Differential regulation of the Hippo pathway by adherens junctions and apical- Basal cell polarity modules

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 6, 2015, Pages 1785-1790

  Yang, Chih Chao ^a,b,c   Graves, Hillary K ^a   Moya, Ivan M ^d   Tao, Chunyao ^a   Hamaratoglu, Fisun ^e   Gladden, Andrew B ^b,c   Halder, Georg ^a,b,d  

^a Department of Biochemistry and Molecular Biology ^*  (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c UNIVERSITY OF TEXAS   (United States)

^d UNIVERSITY OF LEUVEN   (Belgium)

^e UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CATENIN; DROSOPHILA PROTEIN; MEMBRANE PROTEIN; PDZ PROTEIN; SCRIB PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTIONAL COACTIVATOR WITH PDZBINDING MOTIF; UNCLASSIFIED DRUG; UVOMORULIN; YES ASSOCIATED PROTEIN; YORKIE PROTEIN; ALPHA-CAT PROTEIN, DROSOPHILA; CADHERIN; CELL ADHESION MOLECULE; HPO PROTEIN, DROSOPHILA; NUCLEAR PROTEIN; PRIMER DNA; PROTEIN SERINE THREONINE KINASE; SCRIBBLED PROTEIN, DROSOPHILA; SHOTGUN PROTEIN, DROSOPHILA; SIGNAL PEPTIDE; SMALL INTERFERING RNA; TAZMAN PROTEIN, DROSOPHILA; TRANSACTIVATOR PROTEIN; TUMOR SUPPRESSOR PROTEIN; YORKIE PROTEIN, DROSOPHILA;

ANIMAL CELL; ANIMAL TISSUE; APICAL BASAL CELL; ARTICLE; BASAL CELL; BASOLATERAL MEMBRANE; CELL COMMUNICATION; CELL DISRUPTION; CELL JUNCTION; CELL LOSS; CELL POLARITY; CONTROLLED STUDY; DROSOPHILA; EMBRYO; EMBRYO DEVELOPMENT; GENE SILENCING; GROWTH REGULATION; HIPPO PATHWAY; IMAGINAL DISC; NONHUMAN; PDZ DOMAIN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; ANIMAL; CACO 2 CELL LINE; CROSS BREEDING; DOG; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; MDCK CELL LINE; METABOLISM; MORPHOGENESIS; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE;

MAMMALIA;

ADHERENS JUNCTIONS; ALPHA CATENIN; ANIMALS; CACO-2 CELLS; CADHERINS; CELL ADHESION MOLECULES; CELL POLARITY; CROSSES, GENETIC; DNA PRIMERS; DOGS; DROSOPHILA; DROSOPHILA PROTEINS; GENE KNOCKDOWN TECHNIQUES; HUMANS; IMAGINAL DISCS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MADIN DARBY CANINE KIDNEY CELLS; MORPHOGENESIS; NUCLEAR PROTEINS; PROTEIN-SERINE-THREONINE KINASES; REAL-TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TUMOR SUPPRESSOR PROTEINS;

EID: 84922647202     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1420850112     Document Type: Article

References (47)

1. McCaffrey LM, Macara IG (2011) Epithelial organization, cell polarity and tumorigenesis. Trends Cell Biol 21(12):727-735.
2. Dow LE, Humbert PO (2007) Polarity regulators and the control of epithelial architecture, cell migration, and tumorigenesis. Int Rev Cytol 262:253-302.
3. Tepass U (2012) The apical polarity protein network in Drosophila epithelial cells: Regulation of polarity, junctions, morphogenesis, cell growth, and survival. Annu Rev Cell Dev Biol 28:655-685.
4. Baum B, Georgiou M (2011) Dynamics of adherens junctions in epithelial establishment, maintenance, and remodeling. J Cell Biol 192(6):907-917.
5. Gladden AB, Hebert AM, Schneeberger EE, McClatchey AI (2010) The NF2 tumor suppressor, Merlin, regulates epidermal development through the establishment of a junctional polarity complex. Dev Cell 19(5):727-739.
6. Hanahan D, Weinberg RA (2011) Hallmarks of cancer: The next generation. Cell 144(5):646-674.
7. Genevet A, Tapon N (2011) The Hippo pathway and apico-basal cell polarity. Biochem J 436(2):213-224.
8. Schroeder MC, Halder G (2012) Regulation of the Hippo pathway by cell architecture and mechanical signals. Semin Cell Dev Biol 23(7):803-811.
9. Zhao B, Tumaneng K, Guan KL (2011) The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal. Nat Cell Biol 13(8):877-883.
10. Halder G, Johnson RL (2011) Hippo signaling: Growth control and beyond. Development 138(1):9-22.
11. Pan D (2010) The hippo signaling pathway in development and cancer. Dev Cell 19(4): 491-505.
12. Grzeschik NA, Parsons LM, Allott ML, Harvey KF, Richardson HE (2010) Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms. Curr Biol 20(7):573-581.
13. Ling C, et al. (2010) The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded. Proc Natl Acad Sci USA 107(23):10532-10537.
14. Robinson BS, Huang J, Hong Y, Moberg KH (2010) Crumbs regulates Salvador/Warts/ Hippo signaling in Drosophila via the FERM-domain protein Expanded. Curr Biol 20(7):582-590.
15. Chen CL, et al. (2010) The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila. Proc Natl Acad Sci USA 107(36):15810-15815.
16. Grusche FA, Degoutin JL, Richardson HE, Harvey KF (2011) The Salvador/Warts/Hippo pathway controls regenerative tissue growth in Drosophila melanogaster. Dev Biol 350(2):255-266.
17. Chen CL, Schroeder MC, Kango-Singh M, Tao C, Halder G (2012) Tumor suppression by cell competition through regulation of the Hippo pathway. Proc Natl Acad Sci USA 109(2):484-489.
18. Sun G, Irvine KD (2011) Regulation of Hippo signaling by Jun kinase signaling during compensatory cell proliferation and regeneration, and in neoplastic tumors. Dev Biol 350(1):139-151.
19. Varelas X, et al. (2010) The Crumbs complex couples cell density sensing to Hippodependent control of the TGF-β-SMAD pathway. Dev Cell 19(6):831-844.
20. Cordenonsi M, et al. (2011) The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells. Cell 147(4):759-772.
21. Mohseni M, et al. (2014) A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway. Nat Cell Biol 16(1):108-117.
22. Kim NG, Koh E, Chen X, Gumbiner BM (2011) E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components. Proc Natl Acad Sci USA 108(29):11930-11935.
23. Schlegelmilch K, et al. (2011) Yap1 acts downstream of α-catenin to control epidermal proliferation. Cell 144(5):782-795.
24. Silvis MR, et al. (2011) α-catenin is a tumor suppressor that controls cell accumulation by regulating the localization and activity of the transcriptional coactivator Yap1. Sci Signal 4(174):ra33.
25. Doggett K, Grusche FA, Richardson HE, Brumby AM (2011) Loss of the Drosophila cell polarity regulator Scribbled promotes epithelial tissue overgrowth and cooperation with oncogenic Ras-Raf through impaired Hippo pathway signaling. BMC Dev Biol 11:57.
26. Sarpal R, et al. (2012) Mutational analysis supports a core role for Drosophila α-catenin in adherens junction function. J Cell Sci 125(Pt 1):233-245.
27. Tepass U, et al. (1996) shotgun encodes Drosophila E-cadherin and is preferentially required during cell rearrangement in the neurectoderm and other morphogenetically active epithelia. Genes Dev 10(6):672-685.
28. Hamaratoglu F, et al. (2006) The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Nat Cell Biol 8(1):27-36.
29. Nakajima Y, Meyer EJ, Kroesen A, McKinney SA, Gibson MC (2013) Epithelial junctions maintain tissue architecture by directing planar spindle orientation. Nature 500(7462):359-362.
30. Igaki T (2009) Correcting developmental errors by apoptosis: Lessons from Drosophila JNK signaling. Apoptosis 14(8):1021-1028.
31. Brumby AM, Richardson HE (2003) scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila. EMBO J 22(21):5769-5779.
32. Uhlirova M, Jasper H, Bohmann D (2005) Non-cell-autonomous induction of tissue overgrowth by JNK/Ras cooperation in a Drosophila tumor model. Proc Natl Acad Sci USA 102(37):13123-13128.
33. Igaki T, Pagliarini RA, Xu T (2006) Loss of cell polarity drives tumor growth and invasion through JNK activation in Drosophila. Curr Biol 16(11):1139-1146.
34. Dupont S, et al. (2011) Role of YAP/TAZ in mechanotransduction. Nature 474(7350): 179-183.
35. Navarro C, et al. (2005) Junctional recruitment of mammalian Scribble relies on Ecadherin engagement. Oncogene 24(27):4330-4339.
36. Rauskolb C, Pan G, Reddy BV, Oh H, Irvine KD (2011) Zyxin links fat signaling to the hippo pathway. PLoS Biol 9(6):e1000624.
37. Rauskolb C, Sun S, Sun G, Pan Y, Irvine KD (2014) Cytoskeletal tension inhibits Hippo signaling through an Ajuba-Warts complex. Cell 158(1):143-156.
38. Sheikh F, et al. (2006) alpha-E-catenin inactivation disrupts the cardiomyocyte adherens junction, resulting in cardiomyopathy and susceptibility to wall rupture. Circulation 114(10):1046-1055.
39. Nemade RV, et al. (2004) Biogenesis and function of mouse mammary epithelium depends on the presence of functional alpha-catenin. Mech Dev 121(1):91-99.
40. Rogulja D, Rauskolb C, Irvine KD (2008) Morphogen control of wing growth through the Fat signaling pathway. Dev Cell 15(2):309-321.
41. Willecke M, Hamaratoglu F, Sansores-Garcia L, Tao C, Halder G (2008) Boundaries of Dachsous Cadherin activity modulate the Hippo signaling pathway to induce cell proliferation. Proc Natl Acad Sci USA 105(39):14897-14902.
42. Graves HK, Woodfield SE, Yang CC, Halder G, Bergmann A (2012) Notch signaling activates Yorkie non-cell autonomously in Drosophila. PLoS ONE 7(6):e37615.
43. Enomoto M, Igaki T (2013) Src controls tumorigenesis via JNK-dependent regulation of the Hippo pathway in Drosophila. EMBO Rep 14(1):65-72.
44. Sansores-Garcia L, et al. (2011) Modulating F-actin organization induces organ growth by affecting the Hippo pathway. EMBO J 30(12):2325-2335.
45. Wada K, Itoga K, Okano T, Yonemura S, Sasaki H (2011) Hippo pathway regulation by cell morphology and stress fibers. Development 138(18):3907-3914.
46. Smith MA, et al. (2010) A zyxin-mediated mechanism for actin stress fiber maintenance and repair. Dev Cell 19(3):365-376.
47. Zhang J, et al. (2009) YAP-dependent induction of amphiregulin identifies a non-cellautonomous component of the Hippo pathway. Nat Cell Biol 11(12):1444-1450.