Impact of adjunctive therapy with Chlorella vulgaris extract on antioxidant status, pulmonary function, and clinical symptoms of patients with obstructive pulmonary diseases

Scientia Pharmaceutica

Volumn 80, Issue 3, 2012, Pages 719-730

  Panahi, Yunes ^a   Tavana, Sasan ^b   Sahebkar, Amirhossein ^c   Masoudi, Homeira ^d   Madanchi, Nima ^e  

^a BAQIYATALLAH UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d ISLAMIC AZAD UNIVERSITY   (Iran)

^e TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Bronchospasm; Chlorella vulgaris; Inflammation; Lung; Oxidative stress; Spirometry

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; CATALASE; CHLORELLA EXTRACT; GLUTATHIONE; GLUTATHIONE PEROXIDASE; SUPEROXIDE DISMUTASE;

ADULT; ANTIOXIDANT ACTIVITY; ARTICLE; ASTHMA; BRONCHODILATATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; COUGHING; DRUG EFFICACY; DYSPNEA; ENZYME ACTIVITY; FEMALE; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; HUMAN; LUNG FUNCTION; MAJOR CLINICAL STUDY; MALE; RANDOMIZED CONTROLLED TRIAL; SPIROMETRY; SPUTUM ANALYSIS; WHEEZING;

EID: 84866485952     PISSN: 00368709     EISSN: 22180532     Source Type: Journal    
DOI: 10.3797/scipharm.1202-06     Document Type: Article

References (22)

1. Rabe KF, Hurd S, Anzueto A, Barnes PJ, Buist SA, Calverley P, Fukuchi Y, Jenkins C, Rodriguez-Roisin R, van Weel C, Zielinski J. Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med. 2007; 176: 532-555. http://dx.doi.org/10.1164/rccm.200703-456SO.
2. Siafakas NM, Vermeire P, Pride NB, Paoletti P, Gibson J, Howard P, Yernault JC, Decramer M, Higenbottam T, Postma DS, Rees J. Optimal assessment and management of chronic obstructive pulmonary disease (COPD). Eur Respir J. 1995; 8: 1398-1320. http://dx.doi.org/10.1183/09031936.95.08081398.
3. Tkacova R, Kluchova Z, Joppa P, Petrasova D, Molcanyiova A. Systemic inflammation and systemic oxidative stress in patients with acute exacerbations of COPD. Respir Med. 2007; 101: 1670-1676. http://dx.doi.org/10.1016/j.rmed.2007.03.005.
4. MacNee W. Oxidative stress and lung inflammation in airways disease. Eur J Pharmacol. 2001; 429: 195-207. http://dx.doi.org/10.1016/S0014-2999(01)01320-6.
5. Agustí A, MacNee W, Donaldson K, Cosio M. Hypothesis: Does COPD have an autoimmune component? Thorax. 2003; 58: 832-834. http://dx.doi.org/10.1136/thorax.58.10.832.
6. Borowitzka MA. Vitamins and fine chemicals from micro-algae. In: Micro-algal biotechnology. Borowitzka LJ, ed. Cambridge University Press, New York, 1988, p. 153.
7. Schubert LE. The use of spirulina and Chlorella as food resource for animals and humans. In: Progressing physiological research. Round FE, Chapman DJ; eds. Biopress Ltd, Bristol., 1988, p. 237.
8. Jones PW, Quirk FH, Baveystock CM. The St. George's Respiratory Questionnaire. Respir Med. 1991; 85 (Suppl B): 25-31. http://www.ncbi.nlm.nih.gov/pubmed/1759018.
9. Guo R, Pittler MH, Ernst E. Herbal medicines for the treatment of COPD: a systematic review. Eur Respir J. 2006; 28: 330-338. http://dx.doi.org/10.1183/09031936.06.00119905.
10. Kirkham P, Rahman I. Oxidative stress in asthma and COPD: antioxidants as a therapeutic strategy. Pharmacol Ther. 2006; 111: 476-494. http://dx.doi.org/10.1016/j.pharmthera.2005.10.015.
11. Lin JL, Thomas PS. Current Perspectives of Oxidative Stress and its Measurement in Chronic Obstructive Pulmonary Disease. COPD. 2010; 7: 291-306. http://dx.doi.org/10.3109/15412555.2010.496818.
12. Dworski R. Oxidant stress in asthma. Thorax. 2000; 55: S51-S53. http://dx.doi.org/10.1136/thorax.55.suppl_2.S51.
13. Harik-Khan RI, Muller DC, Wise RA. Serum vitamin levels and the risk of asthma in children. Am J Epidemiol. 2004; 159: 351-357. http://dx.doi.org/10.1093/aje/kwh053.
14. Stav D, Raz M. Effectof N-acetylcysteine on airtrapping in COPD: a randomized placebo-controlled study. Chest. 2009; 136: 381-386. http://dx.doi.org/10.1378/chest.09-0421.
15. Sutherland ER, Crapo JD, Bowler RP. N-acetylcysteine and exacerbations of chronic obstructive pulmonary disease. COPD. 2006; 3: 195-202. http://dx.doi.org/10.1080/15412550600977361.
16. Zuin R, Palamidese A, Negrin R, Catozzo L, Scarda A, Balbinot M. High-dose N-acetylcysteine in patietns with exacerbations of chronic obstructive pulmonary disease. Clin Drug Investig 2005; 25: 401-408. http://dx.doi.org/10.2165/00044011-200525060-00005.
17. Aizzat O, Yap SW, Sopiah H, Madiha MM, Hazreen M, Shailah A, Wan JW, Nur SA, Srijit D, Musalmah M, Yasmin AM. Modulation of oxidative stress by Chlorella vulgaris in streptozotocin (STZ) induced diabetic spraguedawley rats. Adv Med Sci. 2010; 55: 281-288. http://dx.doi.org/10.2478/v10039-010-0046-z.
18. Sano T, Tanaka Y. Effect of dried, powdered Chlorella vulgaris on experimental atherosclerosis and alimentary hypercholesterolemia in cholesterol-fed rabbits. Artery. 1987; 14: 76-4. http://www.ncbi.nlm.nih.gov/pubmed/3566534.
19. Sansawa H, Takahashi M, Tsuchikura S, Endo H. Effect of chlorella and its fractions on blood pressure, cerebral stroke lesions, and life-span in strokeprone spontaneously hypertensive rats. J Nutr Sci Vitaminol. 2006; 52: 457-466. http://dx.doi.org/10.3177/jnsv.52.457.
20. Nakashima Y, Ohsawa I, Konishi F, Hasegawa T, Kumamoto S, Suzuki Y, Ohta S. Preventive effects of chlorella on cognitive decline in age-dependent dementia model mice. Neurosci Lett. 2009; 464: 193-198. http://dx.doi.org/10.1016/j.neulet.2009.08.044.
21. Kim YJ, Jeong S, Kwon S, Kim MK. Effect of Chlorella vulgaris intake on antioxidative capacity in rats oxidatively stressed with dietary cadmium. Food Sci Biotechnol. 2009; 18: 1055-1062.
22. Vijayavel K, Anbuselvam C, Balasubramanian MP. Antioxidant effect of the marine algae Chlorella vulgaris against naphthalene-induced oxidative stress in the albino rats. Mol Cell Biochem. 2007; 303: 39-44. http://dx.doi.org/10.1007/s11010-007-9453-2.