis M, Zucchi A, Guerra G, Migliorini V, Negri L, et al. Glutathione in bronchial hyperresponsiveness. Journal of Aerosol Medicine 1996;9(2):207-13. [CRS-ID: 4900100000009077]
26. Cakmak G, Demir T, Gemicioglu B, Aydemir A, Serdaroglu E, Donma O. The effects of add-on zafirlukast treatment to budesonide on bronchial hyperresponsiveness and serum levels of eosinophilic cationic protein and total antioxidant capacity in asthmatic patients. Tohoku Journal of Experimental Medicine 2004;204(4):249-56. [CRS-ID: 4900100000017948]
27. Carlsten C, Pui M, MacNutt M, DyBuncio A, Lay J, Alexis N. Effect of antioxidant supplementation on diesel exhaust (DE)-associated changes in airway reactivity and innate immunity: a controlled crossover exposure study In humans [Abstract]. American Journal of Respiratory and Critical Care Medicine 2011;183(Meeting Abstracts):A3279. [CRS-ID: 4900100000053860]
28. Carlsten C, Pui M, MacNutt M, Lay J, Alexis N. Antioxidant supplementation attenuates changes in innate immunity associated with diesel exhaust (DE) in the lung: a controlled crossover exposure study [Abstract]. European Respiratory Society Annual Congress, Amsterdam, The Netherlands, September 24-28. 2011; Vol. 38, issue 55:611s [3443]. [CRS-ID: 4900100000054156]
29. Carlsten C, Pui M, Macnutt M, DyBuncio A, Lay J, Alexis N. Diesel exhaust (DE)-associated increase in airway reactivity is mitigated by anti-oxidant supplementation in asthmatics [Abstract]. Journal of Allergy and Clinical Immunology 2011;127(2 Suppl 1):AB215. [CRS-ID: 4900100000026706]
30. Chazan R, Droszcz W. Phagocytic activity of the peripheral blood granulocytes in patients treated with triamcinolone acetonide and vitamin C [Aktywnosc fagocytarna granulocytow krwi obwodowej osob leczonych acetonidem triamcinolonu, w trakcie stosowania witaminy C]. Pneumonologia Polska 1981;49(8-9):621-6. [CRS-ID: 4900100000013352]
31. Clark J, Craig L, McNeill G, Smith N, Norrie J, Devereux G. A novel dietary intervention to optimize vitamin E intake of pregnant women to 15 mg/day. Journal of the Academy of Nutrition and Dietetics 2012;112(2):297-301. [CRS-ID: 4900100000060358]
32. Cohen HA, Neuman I, Nahum H. Blocking effect of vitamin C in exercise-induced asthma. Archives of Pediatrics and Adolescent Medicine 1997;151(4):367-70. [CRS-ID: 4900100000005656]
33. Covar R, Gleason M, MacOmber B, Stewart L, Szefler P, Engelhardt K, et al. Impact of a novel nutritional formula on asthma control and biomarkers of allergic airway inflammation in children. Clinical and Experimental Allergy 2010;40(8):1163-74. [CRS-ID: 4900100000025418]
34. Cristofalo MG, Savojardo M, Pecorella G, Galiano S, Lo-Coco L, Parisi A, et al. The end of antioxidizing treatment for pulmonary illness. Our experience [Ruolo degli antiossidanti nel danno polmonare. Nostre esperienze]. Medicina Dello Sport 1999;52(3):165-75. [CRS-ID: 4900100000013372]
35. Cuomo B, Fasoli L, Guerrea T, Cosettini M, Don M, Saretta F, et al. Efficacy of antioxidant supplementation diet in asthmatic children [abstract]. European Respiratory Journal 2004;24(Suppl 48):167s. [CRS-ID: 4900100000018245]
36. Daniliak IG, Kogan AK, Bolevich S. [Aevit and glutamic acid in the treatment of patients with bronchial asthma] [Aevit i glutaminovaia kislota v lechenii bol'nykh bronkhial'noa astmoa]. Klinicheskaia Meditsina 1995;73(5):50-3. [CRS-ID: 4900100000005069]
37. Darabi B, Moin M, Purpbak Z. The effect of vitamin D supplementation over asthma outcome. Iranian Journal of Allergy, Asthma, and Immunology 2013;12(9S):S87. [CRS-ID: 4900100000075334]
38. Dauletbaev N, Rickmann J, Viel K, Buhl R, Wagner TO, Bargon J. Glutathione in induced sputum of healthy individuals and patients with asthma. Thorax 2001;56(1):13-8. [CRS-ID: 4900100000009917]
39. De Lucia F, Bonavia M, Crimi E, Scaricabarozzi I, Brusasco V. Antiinflammatory-antioxidant treatment with a methane sulfonanilide in allergen-induced asthma. Annals of Allergy 1991;66(5):424-9. [CRS-ID: 4900100000003407]
40. Dunstan JA, Breckler L, Hale J, Lehmann H, Franklin P, Lyons G, et al. Supplementation with vitamins C, E, beta-carotene and selenium has no effect on anti-oxidant status and immune responses in allergic adults: a randomized controlled trial. Clinical and Experimental Allergy 2007;37(2):180-7. [CRS-ID: 4900100000019935]
41. Echazarreta AL, Sala E, Rahman I, Peinado V, Barbera JA, Roca J, et al. Effects of platelet-activating factor challenge on oxidant/antioxidant balance and exhaled nitric oxide in asthma. European Respiratory Journal 2000;16(Supplement 31):266s. [CRS-ID: 4900100000013885]
42. Echazarreta AL, Rahman I, Peinado V, Barbera JA, Roca J, MacNee W, et al. Lack of systemic oxidative stress during PAF challenge in mild asthma. Respiratory Medicine 2005;99(5):519-23. [CRS-ID: 4900100000018104;: 4900100000018104]
43. Ensom MH, Chong G, Zhou D, Beaudin B, Shalansky S, Bai TR. Estradiol in premenstrual asthma: a double-blind, randomized, placebo-controlled, crossover study. Pharmacotherapy 2003;23(5):561-71. [CRS-ID: 4900100000015244;: 4900100000015244]
44. Falk B, Gorev R, Zigel L, Ben-Amotz A, Neuman I. Effect of lycopene supplementation on lung function after exercise in young athletes who complain of exercise-induced bronchoconstriction symptoms. Annals of Allergy, Asthma & Immunology 2005;94(4):480-5. [CRS-ID: 4900100000018089]
45. Fogarty A, Lewis SA, Scrivener SL, Antoniak M, Pacey S, Pringle M, et al. Corticosteroid sparing effects of vitamin C and magnesium in asthma: a randomised trial. Respiratory Medicine 2006;100(1):174-9. [CRS-ID: 4900100000019468]
46. Fogarty A, Lewis SA, Scrivener SL, Antoniak M, Pacey S, Pringle M, et al. Oral magnesium and vitamin C supplements in asthma: a parallel group randomized placebo-controlled trial. Clinical and Experimental Allergy 2003;33(10):1355-9. [CRS-ID: 4900100000015864]
47. Greenough A, Shaheen SO, Shennan A, Seed PT, Poston L. Respiratory outcomes in early childhood following antenatal vitamin C and E supplementation. Thorax 2010;65(11):998-1003. [CRS-ID: 4900100000025831]
48. Gazdik F, Gazdikova K, Jahnova E, Pijak MR. Sparing effect of coenzyme Q10, a-tocopherol and ascorbic acid on the consumption of corticosteroids in allergic asthmatics [Abstract]. Allergy & Clinical Immunology International 2003;1 Suppl:Abstract No: P-2-38. [CRS-ID: 4900100000017072]
49. Gazdik F, Gvozdjakova A, Kucharska J, Kucharikova Z, Jahnova E, Gazdikova K. Coenzyme Q(10) supplementary therapy decreased corticoid consumption in patients with bronchial asthma. Advances in Immunopathology and Respiratory Allergy 2005:29-33. [CRS-ID: 4900100000050582;: 4900100000050582]
50. Gvozdjáková A, Kucharská J, Bartkovjaková M, Gazdíková K, Gazdík FE. Coenzyme Q10 supplementation reduces corticosteroids dosage in patients with bronchial asthma. BioFactors 2005;25(1-4):235-40. [CRS-ID: 4900100000019591]
51. Hosseini S, Pishnamazi S, Sadrzadeh SMH, Farid F, Farid R, Watson RR. Pycnogenol in the management of asthma. Journal of Medicinal Food 2001;4(4):201-9. [CRS-ID: 4900100000014253;: 4900100000014253]
52. Houdard YP. Trial of cortibucline. Marseille Medical 1969;106(11):993-7. [CRS-ID: 4900100000009302]
53. Jabbari Azad F, Rafatpanah H, Farid R, Watson R, Hosseini S, Tavallei A, et al. Phycnogenol in the management of asthma [Abstract]. XIX World Allergy Organization Congress; June 26-July 1; Munich. 2005:Abstract 268. [CRS-ID: 4900100000019178]
54. Jahnova E, Horvathova M, Gazdik F, Weissova S. Effects of selenium supplementation on expression of adhesion molecules in corticoid-dependent asthmatics. Bratislavske Lekarske Listy 2002;103(1):12-6. [CRS-ID: 4900100000049742]
55. Kligler B, Homel P, Blank AE, Kenney J, Levenson H, Merrell W. Randomized trial of the effect of an integrative medicine approach to the management of asthma in adults on disease-related quality of life and pulmonary function. Alternative Therapies in Health and Medicine 2011;17(1):10-5. [CRS-ID: 4900100000026399]
56. Kolpakova AF. [Effects of combined therapy with domestic inhalational anti-asthmatic drugs on oxidant status of patients with bronchial asthma]. [Russian]. Terapevticheskii Arkhiv 2007;79(3):41-4. [CRS-ID: 4900100000019994]
57. Kordansky DW, Rosenthal RR, Norman PS. The effect of vitamin C on antigen-induced bronchospasm. Journal of Allergy and Clinical Immunology 1979;63(1):61-4. [CRS-ID: 4900100000000861]
58. Kriukov EV, Novozhenov VG. Efficacy of antioxidants in the prophylaxis of respiratory diseases in young servicemen. Voenno-meditsinskii Zhurnal 2003;324(8):28-31. [CRS-ID: 4900100000050136]
59. Kurth T, Barr RG, Gaziano JM, Buring JE. Randomised aspirin assignment and risk of adult-onset asthma in the Women's Health Study. Thorax 2008;63(6):514-8. [CRS-ID: 4900100000022052]
60. Labhe RU, Mani UV, Iyer UM, Mishra M, Jani K, Bhattacharya A. The effect of spirulina in the treatment of bronchial asthma. Journal of Nutraceuticals, Functional and Medical Foods 2001;3(4):53-61. [CRS-ID: 4900100000017722]
61. Lau BHS, Riesen SK, Truong KP, Lau EW, Rohdewald P, Barreta RA. Pycnogenol as an adjunct in the management of childhood asthma. Journal of Asthma 2004;41(8):825-32. [CRS-ID: 4900100000017860]
62. Lipman WH, Simon SW. A clinical evaluation of a new aerosol for use in the treatment of bronchial asthma. Annals of Allergy 1964;22:460-7. [CRS-ID: 4900100000050062]
63. Lisitsa AV, Soodaeva SK, Klimanov IA, Chuchalin AG. The dynamics of blood plasma antioxidant activity in patients with asthma exacerbation during the course of phosphogliv admission [Abstract]. European Respiratory Journal 2007;30(Suppl 51):616s [P3618]. [CRS-ID: 4900100000022326]
64. Ma J, Strub P, Lavori PW, Buist AS, Camargo CA, Nadeau KC, et al. DASH for asthma: a pilot study of the DASH diet in not-well-controlled adult asthma. Contemporary Clinical Trials 2013;35(2):55-67. [CRS-ID: 4900100000078295]
65. Malo JL, Cartier A, Pineau L, L'Archevêque J, Ghezzo H, Martin RR. Lack of acute effects of ascorbic acid on spirometry and airway responsiveness to histamine in subjects with asthma. Journal of Allergy and Clinical Immunology 1986;78(6):1153-8. [CRS-ID: 4900100000002132]
66. Bime C, Wei CY, Holbrook J, Smith LJ, Wise RA. Association of dietary soy genistein intake with lung function and asthma control: a post-hoc analysis of patients enrolled in a prospective multicentre clinical trial. Primary Care Respiratory Journal 2012;21(4):398-404. [CRS-ID: 4900100000079791]
67. McEvoy C, Schilling D, Clay N, Go M, Jackson K, Bunten C, et al. Daily vitamin C taken by pregnant smoking women decreases wheezing at one year of age in their offspring: a randomized trial. American Journal of Respiratory and Critical Care Medicine 2013;187(Meeting Abstracts):A3802. [CRS-ID: 4900100000087891]
68. Medvedeva IV, Lapik SV, Gur'eva SA, Savina IA. Clinical and biochemical aspects of flixotide administration in patients with moderate bronchial asthma. Terapevticheskii Arkhiv 2002;74(3):21-5. [CRS-ID: 4900100000016602]
69. Moreira A, Moreira P, Delgado L, Fonseca J, Teixeira V, Barros R, et al. Polyunsaturated fatty acids: dietary supplementation has no effect on exhaled nitric oxide on asthmatic patients. A randomized, double-blind, placebo controlled trial [Abstract]. XIX World Allergy Organization Congress; June 26-July 1; Munich,. 2005:Abstract 272. [CRS-ID: 4900100000019150]
70. Moreira A, Moreira P, Delgado L, Fonseca J, Teixeira V, Padrão P, et al. Pilot study of the effects of n-3 polyunsaturated fatty acids on exhaled nitric oxide in patients with stable asthma. Journal of Investigational Allergology and Clinical Immunology 2007;17(5):309-13. [CRS-ID: 4900100000021419]
71. Nadi E, Tavakoli F, Zeraati F, Goodarzi MT, Hashemi SH. Effect of vitamin C administration on leukocyte vitamin C level and severity of bronchial asthma. Acta Medica Iranica 2012;50(4):233-8. [CRS-ID: 4900100000063744]
72. NCT00386178. Comparison of Gamma-tocopherol Supplementation in Allergic Asthmatics and Normal Volunteers. http://clinicaltrials.gov/show/NCT00386178 (accessed 27 January 2014). [CRS-ID: 4900100000089269]
73. NCT00466596. Effect of House Dust Mite Allergen Challenge in Persons Using 1200 mg Gamma Tocopherol Supplements. http://clinicaltrials.gov/show/NCT00466596 (accessed 27 January 2014). [CRS-ID: 4900100000089263]
74. NCT00581048. Oxidant Stress and Allergic Asthma. http://clinicaltrials.gov/show/NCT00581048 (accessed 27 January 2014). [CRS-ID: 4900100000089265]
75. NCT00672529. Orthomolecular Treatment as Add-on Therapy for Childhood Asthma. http://clinicaltrials.gov/show/NCT00672529 (accessed 27 January 2014). [CRS-ID: 4900100000089261]
76. NCT00836368. In Vitro Basophil Responsiveness to Allergen Challenge After Gamma-tocopherol Supplementation in Allergic Asthmatics. http://clinicaltrials.gov/show/NCT00836368 (accessed 27 January 2014). [CRS-ID: 4900100000089259]
77. NCT01317563. Phase 2 Study of Antioxidant Therapy in Lean and Obese Asthmatics. http://clinicaltrials.gov/show/NCT01317563 (accessed 27 January 2014). [CRS-ID: 4900100000089271]
78. NCT01661530. A Double Blind Randomised Placebo Controlled Pilot Study of a Dietary Soup Intervention During Pregnancy to Optimise Dietary Vitamin E Intake in Relation to Childhood Asthma. http://clinicaltrials.gov/show/NCT01661530 (accessed 27 January 2014). [CRS-ID: 4900100000089267]
79. Neuman I, Nahum H, Ben-Amotz A. Prevention of exercise-induced asthma by a natural isomer mixture of beta-carotene. Annals of Allergy, Asthma and Immunology 1999;82(6):549-53. [CRS-ID: 4900100000006435;: 4900100000006435]
80. Neuman I, Nahum H, Ben-Amotz A. Reduction of exercise-induced asthma oxidative stress by lycopene, a natural antioxidant. Allergy 2000;55(12):1184-9. [CRS-ID: 4900100000009984]
81. Nikitin AV, Kashin AV, Karpukhina EP. Correction of antioxidant defense in patients with bronchial asthma by the method of intravascular laser irradiation. Problemy Tuberkuleza 1993;1993(3):46-7. [CRS-ID: 4900100000004581]
82. O'Sullivan S, Doyle S, Cormican L, Gunaratnam C, Poulter LW, Burke CM. Attenuation of bronchial hyperresponsiveness to histamine by vitamin C in asthmatic subjects [abstract]. American Journal of Respiratory and Critical Care Medicine 2000;161(3 Suppl):A106. [CRS-ID: 4900100000014495]
83. Olekhnovich VM, Krylov VI, Sorogin VP, Zhogin SV. Therapeutic effectiveness of antioxidants in complex treatment of bronchial asthma in children [Terapevticheskaia effektivnost' antioksidantov v kompleksnom lechenii bronkhial'noi astmy u detei]. Pediatriia 1982;2:34-5. [CRS-ID: 4900100000009492]
84. Onur E, Kabaroglu C, Günay O, Var A, Yilmaz O, Dündar P, et al. The beneficial effects of physical exercise on antioxidant status in asthmatic children. Allergologia Et Immunopathologia 2011;39(2):90-5. [CRS-ID: 4900100000027060]
85. Panahi Y, Tavana S, Sahebkar A, Masoudi H, Madanchi N. Impact of adjunctive therapy with Chlorella vulgaris extract on antioxidant status, pulmonary function, and clinical symptoms of patients with obstructive pulmonary diseases. Scientia Pharmaceutica 2012;80(3):719-30. [CRS-ID: 4900100000066231]
86. Panina NT, Yakovleva NG, Kotenko TV, Danilov LN, Panina NT, Yakovleva NG, et al. Role of antioxidant and trace element complex in outpatient care of bronchial asthma [Abstract]. European Respiratory Journal 2002;20(Suppl 38):52s. [CRS-ID: 4900100000016045;: 4900100000016045]
87. Pearson PJK, Fogarty A, Lewis AS, Britton JR. Vitamin E supplementation in the treatment of asthma: a randomised controlled trial [Abstract]. European Respiratory Journal 2003;22(Suppl 45):Abstract No: [P724]. [CRS-ID: 4900100000016924]
88. Pearson PJK, Lewis SA, Britton JR, Fogarty A. Oxidative stress during a randomised controlled trial of vitamin E supplementation in atopic asthma [Abstract]. Thorax 2004;59(Suppl II):ii91. [CRS-ID: 4900100000018361]
89. Pearson PJ, Lewis SA, Britton J, Fogarty A. Vitamin E supplements in asthma: a parallel group randomised placebo controlled trial. Thorax 2004;59(8):652-6. [CRS-ID: 4900100000016708]
90. Pearson P, Lewis S, Britton J, Fogarty A. Exhaled carbon monoxide levels in atopic asthma: a longitudinal study. Respiratory Medicine 2005;99(10):1292-6. [CRS-ID: 4900100000019218]
91. Pennings HJ, Borm PJ, Evelo CT, Wouters EF. Changes in levels of catalase and glutathione in erythrocytes of patients with stable asthma, treated with beclomethasone dipropionate. European Respiratory Journal 1999;13(6):1260-6. [CRS-ID: 4900100000006483]
92. Peters EA, Hiltermann JTN, Stolk J. Effect of apocynin on ozone-induced airway hyperresponsiveness to methacholine in asthmatics. Free Radical Biology and Medicine 2001;31(11):1442-7. [CRS-ID: 4900100000011188]
93. Prieto L, Juyol M, Paricio A, Martinez MA, Palop J, Castro J. Oral challenge test with sodium metabisulfite in steroid-dependent asthmatic patients. Allergologia Et Immunopathologia 1988;16(6):393-6. [CRS-ID: 4900100000002778]
94. Pui M, Lay JC, Alexis NE, Carlsten C. Flow cytometry to identify leukocyte sub-populations in blood and induced sputum in asthmatic and healthy volunteers exposed to diesel exhaust [Abstract]. Allergy, Asthma, and Clinical Immunology 2010;6(Suppl 3):P7. [CRS-ID: 4900100000054152]
95. Ratanamaneechat S, George D, Kham A, Baran J, Nagle K, Naples R. Serum superoxide dismutase activity as a predictor of adverse events after H1N1 vaccination [Abstract]. American Journal of Respiratory and Critical Care Medicine 2010;181(Meeting Abstracts):A6791. [CRS-ID: 4900100000025312]
96. Romieu I, Meneses F, Ramirez M, Gerber M, Dekker D, Walda I, et al. Acute effect of ozone on respiratory function among participant in a randomized trial of antioxidant supplementation. American Journal of Respiratory and Critical Care Medicine 1998;157(3 Suppl):A48. [CRS-ID: 4900100000014279]
97. Safa B, Karakoc-Aydiner E, Cagan H, Kiykim A, Tulunay A, Akkoc T, et al. 25 (OH) vitamin D3 as an adjunct to subcutaneous allergen immunotherapy: Is it effective? [Abstract]. Allergy. Blackwell Publishing Ltd, 2012:34. [CRS-ID: 4900100000086252]
98. Schachter EN, Schlesinger A. The attenuation of exercise-induced bronchospasm by ascorbic acid. Annals of Allergy 1982;49(3):146-51. [CRS-ID: 4900100000001283]
99. Schertling M, Winsel K, Müller S, Henning R, Meiske W, Slapke J. Action of ascorbic acid on clinical course of infection related bronchial asthma and on reactive oxygen metabolites by BAL cells [Einfluss von Ascorbinsaure auf den klinischen Verlauf des infektbedingten Asthma bronchiale und die Bildung von reaktiven Sauerstoffmetaboliten durch BAL-Zellen.]. Zeitschrift Fur Klinische Medizin 1990;45(20):1770-4. [CRS-ID: 4900100000007762]
100. Shaheen SO, Newson RB, Rayman MP, Wong AP, Tumilty MK, Phillips JM, et al. Randomised, double blind, placebo-controlled trial of selenium supplementation in adult asthma. Thorax 2007;62(6):483-90. [CRS-ID: 4900100000019933]
101. Shimizu T, Maeda S, Arakawa H, Mochizuki H, Tokuyama K, Morikawa A. Relation between theophylline and circulating vitamin levels in children with asthma. Pharmacology 1996;53(6):384-9. [CRS-ID: 4900100000013610]
102. Smith LJ, Holbrook JT, Wise R, Blumenthal M, Dozor AJ, Mastronarde J, et al. Dietary intake of soy genistein is associated with lung function in patients with asthma. Journal of Asthma 2004;41(8):833-43. [CRS-ID: 4900100000018037]
103. Song Y, Klevak A, Manson JE, Buring JE, Liu S. Asthma, chronic obstructive pulmonary disease, and type 2 diabetes in the Women's Health Study. Diabetes Research and Clinical Practice 2010;90(3):365-71. [CRS-ID: 4900100000050194;: 4900100000050194]
104. Szlagatys-Sidorkiewicz A, Korzon M, Malaczynska T, Renkel J, Popadiuk S, Wozniak M. [The antioxidative-prooxidative balance in children with asthma treated with inhaled corticosteroids and long acting beta2-agonists] [Rownowaga antyoksydacyjno-prooksydacyjna u dzieci z astma leczonych kortykosteroidami wziewnymi i diugo dziaiajacymi beta2-mimetykami]. Pneumonologia I Alergologia Polska 2005;73(2):178-81. [CRS-ID: 4900100000019347;: 4900100000019347]
105. Tecklenburg SL, Mickleborough TD, Fly AD, Bai Y, Stager JM. Ascorbic acid supplementation attenuates exercise-induced bronchoconstriction in patients with asthma. Respiratory Medicine 2007;101(8):1770-8. [CRS-ID: 4900100000021364]
106. Tug T, Godekmerdan A, Sari N, Karatas F, Erdem ES. Effects of supportive treatment such as antioxidant or leukotriene receptor antagonist drugs on inflammatory and respiratory parameters in asthma patients. Clinical Pharmacology and Therapeutics 2007;81(3):371-6. [CRS-ID: 4900100000019875]
107. Tunnicliffe WS, Harrison RM, Kelly FJ, Dunster C, Ayres JG. The effect of sulphurous air pollutant exposures on symptoms, lung function, exhaled nitric oxide, and nasal epithelial lining fluid antioxidant concentrations in normal and asthmatic adults. Occupational and Environmental Medicine 2003;60(11):e15. [CRS-ID: 4900100000015877;: 4900100000015877]
108. Varshavskii BIa, Trubnikov GV, Galaktipmpva LP, Koreniak NA, Koledeznaia IL, Oberemok AN. [Oxidant-antioxidant status of patients with bronchial asthma during inhalation and systemic glucocorticoid therapy]. [Russian] [Oksidantno-antioksidantnyi status bol'nykh bronkhial'noi astmoi pri ingaliatsionnoi u sustenbii gkuyjijirtujiudbii terapii]. Terapevticheskii Arkhiv 2003;75(3):21-4. [CRS-ID: 4900100000015233]
109. Vazquez-Armenta G, Barragan-Alvarez C, Loza-Valdes A, Ramos-Marquez ME, Siller-Lopez F. Protein carbonyl and sputum eosinophil number decrease with alpha-lipoic acid adjuvant therapy in asthma patients [Abstract]. Free Radical Biology and Medicine 2012;53(Suppl 2):S117. [CRS-ID: 4900100000068358]
110. Voitsekhovskaia IuG, Skesters A, Orlikov GA, Silova AA, Rusakova NE, Larmane LT, et al. [Assessment of some oxidative stress parameters in bronchial asthma patients beyond add-on selenium supplementation]. [Russian]. Biomeditsinskaia Khimiia 2007;53(5):577-84. [CRS-ID: 4900100000050111]
111. Wiser J, Alexis NE, Jiang Q, Wu W, Robinette C, Roubey R, et al. In vivo gamma-tocopherol supplementation decreases systemic oxidative stress and cytokine responses of human monocytes in normal and asthmatic subjects. Free Radical Biology and Medicine 2008;45(1):40-9. [CRS-ID: 4900100000055983]
112. Wood LG, Garg ML, Powell H, Gibson PG. Dietary lycopene reduces neutrophilic airway inflammation in asthma [Abstract]. Thoracic Society of Australia and New Zealand Annual Scientific Meeting; 25-28 March; Auckland. 2007:Abstract TP002. [CRS-ID: 4900100000021897]
113. Wood LG, Garg ML, Powell H, Gibson PG. Lycopene-rich treatments modify noneosinophilic airway inflammation in asthma: proof of concept. Free Radical Research 2008;42(1):94-102. [CRS-ID: 4900100000021851]
114. Wood LG, Garg ML, Smart JM, Scott HA, Barker D, Gibson PG. Manipulating antioxidant intake in asthma: a randomized controlled trial 1-3. American Journal of Clinical Nutrition 2012;96(3):534-43. [CRS-ID: 4900100000063662]
115. Wood LG, Garg ML, Smart J, Scott HA, Barker D, Gibson PG. Manipulating antioxidant intake in asthma: a randomized clinical trial [Abstract]. Respirology (Carlton, Vic.) 2012;17(Suppl 1):45. [CRS-ID: 4900100000054223]
116. Yamamoto M, Singh A, Sava F, Pui M, Tebbutt SJ, Carlsten C. MicroRNA expression in response to controlled exposure to diesel exhaust: attenuation by the antioxidant N-acetylcysteine in a randomized crossover study. Environmental Health Perspectives 2013;121(6):670-5. [CRS-ID: 4900100000079934;: 4900100000079934]
117. Liu YL, Zhao X, Gong JQ, Hao XH. Efficacy of antioxidants in treatment of asthma. Medical Journal of the Chinese People's Armed Police Force 2003;14(6):342-3. [CRS-ID: 4900100000016870;: 4900100000016870]
118. Allen S, Britton JR, Leonardi-Bee JA. Association between antioxidant vitamins and asthma outcome measures: systematic review and meta-analysis. Thorax 2009;64(7):610-9.
119. Anderson HR, Gupta R, Strachan DP, Limb ES. 50years of asthma: UK trends from 1955 to 2004. Thorax 2007;62(1):85-90.
120. Arab L, Steck-Scott S, Fleishauer AT. Lycopene and the lung. Experimental Biology and Medicine 2002;227(10):894-9.
121. Asthma UK 2013 Facts and FAQs. www.asthma.org.uk/asthma-facts-and-statistics (accessed 20 May 2013).
122. Blanck HM, Gillespie C, Kimmons JE, Seymour JD, Serdula MK. Trends in fruit and vegetable consumption among U.S. men and women, 1994-2005. Preventing Chronic Disease 2008;5(2):1-10.
123. Castillejos M, Gold D, Dockery D, Tosteron T, Baum T, Speizer FE. Effects of ambient ozone on respiratory function and symptoms in Mexico City schoolchildren. American Review of Respiratory Disease 1992;145:278-82.
124. Centers for Disease Control and Prevention. Trends in asthma prevalence, health care, and mortality in the United States, 2001-2010. www.cdc.gov/nchs/data/databriefs/db94.htm (accessed 10 May 2013).
125. Centers for Disease Control and Prevention. Vital signs. www.cdc.gov/vitalsigns/asthma/ (accessed 10 December 2012).
126. Chatzi L, Apostolaki G, Bibakis I, Skypala I, Bibaki-Liakou V, Tzanakis N, et al. Protective effect of fruits, vegetables and the Mediterranean diet on asthma and allergies among children in Crete. Thorax 2007;62:677-83.
127. Clayton S. Paediatric asthma: overcoming barriers to an improved quality of life. British Journal of Nursing 2005;14(2):80-5.
128. Devereux G, Turner SW, Craig LCA, McNeill G, Martindale S, Harbour PJ, et al. Low maternal vitamin E intake during pregnancy is associated with asthma in 5-year-old children. American Journal of Respiratory and Critical Care Medicine 2006;174:499-507.
129. European Food Information Council. Fruit and vegetable consumption in Europe - do Europeans get enough?. www.eufic.org/article/en/expid/Fruit-vegetable-consumption-Europe/ (accessed 10 December 2012).
130. FitzGerald JM, Gibson PG. Asthma exacerbations. 4: Prevention. Thorax 2006;61:992-9.
131. Fogarty A, Lewis S, Weiss S, Britton J. Dietary vitamin E, IgE concentrations, and atopy. Lancet 2000;365:1573-4.
132. Fogarty A. Antioxidants and asthma: will the patient benefit. International Journal of Tuberculosis and Lung Disease 2012;16(11):1423.
133. Global Initiative for Asthma (GINA). GINA Report, Global Strategy for Asthma Management and Prevention. Updated December 2011. www.ginasthma.org (accessed 10 December 2012).
134. The Global Asthma Report 2011. http://www.theunion.org/what-we-do/publications/english/global_asthma_report2011.pdf (accessed July 2013).
135. Guo CH, Liu PJ, Lin KP, Chen PC. Nutritional supplement therapy improves oxidative stress, immune response, pulmonary function, and quality of life in allergic asthma patients: an open-label pilot study. Alternative Medicine Review 2012;17(1):42-56.
136. Hathcock JN, Azzi A, Blumberg J, Bray T, Dickinson A, Frei B, Jialal I, et al. Vitamins E and C are safe across a broad range of intakes. American Journal of Clinical Nutrition 2005;81(4):736-745.
137. Hemila H. Vitamin C may alleviate exercise-induced bronchoconstriction: a meta-analysis. BMJ Open 2013;3:e002416. [DOI: ]
138. Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1 [updated March 2011]. The Cochrane Collaboration, 2011. www.cochrane-handbook.org.
139. Kaur B, Rowe BH, Stovold E. Vitamin C supplementation for asthma. Cochrane Database of Systematic Reviews 2009, Issue 1. [DOI: ]
140. Kelly FJ, Mudway I, Blomberg A, Frew A, Sandström T. Altered lung antioxidant status in patients with mild asthma. The Lancet 1999;354(9177):482-3.
141. Krishnan V, Diette GB, Rand CS, Bilderback AL, Merriman B, Hansel NN, et al. Mortality in patients hospitalized for asthma exacerbations in the United States. American Journal of Respiratory and Critical Care Medicine 2006;174(6):633-8.
142. Lung and asthma information agency 2006. www.laia.ac.uk/asthma.htm (accessed 20 May 2013).
143. Milan SJ, Hart A, Wilkinson M. Vitamin C for asthma and exercise-induced bronchoconstriction. Cochrane Database of Systematic Reviews 2013, Issue 10. [DOI: ]
144. Misso NLA, Brooks-Wildhaber J, Ray S, Vally H, Thompson PJ. Plasma concentrations of dietary and non dietary antioxidants are low in severe asthma. European Respiratory Journal 2005;26:257-64.
145. NHS 2011 HES online hospital episode statistics. www.hesonline.nhs.uk (accessed 10 December 2012).
146. Niki E, Tsuchiya R, Tanimura R, Kamiya Y. Regeneration of vitamin E from alphachromanoxyl radical by glutathione and vitamin C. Chemistry Letters. Chemical Society of Japan, 1982:789-92.
147. Okoko BJ, Burney PB, Newson RB, Potts JF, Shaheen SO. Childhood asthma and fruit consumption. European Respiratory Journal 2007;29:1161-8.
148. Parsons JP, Hallstrand TS, Mastronarde JG, Kaminsky DA, Rundell KW, Hull JH, et al. An official American Thoracic Society clinical practice guideline: exercise-induced bronchoconstriction. American Journal of Respiratory and Critical Care Medicine 2013;187(9):1016-27.
149. Patel BD, Welch AA, Bingham SA, Luben RN, Day NE, Khaw K-T, et al. Dietary antioxidants and asthma in adults. Thorax 2006;61:388-93.
150. Randolph C. An update on exercise-induced bronchoconstriction with and without asthma. Current Allergy and Asthma Reports 2009;9(6):433-8.
151. The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). 5.2. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2012.
152. Romieu I, Meneses F, Ruiz S, Sienra JJ, Huerta J, White M, et al. Effects of air pollution on the respiratory health of asthmatic children living in Mexico City. American Journal of Respiratory and Critical Care Medicine 1996;154:300-7.
153. Romieu I, Meneses F, Ruiz S, Huerta J, Sienra JJ, White M, et al. Effects of intermittent ozone exposure on peak flow and respiratory symptoms among asthmatic children in Mexico City. Archives of Environmental Health 1997;52:368-76.
154. Seaton A, Godden DJ, Brown K. Increase in asthma: a more toxic environment or a more susceptible population?. Thorax 1994;49(2):171-4.
155. Sharma MK, Buettner GR. Interaction of vitamin C and vitamin E during free radical stress in plasma: an ESR study. Free Radical Biology and Medicine 1992;14:649-53.
156. Bousquet J, Khaltaev N (editors). World Health Organization. Global Surveillance, Prevention and Control of Chronic Respiratory Diseases: A Comprehensive Approach. Geneva: WHO Press, 2007.
157. World Health Organization. Promoting fruit and vegetable consumption around the world. www.who.int/dietphysicalactivity/fruit/en/index2.html (accessed 10 December 2012).
158. Wilson SR, Rand CS, Cabana MD, Foggs MB, Halterman JS, Olson L, et al. Asthma outcomes: quality of life. Journal of Allergy and Clinical Immunology 2012;129(3):S88-S123.
159. Wu F, Takaro TK. Childhood asthma and environmental interventions. Environmental Health Perspectives 2007;115(6):971-5.