Age- and pregnancy-associated dna methylation changes in mammary epithelial cells

Stem Cell Reports

Volumn 4, Issue 2, 2015, Pages 297-311

  Huh, Sung Jin ^a,b,c   Clement, Kendell ^d,e,f,g   Jee, David ^a,b,c   Merlini, Alessandra ^a,h   Choudhury, Sibgat ^a,b,c   Maruyama, Reo ^a,b,c   Yoo, Ronnie ^c,i   Chytil, Anna ^j   Boyle, Patrick ^d   Ran, Fei Ann ^c,i   Moses, Harold L ^j   Barcellos Hoff, Mary Helen ^k   Jackson Grusby, Laurie ^c,f,i   Meissner, Alexander ^d,e,f   Polyak, Kornelia ^a,b,c,d,f  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^e Harvard University   (United States)

^f HARVARD STEM CELL INSTITUTE   (United States)

^g HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

^h UNIVERSITY OF PAVIA   (Italy)

ⁱ BOSTON CHILDREN S HOSPITAL   (United States)

^j VANDERBILT INGRAM CANCER CENTER   (United States)

^k NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTEGRIN; BETA3 INTEGRIN; CD24 ANTIGEN; DNA; PROTEIN P27; TRANSFORMING GROWTH FACTOR BETA; DNA (CYTOSINE 5) METHYLTRANSFERASE; DNA (CYTOSINE-5-)-METHYLTRANSFERASE 1; HISTONE; MEMBRANE ANTIGEN;

AGE; ARTICLE; BREAST EPITHELIUM CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; DNA METHYLATION; EPIGENETICS; FEMALE; GENE EXPRESSION PROFILING; GENETIC ASSOCIATION; HISTONE MODIFICATION; HUMAN; MORPHOLOGY; PREGNANCY; PRIORITY JOURNAL; PROMOTER REGION; T LYMPHOCYTE; ANIMAL; ANTIBODY SPECIFICITY; CLUSTER ANALYSIS; CYTOLOGY; DRUG EFFECTS; ENHANCER REGION; ENZYME ACTIVATION; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; IMMUNOPHENOTYPING; KNOCKOUT MOUSE; METABOLISM; MOUSE; PHENOTYPE; SEXUAL MATURATION; SIGNAL TRANSDUCTION; UDDER;

AGE FACTORS; ANIMALS; ANTIGENS, SURFACE; CELL DIFFERENTIATION; CLUSTER ANALYSIS; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; ENHANCER ELEMENTS, GENETIC; ENZYME ACTIVATION; EPIGENESIS, GENETIC; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HISTONES; IMMUNOPHENOTYPING; MAMMARY GLANDS, ANIMAL; MICE; MICE, KNOCKOUT; ORGAN SPECIFICITY; PHENOTYPE; PREGNANCY; PROMOTER REGIONS, GENETIC; SEXUAL MATURATION; SIGNAL TRANSDUCTION;

EID: 84922559142     PISSN: 22136711     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.stemcr.2014.12.009     Document Type: Article

References (38)

1. M.L. Asselin-Labat, K.D. Sutherland, H. Barker, R. Thomas, M. Shackleton, N.C. Forrest, L. Hartley, L. Robb, F.G. Grosveld, and J. van der Wees Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation Nat. Cell Biol. 9 2007 201 209
2. M.L. Asselin-Labat, F. Vaillant, J.M. Sheridan, B. Pal, D. Wu, E.R. Simpson, H. Yasuda, G.K. Smyth, T.J. Martin, G.J. Lindeman, and J.E. Visvader Control of mammary stem cell function by steroid hormone signalling Nature 465 2010 798 802
3. I. Beerman, C. Bock, B.S. Garrison, Z.D. Smith, H. Gu, A. Meissner, and D.J. Rossi Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging Cell Stem Cell 12 2013 413 425
4. B.E. Bernstein, A. Meissner, and E.S. Lander The mammalian epigenome Cell 128 2007 669 681
5. C. Bock, I. Beerman, W.H. Lien, Z.D. Smith, H. Gu, P. Boyle, A. Gnirke, E. Fuchs, D.J. Rossi, and A. Meissner DNA methylation dynamics during in vivo differentiation of blood and skin stem cells Mol. Cell 47 2012 633 647
6. P. Boyle, K. Clement, H. Gu, Z.D. Smith, M. Ziller, J.L. Fostel, L. Holmes, J. Meldrim, F. Kelley, A. Gnirke, and A. Meissner Gel-free multiplexed reduced representation bisulfite sequencing for large-scale DNA methylation profiling Genome Biol. 13 2012 R92
7. S. Choudhury, V. Almendro, V.F. Merino, Z. Wu, R. Maruyama, Y. Su, F.C. Martins, M.J. Fackler, M. Bessarabova, and A. Kowalczyk Molecular profiling of human mammary gland links breast cancer risk to a p27(+) cell population with progenitor characteristics Cell Stem Cell 13 2013 117 130
8. J.S. Desgrosellier, J. Lesperance, L. Seguin, M. Gozo, S. Kato, A. Franovic, M. Yebra, S.J. Shattil, and D.A. Cheresh Integrin αvβ3 drives slug activation and stemness in the pregnant and neoplastic mammary gland Dev. Cell 30 2014 295 308
9. A. Eijkelenboom, and B.M. Burgering FOXOs: signalling integrators for homeostasis maintenance Nat. Rev. Mol. Cell Biol. 14 2013 83 97
10. K.B. Ewan, G. Shyamala, S.A. Ravani, Y. Tang, R. Akhurst, L. Wakefield, and M.H. Barcellos-Hoff Latent transforming growth factor-beta activation in mammary gland: regulation by ovarian hormones affects ductal and alveolar proliferation Am. J. Pathol. 160 2002 2081 2093
11. K.B. Ewan, H.A. Oketch-Rabah, S.A. Ravani, G. Shyamala, H.L. Moses, and M.H. Barcellos-Hoff Proliferation of estrogen receptor-alpha-positive mammary epithelial cells is restrained by transforming growth factor-beta1 in adult mice Am. J. Pathol. 167 2005 409 417
12. E. Forrester, A. Chytil, B. Bierie, M. Aakre, A.E. Gorska, A.R. Sharif-Afshar, W.J. Muller, and H.L. Moses Effect of conditional knockout of the type II TGF-beta receptor gene in mammary epithelia on mammary gland development and polyomavirus middle T antigen induced tumor formation and metastasis Cancer Res. 65 2005 2296 2302
13. F. Gaudet, J.G. Hodgson, A. Eden, L. Jackson-Grusby, J. Dausman, J.W. Gray, H. Leonhardt, and R. Jaenisch Induction of tumors in mice by genomic hypomethylation Science 300 2003 489 492
14. B. Gu, K. Watanabe, P. Sun, M. Fallahi, and X. Dai Chromatin effector Pygo2 mediates Wnt-notch crosstalk to suppress luminal/alveolar potential of mammary stem and basal cells Cell Stem Cell 13 2013 48 61
15. W. Guo, Z. Keckesova, J.L. Donaher, T. Shibue, V. Tischler, F. Reinhardt, S. Itzkovitz, A. Noske, U. Zürrer-Härdi, and G. Bell Slug and Sox9 cooperatively determine the mammary stem cell state Cell 148 2012 1015 1028
16. L.A. Hanna, R.K. Foreman, I.A. Tarasenko, D.S. Kessler, and P.A. Labosky Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo Genes Dev. 16 2002 2650 2661
17. L. Hennighausen, and G.W. Robinson Information networks in the mammary gland Nat. Rev. Mol. Cell Biol. 6 2005 715 725
18. D.A. Kramerov, and N.S. Vassetzky Short retroposons in eukaryotic genomes Int. Rev. Cytol. 247 2005 165 221
19. Q. Li, F. Zhu, and P. Chen miR-7 and miR-218 epigenetically control tumor suppressor genes RASSF1A and Claudin-6 by targeting HoxB3 in breast cancer Biochem. Biophys. Res. Commun. 424 2012 28 33
20. E.M. Michalak, K. Nacerddine, A. Pietersen, V. Beuger, I. Pawlitzky, P. Cornelissen-Steijger, E. Wientjens, E. Tanger, J. Seibler, M. van Lohuizen, and J. Jonkers Polycomb group gene Ezh2 regulates mammary gland morphogenesis and maintains the luminal progenitor pool Stem Cells 31 2013 1910 1920
21. B. Pal, T. Bouras, W. Shi, F. Vaillant, J.M. Sheridan, N. Fu, K. Breslin, K. Jiang, M.E. Ritchie, and M. Young Global changes in the mammary epigenome are induced by hormonal cues and coordinated by Ezh2 Cell Rep. 3 2013 411 426
22. M.D. Prater, V. Petit, I. Alasdair Russell, R.R. Giraddi, M. Shehata, S. Menon, R. Schulte, I. Kalajzic, N. Rath, and M.F. Olson Mammary stem cells have myoepithelial cell properties Nat. Cell Biol. 16 2014 942 950 1-7
23. A.C. Rios, N.Y. Fu, G.J. Lindeman, and J.E. Visvader In situ identification of bipotent stem cells in the mammary gland Nature 506 2014 322 327
24. J. Russo, D. Mailo, Y.F. Hu, G. Balogh, F. Sheriff, and I.H. Russo Breast differentiation and its implication in cancer prevention Clin. Cancer Res. 11 2005 931s 936s
25. J. Russo, G.A. Balogh, J. Chen, S.V. Fernandez, R. Fernbaugh, R. Heulings, D.A. Mailo, R. Moral, P.A. Russo, and F. Sheriff The concept of stem cell in the mammary gland and its implication in morphogenesis, cancer and prevention Front. Biosci. 11 2006 151 172
26. J. Russo, G.A. Balogh, R. Heulings, D.A. Mailo, R. Moral, P.A. Russo, F. Sheriff, J. Vanegas, and I.H. Russo Molecular basis of pregnancy-induced breast cancer protection Eur. J. Cancer Prev. 15 2006 306 342
27. M.B. Ruzinova, and R. Benezra Id proteins in development, cell cycle and cancer Trends Cell Biol. 13 2003 410 418
28. M. Shackleton, F. Vaillant, K.J. Simpson, J. Stingl, G.K. Smyth, M.L. Asselin-Labat, L. Wu, G.J. Lindeman, and J.E. Visvader Generation of a functional mammary gland from a single stem cell Nature 439 2006 84 88
29. D.L. Silver, L. Hou, R. Somerville, M.E. Young, S.S. Apte, and W.J. Pavan The secreted metalloprotease ADAMTS20 is required for melanoblast survival PLoS Genet. 4 2008 e1000003
30. Z.D. Smith, and A. Meissner DNA methylation: roles in mammalian development Nat. Rev. Genet. 14 2013 204 220
31. B.T. Spike, D.D. Engle, J.C. Lin, S.K. Cheung, J. La, and G.M. Wahl A mammary stem cell population identified and characterized in late embryogenesis reveals similarities to human breast cancer Cell Stem Cell 10 2012 183 197
32. J. Stingl Detection and analysis of mammary gland stem cells J. Pathol. 217 2009 229 241
33. J.C. Tiffen, C.G. Bailey, A.D. Marshall, C. Metierre, Y. Feng, Q. Wang, S.L. Watson, J. Holst, and J.E. Rasko The cancer-testis antigen BORIS phenocopies the tumor suppressor CTCF in normal and neoplastic cells Int. J. Cancer 133 2013 1603 1613
34. L. Tou, Q. Liu, and R.A. Shivdasani Regulation of mammalian epithelial differentiation and intestine development by class I histone deacetylases Mol. Cell. Biol. 24 2004 3132 3139
35. R. van Amerongen, A.N. Bowman, and R. Nusse Developmental stage and time dictate the fate of Wnt/β-catenin-responsive stem cells in the mammary gland Cell Stem Cell 11 2012 387 400
36. A. Van Keymeulen, A.S. Rocha, M. Ousset, B. Beck, G. Bouvencourt, J. Rock, N. Sharma, S. Dekoninck, and C. Blanpain Distinct stem cells contribute to mammary gland development and maintenance Nature 479 2011 189 193
37. Y. Zhang, T. Andl, S.H. Yang, M. Teta, F. Liu, J.T. Seykora, J.W. Tobias, S. Piccolo, R. Schmidt-Ullrich, and A. Nagy Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate Development 135 2008 2161 2172
38. M.J. Ziller, H. Gu, F. Müller, J. Donaghey, L.T. Tsai, O. Kohlbacher, P.L. De Jager, E.D. Rosen, D.A. Bennett, and B.E. Bernstein Charting a dynamic DNA methylation landscape of the human genome Nature 500 2013 477 481