Activation of TRPV1 channels inhibits mechanosensitive piezo channel activity by depleting membrane phosphoinositides

Science Signaling

Volumn 8, Issue 363, 2015, Pages

  Borbiro, Istvan ^a   Badheka, Doreen ^a   Rohacs, Tibor ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CAPSAICIN; ION CHANNEL; MEMBRANE LIPID; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL 4 PHOSPHATE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHOLIPASE C BETA; PHOSPHOLIPASE C DELTA; PROTEIN PIEZO1; PROTEIN PIEZO2; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; COMPLEMENTARY RNA; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL 4-PHOSPHATE; PIEZO1 PROTEIN, HUMAN; PIEZO2 PROTEIN, HUMAN; POLYPHOSPHOINOSITIDE; TRPV1 PROTEIN, HUMAN; VANILLOID RECEPTOR;

ANALGESIC ACTIVITY; ANIMAL CELL; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; HETEROLOGOUS EXPRESSION; HUMAN; HUMAN CELL; MEMBRANE CURRENT; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SPINAL GANGLION; ANALYSIS OF VARIANCE; ANIMAL; CYTOLOGY; FLUORESCENCE MICROSCOPY; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENETICS; HEK293 CELL LINE; METABOLISM; NERVE CELL; OOCYTE; PATCH CLAMP TECHNIQUE; XENOPUS LAEVIS;

ANALYSIS OF VARIANCE; ANIMALS; CAPSAICIN; CELL MEMBRANE; FLUORESCENCE RESONANCE ENERGY TRANSFER; GANGLIA, SPINAL; HEK293 CELLS; HUMANS; ION CHANNELS; MICE; MICROSCOPY, FLUORESCENCE; NEURONS; OOCYTES; PATCH-CLAMP TECHNIQUES; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHATIDYLINOSITOLS; PHOSPHOLIPASE C DELTA; RNA, COMPLEMENTARY; TRPV CATION CHANNELS; XENOPUS LAEVIS;

EID: 84922710134     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2005667     Document Type: Article

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