Lack of the ubiquitin-editing enzyme A20 results in loss of hematopoietic stem cell quiescence

Journal of Experimental Medicine

Volumn 212, Issue 2, 2015, Pages 203-216

  Nakagawa, Masahiro Marshall ^a   Thummar, Keyur ^a   Mandelbaum, Jonathan ^a   Pasqualucci, Laura ^a   Rathinam, Chozha Vendan ^a  

^a Department of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; UBIQUITIN; UBIQUITIN EDITING ENZYME A20; UNCLASSIFIED DRUG; CYSTEINE PROTEINASE; SIGNAL PEPTIDE; TNFAIP3 PROTEIN, MOUSE;

ALLELE; ANEMIA; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL LOSS; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA BINDING; EMBRYO; ENZYME ACTIVATION; ENZYME DEFICIENCY; EXTRAMEDULLARY HEMATOPOIESIS; FEMALE; FIBROBLAST; FLOW CYTOMETRY; GENE EXPRESSION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC SYSTEM; HEPATOMEGALY; IMMUNOPHENOTYPING; LETHALITY; LEUKOCYTE COUNT; LYMPHOCYTOPENIA; MOUSE; MYELOID PROGENITOR CELL; NICK END LABELING; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; RADIATION PROTECTION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPLENOMEGALY; STOP CODON; THYMUS ATROPHY; UPREGULATION; WESTERN BLOTTING; ANIMAL; CELL CYCLE; CYTOLOGY; DEFICIENCY; GENETIC ASSOCIATION STUDY; GENETICS; KNOCKOUT MOUSE; LETHAL GENE; METABOLISM; MUTATION; UBIQUITINATION;

ANIMALS; CELL CYCLE; CYSTEINE ENDOPEPTIDASES; FEMALE; GENES, LETHAL; GENETIC ASSOCIATION STUDIES; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; INTERFERON-GAMMA; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, KNOCKOUT; MUTATION; NF-KAPPA B; PHENOTYPE; SIGNAL TRANSDUCTION; UBIQUITINATION;

EID: 84922699426     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20132544     Document Type: Article

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