Adult-onset Still's disease

Autoimmunity Reviews

Volumn 13, Issue 7, 2014, Pages 708-722

  Gerfaud Valentin, Mathieu ^a,b,c   Jamilloux, Yvan ^a,d,g   Iwaz, Jean ^b,c,e,f   Sève, Pascal ^a,b,c  

^a CROIX ROUSSE HOSPITAL   (France)

^b UNIVERSITÉ LYON 1   (France)

^c UNIVERSITÉ DE LYON   (France)

^d CENTRE INTERNATIONAL DE RECHERCHE EN INFECTIOLOGIE   (France)

^e HOSPICES CIVILS DE LYON   (France)

^f LABORATOIRE DE BIOMÉTRIE ET BIOLOGIE EVOLUTIVE   (France)

^g UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Adult onset still's disease; Anakinra; Autoinflammatory disorder; Hemophagocytic lymphohistiocytosis; Hyperferritinemia; Macrophage activation syndrome

Indexed keywords

ACUTE PHASE PROTEIN; ADALIMUMAB; BIOLOGICAL PRODUCT; C REACTIVE PROTEIN; CORTICOSTEROID; CYTOKINE RECEPTOR ANTAGONIST; DEXAMETHASONE; DISEASE MODIFYING ANTIRHEUMATIC DRUG; ETANERCEPT; GAMMA INTERFERON; IMMUNOGLOBULIN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 17; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 23; INTERLEUKIN 6; INTERLEUKIN 6 ANTAGONIST; METHOTREXATE; NONSTEROID ANTIINFLAMMATORY AGENT; PREDNISONE; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; TOCILIZUMAB; TOLL LIKE RECEPTOR 7; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; UNCLASSIFIED DRUG;

ADAPTIVE IMMUNITY; ADULT ONSET STILL DISEASE; CLINICAL FEATURE; CYTOKINE RELEASE; DIAGNOSTIC TEST; DIFFERENTIAL DIAGNOSIS; FEVER; HEMOPHAGOCYTIC SYNDROME; HISTORY; HUMAN; HYPERFERRITINEMIA; IMMUNOGENETICS; IMMUNOPATHOGENESIS; INNATE IMMUNITY; LABORATORY TEST; LEUKOCYTE ACTIVATION; LEUKOCYTOSIS; LIVER FUNCTION TEST; MACROPHAGE ACTIVATION; MACROPHAGE ACTIVATION SYNDROME; MULTICENTER STUDY (TOPIC); NATURAL KILLER CELL; OUTCOME ASSESSMENT; PATHOPHYSIOLOGY; PROGNOSIS; RANDOMIZED CONTROLLED TRIAL (TOPIC); RASH; REVIEW; SORE THROAT; ADULT; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY; STILL'S DISEASE, ADULT-ONSET;

ADAPTIVE IMMUNITY; ADULT; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMMUNITY, INNATE; PROGNOSIS; STILL'S DISEASE, ADULT-ONSET;

EID: 84898860623     PISSN: 15689972     EISSN: 18730183     Source Type: Journal    
DOI: 10.1016/j.autrev.2014.01.058     Document Type: Review

References (243)

1. Still G.F. On a form of chronic joint disease in children. Med Chir Trans 1897, 80:47-60.
2. Riolet J. Wissler-Fanconi syndrome. Rev Rhum Mal Osteoartic 1964, 31:388-397.
3. Bywaters E.G. Still's disease in the adult. Ann Rheum Dis 1971, 30:121-133.
4. Gerfaud-Valentin M., Maucort-Boulch D., Hot A., Iwaz J., Ninet J., Durieu I., et al. Adult-onset Still disease: manifestations, treatments, outcome, and prognostic factors in 57 patients. Medicine (Baltimore) 2014, 93:91-99.
5. Sampalis J.S., Esdaile J.M., Medsger T.A., Patridge A.J., et al. A controlled study of the long-term prognosis of adult Still's disease. Am J Med 1995, 98:384-388.
6. Ichiki H., Shishido M., Nishiyama S. Two cases of adult onset of Still's disease in the elderly. Jpn J Geriatr 1992, 29:960-964.
7. Wouters J.M., van Rijswijk M.H., van de Putte L.B. Adult onset Still's disease in the elderly: a report of two cases. J Rheumatol 1985, 12:791-793.
8. Magadur-Joly G., Billaud E., Barrier J.H., Pennec Y.L., Masson C., Renou P., et al. Epidemiology of adult Still's disease: estimate of the incidence by a retrospective study in west France. Ann Rheum Dis 1995, 54:587-590.
9. Wakai K., Ohta A., Tamakoshi A., Ohno Y., Kawamura T., Aoki R., et al. Estimated prevalence and incidence of adult Still's disease: findings by a nationwide epidemiological survey in Japan. J Epidemiol 1997, 7:221-225.
10. Evensen K.J., Nossent H.C. Epidemiology and outcome of adult-onset Still's disease in Northern Norway. Scand J Rheumatol 2006, 35:48-51.
11. Cagatay Y., Gul A., Cagatay A., Kamali S., Karadeniz A., Inanc M., et al. Adult-onset Still's disease. Int J Clin Pract 2009, 63:1050-1055.
12. Chen P.-D., Yu S.-L., Chen S., Weng X.-H. Retrospective study of 61 patients with adult-onset Still's disease admitted with fever of unknown origin in China. Clin Rheumatol 2012, 31:175-181.
13. Pouchot J., Sampalis J.S., Beaudet F., Carette S., Décary F., Salusinsky-Sternbach M., et al. Adult Still's disease: manifestations, disease course, and outcome in 62 patients. Medicine (Baltimore) 1991, 70:118-136.
14. Gerfaud-Valentin M., Hot A., Huissoud C., Durieu I., Broussolle C., Sève P. Adult-onset Still's disease and pregnancy: about ten cases and review of the literature. Rheumatol Int 2013, [Epub ahead of print]. 10.1007/s00296-013-2765-5.
15. Terkeltaub R., Esdaile J., Décary F., Harth M., Lister J., Lapointe N. HLA-Bw35 and prognosis in adult Still's disease. Arthritis Rheum 1981, 12:1469-1472.
16. Wouters J.M., Reekers P., van de Putte L.B. Adult-onset Still's disease. Disease course and HLA associations. Arthritis Rheum 1986, 29:415-418.
17. Fujii T., Nojima T., Yasuoka H., Satoh S., Nakamura K., Kuwana M., et al. Cytokine and immunogenetic profiles in Japanese patients with adult Still's disease. Association with chronic articular disease. Rheumatology (Oxford) 2001, 40:1398-1404.
18. Joung C.I., Lee H.S., Lee S.W., Kim C.G., Song Y.H., Jun J.B., et al. Association between HLA-DR B1 and clinical features of adult onset Still's disease in Korea. Clin Exp Rheumatol 2003, 21:489-492.
19. Sugiura T., Maeno N., Kawaguchi Y., Takei S., Imanaka H., Kawano Y., et al. A promoter haplotype of the interleukin-18 gene is associated with juvenile idiopathic arthritis in the Japanese population. Arthritis Res Ther 2006, 8:R60.
20. Wang F.-F., Huang X.-F., Shen N., Leng L., Bucala R., Chen S.-L., et al. A genetic role for macrophage migration inhibitory factor (MIF) in adult-onset Still's disease. Arthritis Res Ther 2013, 15:R65.
21. Fishman D., Faulds G., Jeffery R., Mohamed-Ali V., Yudkin J.S., Humphries S., et al. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 1998, 102:1369-1376.
22. Kim J.J., Kim J.-K., Shim S.-C., Choe J.-Y., Kim T.-H., Jun J.-B., et al. MEFV gene mutations and their clinical significance in Korean patients with adult-onset Still's disease. Clin Exp Rheumatol 2013, 31(Suppl. 77):60-63.
23. Ohta A., Yamaguchi M., Tsunematsu T., Kasukawa R., Mizushima H., Kashiwagi H., et al. Adult Still's disease: a multicenter survey of Japanese patients. J Rheumatol 1990, 17:1058-1063.
24. Wouters J.M., van der Veen J., van de Putte L.B., de Rooij D.J. Adult onset Still's disease and viral infections. Ann Rheum Dis 1988, 47:764-767.
25. Escudero F.J., Len O., Falcó V., de Sevilla T.F., Sellas A. Rubella infection in adult onset Still's disease. Ann Rheum Dis 2000, 59:493.
26. van de Putte L.B., Wouters J.M. Adult-onset Still's disease. Baillieres Clin Rheumatol 1991, 5:263-275.
27. Perez C., Artola V. Adult Still's disease associated with Mycoplasma pneumoniae infection. Clin Infect Dis 2011, 32:E105-E106.
28. Kádár J., Petrovicz E. Adult-onset Still's disease. Best Pract Res Clin Rheumatol 2003, 18:663-676.
29. Liozon E., Ly K.H., Vidal-Cathala E., Fauchais A.L. Adult-onset Still's disease as a manifestation of malignancy: report of a patient with melanoma and literature review. Rev Med Interne 2014, 35:60-64.
30. Larroche C., Mouthon L. Pathogenesis of hemophagocytic syndrome (HPS). Autoimmun Rev 2004, 3:69-75.
31. Choi J.-H., Suh C.-H., Lee Y.-M., Suh Y.-J., Lee S.-K., Kim S.-S., et al. Serum cytokine profiles in patients with adult onset Still's disease. J Rheumatol 2003, 30:2422-2427.
32. Chen D.-Y., Lan J.-L., Lin F.-J., Hsieh T.-Y. Proinflammatory cytokine profiles in sera and pathological tissues of patients with active untreated adult onset Still's disease. J Rheumatol 2004, 31:2189-2198.
33. Komiya A., Matsui T., Nogi S., Iwata K., Futami H., Takaoka H., et al. Neutrophil CD64 is upregulated in patients with active adult-onset Still's disease. Scand J Rheumatol 2012, 41:156-158.
34. Matsui K., Tsuchida T., Hiroishi K., Tominaga K., Hayashi N., Hada T., et al. High serum level of macrophage-colony stimulating factor (M-CSF) in adult-onset Still's disease. Rheumatology (Oxford) 1999, 38:477-478.
35. Hoshino T., Ohta A., Yang D., Kawamoto M., Kikuchi M., Inoue Y., et al. Elevated serum interleukin 6, interferon-gamma, and tumor necrosis factor-alpha levels in patients with adult Still's disease. J Rheumatol 1998, 25:396-398.
36. Jung S.-Y., Park Y.-B., Ha Y.-J., Lee K.-H., Lee S.-K. Serum calprotectin as a marker for disease activity and severity in adult-onset Still's disease. J Rheumatol 2010, 37:1029-1034.
37. Zou Y.-Q., Lu L.-J., Li S.-J., Zeng T., Wang X.-D., Bao C.-D., et al. The levels of macrophage migration inhibitory factor as an indicator of disease activity and severity in adult-onset Still's disease. Clin Biochem 2008, 41:519-524.
38. Chen D.-Y., Lan J.-L., Lin F.-J., Hsieh T.-Y. Association of intercellular adhesion molecule-1 with clinical manifestations and interleukin-18 in patients with active, untreated adult-onset Still's disease. Arthritis Rheum 2005, 53:320-327.
39. Fautrel B., Le Moël G., Saint-Marcoux B., Taupin P., Vignes S., Rozenberg S., et al. Diagnostic value of ferritin and glycosylated ferritin in adult onset Still's disease. J Rheumatol 2001, 28:322-329.
40. Hot A., Toh M.-L., Coppéré B., Perard L., Madoux M.H.G., Mausservey C., et al. Reactive hemophagocytic syndrome in adult-onset Still disease: clinical features and long-term outcome: a case-control study of 8 patients. Medicine (Baltimore) 2010, 89:37-46.
41. Min J.-K., Cho C.-S., Kim H.-Y., Oh E.-J. Bone marrow findings in patients with adult Still's disease. Scand J Rheumatol 2003, 32:119-121.
42. Behrens E.M. Macrophage activation syndrome in rheumatic disease: what is the role of the antigen presenting cell?. Autoimmun Rev 2008, 7:305-308.
43. Mehta B., Efthimiou P. Ferritin in adult-onset still's disease: just a useful innocent bystander?. Int J Inflamm 2012, 2012. 10.1155/2012/298405.
44. Rosário C., Zandman-Goddard G., Meyron-Holtz E.G., D'Cruz D.P., Shoenfeld Y. The Hyperferritinemic Syndrome: macrophage activation syndrome, Still's disease, septic shock and catastrophic antiphospholipid syndrome. BMC Med 2013, 11:185.
45. Zandman-Goddard G., Shoenfeld Y. Ferritin in autoimmune diseases. Autoimmun Rev 2007, 6:457-463.
46. Lee S.-J., Cho Y.-N., Kim T.-J., Park S.-C., Park D.-J., Jin H.-M., et al. Natural killer T cell deficiency in active adult-onset Still's disease: correlation of deficiency of natural killer T cells with dysfunction of natural killer cells. Arthritis Rheum 2012, 64:2868-2877.
47. Park J.H., Kim H.-S., Lee J.S., Kim J.J., Jung K.-H., Park Y.-W., et al. Natural killer cell cytolytic function in Korean patients with adult-onset Still's disease. J Rheumatol 2012, 39:2000-2007.
48. Chaix J., Tessmer M.S., Hoebe K., Fuséri N., Ryffel B., Dalod M., et al. Cutting edge: priming of NK cells by IL-18. J Immunol 2008, 181:1627-1631.
49. Wada T., Kanegane H., Ohta K., Katoh F., Imamura T., Nakazawa Y., et al. Sustained elevation of serum interleukin-18 and its association with hemophagocytic lymphohistiocytosis in XIAP deficiency. Cytokine 2014, 65:74-78.
50. Novick D., Kim S., Kaplanski G., Dinarello C.A. Interleukin-18, more than a Th1 cytokine. Semin Immunol 2013, 10.1016/j.smim.2013.10.014.
51. Janka G.E. Familial and acquired hemophagocytic lymphohistiocytosis. Annu Rev Med 2012, 63:233-246.
52. Wulffraat N.M., Rijkers G.T., Elst E., Brooimans R., Kuis W. Reduced perforin expression in systemic juvenile idiopathic arthritis is restored by autologous stem-cell transplantation. Rheumatology (Oxford) 2003, 42:375-379.
53. Rau M., Schiller M., Krienke S., Heyder P., Lorenz H., Blank N. Clinical manifestations but not cytokine profiles differentiate adult-onset Still's disease and sepsis. J Rheumatol 2010, 37:2369-2376.
54. Kastner D.L., Aksentijevich I., Goldbach-Mansky R. Autoinflammatory disease reloaded: a clinical perspective. Cell 2010, 140:784-790.
55. Pascual V., Allantaz F., Arce E., Punaro M., Banchereau J. Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade. J Exp Med 2005, 201:1479-1486.
56. Youm J.-Y., Woo J.-H., Kim T.-H., Bae S.-C., Yoo D.-H. Interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms in Korean patients with adult-onset Still's disease. Scand J Rheumatol 2007, 36:390-393.
57. Carroll H.P., Paunovic V., Gadina M. Signalling, inflammation and arthritis: crossed signals: the role of interleukin-15 and -18 in autoimmunity. Rheumatology (Oxford) 2008, 47:1269-1277.
58. Lotito A.P.N., Silva C.A.A., Mello S.B.V. Interleukin-18 in chronic joint diseases. Autoimmun Rev 2007, 6:253-256.
59. Rooney T., Murphy E., Benito M., Roux-Lombard P., FitzGerald O., Dayer J.-M., et al. Synovial tissue interleukin-18 expression and the response to treatment in patients with inflammatory arthritis. Ann Rheum Dis 2004, 63:1393-1398.
60. Conigliaro P., Priori R., Bombardieri M., Alessandri C., Barone F., Pitzalis C., et al. Lymph node IL-18 expression in adult-onset Still's disease. Ann Rheum Dis 2009, 68:442-443.
61. Priori R., Barone F., Alessandri C., Colafrancesco S., McInnes I.B., Pitzalis C., et al. Markedly increased IL-18 liver expression in adult-onset Still's disease-related hepatitis. Rheumatology (Oxford) 2011, 50:776-780.
62. Maruyama J., Inokuma S. Cytokine profiles of macrophage activation syndrome associated with rheumatic diseases. J Rheumatol 2010, 37:967-973.
63. Kawaguchi Y., Terajima H., Harigai M., Hara M., Kamatani N. Interleukin-18 as a novel diagnostic marker and indicator of disease severity in adult-onset Still's disease. Arthritis Rheum 2001, 44:1716-1717.
64. Kawashima M., Yamamura M., Taniai M., Yamauchi H., Tanimoto T., Kurimoto M., et al. Levels of interleukin-18 and its binding inhibitors in the blood circulation of patients with adult-onset Still's disease. Arthritis Rheum 2001, 44:550-560.
65. Colafrancesco S., Priori R., Alessandri C., Perricone C., Pendolino M., Picarelli G., et al. IL-18 serum level in adult onset Still's disease: a marker of disease activity. Int J Inflamm 2012, 2012:156890.
66. Nagashima T., Iwamoto M., Matsumoto K., Minota S. Interleukin-18 in adult-onset Still's disease: treatment target or disease activity indicator?. Intern Med 2012, 51:449.
67. Scheinberg M.A., Chapira E., Fernandes M.L., Hubscher O. Interleukin 6: a possible marker of disease activity in adult onset Still's disease. Clin Exp Rheumatol 1996, 14:653-655.
68. Martini A. Systemic juvenile idiopathic arthritis. Autoimmun Rev 2012, 12:56-59.
69. Kasama T., Furuya H., Yanai R., Ohtsuka K., Takahashi R., Yajima N., et al. Correlation of serum CX3CL1 level with disease activity in adult-onset Still's disease and significant involvement in hemophagocytic syndrome. Clin Rheumatol 2012, 31:853-860.
70. Chen D.-Y., Lin C.-C., Chen Y.-M., Lan J.-L., Hung W.-T., Chen H.-H., et al. Involvement of TLR7 MyD88-dependent signaling pathway in the pathogenesis of adult-onset Still's disease. Arthritis Res Ther 2013, 15:R39.
71. Jamilloux Y., Henry T. The inflammasomes: platforms of innate immunity. Med Sci 2013, 29:975-984.
72. Antoniou K.M., Margaritopoulos G.A., Giannarakis I., Choulaki C., Fountoulakis N., Siafakas N.M., et al. Adult onset Still's disease: a case report with a rare clinical manifestation and pathophysiological correlations. Case Rep Med 2013, 2013:981232.
73. Hayem F., Hayem G. Still's disease and the mitochondrion: the other face of an old friend?. Med Hypotheses 2012, 79:136-137.
74. Gattorno M., Tassi S., Carta S., Delfino L., Ferlito F., Pelagatti M.A., et al. Pattern of interleukin-1beta secretion in response to lipopolysaccharide and ATP before and after interleukin-1 blockade in patients with CIAS1 mutations. Arthritis Rheum 2007, 56:3138-3148.
75. Chen D.Y., Lan J.L., Lin F.J., Hsieh T.Y., Wen M.C. Predominance of Th1 cytokine in peripheral blood and pathological tissues of patients with active untreated adult onset Still's disease. Ann Rheum Dis 2004, 63:1300-1306.
76. Bettelli E., Korn T., Oukka M., Kuchroo V.K. Induction and effector functions of T(H)17 cells. Nature 2008, 453:1051-1057.
77. Waite J.C., Skokos D. Th17 response and inflammatory autoimmune diseases. Int J Inflamm 2012, 2012:819467.
78. Meng G., Zhang F., Fuss I., Kitani A., Strober W. A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses. Immunity 2009, 30:860-874.
79. Chen D.-Y., Chen Y.-M., Lan J.-L., Lin C.-C., Chen H.-H., Hsieh C.-W. Potential role of Th17 cells in the pathogenesis of adult-onset Still's disease. Rheumatology (Oxford) 2010, 49:2305-2312.
80. Chen D.-Y., Chen Y.-M., Chen H.-H., Hsieh C.-W., Lin C.-C., Lan J.-L. The associations of circulating CD4+CD25high regulatory T cells and TGF-β with disease activity and clinical course in patients with adult-onset Still's disease. Connect Tissue Res 2010, 51:370-377.
81. Doria A., Zen M., Bettio S., Gatto M., Bassi N., Nalotto L., et al. Autoinflammation and autoimmunity: bridging the divide. Autoimmun Rev 2012, 12:22-30.
82. Hayem F. Is Still's disease an autoinflammatory syndrome. Joint Bone Spine 2009, 76:7-9.
83. Rossi-Semerano L., Koné-Paut I. Is Still's disease an autoinflammatory syndrome?. Int J Inflamm 2012, 2012:480373.
84. Fautrel B., Zing E., Golmard J.-L., Le Moel G., Bissery A., Rioux C., et al. Proposal for a new set of classification criteria for adult-onset still disease. Medicine (Baltimore) 2002, 81:194-200.
85. Pay S., Türkçapar N., Kalyoncu M., Simşek I., Beyan E., Ertenli I., et al. A multicenter study of patients with adult-onset Still's disease compared with systemic juvenile idiopathic arthritis. Clin Rheumatol 2006, 25:639-644.
86. Zhu G., Liu G., Liu Y., Xie Q., Shi G. Liver abnormalities in adult onset Still's disease: a retrospective study of 77 Chinese patients. J Clin Rheumatol 2009, 15:284-288.
87. Kong X.-D., Xu D., Zhang W., Zhao Y., Zeng X., Zhang F. Clinical features and prognosis in adult-onset Still's disease: a study of 104 cases. Clin Rheumatol 2010, 29:1015-1019.
88. Kim Y.J., Koo B.S., Kim Y.-G., Lee C.-K., Yoo B. Clinical features and prognosis in 82 patients with adult-onset Still's disease. Clin Exp Rheumatol 2013, 32:28-33.
89. Colina M., Zucchini W., Ciancio G., Orzincolo C., Trotta F., Govoni M. The evolution of adult-onset Still disease: an observational and comparative study in a cohort of 76 Italian patients. Semin Arthritis Rheum 2011, 41:279-285.
90. Crispín J.C., Martínez-Baños D., Alcocer-Varela J. Adult-onset Still disease as the cause of fever of unknown origin. Medicine (Baltimore) 2005, 84:331-337.
91. Zenone T. Fever of unknown origin in adults: evaluation of 144 cases in a non-university hospital. Scand J Infect Dis 2006, 38:632-638.
92. Elkon K.B., Hughes G.R., Bywaters E.G., Ryan P.F., Inman R.D., Bowley N.B., et al. Adult-onset Still's disease. Twenty-year followup and further studies of patients with active disease. Arthritis Rheum 1982, 25:647-654.
93. Bagnari V., Colina M., Ciancio G., Govoni M., Trotta F. Adult-onset Still's disease. Rheumatol Int 2010, 30:855-862.
94. Nguyen K.H., Weisman M.H. Severe sore throat as a presenting symptom of adult onset Still's disease: a case series and review of the literature. J Rheumatol 1997, 24:592-597.
95. Cheema G.S., Quismorio F.P. Pulmonary involvement in adult-onset Still's disease. Curr Opin Pulm Med 1999, 5:305-309.
96. Sato H., Yokoe I., Nishio S., Onishi T., Takao T., Kobayashi Y., et al. A case of adult onset Still's disease complicated with cryptogenic organizing pneumonia. Intern Med 2011, 50:247-251.
97. Ghosal A., Pal R.B., Das S.K., Das T. An unusual presentation of adult onset Still's disease. Med J Malaysia 2012, 67:532-533.
98. Corbett A.J., Zizic T.M., Stevens M.B. Adult-onset Still's disease with an associated severe restrictive pulmonary defect: a case report. Ann Rheum Dis 1983, 42:452-454.
99. Campos M., Schiopu E. Pulmonary arterial hypertension in adult-onset Still's disease: rapid response to anakinra. Case Rep Rheumatol 2012, 2012:537613.
100. Mubashir E., Ahmed M.M., Hayat S., Heldmann M., Berney S.M. Pulmonary hypertension in a patient with adult-onset Stills disease. Clin Rheumatol 2007, 26:1359-1361.
101. Khobragade A.K., Chogle A.R., Ram R.P., Mascarenhas J., Kothari S., Kawadkar S., et al. Reversible posterior leukoencephalopathy syndrome in a case of adult onset Still's disease with concurrent thrombotic thrombocytopenic purpura: response to high dose immunoglobulin infusions. J Assoc Physicians India 2012, 60:59-62.
102. Zenone T., Boibieux A., Chaumentin G., Margotton A., Ninet J., Peyramond D., et al. Bilateral perception deafness in adult onset Still disease. Presse Med 1996, 25:1213.
103. Akkara Veetil B.M., Yee A.H., Warrington K.J., Aksamit A.J., Mason T.G. Aseptic meningitis in adult onset Still's disease. Rheumatol Int 2012, 32:4031-4034.
104. Sabnis G.R., Gokhale Y.A., Kulkarni U.P. Tocilizumab in refractory adult-onset Still's disease with aseptic meningitis-efficacy of interleukin-6 blockade and review of the literature. Semin Arthritis Rheum 2011, 40:365-368.
105. Tabak F., Tanverdi M., Ozaras R., Mert A., Tartan Z., Ozturk R., et al. Neutrophilic pleocytosis in cerebrospinal fluid: adult-onset Still's disease. Intern Med 2003, 42:1039-1041.
106. Zhao H., Yuan Y., Li Y., Si C.-W., Tian G.-S., Wang G.-Q., et al. Encephalic large arteries narrowness and peripheral neuropathy in a patient with adult-onset Still's disease. Rheumatol Int 2008, 28:1261-1264.
107. Shaikh A.G., Hain T.C., Zee D.S. Oculomotor disorders in adult-onset Still's disease. J Neurol 2010, 257:136-138.
108. Kumar S., Sheaff M., Yaqoob M. Collapsing glomerulopathy in adult still's disease. Am J Kidney Dis 2004, 43:e4-e10.
109. Bennett A.N., Peterson P., Sangle S., Hangartner R., Abbs I.C., Hughes G.R.V., et al. Adult onset Still's disease and collapsing glomerulopathy: successful treatment with intravenous immunoglobulins and mycophenolate mofetil. Rheumatology (Oxford) 2004, 43:795-799.
110. Babacan T., Onat A.M., Pehlivan Y., Comez G., Karakök M. Successful treatment of refractory adult Still's disease and membranous glomerulonephritis with infliximab. Clin Rheumatol 2010, 29:423-426.
111. Sayegh J., Besson V., Lavigne C., Croue A., Augusto J.-F. Necrotizing crescentic immunoglobulin A glomerulonephritis in adult-onset Still's disease. Clin Exp Nephrol 2011, 15:978-979.
112. Thonhofer R., Soleiman A., Kriessmayr M., Thonhofer U., Wipfler E., Gaugg M., et al. Decrease of proteinuria in a patient with adult-onset Still's disease and glomerulonephritis after anti-TNFalpha therapy. Scand J Rheumatol 2006, 35:485-488.
113. Sugimoto T., Yasuda M., Sakaguchi M., Osawa N., Tanaka Y., Uzu T., et al. Hyponatraemia due to renal proximal tubule dysfunction in a patient with adult-onset Still's disease. QJM 2008, 101:163-164.
114. Cush J.J., Leibowitz I.H., Friedman S.A. Adult-onset Still's disease and inflammatory orbital pseudotumor. N Y State J Med 1985, 85:110-111.
115. Liu F.-C., Chiang S.-Y., Chang D.-M., Lai J.-H., Hou T.-Y., Chen C.-H. Purtscher's-like retinopathy as an initial presentation of adult-onset Still's disease: a case report and review of the literature. Clin Rheumatol 2007, 26:1204-1206.
116. Jiang W., Tang L., Duan X., Jiang B. A case of uveitis in adult-onset Still's disease with ophthalmologic symptoms. Rheumatol Int 2013, 33:1867-1872.
117. Marie I., Ducrotté P., Riachi G., François A., Levesque H., Courtois H. Pseudo-angiocholitis revealing adult-onset Still's disease. Dig Dis Sci 2004, 49:627-628.
118. Morita H., Nishiwaki H., Nagayama Y., Yoshimura A. Portal vein thrombosis in adult-onset Still's disease: a case report and literature review. Rheumatol Int 2009, 29:1515-1518.
119. Assimakopoulos S.F., Karamouzos V., Papakonstantinou C., Zolota V., Labropoulou-Karatza C., Gogos C. Suppurative necrotizing granulomatous lymphadenitis in adult-onset Still's disease: a case report. J Med Case Reports 2012, 6:354.
120. Soy M. A case of adult-onset Still's disease presenting with angioedema. Clin Rheumatol 2004, 23:92.
121. Ota T., Higashi S., Suzuki H., Eto S. Increased serum ferritin levels in adult Still's disease. Lancet 1987, 1:562-563.
122. Fautrel B. Ferritin levels in adult Still's disease: any sugar?. Joint Bone Spine 2002, 69:355-357.
123. Yamaguchi M., Ohta A., Tsunematsu T., Kasukawa R., Mizushima Y., Kashiwagi H., et al. Preliminary criteria for classification of adult Still's disease. J Rheumatol 1992, 19:424-430.
124. Zeng T., Zou Y.-Q., Wu M.-F., Yang C.-D. Clinical features and prognosis of adult-onset still's disease: 61 cases from China. J Rheumatol 2009, 36:1026-1031.
125. Lee S.-W., Park Y.-B., Song J.-S., Lee S.-K. The mid-range of the adjusted level of ferritin can predict the chronic course in patients with adult onset Still's disease. J Rheumatol 2009, 36:156-162.
126. Fardet L., Coppo P., Kettaneh A., Dehoux M., Cabane J., Lambotte O. Low glycosylated ferritin, a good marker for the diagnosis of hemophagocytic syndrome. Arthritis Rheum 2008, 58:1521-1527.
127. Vignes S., Le Moël G., Fautrel B., Wechsler B., Godeau P., Piette J.C. Percentage of glycosylated serum ferritin remains low throughout the course of adult onset Still's disease. Ann Rheum Dis 2000, 59:347-350.
128. Zhao D.-B., Dai S.-M., Liu X.-P., Xu H. Interstitial inflammation in visceral organs is a pathologic feature of adult-onset Still's disease. Rheumatol Int 2011, 31:923-927.
129. Dino O., Provenzano G., Giannuoli G., Sciarrino E., Pouyet M., Pagliaro L. Fulminant hepatic failure in adult onset Still's disease. J Rheumatol 1996, 23:784-785.
130. Taccone F.S., Lucidi V., Donckier V., Bourgeois N., Decaux G., Vandergheynst F. Fulminant hepatitis requiring MARS and liver transplantation in a patient with Still's disease. Eur J Intern Med 2008, 19:e26-e28.
131. Jeon Y.K., Paik J.H., Park S.-S., Park S.O., Kim Y.A., Kim J.E., et al. Spectrum of lymph node pathology in adult onset Still's disease; analysis of 12 patients with one follow up biopsy. J Clin Pathol 2004, 57:1052-1056.
132. Wu N., Li Q., Gu C.-X., Ahmed T., Yao X.-P. Paraneoplastic syndrome mimicking adult-onset Still's disease caused by advanced lung cancer: a case report. BMC Cancer 2011, 11:487.
133. Kato T., Tanabe J., Kanemoto M., Kobayashi C., Morita S., Karahashi T. A case of extranodal NK/T-cell lymphoma, nasal type mimicking typical manifestations of adult-onset Still's disease (AOSD) with hemophagocytic syndrome: diagnostic consideration between malignant lymphoma without lymphadenopathy and AOSD. Mod Rheumatol 2009, 19:675-680.
134. Choe J.-Y., Chung D.S., Park S.-H., Kwon H.-H., Kim S.-K. Clinical significance of 18F-fluoro-dexoxyglucose positron emission tomography in patients with adult-onset Still's disease: report of two cases and review of literatures. Rheumatol Int 2010, 30:1673-1676.
135. Kim Y.J., Kim S.I., Hong K.-W., Kang M.W. Diagnostic value of 18F-FDG PET/CT in patients with fever of unknown origin. Intern Med J 2012, 42:834-837.
136. Crouzet J., Boudousq V., Lechiche C., Pouget J.P., Kotzki P.O., Collombier L., et al. Place of (18F-FDG-PET with computed tomography in the diagnostic algorithm of patients with fever of unknown origin. Eur J Clin Microbiol Infect Dis 2012, 31:1727-1733.
137. Yamashita H., Kubota K., Takahashi Y., Minamimoto R., Morooka M., Kaneko H., et al. Clinical value of (18)F-fluoro-dexoxyglucose positron emission tomography/computed tomography in patients with adult-onset Still's disease: a seven-case series and review of the literature. Mod Rheumatol 2013, [Epub ahead of print].
138. Cush J.J., Medsger T.A., Christy W.C., Herbert D.C., Cooperstein L.A. Adult-onset Still's disease. Clinical course and outcome. Arthritis Rheum 1987, 30:186-194.
139. Calabro J.J., Londino A.V. Adult onset Still's disease. J Rheumatol 1986, 13:827-828.
140. Reginato A.J., Schumacher H.R., Baker D.G., O'Connor C.R., Ferreiros J. Adult onset Still's disease: experience in 23 patients and literature review with emphasis on organ failure. Semin Arthritis Rheum 1987, 17:39-57.
141. Jiang L., Wang Z., Dai X., Jin X. Evaluation of clinical measures and different criteria for diagnosis of adult-onset Still's disease in a Chinese population. J Rheumatol 2011, 38:741-746.
142. Wouters J.M., van de Putte L.B. Adult-onset Still's disease; clinical and laboratory features, treatment and progress of 45 cases. QJM 1986, 61:1055-1065.
143. Mavragani C.P., Spyridakis E.G., Koutsilieris M. Adult-onset Still's disease: from pathophysiology to targeted therapies. Int J Inflamm 2012, 2012:879020.
144. Lin Y.-T., Wang C.-T., Gershwin M.E., Chiang B.-L. The pathogenesis of oligoarticular/polyarticular vs systemic juvenile idiopathic arthritis. Autoimmun Rev 2011, 10:482-489.
145. Kim H.-A., Sung J.-M., Suh C.-H. Therapeutic responses and prognosis in adult-onset Still's disease. Rheumatol Int 2012, 32:1291-1298.
146. Dhote R., Simon J., Papo T., Detournay B., Sailler L., Andre M.-H., et al. Reactive hemophagocytic syndrome in adult systemic disease: report of twenty-six cases and literature review. Arthritis Rheum 2003, 49:633-639.
147. Arlet J.-B., Le T.H.D., Marinho A., Amoura Z., Wechsler B., Papo T., et al. Reactive haemophagocytic syndrome in adult-onset Still's disease: a report of six patients and a review of the literature. Ann Rheum Dis 2006, 65:1596-1601.
148. Colina M., Govoni M., Trotta F. Fatal myocarditis in adult-onset Still disease with diffuse intravascular coagulation. Rheumatol Int 2009, 29:1355-1357.
149. Bank I., Marboe C.C., Redberg R.F., Jacobs J. Myocarditis in adult Still's disease. Arthritis Rheum 1985, 28:452-454.
150. Bergemer A.M., Fouquet B., Goupille P., Charbonnier B., Valat J.P. Myocarditis in Still's disease in adults. Rev Rhum Mal Osteoartic 1988, 55:945-948.
151. Sachs R.N., Talvard O., Lanfranchi J. Myocarditis in adult Still's disease. Int J Cardiol 1990, 27:377-380.
152. Roblot P., Boiffard O., Allal J., Breux J., Fieuzal S., Becq-Giraudon B. Myocarditis in adult-onset Still's disease: one case. Rev Med Interne 1990, 11:S368.
153. Hosaka S., Takashina N., Ishikawa A., Kondo H., Kashiwazaki S. Adult Still's disease with myocarditis and peritonitis. Intern Med 1992, 31:812-815.
154. Ueda T., Mizushige K., Sakamoto S., Senda S., Morita H., Tokuda M., et al. Adult Still's disease with myocardial dysfunction induced by microangiopathy. Jpn Circ J 1997, 61:74-77.
155. Nishimagi E., Hirata S., Kawaguchi Y., Okamoto H., Hara M., Kamatani N. Myocardial dysfunction in a patient with adult-onset Still's disease (AOSD). Clin Exp Rheumatol 2004, 22:506-507.
156. Krzossok S., Benck U., van der Woude F.J., Braun C. Disseminated intravascular coagulation, perimyocarditis and bilateral pleural empyema in adult Still's disease. Dtsch Med Wochenschr 2004, 129:2535-2537.
157. Kristensen L.E., Bartosik I. Myocarditis in adult-onset Still's disease despite significant immunosuppressive therapy. Scand J Rheumatol 2006, 35:330-331.
158. Ballard M., Chazerain P., Charpentier J., Manet M., Aerts J., Ziza J. Severe myocarditis in an adult-onset Still's disease. Rev Med Interne 2002, 23:S653.
159. Jadhav P., Nanayakkara N. Myocarditis in adult onset Stills disease. Int J Rheum Dis 2009, 12:272-274.
160. Kuek A., Weerakoon A., Ahmed K., Ostör A.J.K. Adult-onset Still's disease and myocarditis: successful treatment with intravenous immunoglobulin and maintenance of remission with etanercept. Rheumatology (Oxford) 2007, 46:1043-1044.
161. Cavallasca J.A., Vigliano C.A., Perandones C.E., Tate G.A. Myocarditis as a form of relapse in two patients with adult Still's disease. Rheumatol Int 2010, 30:1095-1097.
162. Raffeiner B., Botsios C., Dinarello C., Ometto F., Punzi L., Ramonda R. Adult-onset Still's disease with myocarditis successfully treated with the interleukin-1 receptor antagonist anakinra. Joint Bone Spine 2011, 78:100-101.
163. Fontaine C., Millot O., Reny J., Berdagué P., Rey J., Oziol E. Dilated cardiomyopathy with normal creatin kinase in an adult-onset Still's disease. Rev Med Interne 2003, 24:S116.
164. Parvez N., Carpenter J.L. Cardiac tamponade in Still disease: a review of the literature. South Med J 2009, 102:832-837.
165. Buss S.J., Wolf D., Mereles D., Blank N., Katus H.A., Hardt S.E. A rare case of reversible constrictive pericarditis with severe pericardial thickening in a patient with adult onset Still's disease. Int J Cardiol 2010, 144:e23-e25.
166. García-Porrúa C., González-Juanatey C., González-Gay M.A. Endocarditis in adult onset Still's disease: a 12month followup. J Rheumatol 2001, 28:2141-2142.
167. Mejjad O., Vittecoq O., Tamion F., Girault C., Lecot S., Cailleux N., et al. A shock associated with adult-onset Still's disease. Joint Bone Spine 2001, 68:76-78.
168. Iglesias J., Sathiraju S., Marik P.E. Severe systemic inflammatory response syndrome with shock and ARDS resulting from Still's disease: clinical response with high-dose pulse methylprednisolone, therapy. Chest 1999, 115:1738-1740.
169. Mito K., Yamakami Y., Mizunoe S., Tokimatsu I., Hiramatsu K., Nagai H., et al. A case of adult-onset Still's disease complicated with acute respiratory distress syndrome. J Jpn Respir Soc 2002, 40:894-899.
170. Suleiman M., Wolfovitz E., Boulman N., Levy Y. Adult onset Still's disease as a cause of ARDS and acute respiratory failure. Scand J Rheumatol 2002, 31:181-183.
171. Ota A. Adult Still disease and ARDS. J Jpn Soc Intern Med 2001, 90:1403-1408.
172. Yokoyama M., Suwa A., Shinozawa T., Fujii T., Mimori T., Akizuki M., et al. A case of adult onset Still's disease complicated with adult respiratory distress syndrome and disseminated intravascular coagulation. Jpn J Clin Immunol 1995, 18:207-214.
173. Pedersen J.E. ARDS-associated with adult Still's disease. Intensive Care Med 1991, 17:372.
174. Hirohata S., Kamoshita H., Taketani T., Maeda S. Adult Still's disease complicated with adult respiratory distress. Arch Intern Med 1986, 146:2409-2410.
175. Sari I., Birlik M., Binicier O., Akar S., Yilmaz E., Onen F., et al. A case of adult-onset Still's disease complicated with diffuse alveolar hemorrhage. J Korean Med Sci 2009, 24:155-157.
176. Arai Y., Handa T., Mitani K. Adult-onset Still disease presenting with disseminated intravascular coagulation. Jpn J Clin Hematol 2004, 45:316-318.
177. Park J.-H., Bae J.H., Choi Y.-S., Lee H.-S., Jun J.-B., Jung S., et al. Adult-onset Still's disease with disseminated intravascular coagulation and multiple organ dysfunctions dramatically treated with cyclosporine A. J Korean Med Sci 2004, 19:137-141.
178. Sanada I., Kawano F., Tsukamoto A., Kiyokawa T., Shido T., Koga S. Disseminated intravascular coagulation in a case of adult onset Still's disease. Jpn J Clin Hematol 1997, 38:1194-1198.
179. Bray V.J., Singleton J.D. Disseminated intravascular coagulation in Still's disease. Semin Arthritis Rheum 1994, 24:222-229.
180. Mori T., Tanigawa M., Iwasaki E., Tamaki S., Ono T., Wada H., et al. Cyclosporine therapy of adult onset Still's disease with disseminated intravascular coagulation. Jpn J Clin Hematol 1993, 34:147-152.
181. Aellen P., Raccaud O., Waldburger M., Chamot A.M., Gerster J.C. Still's disease in adults with disseminated intravascular coagulation. Schweiz Rundsch Med Prax 1991, 80:376-378.
182. Salamon L., Salamon T., Morovic-Vergles J. Thrombotic microangiopathy in adult-onset Still's disease: case report and review of the literature. Wien Klin Wochenschr 2009, 121:583-588.
183. Portolés J., de Tomás E., Espinosa A., Gallego E., Nieva G.S., Blanco J. Thrombotic thrombocytopenic purpura and acute renal failure in adult Still's disease. Nephrol Dial Transplant 1997, 12:1471-1473.
184. Quéméneur T., Noel L.-H., Kyndt X., Droz D., Fleury D., Binaut R., et al. Thrombotic microangiopathy in adult Still's disease. Scand J Rheumatol 2005, 34:399-403.
185. Ben Ghorbel I., Khanfir M., Houman M.H. Amyloidosis in adult onset Still's disease. Rev Med Interne 2004, 25:675-677.
186. Ishii T., Sasaki T., Muryoi T., Murai C., Hatakeyama A., Oosaki H., et al. Systemic amyloidosis in a patient with adult onset Still's disease. Intern Med jan. 1993, 32(1):50-52.
187. Oh Y.B., Bae S.C., Jung J.H., Kim T.H., Jun J.B., Jung S.S., et al. Secondary renal amyloidosis in adult onset Still's disease: case report and review of the literature. Korean J Intern Med 2000, 15:131-134.
188. Rivera F., Gil C.M., Gil M.T., Batlle-Gualda E., Trigueros M., Olivares J. Vascular renal AA amyloidosis in adult Still's disease. Nephrol Dial Transplant 1997, 12:1714-1716.
189. Uppal S.S., Al-Mutairi M., Hayat S., Abraham M., Malaviya A. Ten years of clinical experience with adult onset Still's disease: is the outcome improving?. Clin Rheumatol 2007, 26:1055-1060.
190. Michel M., Hayem G., Rat A.C., Meyer O., Palazzo E., Blétry O., et al. Fatal infectious complications in 2 patients with adult onset Still disease. Rev Med Interne 1996, 17:407-409.
191. Manganelli P., Fietta P., Zuccoli P. Adult-onset Still's disease with respiratory distress syndrome, polyserositis and disseminated intravascular coagulation: a case with a fatal outcome. Clin Exp Rheumatol 2003, 21:139.
192. Gianella S., Schaer D.J., Schwarz U., Kurrer M., Heppner F.L., Fehr J., et al. Retinal microangiopathy and rapidly fatal cerebral edema in a patient with adult-onset Still's disease and concurrent macrophage activation syndrome. Am J Hematol 2008, 83:424-427.
193. Domingues R.B., da Gama A.M.C., Caser E.B., Musso C., Santos M.C.S. Disseminated cerebral thrombotic microangiopathy in a patient with adult's still disease. Arq Neuropsiquiatr 2003, 61:259-261.
194. Masuyama A., Kobayashi H., Kobayashi Y., Yokoe I., Sugimura Y., Maniwa K., et al. A case of adult-onset Still's disease complicated by thrombotic thrombocytopenic purpura with retinal microangiopathy and rapidly fatal cerebral edema. Mod Rheumatol 2013, 23:379-385.
195. Hong Y.H., Lee C.K. A case of adult onset Still's disease with systemic inflammatory response syndrome complicated by fatal status epilepticus. Rheumatol Int 2008, 28:931-933.
196. Franchini S., Dagna L., Salvo F., Aiello P., Baldissera E., Sabbadini M.G. Efficacy of traditional and biologic agents in different clinical phenotypes of adult-onset Still's disease. Arthritis Rheum 2010, 62:2530-2535.
197. Koizumi R., Tsukada Y., Ideura H., Ueki K., Maezawa A., Nojima Y. Treatment of adult Still's disease with dexamethasone, an alternative to prednisolone. Scand J Rheumatol 2000, 29:396-398.
198. Fautrel B., Borget C., Rozenberg S., Meyer O., Le Loët X., Masson C., et al. Corticosteroid sparing effect of low dose methotrexate treatment in adult Still's disease. J Rheumatol 1999, 26:373-378.
199. Mitamura M., Tada Y., Koarada S., Inoue H., Suematsu R., Ohta A., et al. Cyclosporin A treatment for Japanese patients with severe adult-onset Still's disease. Mod Rheumatol 2009, 19:57-63.
200. Vignes S., Wechsler B., Amoura Z., Papo T., Francès C., Huong D.L., et al. Intravenous immunoglobulin in adult Still's disease refractory to non-steroidal anti-inflammatory drugs. Clin Exp Rheumatol 1998, 16:295-298.
201. Permal S., Wechsler B., Cabane J., Perrot S., Blum L., Imbert J.C. Treatment of Still disease in adults with intravenous immunoglobulins. Rev Med Interne 1995, 16:250-254.
202. Emmenegger U., Frey U., Reimers A., Fux C., Semela D., Cottagnoud P., et al. Hyperferritinemia as indicator for intravenous immunoglobulin treatment in reactive macrophage activation syndromes. Am J Hematol 2001, 68:4-10.
203. Liozon E., Ly K., Aubard Y., Vidal E. Intravenous immunoglobulins for adult Still's disease and pregnancy. Rheumatology (Oxford) 1999, 38:1024-1025.
204. Husni M.E., Maier A.L., Mease P.J., Overman S.S., Fraser P., Gravallese E.M., et al. Etanercept in the treatment of adult patients with Still's disease. Arthritis Rheum 2002, 46:1171-1176.
205. Felson D.T., Anderson J.J., Boers M., Bombardier C., Furst D., Goldsmith C., et al. American College of Rheumatology. Preliminary definition of improvement in rheumatoid arthritis. Arthritis Rheum 1995, 38:727-735.
206. Cavagna L., Caporali R., Epis O., Bobbio-Pallavicini F., Montecucco C. Infliximab in the treatment of adult Still's disease refractory to conventional therapy. Clin Exp Rheumatol 2001, 19:329-332.
207. Kraetsch H.G., Antoni C., Kalden J.R., Manger B. Successful treatment of a small cohort of patients with adult onset of Still's disease with infliximab: first experiences. Ann Rheum Dis 2001, 60:55-57.
208. Kokkinos A., Iliopoulos A., Greka P., Efthymiou A., Katsilambros N., Sfikakis P.P. Successful treatment of refractory adult-onset Still's disease with infliximab. A prospective, non-comparative series of four patients. Clin Rheumatol 2004, 23:45-49.
209. Fautrel B., Sibilia J., Mariette X., Combe B. Tumour necrosis factor alpha blocking agents in refractory adult Still's disease: an observational study of 20 cases. Ann Rheum Dis 2005, 64:262-266.
210. Benucci M., Li G.F., Del Rosso A., Manfredi M. Adalimumab (anti-TNF-alpha) therapy to improve the clinical course of adult-onset Still's disease: the first case report. Clin Exp Rheumatol 2005, 23:733.
211. Kaneko K., Kaburaki M., Muraoka S., Tanaka N., Yamamoto T., Kusunoki Y., et al. Exacerbation of adult-onset Still's disease, possibly related to elevation of serum tumor necrosis factor-alpha after etanercept administration. Int J Rheum Dis 2010, 13:e67-e69.
212. Agarwal S., Moodley J., Ajani Goel G., Theil K.S., Mahmood S.S., Lang R.S. A rare trigger for macrophage activation syndrome. Rheumatol Int 2011, 31:405-407.
213. Aikawa N.E., Ribeiro A.C.de M., Saad C.G.S., Pereira R.M.R., Levy M., Silva C.A., et al. Is anti-TNF switching in refractory Still's disease safe and effective?. Clin Rheumatol 2011, 30:1129-1134.
214. Koné-Paut I., Piram M. Targeting interleukin-1β in CAPS (cryopyrin-associated periodic) syndromes: what did we learn?. Autoimmun Rev 2012, 12:77-80.
215. Hoffman H.M. Therapy of autoinflammatory syndromes. J Allergy Clin Immunol 2009, 124:1129-1138.
216. Rudinskaya A., Trock D.H. Successful treatment of a patient with refractory adult-onset still disease with anakinra. J Clin Rheumatol 2003, 9:330-332.
217. Vasques Godinho F.M., Parreira Santos M.J., Canas da Silva J. Refractory adult onset Still's disease successfully treated with anakinra. Ann Rheum Dis 2005, 64:647-648.
218. Fitzgerald A.A., Leclercq S.A., Yan A., Homik J.E., Dinarello C.A. Rapid responses to anakinra in patients with refractory adult-onset Still's disease. Arthritis Rheum 2005, 52:1794-1803.
219. Kalliolias G.D., Georgiou P.E., Antonopoulos I.A., Andonopoulos A.P., Liossis S.-N.C. Anakinra treatment in patients with adult-onset Still's disease is fast, effective, safe and steroid sparing: experience from an uncontrolled trial. Ann Rheum Dis 2007, 66:842-843.
220. Kötter I., Wacker A., Koch S., Henes J., Richter C., Engel A., et al. Anakinra in patients with treatment-resistant adult-onset Still's disease: four case reports with serial cytokine measurements and a review of the literature. Semin Arthritis Rheum 2007, 37:189-197.
221. Lequerré T., Quartier P., Rosellini D., Alaoui F., De Bandt M., Mejjad O., et al. Interleukin-1 receptor antagonist (anakinra) treatment in patients with systemic-onset juvenile idiopathic arthritis or adult onset Still disease: preliminary experience in France. Ann Rheum Dis 2008, 67:302-308.
222. Laskari K., Tzioufas A.G., Moutsopoulos H.M. Efficacy and long-term follow-up of IL-1R inhibitor anakinra in adults with Still's disease: a case-series study. Arthritis Res Ther 2011, 13:R91.
223. Giampietro C., Ridene M., Lequerre T., Costedoat Chalumeau N., Amoura Z., Sellam J., et al. Anakinra in adult-onset Still's disease: long-term treatment in patients resistant to conventional therapy. Arthritis Care Res 2013, 65:822-826.
224. Nigrovic P.A., Mannion M., Prince F.H.M., Zeft A., Rabinovich C.E., van Rossum M.A.J., et al. Anakinra as first-line disease-modifying therapy in systemic juvenile idiopathic arthritis: report of forty-six patients from an international multicenter series. Arthritis Rheum 2011, 63:545-555.
225. DeWitt E.M., Kimura Y., Beukelman T., Nigrovic P.A., Onel K., Prahalad S., et al. Juvenile Idiopathic Arthritis Disease-specific Research Committee of Childhood Arthritis Rheumatology and Research Alliance, Consensus treatment plans for new-onset systemic juvenile idiopathic arthritis. Arthritis Care Res 2012, 64:1001-1010.
226. Nordström D., Knight A., Luukkainen R., van Vollenhoven R., Rantalaiho V., Kajalainen A., et al. Beneficial effect of interleukin 1 inhibition with anakinra in adult-onset Still's disease. An open, randomized, multicenter study. J Rheumatol 2012, 39:2008-2011.
227. Moulis G., Sailler L., Astudillo L., Pugnet G., Arlet P. May anakinra be used earlier in adult onset Still disease?. Clin Rheumatol 2010, 29:1199-1200.
228. Gattorno M., Piccini A., Lasigliè D., Tassi S., Brisca G., Carta S., et al. The pattern of response to anti-interleukin-1 treatment distinguishes two subsets of patients with systemic-onset juvenile idiopathic arthritis. Arthritis Rheum 2008, 58:1505-1515.
229. Kontzias A., Efthimiou P. The use of Canakinumab, a novel IL-1β long-acting inhibitor, in refractory adult-onset Still's disease. Semin Arthritis Rheum 2012, 42:201-205.
230. Petryna O., Cush J.J., Efthimiou P. IL-1 Trap rilonacept in refractory adult onset Still's disease. Ann Rheum Dis 2012, 71:2056-2057.
231. Ruperto N., Quartier P., Wulffraat N., Woo P., Ravelli A., Mouy R., et al. Paediatric Rheumatology International Clinical Trials Organisation, A phase II, multicenter, open-label study evaluating dosing and preliminary safety and efficacy of canakinumab in systemic juvenile idiopathic arthritis with active systemic features. Arthritis Rheum 2012, 64:557-567.
232. Ruperto N., Brunner H.I., Quartier P., Constantin T., Wulffraat N., Horneff G., et al. Two randomized trials of canakinumab in systemic juvenile idiopathic arthritis. N Engl J Med 2012, 367:2396-2406.
233. Nakahara H., Mima T., Yoshio-Hoshino N., Matsushita M., Hashimoto J., Nishimoto N. A case report of a patient with refractory adult-onset Still's disease who was successfully treated with tocilizumab over 6years. Mod Rheumatol 2009, 19:69-72.
234. Matsumoto K., Nagashima T., Takatori S., Kawahara Y., Yagi M., Iwamoto M., et al. Glucocorticoid and cyclosporine refractory adult onset Still's disease successfully treated with tocilizumab. Clin Rheumatol 2009, 28:485-487.
235. Sumida K., Ubara Y., Hoshino J., Suwabe T., Hiramatsu R., Hasegawa E., et al. Etanercept-refractory adult-onset Still's disease with thrombotic thrombocytopenic purpura successfully treated with tocilizumab. Clin Rheumatol 2010, 29:1191-1194.
236. Perdan-Pirkmajer K., Praprotnik S., Tomšič M. A case of refractory adult-onset Still's disease successfully controlled with tocilizumab and a review of the literature. Clin Rheumatol 2010, 29:1465-1467.
237. Sakai R., Nagasawa H., Nishi E., Okuyama A., Takei H., Kurasawa T., et al. Successful treatment of adult-onset Still's disease with tocilizumab monotherapy: two case reports and literature review. Clin Rheumatol 2012, 31:569-574.
238. Kobayashi M., Takahashi Y., Yamashita H., Kaneko H., Mimori A. Benefit and a possible risk of tocilizumab therapy for adult-onset Still's disease accompanied by macrophage-activation syndrome. Mod Rheumatol 2011, 21:92-96.
239. Thonhofer R., Hiller M., Just H., Trummer M., Siegel C., Dejaco C. Treatment of refractory adult-onset Still's disease with tocilizumab: report of two cases and review of the literature. Rheumatol Int 2011, 31:1653-1656.
240. Puéchal X., DeBandt M., Berthelot J.-M., Breban M., Dubost J.-J., Fain O., et al. Tocilizumab in refractory adult Still's disease. Arthritis Care Res 2011, 63:155-159.
241. Cipriani P., Ruscitti P., Carubbi F., Pantano I., Liakouli V., Berardicurti O., et al. Tocilizumab for the treatment of adult-onset Still's disease: results from a case series. Clin Rheumatol 2013, 33:49-55.
242. Elkayam O., Jiries N., Dranitzki Z., Kivity S., Lidar M., Levy O., et al. Tocilizumab in adult-onset Still's disease: the Israeli experience. J Rheumatol 2014, [Epub ahead of print]. 10.3899/jrheum.130881.
243. De Benedetti F., Brunner H.I., Ruperto N., Kenwright A., Wright S., Calvo I., et al. PRINTO, PRCSG, randomized trial of tocilizumab in systemic juvenile idiopathic arthritis. N Engl J Med 2012, 367:2385-2395.