Natural antisense RNAs are involved in the regulation of CD45 expression in autoimmune diseases

Lupus

Volumn 24, Issue 3, 2015, Pages 235-239

  Rong, J ^a   Yin, J ^a   Su, Z ^b  

^a THE SECOND AFFILIATED HOSPITAL OF SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

^b SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

Author keywords

alternative splicing; autoimmune diseases; CD45; natural antisense transcript

Indexed keywords

CD45 ANTIGEN; CD45RA ANTIGEN; CD45RB ANTIGEN; CD45RC ANTIGEN; CD45RO ANTIGEN; COMPLEMENTARY RNA; DNA METHYLTRANSFERASE; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; LEUKOCYTE ANTIGEN; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; ANKYLOSING SPONDYLITIS; AUTOIMMUNE DISEASE; CHROMATIN STRUCTURE; DIABETES MELLITUS; DISEASE COURSE; DNA METHYLATION; EPIGENETICS; EXON; GENETIC ASSOCIATION; GENETIC REGULATION; HISTONE ACETYLATION; HISTONE METHYLATION; HISTONE PHOSPHORYLATION; HISTONE UBIQUITINATION; HUMAN; MULTIPLE SCLEROSIS; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; RHEUMATOID ARTHRITIS; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE; GENETIC EPIGENESIS; METABOLISM;

ALTERNATIVE SPLICING; ANTIGENS, CD45; AUTOIMMUNE DISEASES; EPIGENESIS, GENETIC; HUMANS; RNA, ANTISENSE; T-LYMPHOCYTES;

EID: 84922600650     PISSN: 09612033     EISSN: 14770962     Source Type: Journal    
DOI: 10.1177/0961203314558856     Document Type: Review

References (52)

1. Huntington ND, Tarlinton DM. CD45: direct and indirect government of immune regulation. Immunol Lett. 2004 ; 94: 167-174
2. Earl LA, Baum LG. CD45 glycosylation controls T-cell life and death. Immunol Cell Biol. 2008 ; 86: 608-615
3. Saunders AE, Johnson P. Modulation of immune cell signalling by the leukocyte common tyrosine phosphatase, CD45. Cell Signal. 2010 ; 22: 339-348
4. Lynch KW, Weiss A. A model system for activation-induced alternative splicing of CD45 pre-mRNA in T cells implicates protein kinase C and Ras. Mol Cell Biol. 2000 ; 20: 70-80
5. Lynch KW. Consequences of regulated pre-mRNA splicing in the immune system. Nat Rev Immunol. 2004 ; 4: 931-940
6. Zamoyska R. Why is there so much CD45 on T cells?. Immunity. 2007 ; 27: 421-423
7. Zikherman J, Weiss A. Alternative splicing of CD45: The tip of the iceberg. Immunity. 2008 ; 29: 839-841
8. Tchilian EZ, Beverley PC. Altered CD45 expression and disease. Trends Immunol. 2006 ; 27: 146-153
9. Holmes N. CD45: All is not yet crystal clear. Immunology. 2006 ; 117: 145-155
10. Mimura T, Fernsten P, Jarjour W, Winfield JB. Autoantibodies specific for different isoforms of CD45 in systemic lupus erythematosus. J Exp Med. 1990 ; 172: 653-656
11. Pan X, Yuan X, Zheng Y, et al. Increased CD45RA+ FoxP3(low) regulatory T cells with impaired suppressive function in patients with systemic lupus erythematosus. PLoS One. 2012 ; 7: e34662 - e34662
12. Maldonado A, Mueller YM, Thomas P, et al. Decreased effector memory CD45RA+ CD62L- CD8+ T cells and increased central memory CD45RA- CD62L+ CD8+ T cells in peripheral blood of rheumatoid arthritis patients. Arthritis Res Ther. 2003 ; 5: R91 - R96
13. Mikulkova Z, Praksova P, Stourac P, et al. Numerical defects in CD8+CD28- T-suppressor lymphocyte population in patients with type 1 diabetes mellitus and multiple sclerosis. Cell Immunol. 2010 ; 262: 75-79
14. Du W, Shen YW, Lee WH, et al. Foxp3+ Treg expanded from patients with established diabetes reduce Helios expression while retaining normal function compared to healthy individuals. PLoS One. 2013 ; 8: e56209 - e56209
15. Uzawa A, Mori M, Hayakawa S, et al. Expression of chemokine receptors on peripheral blood lymphocytes in multiple sclerosis and neuromyelitis optica. BMC Neurol. 2010 ; 10: 113-113
16. Yang CP, Bell EB. Functional maturation of recent thymic emigrants in the periphery: Development of alloreactivity correlates with the cyclic expression of CD45RC isoforms. Eur J Immunol. 1992 ; 22: 2261-2269
17. Watanabe M, Hosoda Y, Okamoto S, et al. CD45RChighCD4+ intestinal mucosal lymphocytes infiltrating in the inflamed colonic mucosa of a novel rat colitis model induced by TNB immunization. Clin Immunol Immunopathol. 1998 ; 88: 45-55
18. Pan Y, Sawalha AH. Epigenetic regulation and the pathogenesis of systemic lupus erythematosus. Transl Res. 2009 ; 153: 4-10
19. Pedre X, Mastronardi F, Bruck W, et al. Changed histone acetylation patterns in normal-appearing white matter and early multiple sclerosis lesions. J Neurosci. 2011 ; 31: 3435-3445
20. Miao F, Chen Z, Zhang L, et al. Profiles of epigenetic histone post-translational modifications at type 1 diabetes susceptible genes. J Biol Chem. 2012 ; 287: 16335-16645
21. Klein K, Gay S. Epigenetic modifications in rheumatoid arthritis, a review. Curr Opin Pharmacol. 2013 ; 13: 420-425
22. Koch MW, Metz LM, Kovalchuk O. Epigenetic changes in patients with multiple sclerosis. Nat Rev Neurol. 2013 ; 9: 35-43
23. Richardson BC, Strahler JR, et al. Phenotypic and functional similarities between 5-azacytidine-treated T cells and a T cell subset in patients with active systemic lupus erythematosus. Arthritis Rheum. 1992 ; 35: 647-662
24. Kaplan MJ, Lu Q, Wu A, et al. Demethylation of promoter regulatory elements contributes to perforin overexpression in CD4+ lupus T cells. J Immunol. 2004 ; 172: 3652-3661
25. Lu Q, Wu A, Tesmer L, et al. Demethylation of CD40LG on the inactive X in T cells from women with lupus. J Immunol. 2007 ; 179: 6352-6358
26. Zhang Y, Zhao M, Sawalha AH, et al. Impaired DNA methylation and its mechanisms in CD4(+)T cells of systemic lupus erythematosus. J Autoimmun. 2013 ; 41: 92-99
27. Liu CC, Fang TJ, Ou TT, et al. Global DNA methylation, DNMT1, and MBD2 in patients with rheumatoid arthritis. Immunol Lett. 2010 ; 135: 96-99
28. Hedrich CM, Tsokos GC. Epigenetic mechanisms in systemic lupus erythematosus and other autoimmune diseases. Trends Mol Med. 2011 ; 17: 714-724
29. Balada E, Castro-Marrero J, et al. Associations between the expression of epigenetically regulated genes and the expression of DNMTs and MBDs in systemic lupus erythematosus. PLoS One. 2012 ; 7: e45897 - e45897
30. Wiley KL, Treadwell E, Manigaba K, et al. Ethnic differences in DNA methyltransferases expression in patients with systemic lupus erythematosus. J Clin Immunol. 2013 ; 33: 342-348
31. Grabiec AM, Reedquist KA. The ascent of acetylation in the epigenetics of rheumatoid arthritis. Nat Rev Rheumatol. 2013 ; 9: 311-318
32. Reilly CM, Regna N, Mishra N. HDAC inhibition in lupus models. Mol Med. 2011 ; 17: 417-425
33. Pointon JJ, Harvey D, Karaderi T, et al. The histone demethylase JARID1A is associated with susceptibility to ankylosing spondylitis. Genes Immun. 2011 ; 12: 395-398
34. Vojinovic J, Damjanov N. HDAC inhibition in rheumatoid arthritis and juvenile idiopathic arthritis. Mol Med. 2011 ; 17: 397-403
35. Christensen DP, Dahllof M, Lundh M, et al. Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus. Mol Med. 2011 ; 17: 378-390
36. Faraco G, Cavone L, Chiarugi A. The therapeutic potential of HDAC inhibitors in the treatment of multiple sclerosis. Mol Med. 2011 ; 17: 442-447
37. Luco RF, Pan Q, Tominaga K, et al. Regulation of alternative splicing by histone modifications. Science. 2010 ; 327: 996-1000
38. Luco RF, Allo M, Schor IE, et al. Epigenetics in alternative pre-mRNA splicing. Cell. 2011 ; 144: 16-26
39. Huff JT, Plocik AM, Guthrie C, et al. Reciprocal intronic and exonic histone modification regions in humans. Nat Struct Mol Biol. 2010 ; 17: 1495-1499
40. Schor IE, Rascovan N, Pelisch F, et al. Neuronal cell depolarization induces intragenic chromatin modifications affecting NCAM alternative splicing. Proc Natl Acad Sci U S A. 2009 ; 106: 4325-4330
41. Shukla S, Kavak E, Gregory M, et al. CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing. Nature. 2011 ; 479: 74-79
42. Shukla S, Oberdoerffer S. Co-transcriptional regulation of alternative pre-mRNA splicing. Biochim Biophys Acta. 2012 ; 1819: 673-683
43. Yang F, Yi F, Zheng Z, et al. Characterization of a carcinogenesis-associated long non-coding RNA. RNA Biol. 2012 ; 9: 110-116
44. Kretz M, Siprashvili Z, Chu C, et al. Control of somatic tissue differentiation by the long non-coding RNA TINCR. Nature. 2013 ; 493: 231-235
45. Li Q, Su Z, Xu X, et al. AS1DHRS4, a head-to-head natural antisense transcript, silences the DHRS4 gene cluster in cis and trans. Proc Natl Acad Sci U S A. 2012 ; 109: 14110-14115
46. Nagano T, Mitchell JA, Sanz LA, et al. The Air noncoding RNA epigenetically silences transcription by targeting G9a to chromatin. Science. 2008 ; 322: 1717-1720
47. Mohammad F, Mondal T, Guseva N, et al. Kcnq1ot1 noncoding RNA mediates transcriptional gene silencing by interacting with Dnmt1. Development. 2010 ; 137: 2493-2499
48. Kong L, Zhang Y, Ye ZQ, et al. CPC: assess the protein-coding potential of transcripts using sequence features and support vector machine. Nucleic Acids Res. 2007 ; 35: W345 - W349
49. Wang KC, Chang HY. Molecular mechanisms of long noncoding RNAs. Mol Cell. 2011 ; 43: 904-914
50. Sigova AA, Mullen AC, Molinie B, et al. Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells. Proc Natl Acad Sci U S A. 2013 ; 110: 2876-2881
51. Mourich DV, Iversen PL. Splicing in the immune system: potential targets for therapeutic intervention by antisense-mediated alternative splicing. Curr Opin Mol Ther. 2009 ; 11: 124-132
52. Aartsma-Rus A. Antisense-mediated modulation of splicing: Therapeutic implications for Duchenne muscular dystrophy. RNA Biol. 2010 ; 7: 453-461