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Volumn 44, Issue 3, 2015, Pages 797-808

Potassium channel Kv1.3 is highly expressed by microglia in human Alzheimer's disease

Author keywords

Alzheimer's disease; Kv1.3; microglia; neuroinflammation; potassium channel

Indexed keywords

AMYLOID BETA PROTEIN; POTASSIUM CHANNEL KV1.3; AIF1 PROTEIN, HUMAN; DNA BINDING PROTEIN; GLIAL FIBRILLARY ACIDIC PROTEIN; TUBB3 PROTEIN, HUMAN; TUBULIN;

EID: 84922598763     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-141704     Document Type: Article
Times cited : (91)

References (47)
  • 1
    • 75849151435 scopus 로고    scopus 로고
    • Innate immunity and neuroinflammation in the CNS: The role of microglia in Toll-like receptor-mediated neuronal injury
    • Lehnardt S (2010) Innate immunity and neuroinflammation in the CNS: The role of microglia in Toll-like receptor-mediated neuronal injury. Glia 58, 253-263.
    • (2010) Glia , vol.58 , pp. 253-263
    • Lehnardt, S.1
  • 2
    • 84865973639 scopus 로고    scopus 로고
    • The classification of microglial activation phenotypes on neurodegeneration and regeneration in Alzheimer's disease brain
    • Varnum MM, Ikezu T (2012) The classification of microglial activation phenotypes on neurodegeneration and regeneration in Alzheimer's disease brain. Arch Immunol Ther Exp (Warsz) 60, 251-266.
    • (2012) Arch Immunol Ther Exp (Warsz) , vol.60 , pp. 251-266
    • Varnum, M.M.1    Ikezu, T.2
  • 3
    • 51149120624 scopus 로고    scopus 로고
    • Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice
    • Hickman SE, Allison EK, El Khoury J (2008) Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice. J Neurosci 28, 8354-8360.
    • (2008) J Neurosci , vol.28 , pp. 8354-8360
    • Hickman, S.E.1    Allison, E.K.2    El Khoury, J.3
  • 7
    • 0033573529 scopus 로고    scopus 로고
    • A Kv1. 5 to Kv1. 3 switch in endogenous hippocampal microglia and a role in proliferation
    • Kotecha SA, Schlichter LC (1999) A Kv1. 5 to Kv1. 3 switch in endogenous hippocampal microglia and a role in proliferation. J Neurosci 19, 10680-10693.
    • (1999) J Neurosci , vol.19 , pp. 10680-10693
    • Kotecha, S.A.1    Schlichter, L.C.2
  • 8
    • 79961094209 scopus 로고    scopus 로고
    • Amyloid-beta-induced reactive oxygen species production and priming are differentially regulated by ion channels in microglia
    • Schilling T, Eder C (2011) Amyloid-beta-induced reactive oxygen species production and priming are differentially regulated by ion channels in microglia. J Cell Physiol 226, 3295-3302.
    • (2011) J Cell Physiol , vol.226 , pp. 3295-3302
    • Schilling, T.1    Eder, C.2
  • 11
    • 0026569388 scopus 로고
    • An improved thioflavine S method for staining neurofibrillary tangles and senile plaques in Alzheimer's disease
    • Guntern R, Bouras C, Hof PR, Vallet PG (1992) An improved thioflavine S method for staining neurofibrillary tangles and senile plaques in Alzheimer's disease. Experientia 48, 8-10.
    • (1992) Experientia , vol.48 , pp. 8-10
    • Guntern, R.1    Bouras, C.2    Hof, P.R.3    Vallet, P.G.4
  • 13
    • 3142775617 scopus 로고    scopus 로고
    • K+ channel expression during B cell differentiation: Implications for immunomodulation and autoimmunity
    • Wulff H, Knaus HG, Pennington M, Chandy KG (2004) K+ channel expression during B cell differentiation: Implications for immunomodulation and autoimmunity. J Immunol 173, 776-786.
    • (2004) J Immunol , vol.173 , pp. 776-786
    • Wulff, H.1    Knaus, H.G.2    Pennington, M.3    Chandy, K.G.4
  • 17
    • 80355143546 scopus 로고    scopus 로고
    • Microglial cell origin and phenotypes in health and disease
    • Saijo K, Glass CK (2011) Microglial cell origin and phenotypes in health and disease. Nat Rev Immunol 11, 775-787.
    • (2011) Nat Rev Immunol , vol.11 , pp. 775-787
    • Saijo, K.1    Glass, C.K.2
  • 18
    • 70449526190 scopus 로고    scopus 로고
    • Heterogeneity of microglial activation in the innate immune response in the brain
    • Colton CA (2009) Heterogeneity of microglial activation in the innate immune response in the brain. J Neuroimmune Pharmacol 4, 399-418.
    • (2009) J Neuroimmune Pharmacol , vol.4 , pp. 399-418
    • Colton, C.A.1
  • 20
    • 84863672009 scopus 로고    scopus 로고
    • Microglia in Alzheimer's disease: It's all about context
    • Weitz TM, Town T (2012) Microglia in Alzheimer's disease: It's all about context. Int J Alzheimers Dis 2012, 314185.
    • (2012) Int J Alzheimers Dis , vol.2012 , pp. 314185
    • Weitz, T.M.1    Town, T.2
  • 21
    • 70349162817 scopus 로고    scopus 로고
    • The functional network of ion channels in T lymphocytes
    • Cahalan MD, Chandy KG (2009) The functional network of ion channels in T lymphocytes. Immunol Rev 231, 59-87.
    • (2009) Immunol Rev , vol.231 , pp. 59-87
    • Cahalan, M.D.1    Chandy, K.G.2
  • 22
    • 0028814350 scopus 로고
    • Cytokine-dependent K+ channel profile of microglia at immunologically defined functional states
    • Fischer HG, Eder C, Hadding U, Heinemann U (1995) Cytokine-dependent K+ channel profile of microglia at immunologically defined functional states. Neuroscience 64, 183-191.
    • (1995) Neuroscience , vol.64 , pp. 183-191
    • Fischer, H.G.1    Eder, C.2    Hadding, U.3    Heinemann, U.4
  • 23
    • 33846122620 scopus 로고    scopus 로고
    • The Ca2+-activated K+ channel KCNN4/KCa3. 1 contributes to microglia activation and nitric oxide-dependent neurodegeneration
    • Kaushal V, Koeberle PD, Wang Y, Schlichter LC (2007) The Ca2+-activated K+ channel KCNN4/KCa3. 1 contributes to microglia activation and nitric oxide-dependent neurodegeneration. J Neurosci 27, 234-244.
    • (2007) J Neurosci , vol.27 , pp. 234-244
    • Kaushal, V.1    Koeberle, P.D.2    Wang, Y.3    Schlichter, L.C.4
  • 25
    • 71749093046 scopus 로고    scopus 로고
    • Importance of the non-selective cation channel TRPV1 for microglial reactive oxygen species generation
    • Schilling T, Eder C (2009) Importance of the non-selective cation channel TRPV1 for microglial reactive oxygen species generation. J Neuroimmunol 216, 118-121.
    • (2009) J Neuroimmunol , vol.216 , pp. 118-121
    • Schilling, T.1    Eder, C.2
  • 28
    • 23444436221 scopus 로고    scopus 로고
    • Microglia Kv1. 3 channels contribute to their ability to kill neurons
    • Fordyce CB, Jagasia R, Zhu X, Schlichter LC (2005) Microglia Kv1. 3 channels contribute to their ability to kill neurons. J Neurosci 25, 7139-7149.
    • (2005) J Neurosci , vol.25 , pp. 7139-7149
    • Fordyce, C.B.1    Jagasia, R.2    Zhu, X.3    Schlichter, L.C.4
  • 29
    • 79960776760 scopus 로고    scopus 로고
    • Ion channels on microglia: Therapeutic targets for neuroprotection
    • Skaper SD (2011) Ion channels on microglia: Therapeutic targets for neuroprotection. CNS Neurol Disord Drug Targets 10, 44-56.
    • (2011) CNS Neurol Disord Drug Targets , vol.10 , pp. 44-56
    • Skaper, S.D.1
  • 30
    • 79952810857 scopus 로고    scopus 로고
    • Amyloid-beta protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity
    • Maezawa I, Zimin PI,Wulff H, Jin LW(2011) Amyloid-beta protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity. J Biol Chem 286, 3693-3706.
    • (2011) J Biol Chem , vol.286 , pp. 3693-3706
    • Maezawa, I.1    Zimin, P.I.2    Wulff, H.3    Jin, L.W.4
  • 36
    • 0028228251 scopus 로고
    • Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1. 1, 1. 2, 1. 3, 1. 5, and 3. 1, stably expressed in mammalian cell lines
    • Grissmer S, Nguyen AN, Aiyar J, Hanson DC, Mather RJ, Gutman GA, Karmilowicz MJ, Auperin DD, Chandy KG (1994) Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1. 1, 1. 2, 1. 3, 1. 5, and 3. 1, stably expressed in mammalian cell lines. Mol Pharmacol 45, 1227-1234.
    • (1994) Mol Pharmacol , vol.45 , pp. 1227-1234
    • Grissmer, S.1    Nguyen, A.N.2    Aiyar, J.3    Hanson, D.C.4    Mather, R.J.5    Gutman, G.A.6    Karmilowicz, M.J.7    Auperin, D.D.8    Chandy, K.G.9
  • 37
    • 0028886969 scopus 로고
    • Immunohistochemical localization of five members of the Kv1 channel subunits: Contrasting subcellular locations and neuron-specific co-localizations in rat brain
    • Veh RW, Lichtinghagen R, Sewing S, Wunder F, Grumbach IM, PongsO(1995) Immunohistochemical localization of five members of the Kv1 channel subunits: Contrasting subcellular locations and neuron-specific co-localizations in rat brain. Eur J Neurosci 7, 2189-2205.
    • (1995) Eur J Neurosci , vol.7 , pp. 2189-2205
    • Veh, R.W.1    Lichtinghagen, R.2    Sewing, S.3    Wunder, F.4    Grumbach, I.M.5    Pongs, O.6
  • 40
    • 84860755679 scopus 로고    scopus 로고
    • The safety profile of dalfampridine extended release in multiple sclerosis clinical trials
    • Cornblath DR, Bienen EJ, Blight AR (2012) The safety profile of dalfampridine extended release in multiple sclerosis clinical trials. Clin Ther 34, 1056-1069.
    • (2012) Clin Ther , vol.34 , pp. 1056-1069
    • Cornblath, D.R.1    Bienen, E.J.2    Blight, A.R.3
  • 44
    • 84922601791 scopus 로고    scopus 로고
    • Kineta, Accessed 01/11/2014
    • Kineta, http://www. kinetabio. com/pipeline. html, Accessed 01/11/2014.
  • 45
    • 69849090285 scopus 로고    scopus 로고
    • Predominant functional expression of Kv1. 3 by activated microglia of the hippocampus after Status epilepticus
    • Menteyne A, Levavasseur F, Audinat E, Avignone E (2009) Predominant functional expression of Kv1. 3 by activated microglia of the hippocampus after Status epilepticus. PLoS One 4, e6770.
    • (2009) PLoS One , vol.4 , pp. e6770
    • Menteyne, A.1    Levavasseur, F.2    Audinat, E.3    Avignone, E.4
  • 46
    • 84878518887 scopus 로고    scopus 로고
    • HIV-1 Tat protein increases microglial outward K(+) current and resultant neurotoxic activity
    • Liu J, Xu P, Collins C, Liu H, Zhang J, Keblesh JP, Xiong H (2013) HIV-1 Tat protein increases microglial outward K(+) current and resultant neurotoxic activity. PLoS One 8, e64904.
    • (2013) PLoS One , vol.8 , pp. e64904
    • Liu, J.1    Xu, P.2    Collins, C.3    Liu, H.4    Zhang, J.5    Keblesh, J.P.6    Xiong, H.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.