Overexpression of B7-H3 augments anti-apoptosis of colorectal cancer cells by Jak2-STAT3

World Journal of Gastroenterology

Volumn 21, Issue 6, 2015, Pages 1804-1813

  Zhang, Ting ^a   Jiang, Bo ^a   Zou, Shi Tao ^a   Liu, Fen ^a   Hua, Dong ^a  

^a JIANGNAN UNIVERSITY   (China)

Author keywords

Apoptosis; B Cell CLL lymphoma 2; B7 H3; Colorectal cancer; Jak2 STAT3; Overexpression; Signaling pathway

Indexed keywords

B7 H3 PROTEIN; CASPASE 3; FLUOROURACIL; JANUS KINASE 2; OXALIPLATIN; PROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; STAT3 PROTEIN; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; APOPTOSIS REGULATORY PROTEIN; B7 ANTIGEN; CD276 PROTEIN, HUMAN; JAK2 PROTEIN, HUMAN; PROTEIN KINASE INHIBITOR; STAT3 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; CANCER CELL; CELL PROLIFERATION; CELL SURVIVAL; COLORECTAL CANCER; CONTROLLED STUDY; DOWN REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; ANTAGONISTS AND INHIBITORS; COLORECTAL TUMOR; DOSE RESPONSE; DRUG EFFECTS; DRUG RESISTANCE; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; METABOLISM; PATHOLOGY; PHOSPHORYLATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TUMOR CELL LINE; UPREGULATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; B7 ANTIGENS; CELL LINE, TUMOR; CELL SURVIVAL; COLORECTAL NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; JANUS KINASE 2; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRANSFECTION; UP-REGULATION;

EID: 84922693911     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v21.i6.1804     Document Type: Article

References (36)

1. Chapoval AI, Ni J, Lau JS, Wilcox RA, Flies DB, Liu D, Dong H, Sica GL, Zhu G, Tamada K, Chen L. B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nat Immunol 2001; 2: 269-274 [PMID: 11224528 DOI: 10.1038/85339]
2. Hofmeyer KA, Ray A, Zang X. The contrasting role of B7-H3. Proc Natl Acad Sci USA 2008; 105: 10277-10278 [PMID: 18650376 DOI: 10.1073/pnas.0805458105]
3. Zang X, Allison JP. The B7 family and cancer therapy: costimulation and coinhibition. Clin Cancer Res 2007; 13: 5271-5279 [PMID: 17875755 DOI: 10.1158/1078-0432.CCR-07-1030]
4. Yuan H, Wei X, Zhang G, Li C, Zhang X, Hou J. B7-H3 over expression in prostate cancer promotes tumor cell progression. J Urol 2011; 186: 1093-1099 [PMID: 21784485 DOI: 10.1016/j.juro.2011.04.103]
5. Zhao X, Li DC, Zhu XG, Gan WJ, Li Z, Xiong F, Zhang ZX, Zhang GB, Zhang XG, Zhao H. B7-H3 overexpression in pancreatic cancer promotes tumor progression. Int J Mol Med 2013; 31: 283-291 [PMID: 23242015 DOI: 10.3892/ijmm.2012.1212]
6. Liu C, Liu J, Wang J, Liu Y, Zhang F, Lin W, Gao A, Sun M, Wang Y, Sun Y. B7-H3 expression in ductal and lobular breast cancer and its association with IL-10. Mol Med Rep 2013; 7: 134-138 [PMID: 23128494 DOI: 10.3892/mmr.2012.1158]
7. Arigami T, Uenosono Y, Hirata M, Yanagita S, Ishigami S, Natsugoe S. B7-H3 expression in gastric cancer: a novel molecular blood marker for detecting circulating tumor cells. Cancer Sci 2011; 102: 1019-1024 [PMID: 21251161 DOI: 10.1111/j.1349-7006.2011.01877.x]
8. Brunner A, Hinterholzer S, Riss P, Heinze G, Brustmann H. Immunoexpression of B7-H3 in endometrial cancer: relation to tumor T-cell infiltration and prognosis. Gynecol Oncol 2012; 124: 105-111 [PMID: 21982044 DOI: 10.1016/j.ygyno.2011.09.012]
9. Katayama A, Takahara M, Kishibe K, Nagato T, Kunibe I, Katada A, Hayashi T, Harabuchi Y. Expression of B7-H3 in hypopharyngeal squamous cell carcinoma as a predictive indicator for tumor metastasis and prognosis. Int J Oncol 2011; 38: 1219-1226 [PMID: 21344157 DOI: 10.3892/ijo.2011.949]
10. Ingebrigtsen VA, Boye K, Nesland JM, Nesbakken A, Flatmark K, Fodstad Ø. B7-H3 expression in colorectal cancer: associations with clinicopathological parameters and patient outcome. BMC Cancer 2014; 14: 602 [PMID: 25139714 DOI: 10.1186/1471-2407-14-602]
11. Ingebrigtsen VA, Boye K, Tekle C, Nesland JM, Flatmark K, Fodstad O. B7-H3 expression in colorectal cancer: nuclear localization strongly predicts poor outcome in colon cancer. Int J Cancer 2012; 131: 2528-2536 [PMID: 22473715 DOI: 10.1002/ijc.27566]
12. Sun J, Chen LJ, Zhang GB, Jiang JT, Zhu M, Tan Y, Wang HT, Lu BF, Zhang XG. Clinical significance and regulation of the costimulatory molecule B7-H3 in human colorectal carcinoma. Cancer Immunol Immunother 2010; 59: 1163-1171 [PMID: 20333377 DOI: 10.1007/s00262-010-0841-1]
13. Lee H, Kim JH, Yang SY, Kong J, Oh M, Jeong DH, Chung JI, Bae KB, Shin JY, Hong KH, Choi I. Peripheral blood gene expression of B7 and CD28 family members associated with tumor progression and microscopic lymphovascular invasion in colon cancer patients. J Cancer Res Clin Oncol 2010; 136: 1445-1452 [PMID: 20140740 DOI: 10.1007/s00432-010-0800-4]
14. Lupu CM, Eisenbach C, Lupu AD, Kuefner MA, Hoyler B, Stremmel W, Encke J. Adenoviral B7-H3 therapy induces tumor specific immune responses and reduces secondary metastasis in a murine model of colon cancer. Oncol Rep 2007; 18: 745-748 [PMID: 17671729]
15. Hassan M, Watari H, AbuAlmaaty A, Ohba Y, Sakuragi N. Apoptosis and molecular targeting therapy in cancer. Biomed Res Int 2014; 2014: 150845 [PMID: 25013758 DOI: 10.1155/2014/150845]
16. Liu H, Tekle C, Chen YW, Kristian A, Zhao Y, Zhou M, Liu Z, Ding Y, Wang B, Mælandsmo GM, Nesland JM, Fodstad O, Tan M. B7-H3 silencing increases paclitaxel sensitivity by abrogating Jak2/Stat3 phosphorylation. Mol Cancer Ther 2011; 10: 960-971 [PMID: 21518725 DOI: 10.1158/1535-7163.MCT-11-0072]
17. Gómez-Fernández JC. Functions of the C-terminal domains of apoptosis-related proteins of the Bcl-2 family. Chem Phys Lipids 2014; 183: 77-90 [PMID: 24892727 DOI: 10.1016/j.chemphyslip.2014.05.003]
18. Czabotar PE, Lessene G, Strasser A, Adams JM. Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy. Nat Rev Mol Cell Biol 2014; 15: 49-63 [PMID: 24355989 DOI: 10.1038/nrm3722]
19. Zhao X, Zhang GB, Gan WJ, Xiong F, Li Z, Zhao H, Zhu DM, Zhang B, Zhang XG, Li DC. Silencing of B7-H3 increases gemcitabine sensitivity by promoting apoptosis in pancreatic carcinoma. Oncol Lett 2013; 5: 805-812 [PMID: 23426281 DOI: 10.3892/ol.2013.1118]
20. Nguyen AV, Wu YY, Lin EY. STAT3 and sphingosine-1-phosphate in inflammation-associated colorectal cancer. World J Gastroenterol 2014; 20: 10279-10287 [PMID: 25132744 DOI: 10.3748/wjg.v20.i30.10279]
21. Qi QR, Yang ZM. Regulation and function of signal transducer and activator of transcription 3. World J Biol Chem 2014; 5: 231-239 [PMID: 24921012 DOI: 10.4331/wjbc.v5.i2.231]
22. De Simone V, Franzè E, Ronchetti G, Colantoni A, Fantini MC, Di Fusco D, Sica GS, Sileri P, MacDonald TT, Pallone F, Monteleone G, Stolfi C. Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth. Oncogene 2014; Epub ahead of print [PMID: 25174402 DOI: 10.1038/onc.2014.286]
23. Kim SM, Lee JH, Sethi G, Kim C, Baek SH, Nam D, Chung WS, Kim SH, Shim BS, Ahn KS. Bergamottin, a natural furanocoumarin obtained from grapefruit juice induces chemosensitization and apoptosis through the inhibition of STAT3 signaling pathway in tumor cells. Cancer Lett 2014; 354 : 153-163 [PMID: 25130169 DOI: 10.1016/j.canlet.2014.08.002]
24. Gritsko T, Williams A, Turkson J, Kaneko S, Bowman T, Huang M, Nam S, Eweis I, Diaz N, Sullivan D, Yoder S, Enkemann S, Eschrich S, Lee JH, Beam CA, Cheng J, Minton S, Muro-Cacho CA, Jove R. Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells. Clin Cancer Res 2006; 12: 11-19 [PMID: 16397018 DOI: 10.1158/1078-0432.CCR-04-1752]
25. Teng Y, Ross JL, Cowell JK. The involvement of JAK-STAT3 in cell motility, invasion, and metastasis. JAKSTAT 2014; 3: e28086 [PMID: 24778926 DOI: 10.4161/jkst.28086]
26. Kim ER, Chang DK. Colorectal cancer in inflammatory bowel disease: the risk, pathogenesis, prevention and diagnosis. World J Gastroenterol 2014; 20: 9872-9881 [PMID: 25110418 DOI: 10.3748/wjg.v20.i29.9872]
27. Arthur JC, Gharaibeh RZ, Mühlbauer M, Perez-Chanona E, Uronis JM, McCafferty J, Fodor AA, Jobin C. Microbial genomic analysis reveals the essential role of inflammation in bacteria-induced colorectal cancer. Nat Commun 2014; 5: 4724 [PMID: 25182170 DOI: 10.1038/ncomms5724]
28. Wimberly AL, Forsyth CB, Khan MW, Pemberton A, Khazaie K, Keshavarzian A. Ethanol-induced mast cell-mediated inflammation leads to increased susceptibility of intestinal tumorigenesis in the APC Δ468 min mouse model of colon cancer. Alcohol Clin Exp Res 2013; 37 Suppl 1: E199-E208 [PMID: 23320800 DOI: 10.1111/j.1530-0277.2012.01894.x]
29. Cario E. The human TLR4 variant D299G mediates inflammation-associated cancer progression in the intestinal epithelium. Oncoimmunology 2013; 2: e24890 [PMID: 24073372 DOI: 10.4161/onci.24890]
30. Janakiram NB, Rao CV. The role of inflammation in colon cancer. Adv Exp Med Biol 2014; 816: 25-52 [PMID: 24818718 DOI: 10.1007/978-3-0348-0837-8-2]
31. Saravanan S, Islam VI, Babu NP, Pandikumar P, Thirugnanasambantham K, Chellappandian M, Raj CS, Paulraj MG, Ignacimuthu S. Swertiamarin attenuates inflammation mediators via modulating NF-κB/I κB and JAK2/STAT3 transcription factors in adjuvant induced arthritis. Eur J Pharm Sci 2014; 56: 70-86 [PMID: 24582615 DOI: 10.1016/j.ejps.2014.02.005]
32. Zhang ZH, Yu LJ, Hui XC, Wu ZZ, Yin KL, Yang H, Xu Y. Hydroxy-safflor yellow A attenuates Aβ-42-induced inflammation by modulating the JAK2/STAT3/NF-κB pathway. Brain Res 2014; 1563: 72-80 [PMID: 24690200 DOI: 10.1016/j.brainres.2014.03.036]
33. Gyurkovska V, Stefanova T, Dimitrova P, Danova S, Tropcheva R, Ivanovska N. Tyrosine kinase inhibitor tyrphostin AG490 retards chronic joint inflammation in mice. Inflammation 2014; 37: 995-1005 [PMID: 24473905 DOI: 10.1007/s10753-014-9820-6]
34. Regis G, Pensa S, Boselli D, Novelli F, Poli V. Ups and downs: the STAT1: STAT3 seesaw of Interferon and gp130 receptor signalling. Semin Cell Dev Biol 2008; 19: 351-359 [PMID: 18620071 DOI: 10.1016/j.semcdb.2008.06.004]
35. Planas AM, Gorina R, Chamorro A. Signalling pathways mediating inflammatory responses in brain ischaemia. Biochem Soc Trans 2006; 34: 1267-1270 [PMID: 17073799 DOI: 10.1042/BST0341267]
36. Nicolas CS, Amici M, Bortolotto ZA, Doherty A, Csaba Z, Fafouri A, Dournaud P, Gressens P, Collingridge GL, Peineau S. The role of JAK-STAT signaling within the CNS. JAKSTAT 2013; 2: e22925 [PMID: 24058789 DOI: 10.4161/jkst.22925]