MiR-7 and miR-218 epigenetically control tumor suppressor genes RASSF1A and Claudin-6 by targeting HoxB3 in breast cancer

Biochemical and Biophysical Research Communications

Volumn 424, Issue 1, 2012, Pages 28-33

  Li, Qiaoyan ^a   Zhu, Fufan ^a   Chen, Puxiang ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

DNA methylation; Histone modification; HoxB3; MicroRNA 218; MicroRNA 7

Indexed keywords

CLAUDIN 6; HOX PROTEIN; HOXB3 PROTEIN; MICRORNA; MICRORNA 218; MICRORNA 7; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CELL CYCLE; CLONOGENESIS; CONTROLLED STUDY; DNA METHYLATION; EPIGENETICS; GENE ACTIVATION; HISTONE MODIFICATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

3' UNTRANSLATED REGIONS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CLAUDINS; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HOMEODOMAIN PROTEINS; HUMANS; MICRORNAS; TUMOR SUPPRESSOR PROTEINS;

EID: 84864082356     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.06.028     Document Type: Article

References (38)

1. Lujambio A., Lowe S.W. The microcosmos of cancer. Nature 2012, 482:347-355.
2. Bartel D.P. MicroRNAs: target recognition and regulatory functions. Cell 2009, 136:215-233.
3. Ma L., Teruya-Feldstein J., Weinberg R.A. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 2007, 449:682-688.
4. Saito Y., Liang G., Egger G., Friedman J.M., Chuang J.C., Coetzee G.A., Jones P.A. Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer cell 2006, 9:435-443.
5. Cao Q., Mani R.S., Ateeq B., Dhanasekaran S.M., Asangani I.A., Prensner J.R., Kim J.H., Brenner J.C., Jing X., Cao X., Wang R., Li Y., Dahiya A., Wang L., Pandhi M., Lonigro R.J., Wu Y.M., Tomlins S.A., Palanisamy N., Qin Z., Yu J., Maher C.A., Varambally S., Chinnaiyan A.M. Coordinated regulation of polycomb group complexes through microRNAs in cancer. Cancer Cell 2011, 20:187-199.
6. Shah N., Sukumar S. The Hox genes and their roles in oncogenesis. Nat Rev Cancer 2010, 10:361-371.
7. Eklund E. The role of Hox proteins in leukemogenesis: insights into key regulatory events in hematopoiesis. Crit Rev Oncogene 2011, 16:65-76.
8. Palakurthy R.K., Wajapeyee N., Santra M.K., Gazin C., Lin L., Gobeil S., Green M.R. Epigenetic silencing of the RASSF1A tumor suppressor gene through HOXB3-mediated induction of DNMT3B expression. Mol Cell 2009, 36:219-230.
9. Chopra V.S., Mishra R.K. "Mir" acles in hox gene regulation. BioEssays 2006, 28:445-448.
10. Naguibneva I., Ameyar-Zazoua M., Polesskaya A., Ait-Si-Ali S., Groisman R., Souidi M., Cuvellier S., Harel-Bellan A. The microRNA miR-181 targets the homeobox protein Hox-A11 during mammalian myoblast differentiation. Nat Cell Biol 2006, 8:278-284.
11. Almeida M.I., Nicoloso M.S., Zeng L., Ivan C., Spizzo R., Gafa R., Xiao L., Zhang X., Vannini I., Fanini F., Fabbri M., Lanza G., Reis R.M., Zweidler-McKay P.A., Calin G.A. Strand-specific miR-28-5p and miR-28-3p have distinct effects in colorectal cancer cells. Gastroenterology 2012, 142:886-896 e889.
12. Mueller D.W., Bosserhoff A.K. MicroRNA miR-196a controls melanoma-associated genes by regulating HOX-C8 expression. Int J Cancer 2011, 129:1064-1074.
13. Griffiths-Jones S., Grocock R.J., van Dongen S., Bateman A., Enright A.J. MiRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res 2006, 34:D140-144.
14. Tao Y., Liu S., Briones V., Geiman T.M., Muegge K. Treatment of breast cancer cells with DNA demethylating agents leads to a release of Pol II stalling at genes with DNA-hypermethylated regions upstream of TSS. Nucleic Acids Res 2011, 39:9508-9520.
15. Xi S., Geiman T.M., Briones V., Guang Tao Y., Xu H., Muegge K. Lsh participates in DNA methylation and silencing of stem cell genes. Stem Cells 2009, 27:2691-2702.
16. Saito Y., Kanai Y., Sakamoto M., Saito H., Ishii H., Hirohashi S. Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis. Proc Natl Acad Sci U S A 2002, 99:10060-10065.
17. Cheng W., Liu J., Yoshida H., Rosen D., Naora H. Lineage infidelity of epithelial ovarian cancers is controlled by HOX genes that specify regional identity in the reproductive tract. Nat Med 2005, 11:531-537.
18. Yekta S., Shih I.H., Bartel D.P. MicroRNA-directed cleavage of HOXB8 mRNA. Science 2004, 304:594-596.
19. Foekens J.A., Sieuwerts A.M., Smid M., Look M.P., de Weerd V., Boersma A.W., Klijn J.G., Wiemer E.A., Martens J.W. Four miRNAs associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer. Proc Natl Acad Sci U S A 2008, 105:13021-13026.
20. Kong D., Piao Y.S., Yamashita S., Oshima H., Oguma K., Fushida S., Fujimura T., Minamoto T., Seno H., Yamada Y., Satou K., Ushijima T., Ishikawa T.O., Oshima M. Inflammation-induced repression of tumor suppressor miR-7 in gastric tumor cells. Oncogene 2011.
21. Webster R.J., Giles K.M., Price K.J., Zhang P.M., Mattick J.S., Leedman P.J. Regulation of epidermal growth factor receptor signaling in human cancer cells by microRNA-7. J Biol Chem 2009, 284:5731-5741.
22. Kefas B., Godlewski J., Comeau L., Li Y., Abounader R., Hawkinson M., Lee J., Fine H., Chiocca E.A., Lawler S., Purow B. MicroRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma. Cancer Res 2008, 68:3566-3572.
23. Fang Y.X., Xue J.L., Shen Q., Chen J., Tian L. miR-7 inhibits tumor growth and metastasis by targeting the PI3K/AKT pathway in hepatocellular carcinoma. Hepatology 2012.
24. Xiong S., Zheng Y., Jiang P., Liu R., Liu X., Chu Y. MicroRNA-7 inhibits the growth of human non-small cell lung cancer A549 cells through targeting BCL-2. Int J Biol Sci 2011, 7:805-814.
25. McInnes N., Sadlon T.J., Brown C.Y., Pederson S., Beyer M., Schultze J.L., McColl S., Goodall G.J., Barry S.C. FOXP3 and FOXP3-regulated microRNAs suppress SATB1 in breast cancer cells. Oncogene 2012, 31:1045-1054.
26. Reddy S.D., Ohshiro K., Rayala S.K., Kumar R. MicroRNA-7, a homeobox D10 target, inhibits p21-activated kinase 1 and regulates its functions. Cancer Res 2008, 68:8195-8200.
27. Saydam O., Senol O., Wurdinger T., Mizrak A., Ozdener G.B., Stemmer-Rachamimov A.O., Yi M., Stephens R.M., Krichevsky A.M., Saydam N., Brenner G.J., Breakefield X.O. MiRNA-7 attenuation in Schwannoma tumors stimulates growth by upregulating three oncogenic signaling pathways. Cancer Res 2011, 71:852-861.
28. Tatarano S., Chiyomaru T., Kawakami K., Enokida H., Yoshino H., Hidaka H., Yamasaki T., Kawahara K., Nishiyama K., Seki N., Nakagawa M. MiR-218 on the genomic loss region of chromosome 4p15.31 functions as a tumor suppressor in bladder cancer. Int J Oncol 2011, 39:13-21.
29. White N.M., Bao T.T., Grigull J., Youssef Y.M., Girgis A., Diamandis M., Fatoohi E., Metias M., Honey R.J., Stewart R., Pace K.T., Bjarnason G.A., Yousef G.M. MiRNA profiling for clear cell renal cell carcinoma: biomarker discovery and identification of potential controls and consequences of miRNA dysregulation. J Urology 2011, 186:1077-1083.
30. Martinez I., Gardiner A.S., Board K.F., Monzon F.A., Edwards R.P., Khan S.A. Human papillomavirus type 16 reduces the expression of microRNA-218 in cervical carcinoma cells. Oncogene 2008, 27:2575-2582.
31. Zhou X., Chen X., Hu L., Han S., Qiang F., Wu Y., Pan L., Shen H., Li Y., Hu Z. Polymorphisms involved in the miR-218-LAMB3 pathway and susceptibility of cervical cancer, a case-control study in Chinese women. Gynecol Oncol 2010, 117:287-290.
32. Tie J., Pan Y., Zhao L., Wu K., Liu J., Sun S., Guo X., Wang B., Gang Y., Zhang Y., Li Q., Qiao T., Zhao Q., Nie Y., Fan D. MiR-218 inhibits invasion and metastasis of gastric cancer by targeting the Robo1 receptor. PLoS Genet 2010, 6:e1000879.
33. Alajez N.M., Lenarduzzi M., Ito E., Hui A.B., Shi W., Bruce J., Yue S., Huang S.H., Xu W., Waldron J., O'Sullivan B., Liu F.F. MiR-218 suppresses nasopharyngeal cancer progression through downregulation of survivin and the SLIT2-ROBO1 pathway. Cancer Res 2011, 71:2381-2391.
34. Davidson M.R., Larsen J.E., Yang I.A., Hayward N.K., Clarke B.E., Duhig E.E., Passmore L.H., Bowman R.V., Fong K.M. MicroRNA-218 is deleted and downregulated in lung squamous cell carcinoma. PLoS One 2010, 5:e12560.
35. Wu D.W., Cheng Y.W., Wang J., Chen C.Y., Lee H. Paxillin predicts survival and relapse in non-small cell lung cancer by microRNA-218 targeting. Cancer Res 2010, 70:10392-10401.
36. Lowery A.J., Miller N., Devaney A., McNeill R.E., Davoren P.A., Lemetre C., Benes V., Schmidt S., Blake J., Ball G., Kerin M.J. MicroRNA signatures predict oestrogen receptor, progesterone receptor and HER2/neu receptor status in breast cancer. Breast Cancer Res 2009, 11:R27.
37. Pogribny I.P., Filkowski J.N., Tryndyak V.P., Golubov A., Shpyleva S.I., Kovalchuk O. Alterations of microRNAs and their targets are associated with acquired resistance of MCF-7 breast cancer cells to cisplatin. Int J Cancer 2010, 127:1785-1794.
38. Kastl L., Brown I., Schofield A.C. MiRNA-34a is associated with docetaxel resistance in human breast cancer cells. Breast Cancer Res Tr 2012, 131:445-454.