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Volumn 62, Issue 3, 2010, Pages 187-206

Modafinil and methylphenidate for neuroenhancement in healthy individuals: A systematic review

Author keywords

Cognitive enhancement; Cognitive performance; Enhancement; Healthy young adults; Methylphenidate; Modafinil; Neuroenhancement; Neuroethics; Sleep deprivation; Systematic review

Indexed keywords

METHYLPHENIDATE; MODAFINIL; PLACEBO; BENZHYDRYL DERIVATIVE; CENTRAL STIMULANT AGENT;

EID: 77954216118     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2010.04.002     Document Type: Review
Times cited : (418)

References (82)
  • 1
    • 77954218558 scopus 로고    scopus 로고
    • (Neuro-)enhancement
    • Springer, New York, H. Helmchen, N. Sartorius (Eds.)
    • Schöne-Seifert B., Talbot D. (Neuro-)enhancement. Textbook of Psychiatry 2009, Springer, New York. H. Helmchen, N. Sartorius (Eds.).
    • (2009) Textbook of Psychiatry
    • Schöne-Seifert, B.1    Talbot, D.2
  • 2
    • 70350560786 scopus 로고    scopus 로고
    • Responding to requests from adult patients for neuroenhancements: guidance of the Ethics, Law and Humanities Committee
    • Larriviere D., Williams M.A., Rizzo M., Bonnie R.J. Responding to requests from adult patients for neuroenhancements: guidance of the Ethics, Law and Humanities Committee. Neurology 2009, 73:1406-1412.
    • (2009) Neurology , vol.73 , pp. 1406-1412
    • Larriviere, D.1    Williams, M.A.2    Rizzo, M.3    Bonnie, R.J.4
  • 4
    • 40149110007 scopus 로고    scopus 로고
    • Botox for the brain: enhancement of cognition, mood and pro-social behavior and blunting of unwanted memories
    • de Jongh R., Bolt I., Schermer M., Olivier B. Botox for the brain: enhancement of cognition, mood and pro-social behavior and blunting of unwanted memories. Neurosci Biobehav Rev 2008, 32:760-776.
    • (2008) Neurosci Biobehav Rev , vol.32 , pp. 760-776
    • de Jongh, R.1    Bolt, I.2    Schermer, M.3    Olivier, B.4
  • 5
    • 37549063465 scopus 로고    scopus 로고
    • Professor's little helper
    • Sahakian B., Morein-Zamir S. Professor's little helper. Nature 2007, 450:1157-1159.
    • (2007) Nature , vol.450 , pp. 1157-1159
    • Sahakian, B.1    Morein-Zamir, S.2
  • 6
    • 77954214094 scopus 로고    scopus 로고
    • The Economist. All on the mind. The Economist
    • The Economist. All on the mind. The Economist 2008
    • (2008)
  • 7
    • 12744259911 scopus 로고    scopus 로고
    • Non-medical use of prescription stimulants among US college students: prevalence and correlates from a national survey
    • McCabe S.E., Knight J.R., Teter C.J., Wechsler H. Non-medical use of prescription stimulants among US college students: prevalence and correlates from a national survey. Addiction 2005, 100:96-106.
    • (2005) Addiction , vol.100 , pp. 96-106
    • McCabe, S.E.1    Knight, J.R.2    Teter, C.J.3    Wechsler, H.4
  • 8
    • 42049116942 scopus 로고    scopus 로고
    • Poll results: look who's doping
    • Maher B. Poll results: look who's doping. Nature 2008, 452:674-675.
    • (2008) Nature , vol.452 , pp. 674-675
    • Maher, B.1
  • 9
    • 77954217644 scopus 로고    scopus 로고
    • DAK-Gesundheitsreport. Schwerpunktthema Doping am Arbeitsplatz
    • DAK-Gesundheitsreport. Schwerpunktthema Doping am Arbeitsplatz 2009;37-91.
    • (2009) , pp. 37-91
  • 10
    • 4644259233 scopus 로고    scopus 로고
    • Cognition-enhancing drugs
    • Mehlman M. Cognition-enhancing drugs. Milbank Quart 2004, 82:483-506.
    • (2004) Milbank Quart , vol.82 , pp. 483-506
    • Mehlman, M.1
  • 11
    • 77954218849 scopus 로고    scopus 로고
    • Physicians' desk reference. Physicians' desk reference. 63rd ed. Montvale, NJ: Thomson Reuters;
    • Physicians' desk reference. Physicians' desk reference. 63rd ed. Montvale, NJ: Thomson Reuters; 2009.
    • (2009)
  • 13
    • 20644441994 scopus 로고    scopus 로고
    • Mechanisms of neurotransmitter release by amphetamines: a review
    • Sulzer D., Sonders M.S., Poulsen N.W., Galli A. Mechanisms of neurotransmitter release by amphetamines: a review. Prog Neurobiol 2005, 75:406-433.
    • (2005) Prog Neurobiol , vol.75 , pp. 406-433
    • Sulzer, D.1    Sonders, M.S.2    Poulsen, N.W.3    Galli, A.4
  • 14
    • 62649136134 scopus 로고    scopus 로고
    • Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications
    • Volkow N.D., Fowler J.S., Logan J., Alexoff D., Zhu W., Telang F., et al. Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications. JAMA 2009, 301:1148-1154.
    • (2009) JAMA , vol.301 , pp. 1148-1154
    • Volkow, N.D.1    Fowler, J.S.2    Logan, J.3    Alexoff, D.4    Zhu, W.5    Telang, F.6
  • 15
    • 43649090464 scopus 로고    scopus 로고
    • A review of neurochemical actions and effects on cognition
    • Minzenberg M.J., Carter C.S., Modafinil: A review of neurochemical actions and effects on cognition. Neuropsychopharmacology 2008, 33(7):1477-1502.
    • (2008) Neuropsychopharmacology , vol.33 , Issue.7 , pp. 1477-1502
    • Minzenberg, M.J.1    Carter, C.S.2
  • 16
    • 33646768643 scopus 로고    scopus 로고
    • A systematic review of modafinil: potential clinical uses and mechanisms of action
    • Ballon J.S., Feifel D. A systematic review of modafinil: potential clinical uses and mechanisms of action. J Clin Psychiatr 2006, 67:554-566.
    • (2006) J Clin Psychiatr , vol.67 , pp. 554-566
    • Ballon, J.S.1    Feifel, D.2
  • 17
    • 0029914622 scopus 로고    scopus 로고
    • Assessing the quality of reports of randomized clinical trials: Is blinding necessary?
    • Jadad A.R., Moore R.A., Carroll D., Jenkinson C., Reynolds D.J., et al. Assessing the quality of reports of randomized clinical trials: Is blinding necessary?. Control Clin Trials 1996, 17:1-12.
    • (1996) Control Clin Trials , vol.17 , pp. 1-12
    • Jadad, A.R.1    Moore, R.A.2    Carroll, D.3    Jenkinson, C.4    Reynolds, D.J.5
  • 18
    • 18244370235 scopus 로고    scopus 로고
    • Biomarkers for the effects of selective serotonin reuptake inhibitors (SSRIs) in healthy subjects
    • Dumont G.J., de-Visser S.J., Cohen A.F., van-Gerven J.M. Biomarkers for the effects of selective serotonin reuptake inhibitors (SSRIs) in healthy subjects. Br J Clin Pharmacol 2005, 59:495-510.
    • (2005) Br J Clin Pharmacol , vol.59 , pp. 495-510
    • Dumont, G.J.1    de-Visser, S.J.2    Cohen, A.F.3    van-Gerven, J.M.4
  • 21
    • 24644451747 scopus 로고    scopus 로고
    • Neurobehavioural and physiological outcomes from modafinil during severe sleep loss (abstract)
    • Rogers N.L., Maislin G., Van Dongen H.P., Dinges D.F. Neurobehavioural and physiological outcomes from modafinil during severe sleep loss (abstract). Int Med J 2004, 34:A19.
    • (2004) Int Med J , vol.34
    • Rogers, N.L.1    Maislin, G.2    Van Dongen, H.P.3    Dinges, D.F.4
  • 22
    • 26444573309 scopus 로고    scopus 로고
    • Modafinil reverses the marked attentional deficits produced by acute sleep deprivation in healthy volunteers
    • Wesnes K.A., Macher J.P. Modafinil reverses the marked attentional deficits produced by acute sleep deprivation in healthy volunteers. Eur Neuropsychopharm 2004, 14:S380.
    • (2004) Eur Neuropsychopharm , vol.14
    • Wesnes, K.A.1    Macher, J.P.2
  • 23
    • 0041352232 scopus 로고    scopus 로고
    • Effects of modafinil on visual and auditory reaction abilities and subjective fatigue level during 48h sleep deprivation
    • Li Y.F., Zhan H., Xin Y.M., Tang G.X., Wei S.H., et al. Effects of modafinil on visual and auditory reaction abilities and subjective fatigue level during 48h sleep deprivation. Space Med Med Eng (Beijing) 2003, 16:277-280.
    • (2003) Space Med Med Eng (Beijing) , vol.16 , pp. 277-280
    • Li, Y.F.1    Zhan, H.2    Xin, Y.M.3    Tang, G.X.4    Wei, S.H.5
  • 24
    • 0033923478 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled investigation of the efficacy of modafinil for sustaining the alertness and performance of aviators: a helicopter simulator study
    • Caldwell J.A., Caldwell J.L., Smythe N.K., Hall K.K. A double-blind, placebo-controlled investigation of the efficacy of modafinil for sustaining the alertness and performance of aviators: a helicopter simulator study. Psychopharmacology (Berl) 2000, 150:272-282.
    • (2000) Psychopharmacology (Berl) , vol.150 , pp. 272-282
    • Caldwell, J.A.1    Caldwell, J.L.2    Smythe, N.K.3    Hall, K.K.4
  • 25
    • 4344665010 scopus 로고    scopus 로고
    • Modafinil's effects on simulator performance and mood in pilots during 37h without sleep
    • Caldwell J.A., Caldwell J.L., Smith J.K., Brown D.L. Modafinil's effects on simulator performance and mood in pilots during 37h without sleep. Aviat Space Environ Med 2004, 75:777-784.
    • (2004) Aviat Space Environ Med , vol.75 , pp. 777-784
    • Caldwell, J.A.1    Caldwell, J.L.2    Smith, J.K.3    Brown, D.L.4
  • 26
    • 77954218272 scopus 로고    scopus 로고
    • An assessment of modafinil for vestibular and aviation-related effects. AFRL-HE-BR-TR-2005-0129 ed. United States Air Force Research Laboratory;
    • Eddy D, Storm W, French J, Barton E, Cardenas R. An assessment of modafinil for vestibular and aviation-related effects. AFRL-HE-BR-TR-2005-0129 ed. United States Air Force Research Laboratory; 2005.
    • (2005)
    • Eddy, D.1    Storm, W.2    French, J.3    Barton, E.4    Cardenas, R.5
  • 27
    • 77954216637 scopus 로고    scopus 로고
    • The efficacy of modafinil as an operational fatigue countermeasure over several days of reduced sleep during a simulated escape and evasion scenario. AFRL-HE-BR-TR-2004-0021 ed. United States Air Force Research Laboratory; .
    • Whitmore J, Doan B, Heintz T, Hurtle W, Kisner J, Smith JK. The efficacy of modafinil as an operational fatigue countermeasure over several days of reduced sleep during a simulated escape and evasion scenario. AFRL-HE-BR-TR-2004-0021 ed. United States Air Force Research Laboratory; 2004.
    • (2004)
    • Whitmore, J.1    Doan, B.2    Heintz, T.3    Hurtle, W.4    Kisner, J.5    Smith, J.K.6
  • 28
    • 77954214045 scopus 로고    scopus 로고
    • A double-blind placebo controlled investigation of the efficacy of modafinil for maintaining alertness and performance in sustained military ground operations. AFRL-HE-BR-TR-2006-0005 ed. United States Air Force Research Laboratory;
    • Whitmore J, Hickey P, Doan B, Harrison R, Kisner J, Beltran T, et al. A double-blind placebo controlled investigation of the efficacy of modafinil for maintaining alertness and performance in sustained military ground operations. AFRL-HE-BR-TR-2006-0005 ed. United States Air Force Research Laboratory; 2006.
    • (2006)
    • Whitmore, J.1    Hickey, P.2    Doan, B.3    Harrison, R.4    Kisner, J.5    Beltran, T.6
  • 29
    • 24644435842 scopus 로고    scopus 로고
    • The use of stimulants to modify performance during sleep loss: a review by the sleep deprivation and Stimulant Task Force of the American Academy of Sleep Medicine
    • Bonnet M.H., Balkin T.J., Dinges D.F., Roehrs T., Rogers N.L., Wesensten N.J. The use of stimulants to modify performance during sleep loss: a review by the sleep deprivation and Stimulant Task Force of the American Academy of Sleep Medicine. Sleep 2005, 28:1163-1187.
    • (2005) Sleep , vol.28 , pp. 1163-1187
    • Bonnet, M.H.1    Balkin, T.J.2    Dinges, D.F.3    Roehrs, T.4    Rogers, N.L.5    Wesensten, N.J.6
  • 30
    • 0008737390 scopus 로고
    • Pemoline and methylphenidate: interaction with mood, sleepiness, and cognitive performance during64 hours of sleep deprivation
    • Babkoff H., Kelly T., Matteson L., Gomez S., Lopez A., Hauser S., et al. Pemoline and methylphenidate: interaction with mood, sleepiness, and cognitive performance during64 hours of sleep deprivation. Mil Psychol 1992, 4:235-265.
    • (1992) Mil Psychol , vol.4 , pp. 235-265
    • Babkoff, H.1    Kelly, T.2    Matteson, L.3    Gomez, S.4    Lopez, A.5    Hauser, S.6
  • 31
    • 0030671005 scopus 로고    scopus 로고
    • Alerting effects of methylphenidate under basal and sleep-deprived conditions
    • Bishop C., Roehrs T., Rosenthal L., Roth T. Alerting effects of methylphenidate under basal and sleep-deprived conditions. Exp Clin Psychopharm 1997, 5:344-352.
    • (1997) Exp Clin Psychopharm , vol.5 , pp. 344-352
    • Bishop, C.1    Roehrs, T.2    Rosenthal, L.3    Roth, T.4
  • 32
    • 0015878736 scopus 로고
    • Effect of magnesium pemoline and methylphenidate on memory improvement and mood in normal aging subjects
    • Gilbert J.G., Donnelly K.J., Zimmer L.E., Kubis J.F. Effect of magnesium pemoline and methylphenidate on memory improvement and mood in normal aging subjects. Int J Aging Hum Dev 1973, 4:35-51.
    • (1973) Int J Aging Hum Dev , vol.4 , pp. 35-51
    • Gilbert, J.G.1    Donnelly, K.J.2    Zimmer, L.E.3    Kubis, J.F.4
  • 33
    • 0038384130 scopus 로고    scopus 로고
    • Neurochemical and psychotropic effects of bupropion in healthy male subjects
    • Gobbi G., Slater S., Boucher N., Debonnel G., Blier P. Neurochemical and psychotropic effects of bupropion in healthy male subjects. J Clin Psychopharm 2003, 23:233-239.
    • (2003) J Clin Psychopharm , vol.23 , pp. 233-239
    • Gobbi, G.1    Slater, S.2    Boucher, N.3    Debonnel, G.4    Blier, P.5
  • 34
    • 3042849061 scopus 로고    scopus 로고
    • Methylphenidate does not improve cognitive function in healthy sleep-deprived young adults
    • Bray C.L., Cahill K.S., Oshier J.T., Peden C.S., Theriaque D.W., et al. Methylphenidate does not improve cognitive function in healthy sleep-deprived young adults. J Invest Med 2004, 52:192-201.
    • (2004) J Invest Med , vol.52 , pp. 192-201
    • Bray, C.L.1    Cahill, K.S.2    Oshier, J.T.3    Peden, C.S.4    Theriaque, D.W.5
  • 35
    • 0032965320 scopus 로고    scopus 로고
    • Sleepiness and the reinforcing and subjective effects of methylphenidate
    • Roehrs T., Papineau K., Rosenthal L., Roth T. Sleepiness and the reinforcing and subjective effects of methylphenidate. Exp Clin Psychopharm 1999, 7:145-150.
    • (1999) Exp Clin Psychopharm , vol.7 , pp. 145-150
    • Roehrs, T.1    Papineau, K.2    Rosenthal, L.3    Roth, T.4
  • 36
    • 3342964037 scopus 로고    scopus 로고
    • Reinforcing and subjective effects of methylphenidate: dose and time in bed
    • Roehrs T., Meixner R., Turner L., Johanson C.E., Roth T. Reinforcing and subjective effects of methylphenidate: dose and time in bed. Exp Clin Psychopharm 2004, 12:180-189.
    • (2004) Exp Clin Psychopharm , vol.12 , pp. 180-189
    • Roehrs, T.1    Meixner, R.2    Turner, L.3    Johanson, C.E.4    Roth, T.5
  • 37
    • 11144328138 scopus 로고    scopus 로고
    • The effect of modafinil on counter-regulatory and cognitive responses to hypoglycaemia
    • Smith D., Pernet A., Rosenthal J.M., Bingham E.M., Reid H., Macdonald I.A., et al. The effect of modafinil on counter-regulatory and cognitive responses to hypoglycaemia. Diabetologia 2004, 47:1704-1711.
    • (2004) Diabetologia , vol.47 , pp. 1704-1711
    • Smith, D.1    Pernet, A.2    Rosenthal, J.M.3    Bingham, E.M.4    Reid, H.5    Macdonald, I.A.6
  • 38
    • 33846191926 scopus 로고    scopus 로고
    • A randomized, double-blind, crossover trial of modafinil on mood
    • Taneja I., Haman K., Shelton R.C., Robertson D. A randomized, double-blind, crossover trial of modafinil on mood. J Clin Psychopharm 2007, 27:76-79.
    • (2007) J Clin Psychopharm , vol.27 , pp. 76-79
    • Taneja, I.1    Haman, K.2    Shelton, R.C.3    Robertson, D.4
  • 40
    • 0348016663 scopus 로고
    • Use of stimulants to ameliorate the effects of sleep loss during sustained performance
    • Babkoff H., Krueger G. Use of stimulants to ameliorate the effects of sleep loss during sustained performance. Mil Psychol 1992, 4:191-205.
    • (1992) Mil Psychol , vol.4 , pp. 191-205
    • Babkoff, H.1    Krueger, G.2
  • 41
    • 30844471783 scopus 로고    scopus 로고
    • Pharmacodynamic effects on alertness of single doses of armodafinil in healthy subjects during a nocturnal period of acute sleep loss
    • Dinges D.F., Arora S., Darwish M., Niebler G.E. Pharmacodynamic effects on alertness of single doses of armodafinil in healthy subjects during a nocturnal period of acute sleep loss. Curr Med Res Opin 2006, 22:159-167.
    • (2006) Curr Med Res Opin , vol.22 , pp. 159-167
    • Dinges, D.F.1    Arora, S.2    Darwish, M.3    Niebler, G.E.4
  • 43
    • 68249149468 scopus 로고    scopus 로고
    • Antidepressants for neuroenhancement in healthy individuals: a systematic review
    • Repantis D., Schlattmann P., Laisney O., Heuser I. Antidepressants for neuroenhancement in healthy individuals: a systematic review. Poiesis Prax 2009, 6:139-174.
    • (2009) Poiesis Prax , vol.6 , pp. 139-174
    • Repantis, D.1    Schlattmann, P.2    Laisney, O.3    Heuser, I.4
  • 45
    • 0031799561 scopus 로고    scopus 로고
    • Neural correlates of attention and arousal: insights from electrophysiology, functional neuroimaging and psychopharmacology
    • Coull J.T. Neural correlates of attention and arousal: insights from electrophysiology, functional neuroimaging and psychopharmacology. Progr Neurobiol 1998, 55:343-361.
    • (1998) Progr Neurobiol , vol.55 , pp. 343-361
    • Coull, J.T.1
  • 47
    • 0036884150 scopus 로고    scopus 로고
    • 'Smart drugs': do they work? Are they ethical? Will they be legal?
    • Rose S.P. 'Smart drugs': do they work? Are they ethical? Will they be legal?. Nat Rev Neurosci 2002, 3:975-979.
    • (2002) Nat Rev Neurosci , vol.3 , pp. 975-979
    • Rose, S.P.1
  • 50
    • 20844446638 scopus 로고    scopus 로고
    • Evidence that methylphenidate enhances the saliency of a mathematical task by increasing dopamine in the human brain
    • Volkow N.D., Wang G.J., Fowler J.S., Telang F., Maynard L., et al. Evidence that methylphenidate enhances the saliency of a mathematical task by increasing dopamine in the human brain. Am J Psychiat 2004, 161:1173-1180.
    • (2004) Am J Psychiat , vol.161 , pp. 1173-1180
    • Volkow, N.D.1    Wang, G.J.2    Fowler, J.S.3    Telang, F.4    Maynard, L.5
  • 51
    • 0030755899 scopus 로고    scopus 로고
    • Self-monitoring cognitive performance during sleep deprivation: effects of modafinil, d-amphetamine and placebo
    • Baranski J., Pigeau R.A. Self-monitoring cognitive performance during sleep deprivation: effects of modafinil, d-amphetamine and placebo. J Sleep Res 1997, 6:84-91.
    • (1997) J Sleep Res , vol.6 , pp. 84-91
    • Baranski, J.1    Pigeau, R.A.2
  • 52
    • 77954217865 scopus 로고    scopus 로고
    • The effects of modafinil on aviator performance during 40hours of continuous wakefulness: a UH-60 helicopter simulator study. United States Air Force Research Laboratory ; USAARL Report No. 99-17:
    • Caldwell JA, Smythe NK, Caldwell JL, Hall KK, Norman DN, et al. The effects of modafinil on aviator performance during 40hours of continuous wakefulness: a UH-60 helicopter simulator study. United States Air Force Research Laboratory 1999; USAARL Report No. 99-17:.
    • (1999)
    • Caldwell, J.A.1    Smythe, N.K.2    Caldwell, J.L.3    Hall, K.K.4    Norman, D.N.5
  • 53
    • 31544471840 scopus 로고    scopus 로고
    • Cognitive performance following modafinil versus placebo in sleep-deprived emergency physicians: a double-blind randomized crossover study
    • Gill M., Haerich P., Westcott K., Godenick K.L., Tucker J.A. Cognitive performance following modafinil versus placebo in sleep-deprived emergency physicians: a double-blind randomized crossover study. Acad Emerg Med 2006, 13:158-165.
    • (2006) Acad Emerg Med , vol.13 , pp. 158-165
    • Gill, M.1    Haerich, P.2    Westcott, K.3    Godenick, K.L.4    Tucker, J.A.5
  • 55
    • 0029032777 scopus 로고
    • Interest of modafinil, a new psychostimulant, during a sixty-hour sleep deprivation experiment
    • Lagarde D., Batejat D., Van-Beers P., Sarafian D., Pradella S. Interest of modafinil, a new psychostimulant, during a sixty-hour sleep deprivation experiment. Fund Clin Pharmacol 1995, 9:271-279.
    • (1995) Fund Clin Pharmacol , vol.9 , pp. 271-279
    • Lagarde, D.1    Batejat, D.2    Van-Beers, P.3    Sarafian, D.4    Pradella, S.5
  • 56
    • 0029560394 scopus 로고
    • Modafinil, d-amphetamine and placebo during 64hours of sustained mental work. I. Effects on mood, fatigue, cognitive performance and body temperature
    • Pigeau R., Naitoh P., Buguet A., McCann C., Baranski J., Taylor M., et al. Modafinil, d-amphetamine and placebo during 64hours of sustained mental work. I. Effects on mood, fatigue, cognitive performance and body temperature. J Sleep Res 1995, 4:212-228.
    • (1995) J Sleep Res , vol.4 , pp. 212-228
    • Pigeau, R.1    Naitoh, P.2    Buguet, A.3    McCann, C.4    Baranski, J.5    Taylor, M.6
  • 58
    • 0031983957 scopus 로고    scopus 로고
    • Methylphenidate's effects on paired-associate learning and event-related potentials of young adults
    • Brumaghim J.T., Klorman R. Methylphenidate's effects on paired-associate learning and event-related potentials of young adults. Psychophysiology 1998, 35:73-85.
    • (1998) Psychophysiology , vol.35 , pp. 73-85
    • Brumaghim, J.T.1    Klorman, R.2
  • 59
    • 0022922234 scopus 로고
    • Role of monoamine pathways in attention and effort: effects of clonidine and methylphenidate in normal adult humans
    • Clark C.R., Geffen G.M., Geffen L.B. Role of monoamine pathways in attention and effort: effects of clonidine and methylphenidate in normal adult humans. Psychopharmacology (Berl) 1986, 90:35-39.
    • (1986) Psychopharmacology (Berl) , vol.90 , pp. 35-39
    • Clark, C.R.1    Geffen, G.M.2    Geffen, L.B.3
  • 60
    • 0023923751 scopus 로고
    • Effects of methylphenidate on stimulus evaluation and response processes: evidence from performance and event-related potentials
    • Fitzpatrick P., Klorman R., Brumaghim J.T., Keefover R.W. Effects of methylphenidate on stimulus evaluation and response processes: evidence from performance and event-related potentials. Psychophysiology 1988, 25:292-304.
    • (1988) Psychophysiology , vol.25 , pp. 292-304
    • Fitzpatrick, P.1    Klorman, R.2    Brumaghim, J.T.3    Keefover, R.W.4
  • 61
    • 0018180447 scopus 로고
    • The distribution of attention across auditory input channels: an assessment using the human evoked potential
    • Hink R.F., Fenton W.H., Pfefferbaum A., Tinklenberg J.R., Kopell B.S. The distribution of attention across auditory input channels: an assessment using the human evoked potential. Psychophysiology 1978, 15:466-473.
    • (1978) Psychophysiology , vol.15 , pp. 466-473
    • Hink, R.F.1    Fenton, W.H.2    Pfefferbaum, A.3    Tinklenberg, J.R.4    Kopell, B.S.5
  • 62
    • 0345489068 scopus 로고    scopus 로고
    • Methylphenidate enhances working memory by modulating discrete frontal and parietal lobe regions in the human brain
    • Mehta M.A., Owen A.M., Sahakian B.J., Mavaddat N., Pickard J.D., Robbins T.W. Methylphenidate enhances working memory by modulating discrete frontal and parietal lobe regions in the human brain. J Neurosci 2000, 20:RC65.
    • (2000) J Neurosci , vol.20
    • Mehta, M.A.1    Owen, A.M.2    Sahakian, B.J.3    Mavaddat, N.4    Pickard, J.D.5    Robbins, T.W.6
  • 63
    • 0022885213 scopus 로고
    • Effects of methylphenidate on normal children's mood, event-related potentials, and performance in memory scanning and vigilance
    • Peloquin L.J., Klorman R. Effects of methylphenidate on normal children's mood, event-related potentials, and performance in memory scanning and vigilance. J. Abnorm Psychol 1986, 95:88-98.
    • (1986) J. Abnorm Psychol , vol.95 , pp. 88-98
    • Peloquin, L.J.1    Klorman, R.2
  • 64
    • 2442594676 scopus 로고    scopus 로고
    • Tryptophan depletion impairs stimulus-reward learning while methylphenidate disrupts attentional control in healthy young adults: implications for the monoaminergic basis of impulsive behaviour
    • Rogers R.D., Blackshaw A.J., Middleton H.C., Matthews K., Hawtin K., Crowley C., et al. Tryptophan depletion impairs stimulus-reward learning while methylphenidate disrupts attentional control in healthy young adults: implications for the monoaminergic basis of impulsive behaviour. Psychopharmacology 1999, 146:482-491.
    • (1999) Psychopharmacology , vol.146 , pp. 482-491
    • Rogers, R.D.1    Blackshaw, A.J.2    Middleton, H.C.3    Matthews, K.4    Hawtin, K.5    Crowley, C.6
  • 65
    • 0021746649 scopus 로고
    • Effects of methylphenidate on young adults' performance and event-related potentials in a vigilance and a paired-associates learning test
    • Strauss J., Lewis J.L., Klorman R., Peloquin L.J., Perlmutter R.A., Salzman L.F. Effects of methylphenidate on young adults' performance and event-related potentials in a vigilance and a paired-associates learning test. Psychophysiology 1984, 21:609-621.
    • (1984) Psychophysiology , vol.21 , pp. 609-621
    • Strauss, J.1    Lewis, J.L.2    Klorman, R.3    Peloquin, L.J.4    Perlmutter, R.A.5    Salzman, L.F.6
  • 66
    • 0031660871 scopus 로고    scopus 로고
    • Dopamine transporter occupancies in the human brain induced by therapeutic doses of oral methylphenidate
    • Volkow N.D., Wang G.J., Fowler J.S., Gatley S.J., Logan J., Ding Y.S., et al. Dopamine transporter occupancies in the human brain induced by therapeutic doses of oral methylphenidate. Am J Psychiatry 1998, 155:1325-1331.
    • (1998) Am J Psychiatry , vol.155 , pp. 1325-1331
    • Volkow, N.D.1    Wang, G.J.2    Fowler, J.S.3    Gatley, S.J.4    Logan, J.5    Ding, Y.S.6
  • 67
    • 0032843942 scopus 로고    scopus 로고
    • Reinforcing effects of psychostimulants in humans are associated with increases in brain dopamine and occupancy of D2 receptors
    • Volkow N.D., Wang G.J., Fowler J.S., Logan J., Gatley S.J., Wong C., et al. Reinforcing effects of psychostimulants in humans are associated with increases in brain dopamine and occupancy of D2 receptors. J Pharmacol Exp Therapeut 1999, 291:409-415.
    • (1999) J Pharmacol Exp Therapeut , vol.291 , pp. 409-415
    • Volkow, N.D.1    Wang, G.J.2    Fowler, J.S.3    Logan, J.4    Gatley, S.J.5    Wong, C.6
  • 68
    • 0032956021 scopus 로고    scopus 로고
    • Blockade of striatal dopamine transporters by intravenous methylphenidate is not sufficient to induce self-reports of 'high'
    • Volkow N.D., Wang G.J., Fowler J.S., Gatley S.J., Logan J., Ding Y., et al. Blockade of striatal dopamine transporters by intravenous methylphenidate is not sufficient to induce self-reports of 'high'. J Pharmacol Exp Therapeut 1999, 288:14-20.
    • (1999) J Pharmacol Exp Therapeut , vol.288 , pp. 14-20
    • Volkow, N.D.1    Wang, G.J.2    Fowler, J.S.3    Gatley, S.J.4    Logan, J.5    Ding, Y.6
  • 69
    • 0019861768 scopus 로고
    • Methylphenidate impairs learning and memory in normal adults
    • Wetzel C.D., Squire L.R., Janowsky D.S. Methylphenidate impairs learning and memory in normal adults. Behav Neural Biol 1981, 31:413-424.
    • (1981) Behav Neural Biol , vol.31 , pp. 413-424
    • Wetzel, C.D.1    Squire, L.R.2    Janowsky, D.S.3
  • 74
    • 0034320441 scopus 로고    scopus 로고
    • Student perceptions of methylphenidate abuse at a public liberal arts college
    • Babcock Q., Byrne T. Student perceptions of methylphenidate abuse at a public liberal arts college. J Am Coll Health 2000, 49:143-145.
    • (2000) J Am Coll Health , vol.49 , pp. 143-145
    • Babcock, Q.1    Byrne, T.2
  • 75
    • 0032422237 scopus 로고    scopus 로고
    • Comparison of acute behavioral effects of sustained-release and immediate-release methylphenidate
    • Kollins S.H., Rush C.R., Pazzaglia P.J., Ali J.A. Comparison of acute behavioral effects of sustained-release and immediate-release methylphenidate. Exp Clin Psychopharmacol 1998, 6:367-374.
    • (1998) Exp Clin Psychopharmacol , vol.6 , pp. 367-374
    • Kollins, S.H.1    Rush, C.R.2    Pazzaglia, P.J.3    Ali, J.A.4
  • 76
    • 0027363308 scopus 로고
    • Subjective effects of modafinil, a new central adrenergic stimulant in healthy volunteers: a comparison with amphetamine, caffeine and placebo
    • Warot D., Corruble E., Payan C., Weil J.S., Puech A.J. Subjective effects of modafinil, a new central adrenergic stimulant in healthy volunteers: a comparison with amphetamine, caffeine and placebo. Eur Psychiat 1993, 8:201-208.
    • (1993) Eur Psychiat , vol.8 , pp. 201-208
    • Warot, D.1    Corruble, E.2    Payan, C.3    Weil, J.S.4    Puech, A.J.5
  • 77
    • 0005182406 scopus 로고    scopus 로고
    • Effects of modafinil on cognitive performance during 40hr of sleep deprivation in a warm environment
    • Baranski J., Gil V., McLellan T.M., Moroz D., Buguet A., Radomski M.W. Effects of modafinil on cognitive performance during 40hr of sleep deprivation in a warm environment. Military Psychol 2002, 14:23-47.
    • (2002) Military Psychol , vol.14 , pp. 23-47
    • Baranski, J.1    Gil, V.2    McLellan, T.M.3    Moroz, D.4    Buguet, A.5    Radomski, M.W.6
  • 78
    • 26444494547 scopus 로고    scopus 로고
    • Cognitive effects of modafinil in student volunteers may depend on IQ
    • Randall D.C., Shneerson J.M., File S.E. Cognitive effects of modafinil in student volunteers may depend on IQ. Pharmacol Biochem Behav 2005, 82:133-139.
    • (2005) Pharmacol Biochem Behav , vol.82 , pp. 133-139
    • Randall, D.C.1    Shneerson, J.M.2    File, S.E.3
  • 79
    • 67650338039 scopus 로고    scopus 로고
    • Is it acceptable for people to take methylphenidate to enhance performance? No
    • Chatterjee A. Is it acceptable for people to take methylphenidate to enhance performance? No. BMJ 2009, 338:b1956.
    • (2009) BMJ , vol.338
    • Chatterjee, A.1
  • 80
    • 77954218823 scopus 로고    scopus 로고
    • Brain science, addiction and drugs. An Academy of Medical Sciences working group report. Acad Med Sci.
    • Horn G. Brain science, addiction and drugs. An Academy of Medical Sciences working group report. Acad Med Sci 2008.
    • (2008)
    • Horn, G.1
  • 82
    • 67650034348 scopus 로고    scopus 로고
    • Is it acceptable for people to take methylphenidate to enhance performance? Yes
    • Harris J. Is it acceptable for people to take methylphenidate to enhance performance? Yes. BMJ 2009, 338:b1955.
    • (2009) BMJ , vol.338
    • Harris, J.1


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