Modafinil as a cognitive enhancer of spatial working memory in rats

Physiology and Behavior

Volumn 142, Issue , 2015, Pages 126-130

  Murphy, Helen M ^a   Ekstrand, Dylan ^a   Tarchick, Matthew ^a   Wideman, Cyrilla H ^a  

^a JOHN CARROLL UNIVERSITY   (United States)

Author keywords

Morris Water Maze; Psychostimulant; Rat; Spatial learning; Working memory

Indexed keywords

MODAFINIL; BENZHYDRYL DERIVATIVE; NOOTROPIC AGENT;

ANIMAL EXPERIMENT; ARTICLE; COGNITION; CONTROLLED STUDY; DRUG EFFECT; GOAL ATTAINMENT; HABITUATION; MALE; MORRIS WATER MAZE TEST; NONHUMAN; PRIORITY JOURNAL; RAT; SPATIAL MEMORY; TREADMILL EXERCISE; WORKING MEMORY; ANIMAL; BODY WEIGHT; DRUG EFFECTS; EATING; LONG EVANS RAT; MAZE TEST; MOTOR ACTIVITY; PSYCHOLOGIC TEST; RANDOMIZATION; SHORT TERM MEMORY;

ANIMALS; BENZHYDRYL COMPOUNDS; BODY WEIGHT; EATING; MALE; MAZE LEARNING; MEMORY, SHORT-TERM; MOTOR ACTIVITY; NOOTROPIC AGENTS; PSYCHOLOGICAL TESTS; RANDOM ALLOCATION; RATS, LONG-EVANS; SPATIAL MEMORY;

EID: 84922605858     PISSN: 00319384     EISSN: 1873507X     Source Type: Journal    
DOI: 10.1016/j.physbeh.2015.02.003     Document Type: Article

References (22)

1. Minzenberg M.J., Carter C.S. Modafinil: a review of neurochemical actions and effects on cognition. Neuropsychopharmacology 2008, 33:1477-1502.
2. Loland C.J., Mereu M., Okunola O.M., Cao J., Prisinzano T.E., Mazier S., et al. R-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant abuse. Biol. Psychiatry 2012, 72:405-413.
3. Saletu B., Saletu M., Grunberger J., Frey R., Zatschek I., Mader R. On the treatment of the alcoholic organic brain syndrome with an alpha-adrenergic agonist modafinil: double-blind, placebo-controlled clinical, psychometric and neurophysiological studies. Prog. Neuropsychopharmacol. Biol. Psychiatry 1990, 14:195-214.
4. Volkow N.D., Fowler J.S., Logan J., Alexoff D., Zhu W., Telang F., et al. Effects of modafinil on dopamine and dopamine transporters in the male human brain. JAMA 2009, 301:1148-1154.
5. Estrada A., Kelley A.M., Webb C.M., Athy J.R., Crowley J.S. Modafinil as a replacement for dextroamphetamine for sustaining alertness in military helicopter pilots. Aviat. Space Environ. Med. 2012, 83:556-564.
6. Teter C.J., McCabe S.E., Cranford J.A., Boyd C.J., Guthrie S.K. Prevalence and motives for illicit use of prescription stimulants in an undergraduate student sample. J. Am. Coll. Health 2005, 53:253-262.
7. Weyandt L., Janusis G., Wilson K., Verdi G., Paquin G., Lopes J., et al. Nonmedical prescription stimulant use among a sample of college students. J. Atten. Disord. 2009, 13:284-296.
8. Müller U., Steffenhagen N., Regenthal R., Bublak P. Effects of modafinil on working memory processes in humans. Psychopharmacology 2004, 177:161-169.
9. Repantis D., Schlattmann P., Laisney O., Heuser I. Modafinil and methylphenidate for neuroenhancement in healthy individuals: a systematic review. Pharmacol. Res. 2010, 62:187-206.
10. Scoriels L., Jones P.B., Sahakian B.J. Modafinil effects on cognition and emotion in schizophrenia and its neurochemical modulation in the brain. Neuropharmacology 2013, 64:168-184.
11. Beracochea D., Cagnard B., Celerier A., le Merrer J., Peres M., Pierard C. First evidence of a delay-dependent working memory-enhancing effect of modafinil in mice. Neuroreport 2001, 12:375-378.
12. Ward C.P., Harsh J.R., York K.M., Stewart K.L., McCoy J.G. Modafinil facilitates performance on a delayed nonmatching to position swim task in rats. Pharmacol. Biochem. Behav. 2004, 78:735-741.
13. Waters K.A., Burnham K.E., O'Conner D., Dawson G.R., Dias R. Assessment of modafinil on attentional processes in a five-choice serial reaction time test in the rat. J. Psychopharmacol. 2005, 19:149-158.
14. Morgan R.E., Crowley J.M., Smith R.H., LaRoche R.B., Dopheide M.M. Modafinil improves attention, inhibitory control, and reaction time in healthy, middle-aged rats. Pharmacol. Biochem. Behav. 2007, 86:531-541.
15. Vorhees C.V., Williams M.T. Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat. Protoc. 2006, 1:848-858.
16. Wong Y.N., King S.P., Laughton W.B., McCormick G.C., Grebow P.E. Single-dose pharmacokinetics of modafinil and methylphenidate given alone or in combination in healthy male volunteers. J. Clin. Pharmacol. 1998, 38:276-282.
17. Ferraro L., Antonelli T., O'Connor W.T., Tanganelli S., Rambert F., Fuxe K. The antinarcoleptic drug modafinil increases glutamate release in thalamic areas and hippocampus. Neuroreport 1997, 8:2883-2887.
18. Ferraro L., Antonelli T., O'Connor W.T., Tanganelli S., Rambert F.A., Fuxe K. The effects of modafinil on striatal, pallidal and nigral GABA and glutamate release in the conscious rat: evidence for a preferential inhibition of striato-pallidal GABA transmission. Neurosci. Lett. 1998, 253:135-138.
19. Ferraro L., Antonelli T., Tanganelli S., O'Connor W.T., Perez de la Mora M., Mendez-Franco J., et al. The vigilance promoting drug modafinil increases extracellular glutamate levels in the medial preoptic area and the posterior hypothalamus of the conscious rat: prevention by local GABAA receptor blockade. Neuropsychopharmacology 1999, 20:346-356.
20. Ishizuka T., Murotani T., Yamatodani A. Modafinil activates the histaminergic system through orexinergic neurons. Neurosci. Lett. 2010, 483:193-196.
21. Callaway C.W., Johnson M.P., Gold L.H., Geyer M.A. Amphetamine derivatives induce locomotor hyperactivity by acting as indirect serotonin antagonists. Psychopharmacology 1991, 104:293-301.
22. Rasmussen N. America's first amphetamine epidemic 1929-1971: a quantitative and qualitative retrospective with implications for the present. Am. J. Public Health 2008, 98:974-985.