Pravastatin suppresses matrix metalloproteinase expression and activity in human articular chondrocytes stimulated by interleukin-1β

Journal of Orthopaedics and Traumatology

Volumn 13, Issue 3, 2012, Pages 119-123

  Baker, Joseph F ^a,b   Walsh, Pauline M ^a   Byrne, Damien P ^c   Mulhall, Kevin J ^d  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b CAPPAGH NATIONAL ORTHOPAEDIC HOSPITAL   (Ireland)

^c Orthopaedic Research and Innovation Foundation   (Ireland)

^d MATER MISERICORDIAE UNIVERSITY HOSPITAL   (Ireland)

Author keywords

Articular cartilage; Matrix metalloproteinases; Statins

Indexed keywords

GELATINASE B; INTERLEUKIN 1BETA; MATRIX METALLOPROTEINASE; MESSENGER RNA; PRAVASTATIN; STROMELYSIN;

ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CATABOLISM; CELL LYSATE; CELL PROLIFERATION; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION; RNA EXTRACTION; SUPERNATANT;

BLOTTING, WESTERN; CARTILAGE, ARTICULAR; CELLS, CULTURED; CHONDROCYTES; DOWN-REGULATION; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INTERLEUKIN-1BETA; MATRIX METALLOPROTEINASES; PRAVASTATIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84869117742     PISSN: 15909921     EISSN: 15909999     Source Type: Journal    
DOI: 10.1007/s10195-012-0200-4     Document Type: Article

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