Autoimmunity and autoinflammation as the yin and yang of idiopathic recurrent acute pericarditis

Autoimmunity Reviews

Volumn 14, Issue 2, 2015, Pages 90-97

  Cantarini, Luca ^a   Lopalco, Giuseppe ^b   Selmi, Carlo ^c,d   Napodano, Salvatore ^e   De Rosa, Gabriella ^e   Caso, Francesco ^a,f   Costa, Luisa ^g   Iannone, Florenzo ^b   Rigante, Donato ^e  

^a UNIVERSITY OF SIENA   (Italy)

^b UNIVERSITY OF BARI   (Italy)

^c HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

^d UNIVERSITY OF MILAN   (Italy)

^e CATHOLIC UNIVERSITY   (Italy)

^f UNIVERSITY OF PADOVA   (Italy)

^g UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Anakinra; Interleukin 1; Pericardial effusion; Recurrence

Indexed keywords

CORTICOSTEROID; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT;

AUTOIMMUNE DISEASE; AUTOIMMUNITY; AUTOINFLAMMATORY DISEASE; CORTICOSTEROID THERAPY; ECG ABNORMALITY; FAMILIAL MEDITERRANEAN FEVER; HUMAN; IDIOPATHIC RECURRENT ACUTE PERICARDITIS; PERICARDIAL EFFUSION; PERICARDITIS; RECURRENT DISEASE; REVIEW; THORAX PAIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED PERIODIC SYNDROME; VIRUS INFECTION; ACUTE DISEASE; IMMUNOLOGY; INFLAMMATION;

ACUTE DISEASE; AUTOIMMUNE DISEASES; AUTOIMMUNITY; HUMANS; INFLAMMATION; PERICARDITIS; RECURRENCE;

EID: 84922657765     PISSN: 15689972     EISSN: 18730183     Source Type: Journal    
DOI: 10.1016/j.autrev.2014.10.005     Document Type: Review

References (107)

1. Brucato A., Brambilla G., Adler Y., Spodick D.H., Canesi B. Therapy for recurrent acute pericarditis: a rheumatological solution?. Clin Exp Rheumatol 2006, 24:45-50.
2. Soler-Soler J., Sagristà-Sauleda J., Permanyer-Miralda G. Relapsing pericarditis. Heart 2004, 90:1364-1368.
3. Fowler N.O., Harbin A.D. Recurrent acute pericarditis: follow-up study of 31 patients. J Am Coll Cardiol 1986, 7:300-305.
4. Tuna I.C., Danielson G.K. Surgical management of pericardial diseases. Cardiol Clin 1990, 8:683-696.
5. Imazio M., Bobbio M., Cecchi E., Demarie D., Demichelis B., Pomari F., et al. Colchicine in addition to conventional therapy for acute pericarditis: results of the COlchicine for acute PEricarditis (COPE) trial. Circulation 2005, 112:2012-2016.
6. Rigante D., La Torraca I., Avallone L., Pugliese A.L., Gaspari S., Stabile A. The pharmacologic basis of treatment with colchicine in children with familial Mediterranean fever. Eur Rev Med Pharmacol Sci 2006, 10:173-178.
7. Stack J., Ryan J., McCarthy G. Colchicine: new insights to an old drug. Am J Ther 2013, [Epub ahead of print]. 10.1097/01.mjt.0000433937.07244.e1.
8. Comarmond C., Wechsler B., Bodaghi B., Cacoub P., Saadoun D. Biotherapies in Behçet's disease. Autoimmun Rev 2014, 13:762-769.
9. Kabbani S.S., LeWinter M.M. Pericardial diseases. Curr Treat Options Cardiovasc Med 2002, 4:487-495.
10. Adler Y., Finkelstein Y., Guindo J., Rodriguez De La Serna A., Shoenfeld Y., Bayes-Genis A., et al. Colchicine treatment for recurrent pericarditis. A decade of experience. Circulation 1998, 97:2183-2185.
11. Adler Y., Shoenfeld Y. Colchicine as therapy for recurrent pericarditis. Harefuah 1997, 133:100-102.
12. Adler Y., Zandman-Goddard G., Ravid M., Avidan B., Zemer D., Ehrenfeld M., et al. Usefulness of colchicine in preventing recurrences of pericarditis. Am J Cardiol 1994, 73:916-917.
13. Shabetai R. Corticosteroids for recurrent pericarditis: on the road to evidence-based medicine. Circulation 2008, 118:612-613.
14. Maisch B., Ristić A.D., Pankuweit S. Intrapericardial treatment of autoreactive pericardial effusion with triamcinolone; the way to avoid side effects of systemic corticosteroid therapy. Eur Heart J 2002, 23:1503-1508.
15. Bogdanos D.P., Smyk D.S., Invernizzi P., Rigopoulou E.I., Blank M., Pouria S., et al. Infectome: a platform to trace infectious triggers of autoimmunity. Autoimmun Rev 2013, 12:726-740.
16. Selmi C., Mackay I.R., Gershwin M.E. The immunological milieu of the liver. Semin Liver Dis 2007, 27:129-139.
17. Agmon-Levin N., Ram M., Barzilai O., Porat-Katz B.S., Parikman R., Selmi C., et al. Prevalence of hepatitis C serum antibody in autoimmune diseases. J Autoimmun 2009, 32:261-266.
18. Selmi C., Leung P.S., Sherr D.H., Diaz M., Nyland J.F., Monestier M., et al. Mechanisms of environmental influence on human autoimmunity: a National Institute of Environmental Health Sciences expert panel workshop. J Autoimmun 2012, 39:272-284.
19. Maisch B., Drude L., Hengstenberg C., Hufnagel G., Schönian U., Schwab D. Cytolytic anticardiac membrane antibodies in the pathogenesis of myopericarditis. Postgrad Med J 1992, 68(Suppl. 1):S11-S16.
20. Pisetsky D.S. The role of innate immunity in the induction of autoimmunity. Autoimmun Rev 2008, 8:69-72.
21. Wildner G., Kaufmann U. What causes relapses of autoimmune diseases? The etiological role of autoreactive T cells. Autoimmun Rev 2013, 12:1070-1075.
22. Temajo N.O., Howard N. The viral enterprises in autoimmunity: conversion of target cells into de novo APCs is the presage to autoimmunity. Autoimmun Rev 2012, 11:653-658.
23. Waldner H. The role of innate immune responses in autoimmune disease development. Autoimmun Rev 2009, 8:400-404.
24. Perricone R., Perricone C., De Carolis C., Shoenfeld Y. NK cells in autoimmunity: a two-edg'd weapon of the immune system. Autoimmun Rev 2008, 7:384-390.
25. Nussinovitch U., Shoenfeld Y. Autoimmunity and heart diseases: pathogenesis and diagnostic criteria. Arch Immunol Ther Exp (Warsz) 2009, 57:95-104.
26. Maisch B., Berg P.A., Kocksiek K. Clinical significance of immunopathological findings in patients with post-pericardiotomy syndrome. Relevance of antibody pattern. Clin Exp Immunol 1979, 38:189e97.
27. Levy Y., Shovman O., Granit C., Luria D., Gurevitz O., Bar-Lev D., et al. Pericarditis following permanent pacemaker insertion. Isr Med Assoc J 2004, 6:599-602.
28. Warraich R.S., Griffiths E., Falconar A., Pabbathi V., Bell C., Angelini G., et al. Human cardiac myosin autoantibodies impair myocyte contractility: a cause-and-effect relationship. FASEB J 2006, 20:651-660.
29. Caforio A.L., Brucato A., Doria A., Brambilla G., Angelini A., Ghirardello A., et al. Anti-heart and anti-intercalated disk autoantibodies: evidence for autoimmunity in idiopathic recurrent acute pericarditis. Heart 2010, 96:779-784.
30. Latif N., Baker C.S., Dunn M.J., Rose M.L., Brady P., Yacoub M.H. Frequency and specificity of antiheart antibodies in patients with dilated cardiomyopathy detected using SDS-PAGE and western blotting. J Am Coll Cardiol 1993, 22:1378-1384.
31. Caforio A.L., Bonifacio E., Stewart J.T., Neglia D., Parodi O., Bottazzo G.F., et al. Novel organ-specific circulating cardiac autoantibodies in dilated cardiomyopathy. J Am Coll Cardiol 1990, 15:1527-1534.
32. Rose N.R., Bona C. Defining criteria for autoimmune diseases (Witebsky's postulates revisited). Immunol Today 1993, 14:426-430.
33. Arbuckle M.R., McClain M.T., Rubertone M.V., Scofield R.H., Dennis G.J., James J.A., et al. Development of autoantibodies before the clinical onset of systemic lupus erythematosus. N Engl J Med 2003, 349:1526-1533.
34. Hollan I., Meroni P.L., Ahearn J.M., Cohen Tervaert J.W., Curran S., Goodyear C.S., et al. Cardiovascular disease in autoimmune rheumatic diseases. Autoimmun Rev 2013, 12:1004-1015.
35. Sherer Y., Kuechler S., Jose Scali J., Rovensky J., Levy Y., Zandman-Goddard G., et al. Low dose intravenous immunoglobulin in systemic lupus erythematosus: analysis of 62 cases. Isr Med Assoc J 2008, 10:55-57.
36. Tincani A., Rebaioli C.B., Taglietti M., Shoenfeld Y. Heart involvement in systemic lupus erythematosus, anti-phospholipid syndrome and neonatal lupus. Rheumatology (Oxford) 2006, 45(Suppl. 4):iv8-iv13.
37. Zandman-Goddard G., Levy Y., Shoenfeld Y. Intravenous immunoglobulin therapy and systemic lupus erythematosus. Clin Rev Allergy Immunol 2005, 29:219-228.
38. Pankuweit S., Wadlich A., Meyer E., Porting I., Hufnagel G., Maisch B., et al. Cytokine activation in pericardial fluids in different forms of pericarditis. Herz 2000, 25:748-754.
39. Brucato A., Maestroni S., Cumetti D., Thiella G., Alari G., Brambilla G., et al. Recurrent pericarditis: infectious or autoimmune?. Autoimmun Rev 2008, 8:44-47.
40. Imazio M., Brucato A., Doria A., Brambilla G., Ghirardello A., Romito A., et al. Antinuclear antibodies in recurrent idiopathic pericarditis: prevalence and clinical significance. Int J Cardiol 2009, 136:289-293.
41. Satoh M., Chan E.K., Ho L.A., Rose K.M., Parks C.G., Cohn R.D., et al. Prevalence and sociodemographic correlates of antinuclear antibodies in the United States. Arthritis Rheum 2012, 64:2319-2327.
42. Bizzaro N., Antico A., Platzgummer S., Tonutti E., Bassetti D., Pesente F., et al. Study Group on Autoimmune Diseases of the Italian Society of Laboratory Medicine, Italy. Automated antinuclear immunofluorescence antibody screening: a comparative study of six computer-aided diagnostic systems. Autoimmun Rev 2014, 13:292-298.
43. Op De Beéck K., Vermeersch P., Verschueren P., Westhovens R., Mariën G., Blockmans D., et al. Antinuclear antibody detection by automated multiplex immunoassay in untreated patients at the time of diagnosis. Autoimmun Rev 2012, 12:137-143.
44. Maisch B., Seferović P.M., Ristić A.D., Erbel R., Rienmüller R., Adler Y., et al. Task Force on the Diagnosis and Management of Pericardial Diseases of the European Society of Cardiology. Guidelines on the diagnosis and management of pericardial diseases executive summary; The Task force on the diagnosis and management of pericardial diseases of the European Society of Cardiology. Eur Heart J 2004, 25:587-610.
45. Cantarini L., Rigante D., Brizi M.G., Lucherini O.M., Sebastiani G.D., Vitale A., et al. Clinical and biochemical landmarks in systemic autoinflammatory diseases. Ann Med 2012, 44:664-673.
46. Touitou I. New genetic interpretation of old diseases. Autoimmun Rev 2012, 12:5-9.
47. Gerfaud-Valentin M., Jamilloux Y., Iwaz J., Sève P. Adult-onset Still's disease. Autoimmun Rev 2014, 13:708-722.
48. Berkun Y., Eisenstein E.M. Diagnostic criteria of familial Mediterranean fever. Autoimmun Rev 2014, 13:388-390.
49. Sfriso P., Caso F., Tognon S., Galozzi P., Gava A., Punzi L. Blau syndrome, clinical and genetic aspects. Autoimmun Rev 2012, 12:44-51.
50. Drenth J.P., van der Meer J.W. The inflammasome - a linebacker of innate defense. N Engl J Med 2006, 355:730-732.
51. Rigante D., Frediani B., Galeazzi M., Cantarini L. From the Mediterranean to the sea of Japan: the transcontinental odyssey of autoinflammatory diseases. Biomed Res Int 2013, 2013:485103.
52. Rigante D. The protean visage of systemic autoinflammatory syndromes: a challenge for inter-professional collaboration. Eur Rev Med Pharmacol Sci 2010, 14:1-18.
53. Doria A., Dayer J.M., Punzi L. Autoinflammatory diseases: how to put the fire inside the body out?. Autoimmun Rev 2012, 12:1-4.
54. Rigante D., La Torraca I., Ansuini V., Compagnone A., Sallì A., Stabile A. The multi-face expression of familial Mediterranean fever in the child. Eur Rev Med Pharmacol Sci 2006, 10:163-171.
55. Vigo G., Zulian F. Periodic fevers with aphthous stomatitis, pharyngitis, and adenitis (PFAPA). Autoimmun Rev 2012, 12:52-55.
56. Lin Y.T., Wang C.T., Gershwin M.E., Chiang B.L. The pathogenesis of oligoarticular/polyarticular vs systemic juvenile idiopathic arthritis. Autoimmun Rev 2011, 10:482-489.
57. Tinazzi E., Puccetti A., Patuzzo G., Sorleto M., Barbieri A., Lunardi C. Schnitzler syndrome, an autoimmune-autoinflammatory syndrome: report of two new cases and review of the literature. Autoimmun Rev 2011, 10:404-409.
58. Rigante D. The fresco of autoinflammatory diseases from the pediatric perspective. Autoimmun Rev 2012, 11:348-356.
59. Cantarini L., Lucherini O.M., Galeazzi M., Fanti F., Simonini G., Baldari C.T., et al. Tumour necrosis factor receptor-associated periodic syndrome caused by a rare mutation in the TNFRSF1A gene, and with excellent response to etanercept treatment. Clin Exp Rheumatol 2009, 27:890-891.
60. Cantarini L., Rigante D., Lucherini O.M., Cimaz R., Laghi Pasini F., Baldari C.T., et al. Role of etanercept in the treatment of tumor necrosis factor receptor-associated periodic syndrome: personal experience and review of the literature. Int J Immunopathol Pharmacol 2010, 23:701-707.
61. Caso F., Rigante D., Vitale A., Lucherini O.M., Costa L., Atteno M., et al. Monogenic autoinflammatory syndromes: state of the art on genetic, clinical, and therapeutic issues. Int J Rheumatol 2013, 2013:513782.
62. Caso F., Cantarini L., Lucherini O.M., Sfriso P., Fioretti M., Costa L., et al. Working the endless puzzle of hereditary autoinflammatory disorders. Mod Rheumatol 2014, 24:381-389.
63. Vitale A., Rigante D., Lucherini O.M., Caso F., Muscari I., Magnotti F., et al. Biological treatments: new weapons in the management of monogenic autoinflammatory disorders. Mediators Inflamm 2013, 2013:939847.
64. Brizi M.G., Galeazzi M., Lucherini O.M., Cantarini L., Cimaz R. Successful treatment of tumor necrosis factor receptor-associated periodic syndrome with canakinumab. Ann Intern Med 2012, 156:907-908.
65. Punzi L., Scanu A., Ramonda R., Oliviero F. Gout as autoinflammatory disease: new mechanisms for more appropriated treatment targets. Autoimmun Rev 2012, 12:66-71.
66. Rigante D., Ansuini V., Caldarelli M., Bertoni B., La Torraca I., Stabile A. Hydrocephalus in CINCA syndrome treated with anakinra. Childs Nerv Syst 2006, 22:334-337.
67. Koné-Paut I., Piram M. Targeting interleukin-1β in CAPS (cryopyrin-associated periodic) syndromes: what did we learn?. Autoimmun Rev 2012, 12:77-80.
68. Rigante D., Cantarini L., Imazio M., Lucherini O.M., Sacco E., Galeazzi M., et al. Autoinflammatory diseases and cardiovascular manifestations. Ann Med 2011, 43:341-346.
69. Cantarini L., Lucherini O.M., Iacoponi F., Cimaz R., Simonini G., Rigante D., et al. Development and preliminary validation of a diagnostic score for identifying patients affected with adult-onset autoinflammatory disorders. Int J Immunopathol Pharmacol 2010, 23:1133-1141.
70. Cantarini L., Iacoponi F., Lucherini O.M., Obici L., Brizi M.G., Cimaz R., et al. Validation of a diagnostic score for the diagnosis of autoinflammatory diseases in adults. Int J Immunopathol Pharmacol 2011, 24:695-702.
71. Muscari I., Iacoponi F., Cantarini L., Lucherini O.M., Simonini G., Brizi M.G., et al. The diagnostic evaluation of patients with potential adult-onset autoinflammatory disorders: our experience and review of the literature. Autoimmun Rev 2012, 12:10-13.
72. Cantarini L., Vitale A., Lucherini O.M., Muscari I., Magnotti F., Brizi G., et al. Childhood versus adulthood-onset autoinflammatory disorders: myths and truths intertwined. Reumatismo 2013, 65:55-62.
73. Cantarini L., Vitale A., Lucherini O.M., De Clemente C., Caso F., Costa L., et al. The labyrinth of autoinflammatory disorders: a snapshot on the activity of a third-level center in Italy. Clin Rheumatol 2014, [Epub ahead of print]. 10.1007/s10067-014-2721-0.
74. Maggiolini S., Tiberti G., Cantarini L., Carbone C., Mariani S., Achilli F., et al. Large pericardial effusion in a family with recurrent pericarditis: a report of probable x-linked transmission. Exp Clin Cardiol 2011, 16:54-56.
75. Cantarini L., Lucherini O.M., Muscari I., Frediani B., Galeazzi M., Brizi M.G., et al. Tumour necrosis factor receptor-associated periodic syndrome (TRAPS): state of the art and future perspectives. Autoimmun Rev 2012, 12:38-43.
76. Kastner D.L., Aksentijevich I., Goldbach-Mansky R. Autoinflammatory disease reloaded: a clinical perspective. Cell 2010, 140:784-790.
77. Kees S., Langevitz P., Zemer D., Padeh S., Pras M., Livneh A. Attacks of pericarditis as a manifestation of familial Mediterranean fever (FMF). QJM 1997, 90:643-647.
78. Tunca M., Akar S., Onen F., Ozdogan H., Kasapcopur O., Yalcinkaya F., et al. Turkish FMF Study Group. Familial Mediterranean fever (FMF) in Turkey: results of a nationwide multicenter study. Medicine (Baltimore) 2005, 84:1-11.
79. Ercan Tutar H., Imamoglu A., Atalay S. Recurrent pericarditis as a manifestation of familial Mediterranean fever. Circulation 2000, 101:E71-E72.
80. Okutur K., Seber S., Oztekin E., Bes C., Borlu F. Recurrent pericarditis as the initial manifestation of familial Mediterranean fever. Med Sci Monit 2008, 14:CS139-CS141.
81. Brucato A., Brambilla G., Moreo A., Alberti A., Munforti C., Ghirardello A., et al. Long-term outcomes in difficult-to-treat patients with recurrent pericarditis. Am J Cardiol 2006, 98:267-271.
82. Brucato A., Shinar Y., Brambilla G., Robbiolo L., Ferrioli G., Patrosso M.C., et al. Idiopathic recurrent acute pericarditis: familial Mediterranean fever mutations and disease evolution in a large cohort of Caucasian patients. Lupus 2005, 14:670-674.
83. Dodé C., André M., Bienvenu T., Hausfater P., Pêcheux C., Bienvenu J., et al. French Hereditary Recurrent Inflammatory Disorder Study Group: the enlarging clinical, genetic, and population spectrum of tumor necrosis factor receptor-associated periodic syndrome. Arthritis Rheum 2002, 46:2181-2188.
84. Cantarini L., Lucherini O.M., Cimaz R., Baldari C.T., Laghi Pasini F., Galeazzi M. Sacroileitis and pericarditis: atypical presentation of tumor necrosis factor receptor-associated periodic syndrome and response to etanercept therapy. Clin Exp Rheumatol 2010, 28:290-291.
85. Rigante D., Lopalco G., Vitale A., Lucherini O.M., De Clemente C., Caso F., et al. Key facts and hot spots on tumor necrosis factor receptor-associated periodic syndrome. Clin Rheumatol 2014, 33(9):1197-1207.
86. Magnotti F., Vitale A., Rigante D., Lucherini O.M., Cimaz R., Muscari I., et al. The most recent advances in pathophysiology and management of tumour necrosis factor receptor-associated periodic syndrome (TRAPS): personal experience and literature review. Clin Exp Rheumatol 2013, 31(3 Suppl. 77):141-149.
87. Ravet N., Rouaghe S., Dodé C., Bienvenu J., Stirnemann J., Lévy P., et al. Clinical significance of P46L and R92Q substitutions in the tumour necrosis factor superfamily 1A gene. Ann Rheum Dis 2006, 65:1158-1162.
88. Lachmann H.J., Papa R., Gerhold K., Obici L., Touitou I., Cantarini L., et al. For the Paediatric Rheumatology International Trials Organisation (PRINTO), the EUROTRAPS and the Eurofever Project. The phenotype of TNF receptor-associated autoinflammatory syndrome (TRAPS) at presentation: a series of 158 cases from the Eurofever/EUROTRAPS international registry. Ann Rheum Dis 2013, [Epub ahead of print]. 10.1136/annrheumdis-2013-204184.
89. Cantarini L., Lucherini O.M., Cimaz R., Baldari C.T., Bellisai F., Rossi Paccani S., et al. Idiopathic recurrent pericarditis refractory to colchicine treatment can reveal tumor necrosis factor receptor-associated periodic syndrome. Int J Immunopathol Pharmacol 2009, 22:1051-1058.
90. Cantarini L., Lucherini O.M., Baldari C.T., Laghi Pasini F., Galeazzi M. Familial clustering of recurrent pericarditis may disclose tumour necrosis factor receptor-associated periodic syndrome. Clin Exp Rheumatol 2010, 28:405-407.
91. Cantarini L., Imazio M., Brucato A., Lucherini O.M., Galeazzi M. Innate versus acquired immune response in the pathogenesis of recurrent idiopathic pericarditis. Autoimmun Rev 2010, 9:436-440.
92. Cantarini L., Lucherini O.M., Vitale A., Sabadini L., Brizi M.G., Frediani B., et al. Expanding spectrum of TNFRSF1A gene mutations among patients with idiopathic recurrent acute pericarditis. Intern Med J 2013, 43:725-727.
93. Cantarini L., Rigante D., Merlini G., Vitale A., Caso F., Lucherini O.M., et al. The expanding spectrum of low-penetrance TNFRSF1A gene variants in adults presenting with recurrent inflammatory attacks: clinical manifestations and long-term follow-up. Semin Arthritis Rheum 2014, 43:818-823.
94. McGonagle D., McDermott M.F. A proposed classification of the immunological diseases. PLoS Med 2006, 3:e297.
95. Maestroni S., Di Corato P.R., Cumetti D., Chiara D.B., Ghidoni S., Prisacaru L., et al. Recurrent pericarditis: autoimmune or autoinflammatory?. Autoimmun Rev 2012, 12:60-65.
96. Cantarini L., Lucherini O.M., Brucato A., Barone L., Cumetti D., Iacoponi F., et al. Clues to detect tumor necrosis factor receptor-associated periodic syndrome (TRAPS) among patients with idiopathic recurrent acute pericarditis: results of a multicentre study. Clin Res Cardiol 2012, 101:525-531.
97. Cantarini L., Lucherini O.M., Cimaz R., Galeazzi M. Recurrent pericarditis caused by a rare mutation in the TNFRSF1A gene and with excellent response to anakinra treatment. Clin Exp Rheumatol 2010, 28:802.
98. Obici L., Merlini G. Amyloidosis in autoinflammatory syndromes. Autoimmun Rev 2012, 12:14-17.
99. Picco P., Brisca G., Traverso F., Loy A., Gattorno M., Martini A. Successful treatment of idiopathic recurrent pericarditis in children with interleukin-1beta receptor antagonist (anakinra): an unrecognized autoinflammatory disease?. Arthritis Rheum 2009, 60:264-268.
100. Vassilopoulos D., Lazaros G., Tsioufis C., Vasileiou P., Stefanadis C., Pectasides D. Successful treatment of adult patients with idiopathic recurrent pericarditis with an interleukin-1 receptor antagonist (anakinra). Int J Cardiol 2012, 160:66-68.
101. Camacho-Lovillo M., Mendez-Santos A. Successful treatment of idiopathic recurrent pericarditis with interleukin-1 receptor antagonist (anakinra). Pediatr Cardiol 2013, 34:1293-1294.
102. Scardapane A., Brucato A., Chiarelli F., Breda L. Efficacy of an interleukin-1beta receptor antagonist (anakinra) in idiopathic recurrent pericarditis. Pediatr Cardiol 2013, 36:1989-1993.
103. Finetti M., Insalaco A., Cantarini L., Meini A., Breda L., Alessio M., et al. Long-term efficacy of interleukin-1 receptor antagonist (anakinra) in corticosteroid-dependent and colchicine-resistant recurrent pericarditis. J Pediatr 2014, 164:1425-1431.
104. Cantarini L., Imazio M., Brizi M.G., Lucherini O.M., Brucato A., Cimaz R., et al. Role of autoimmunity and autoinflammation in the pathogenesis of idiopathic recurrent pericarditis. Clin Rev Allergy Immunol 2013, 44:6-13.
105. Caforio A.L., Marcolongo R., Brucato A., Cantarini L., Imazio M., Iliceto S. Acute idiopathic pericarditis: current immunological theories. Res Rep Clin Cardiol 2012, 3:49-55.
106. Lazaros G., Karavidas A., Spyropoulou M., Tsiachris D., Halapas A., Zacharoulis A., et al. The role of the immunogenetic background in the development and recurrence of acute idiopathic pericarditis. Cardiology 2011, 118:55-62.
107. Doria A., Zen M., Bettio S., Gatto M., Bassi N., Nalotto L., et al. Autoinflammation and autoimmunity: bridging the divide. Autoimmun Rev 2012, 12:22-30.