Targeting protein-protein interactions with trimeric ligands: High affinity inhibitors of the maguk protein family

PLoS ONE

Volumn 10, Issue 2, 2015, Pages

  Nissen, Klaus B ^a   Haugaard Kedström, Linda M ^a   Wilbek, Theis S ^a   Nielsen, Line S ^a   Aberg, Emma ^b   Kristensen, Anders S ^a   Bach, Anders ^a   Jemth, Per ^b   Strømgaard, Kristian ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

DIMER; MEMBRANE ASSOCIATED GUANYLATE CYCLASE KINASE; POSTSYNAPTIC DENSITY PROTEIN 93; POSTSYNAPTIC DENSITY PROTEIN 95; SYNAPSE ASSOCIATED PROTEIN 102; SYNAPSE ASSOCIATED PROTEIN 97; UNCLASSIFIED DRUG; DLG1 PROTEIN, HUMAN; DLG2 PROTEIN, HUMAN; DLG3 PROTEIN, HUMAN; DLG4 PROTEIN, HUMAN; GUANYLATE KINASE; LIGAND; MEMBRANE PROTEIN; NUCLEAR PROTEIN; PEPTIDE; PROTEIN BINDING; SIGNAL PEPTIDE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; BINDING AFFINITY; DISSOCIATION CONSTANT; DRUG TARGETING; FLUORESCENCE POLARIZATION; LIGAND BINDING; PDZ DOMAIN; PROTEIN PROTEIN INTERACTION; SPECTROMETRY; AMINO ACID SEQUENCE; ANTAGONISTS AND INHIBITORS; BINDING COMPETITION; BINDING SITE; CHEMISTRY; GENETICS; KINETICS; METABOLISM; MUTAGENESIS; PROTEIN MULTIMERIZATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; BINDING SITES; BINDING, COMPETITIVE; FLUORESCENCE POLARIZATION; GUANYLATE KINASES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KINETICS; LIGANDS; MEMBRANE PROTEINS; MUTAGENESIS; NUCLEAR PROTEINS; PDZ DOMAINS; PEPTIDES; PROTEIN BINDING; PROTEIN MULTIMERIZATION; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS;

EID: 84922601860     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0117668     Document Type: Article

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