Effect of atorvastatin, a HMG-CoA reductase inhibitor in monosodium iodoacetate-induced osteoarthritic pain: Implication for osteoarthritis therapy

Pharmacological Reports

Volumn 67, Issue 3, 2015, Pages 513-519

  Pathak, Nitya N ^a   Balaganur, Venkanna ^a   Lingaraju, Madhu C ^a   Kant, Vinay ^a   Kumar, Dhirendra ^a   Kumar, Dinesh ^a   Sharma, Anil K ^b   Tandan, Surendra K ^a  

^a Division of Pharmacology and Toxicology Division of Pharmacology and Toxicology   (India)

^b INDIAN VETERINARY RESEARCH INSTITUTE   (India)

Author keywords

Atorvastatin; Hyperalgesia; Monosodium iodoacetate; Osteoarthritis; Oxidative stress

Indexed keywords

ANTIOXIDANT; ATORVASTATIN; BIOLOGICAL MARKER; CARBONYL DERIVATIVE; CATALASE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; IODOACETIC ACID; NITRIC OXIDE; SUPEROXIDE; THIOL DERIVATIVE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARTILAGE DEGENERATION; DRUG MECHANISM; ENZYME ACTIVITY; HISTOPATHOLOGY; HYPERALGESIA; KNEE OSTEOARTHRITIS; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; PAIN ASSESSMENT; RAT; ANIMAL; CHEMICALLY INDUCED; DOSE RESPONSE; DRUG EFFECTS; INTRAARTICULAR DRUG ADMINISTRATION; OSTEOARTHRITIS; PAIN; PAIN MEASUREMENT; PATHOLOGY; PROCEDURES; TREATMENT OUTCOME; WISTAR RAT;

ANIMALS; ATORVASTATIN CALCIUM; DOSE-RESPONSE RELATIONSHIP, DRUG; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INJECTIONS, INTRA-ARTICULAR; IODOACETIC ACID; MALE; OSTEOARTHRITIS; PAIN; PAIN MEASUREMENT; RATS; RATS, WISTAR; TREATMENT OUTCOME;

EID: 84922464541     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: 10.1016/j.pharep.2014.12.005     Document Type: Article

References (58)

1. Y. Henrotin, B. Kurz, and T. Aigner Oxygen and reactive oxygen species in cartilage degradation: friends or foes? Osteoarthritis Cartilage 13 8 2005 643 654
2. K. Yudoh, T. Nguyen, H. Nakamura, K. Hongo-Masuko, T. Kato, and K. Nishioka Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function Arthritis Res Ther 7 2 2005 R380 R391
3. T. Aigner, K. Fundel, J. Saas, P.M. Gebhard, J. Haag, and T. Weiss Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis Arthritis Rheum 54 11 2006 3533 3544
4. O. Altindag, O. Erel, N. Aksoy, S. Selek, H. Celik, and M. Karaoglanoglu Increased oxidative stress and its relation with collagen metabolism in knee osteoarthritis Rheumatol Int 27 4 2007 339 344
5. P.H. Canter, B. Wider, and E. Ernst The antioxidant vitamins A, C, E and selenium in the treatment of arthritis: a systematic review of randomized clinical trials Rheumatology 46 8 2007 1223 1233
6. Y. Henrotin, and B. Kurz Antioxidant to treat osteoarthritis: dream or reality? Curr Drug Targets 8 2 2007 347 357
7. J.K. Liao, and U. Laufs Pleiotropic effects of statins Annu Rev Pharmacol Toxicol 45 2005 89 118
8. M.K.H. Puttananjaiah, M.A. Dhale, V. Gaonkar, and S. Keni Statins: 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitors demonstrate anti-atherosclerotic character due to their antioxidant capacity Appl Biochem Biotechnol 163 2 2011 215 222
9. T. Simopoulou, K.N. Malizos, L. Poultsides, and A. Tsezou Protective effect of atorvastatin in cultured osteoarthritic chondrocytes J Orthop Res 28 1 2010 110 115
10. J.F. Baker, P.M. Walsh, D.P. Byrne, and K.J. Mulhall Pravastatin suppresses matrix metalloproteinase expression and activity in human articular chondrocytes stimulated by interleukin-1β J Orthopaed Traumatol 13 3 2012 119 123
11. E. Aktas, E. Sener, and P.U. Gocun Mechanically induced experimental knee osteoarthritis benefits from anti-inflammatory and immunomodulatory properties of simvastatin via inhibition of matrix metalloproteinase-3 J Orthopaed Traumatol 12 3 2011 145 151
12. J. Fernihough, C. Gentry, M. Malcangio, A. Fox, J. Rediske, and T. Pellas Pain related behavior in two models of osteoarthritis in the rat knee Pain 112 1-2 2004 83 93
13. J.L. Vonsy, J. Ghandehari, and A.H. Dickenson Differential analgesic effects of morphine and gabapentin on behavioural measures of pain and disability in a model of osteoarthritis pain in rats Eur J Pain 13 8 2009 786 793
14. M.J. Janusz, E.B. Hoofkin, S.A. Heitmeyer, J.F. Woessner, A.J. Freemont, and J.A. Hoyland Moderation of iodoacetate-induced experimental osteoarthritis in rats by matrix metalloproteinase inhibitors Osteoarthritis Cartilage 9 8 2001 751 760
15. C. Guingamp, P. Gegout-Pottie, L. Philippe, B. Terlain, P. Netter, and P. Gillet Monoiodoacetate-induced experimental osteoarthritis: a dose-response study of loss of mobility, morphology, and biochemistry Arthritis Rheum 40 9 1997 1670 1679
16. L.O. Randall, and J.A. Selitto A method for measurement of analgesic activity of inflamed tissue Arch Int Pharmacodyn 111 4 1957 209 219
17. K. Hargreaves, R. Dubner, F. Brown, C. Flores, and J. Joris A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia Pain 32 1 1988 77 88
18. Shafiq-Ur-Rehman Lead-induced regional lipid peroxidation in brain Toxicol Lett 21 3 1984 333 337
19. R.L. Levine, D. Garland, C.N. Oliver, A. Amici, I. Climent, and A.G. Lenz Determination of carbonyl content in oxidatively modified proteins Meth Enzymol. 186 1990 464 478
20. H.D. Wang, P.J. Pagano, Y. Du, A.J. Cayatte, M.T. Quinn, and P. Brecher Superoxide anion from the adventitia of the rat thoracic aorta inactivates nitric oxide Circ Res 82 7 1998 810 818
21. K.V. Sastry, R.P. Moudgal, J. Mohan, J.S. Tyagi, and G.S. Rao Spectrophotometric determination of serum nitrite and nitrate by copper-cadmium alloy Anal Biochem 306 1 2002 79 82
22. M. Madesh, and K.A. Balasubramanian Microtiter plate assay for superoxide dismutase using MTT reduction by superoxide Indian J Biochem Biophys 35 3 1998 184 188
23. H. Aebi Catalase in vitro L. Packer, Methods in enzymology. Oxygen radicals in biological systems vol. 105 1984 Academic Press Orlando, FL 121 126
24. W.H. Habig, M.J. Pabst, and W.B. Jakoby Glutathione-S-transferase. The first enzymatic step in mercapturic acid formation J Biol Chem 249 22 1974 7130 7139
25. J. Sedlak, and R.H.C. Lindsay Estimation of total, protein bound and nonprotein sulfhydryl groups in tissue with Ellmann's reagent Anal Biochem 25 1 1968 192 205
26. R.M. Silverstein The determination of the molar extinction coefficient of reduced DTNB Anal Biochem 63 1 1975 281 282
27. O.H. Lowry, N.J. Rosebrough, A.L. Farr, and R.J. Randall Protein measurement with the Folin phenol reagent J Biol Chem 193 1951 265 275
28. B. Beyreuther, N. Callizot, and T. Stohr Antinociceptive efficacy of lacosamide in the monosodium iodoacetate rat model for osteoarthritis pain Arthritis Res Ther 9 1 2007 R14
29. H.J. Im, J.S. Kim, X. Li, N. Kotwal, D.R. Sumner, and A.J. van Wijnen Alteration of sensory neurons and spinal response to an experimental osteoarthritis pain model Arthritis Rheum 62 10 2010 2995 3005
30. N.N. Pathak, V. Balaganur, M.C. Lingaraju, A.S. More, V. Kant, and D. Kumar Antihyperalgesic and anti-inflammatory effects of atorvastatin in chronic constriction injury-induced neuropathic pain in rats Inflammation 36 6 2013 1468 1478
31. X.Q. Shi, T.K. Lim, S. Lee, Y.Q. Zhao, and J. Zhang Statins alleviate experimental nerve injury-induced neuropathic pain Pain 152 5 2011 1033 1043
32. M. Chevion, E. Berenshtein, and E.R. Stadtman Human studies related to protein oxidation: protein carbonyl content as a marker of damage Free Radical Res 33 2000 S99 S108
33. D.J. Cifuentes, L.G. Rocha, L.A. Silva, A.C. Brito, C.R. Rueff-Barroso, and L.C. Porto Decrease in oxidative stress and histological changes induced by physical exercise calibrated in rats with osteoarthritis induced by monosodium iodoacetate Osteoarthritis Cartilage 18 8 2010 1088 1095
34. C. Bakogiannis, C. Antoniades, D. Tousoulis, M. Demosthenous, A.S. Antonopoulos, and T. Psarros Atorvastatin directly reduces vascular superoxide generation in human vein grafts ex vivo, by improving eNOS coupling and reducing NADPH-oxidase activity JACC 55 10s1 2010 A51.E480
35. S. Aydin, H. Uzun, V. Sozer, and T. Altug Effects of atorvastatin therapy on protein oxidation and oxidative DNA damage in hypercholesterolemic rabbits Pharmacol Res 59 4 2009 242 247
36. C.M. Davies, F. Guilak, J.B. Weinberg, and B. Fermor Reactive nitrogen and oxygen species in interleukin-1-mediated DNA damage associated with osteoarthritis Osteoarthritis Cartilage 16 5 2008 624 630
37. M. Del Carlo Jr., and R.F. Loeser Nitric oxide-mediated chondrocytes cell death requires the generation of additional reactive oxygen species Arthritis Rheum 46 2 2002 394 403
38. P. Pacher, J.S. Beckman, and L. Liaudet Nitric oxide and peroxynitrite in health and disease Physiol Rev 87 1 2007 315 424
39. B.P. Leung, N. Sattar, A. Crilly, M. Prach, D.W. McCarey, and H. Payne A novel anti inflammatory role for simvastatin in inflammatory arthritis J Immunol 170 3 2003 1524 1530
40. Y. Kono, and I. Fridovich Superoxide radicals inhibit catalase J Biol Chem 257 10 1982 5751 5754
41. F. Vaillancourt, H. Fahmi, Q. Shi, P. Lavigne, P. Ranger, and J.C. Fernandes 4-Hydroxynonenal induces apoptosis in human osteoarthritic chondrocytes: the protective role of glutathione-S-transferase Arthritis Res Ther 10 5 2008 R107
42. J.S. Bains, and C.A. Shaw Neurodegenerative disorders in humans: the role of glutathione in oxidative stress-mediated neuronal death Brain Res Brain Res Rev 25 3 1997 335 358
43. R.U. Koladiya, A.S. Jaggi, N. Singh, and B.K. Sharma Ameliorative role of atorvastatin and pitavastatin in l-methionine induced vascular dementia in rats BMC Pharmacol 8 2008 14
44. Y. An, H. Xin, W. Yan, and X. Zhou Amelioration of cisplatin-induced nephrotoxicity by pravastatin in mice Exp Toxicol Pathol 63 3 2011 215 219
45. K. Kobayashi, R. Imaizumi, H. Sumichika, H. Tanaka, M. Goda, and A. Fukunari Sodium iodoacetate-induced experimental osteoarthritis and associated pain model in rats J Vet Med Sci 65 11 2003 1195 1199
46. A.S. More, R.R. Kumari, G. Gupta, M.C. Lingaraju, V. Balaganur, and N.N. Pathak Effect of iNOS inhibitor S-methylisothiourea in monosodium iodoacetate-induced osteoarthritic pain: Implication for osteoarthritis therapy Pharmacol Biochem Behav 103 4 2013 764 772
47. G.W. Stevenson, H. Mercer, J. Cormier, C. Dunbar, L. Benoit, and C. Adams Monosodium iodoacetate-induced osteoarthritis produces pain-depressed wheel running in rats: Implications for preclinical behavioral assessment of chronic pain Pharmacol Biochem Behav 98 1 2011 35 42
48. S.B. Abramson, and M. Attur Developments in the scientific understanding of osteoarthritis Arthritis Res Ther 11 3 2009 227
49. P.H. Jones, M.H. Davidson, E.A. Stein, H.E. Bays, J.M. McKenney, and E. Miller Comparison of the efficacy and safety of rosuvastatin versus atorvastatin, simvastatin, and pravastatin across doses (STELLAR∗ Trial) Am J Cardiol 92 2 2003 152 160
50. D.D. Waters Safety of high-dose atorvastatin therapy Am J Cardiol 96 5A 2005 69F 75F
51. Y. Birnbaum, Y. Ye, Y. Lin, S.Y. Freeberg, S.P. Nishi, and J.D. Martinez Augmentation of myocardial production of 15-epi-lipoxin-a4 by pioglitazone and atorvastatin in the rat Circulation 114 9 2006 929 935
52. M.M. Barsantea, E. Roffea, C.M. Yokorob, W.L. Tafuric, D.G. Souzab, and V. Pinhoa Anti-inflammatory and analgesic effects of atorvastatin in a rat model of adjuvant-induced arthritis Eur J Pharmacol 516 3 2005 282 289
53. M. Weis, C. Heeschen, A.J. Glassford, and J.P. Cooke Statins have biphasic effects on angiogenesis Circulation 105 6 2002 739 745
54. D. Yang, Y. Han, J. Zhang, M. Chopp, and D.M. Seyfried Statins enhance expression of growth factors and activate the PI3K/Akt-mediated signaling pathway after experimental intracerebral hemorrhage World J Neurosci 2 2 2012 74 80
55. H.C. Pan, D.Y. Yang, Y.C. Ou, S.P. Ho, F.C. Cheng, and C.J. Chen Neuroprotective effect of atorvastatin in an experimental model of nerve crush injury Neurosurgery 67 2 2010 376 388
56. G.G. Garcia, H.F. Miranda, V. Noriega, F. Sierralta, L. Olavarría, and R.J. Zepeda Antinociception induced by atorvastatin in different pain models Pharmacol Biochem Behav 100 1 2011 125 129
57. L.W. Chu, J.Y. Chen, K.L. Yu, K.I. Cheng, P.C. Wu, and B.N. Wu Neuroprotective and anti-inflammatory activities of atorvastatin in a rat chronic constriction injury model Int J Immunopathol Pharmacol 25 1 2012 219 230
58. M. Thakur, W. Rahman, C. Hobbs, A.H. Dickenson, and D.L.H. Bennett Characterisation of a peripheral neuropathic component of the rat monoiodoacetate model of osteoarthritis PLoS ONE 7 2012 e33730