Conformational dynamics of nonsynonymous variants at protein interfaces reveals disease association

Proteins: Structure, Function and Bioinformatics

Volumn 83, Issue 3, 2015, Pages 428-435

  Butler, Brandon M ^a   Gerek, Z Nevin ^b   Kumar, Sudhir ^b,c,d   Ozkan, S Banu ^a  

^a ARIZONA STATE UNIVERSITY   (United States)

^b TEMPLE UNIVERSITY   (United States)

^c Temple University   (United States)

^d KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

Conformational dynamics; Dynamic flexibility; Elastic network model; Evolutionary conservation; Interfaces; Linear response theory; Perturbation response scanning; Phenotypic prediction; Protein protein interactions; Single nucleotide polymorphisms

Indexed keywords

AMINO ACID; PROTEIN;

ARTICLE; DISEASE ASSOCIATION; EVOLUTIONARY RATE; MOLECULAR DYNAMICS; PREDICTION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN CONFORMATION; PROTEIN STRUCTURE; PROTEOMICS; SURFACE PROPERTY; CHEMICAL STRUCTURE; CHEMISTRY; DISEASES; GENETICS; HUMAN; PHYSIOLOGY; PLIABILITY; PROTEIN DATABASE; SINGLE NUCLEOTIDE POLYMORPHISM;

DATABASES, PROTEIN; DISEASE; HUMANS; MODELS, MOLECULAR; PLIABILITY; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN CONFORMATION; PROTEINS; PROTEOMICS; SURFACE PROPERTIES;

EID: 84922572528     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.24748     Document Type: Article

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