Effects of atorvastatin therapy on protein oxidation and oxidative DNA damage in hypercholesterolemic rabbits

Pharmacological Research

Volumn 59, Issue 4, 2009, Pages 242-247

  Aydin, S ^a   Uzun, H ^a   Sozer, V ^b   Altug, T ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

^b YILDIZ TECHNICAL UNIVERSITY   (Turkey)

Author keywords

Atorvastatin; Hypercholesterolemia; Lipid peroxidation; Oxidative DNA damage; Protein oxidation; Rat

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ATORVASTATIN; CARBONYL DERIVATIVE; CHOLESTEROL; GLUTATHIONE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MALONALDEHYDE; PROTEIN; THIOL DERIVATIVE; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CHOLESTEROL DIET; CONTROLLED STUDY; DNA DAMAGE; DRUG EFFECT; ERYTHROCYTE LEVEL; EXPERIMENTAL RABBIT; HYPERCHOLESTEROLEMIA; LIPID PEROXIDATION; LIVER LEVEL; MALE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN MODIFICATION; TREATMENT DURATION;

ANIMALS; ANTICHOLESTEREMIC AGENTS; DEOXYGUANOSINE; DNA DAMAGE; GLUTATHIONE; HEPTANOIC ACIDS; HYPERCHOLESTEROLEMIA; LIPID PEROXIDATION; LIVER; MALE; MALONDIALDEHYDE; OXIDATION-REDUCTION; OXIDATIVE STRESS; PROTEIN CARBONYLATION; PYRROLES; RABBITS; RANDOM ALLOCATION; SULFHYDRYL COMPOUNDS;

EID: 61349172431     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2009.01.004     Document Type: Article

References (39)

1. Lusis A.J. Atherosclerosis. Nature 407 (2000) 233-241
2. Stoll L.L., McCormick M.L., Denning G.M., and Weintraub N.L. Antioxidant effects of statins. Drugs Today (Barc) 40 (2004) 975-990
3. Berlett B.S., and Stadtman E.R. Protein oxidation in aging, disease, and oxidative stress. J Biol Chem 272 (1997) 20313-20316
4. Stadtman E.R. Role of oxidant species in aging. Curr Med Chem 11 (2004) 1105-1112
5. Anderson M.E., and Meister A. Glutathione monoesters. Anal Biochem 183 (1989) 16-20
6. Halliwell B., and Gutteridge J.M.C. Free radicals in biology and medicine (1999), Oxford University Press, London
7. Cooke M.S., Evans M.D., Dizdaroglu M., and Lunec J. Oxidative DNA damage: mechanisms, mutation, and disease. FASEB J 17 (2003) 1195-1214
8. Evans M.D., and Cooke M.S. Factors contributing to the outcome of oxidative damage to nucleic acids. Bioessays 26 (2004) 533-542
9. Martinet W., Knaapen M.W., De Meyer G.R., Herman A.G., and Kockx M.M. Oxidative DNA damage and repair in experimental atherosclerosis are reversed by dietary lipid lowering. Circ Res 88 (2001) 733-739
10. Reznick A.Z., and Packer L. Oxidative damage to proteins: spectrophotometric method for carbonyl assay. Methods Enzymol 233 (1994) 357-363
11. Buege J.A., and Aust S.D. Microsomal lipid peroxidation. Methods Enzymol 52 (1978) 302-310
12. Hu M.L. Measurement of protein thiol groups and glutathione in plasma. Methods Enzymol 233 (1994) 381-385
13. Beutler E., Duran O., and Kelly M.B. Improved method for the determination of blood glutathione. J Lab Clin Med 61 (1963) 882-888
14. Çakatay U., Kayali R., and Uzun H. Relation of plasma protein oxidation parameters and paraoxonase activity in the ageing population. Clin Exp Med 8 (2008) 51-57
15. Reaven P.D., Napoli C., Merat S., and Witztumc J.I. Lipoprotein modification and atherosclerosis in aging. Exp Gerontol 34 (2000) 527-537
16. Bonnefont-Rousselot D., Therond P., Beaudeux J.L., Peynet J., Le-grand A., and Delattre J. High density lipoproteins (HDL) and oxidative hypothesis of atherosclerosis. Clin Chem Lab Med 37 (1999) 938-948
17. Chinellato A., Pandolfo L., Ragazzi E., Zambonin M.R., Froldi G., De Biasi M., et al. Effect of age on rabbit aortic responses to relaxant endothelium-dependent and endothelium-independent agents. Blood Vessels 28 (1991) 358-365
18. Park J.E., Kim K.B., Bae S.K., Moon B.S., Liu K.H., and Shin J.G. Contribution of cytochrome P450 3A4 and 3A5 to the metabolism of atorvastatin. Xenobiotica 38 (2008) 1240-1251
19. Matafome P., Nunes E., Louro T., Amaral C., Crisóstomo J., Rodrigues L., et al. A role for atorvastatin and insulin combination in protecting from liver injury in a model of type 2 diabetes with hyperlipidemia. Naunyn Schmiedebergs Arch Pharmacol 379 (2009) 241-251
20. Blanco-Colio L.M., Tuñón J., Martín-Ventura J.L., and Egido J. Inflammatory biomarkers and statins. Timely Top Med Cardiovasc Dis 1 9 (2005) E16
21. Prasad K. Reduction of serum cholesterol and hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinol diglucoside isolated from flaxseed. Circulation 99 (1999) 1355-1362
22. Hong S.C., Zhao S.P., and Wu Z.H. Probucol up-regulates paraoxonase 1 expression in hepatocytes of hypercholesterolemic rabbits. J Cardiovasc Pharmacol 47 (2006) 77-81
23. Böger R.H., Bode-Boger S.M., Brandes R.P., Phiythong-ngam L., Böhme M., Nafe R., et al. Dietary l-arginine reduces the progression of atherosclerosis in cholesterol fed rabbits. Circulation 96 (1997) 1282-1290
24. Al-Zuhair H., Abd el-Fattah A.A., and Abd el Latif H.A. Efficacy of simvastatin and pumpkin-seed oil in the management of dietary-induced hypercholesterolemia. Pharmacol Res 35 (1997) 403-408
25. Liu B.W., Jiang Y., Fu M.D., Liu Y., and Fan P. Oxidative modification of lipoproteins in hypertriglyceridemic patients and hypercholesterolemic rabbits in vivo. Molec Cell Biochem 207 (2000) 131-135
26. Guidelines for Ethical Conduct in the Care and Use of Animals, American Physiological Association, Board of Scientific Affairs, Committee on Animal Research and Ethics. http://www.apa.org/science/anguide.html.
27. Shacher E. Quantification and significance of protein oxidation in biological samples. Drug Metab Rev 32 (2000) 307-326
28. Himmelfarb J., McMonagle E., and McMenamin E. Plasma protein thiol oxidation and carbonyl formation in chronic renal failure. Kidney Int 58 (2000) 2571-2578
29. Meister A., and Anderson M.E. Glutathione. Ann Rev Biochem 52 (1983) 711-760
30. Takenaka Y., Miki M., Yasuda H., and Mino M. The effect of α-tocopherol as an antioxidant on the oxidation of membrane protein thiols induced by free radicals generated in different sites. Arch Biochem Biophys 285 (1991) 344-350
31. Shacter E. Protein oxidative damage. Methods Enzymol 319 (2000) 428-436
32. Avisar I., Brook J.G., and Wolfovitz E. Atorvastatin monotherapy vs. combination therapy in the management of patients with combined hyperlipidemia. Eur J Intern Med 19 (2008) 203-208
33. Chung Y.H., Shin C.M., Joo K.M., Kim M.J., and Cha C.I. Immunohistochemical study on the distribution of nitrotyrosine and neuronal nitric oxide synthase in aged rat cerebellum. Brain Res 951 (2002) 316-321
34. Sodha N.R., Boodhwani M., Ramlawi B., Clements R.T., Mieno S., Feng J., et al. Atorvastatin increases myocardial indices of oxidative stress in a porcine model of hypercholesterolemia and chronic ischemia. J Card Surg 23 (2008) 312-320
35. Muldoon M.F., Kritchevsky S.B., Evans R.W., and Kagan V.E. Serum total antioxidant activity in relative hypo- and hypercholesterolemia. Free Radic Res 25 (1996) 239-245
36. Tretjakovs P., Kalnins U., Dabina I., Dinne I., Erglis A., Kumsars I., et al. Plasma HDL-cholesterol has an effect on nitric oxide production and arachidonic acid metabolism in the platelet membranes of coronary heart disease patients without LDL-hypercholesterolemia. Med Sci Monit 6 (2000) 507-511
37. Andreassi M.G. Oxidative stress, DNA damage and vascular endothelial function. Biomed Pharmacother 60 (2006) 480-487
38. Kim K.S., Kang K.W., Seu Y.B., Baek S.H., and Kim J.R. Interferon-gamma induces cellular senescence through p53-dependent DNA damage signaling in human endothelial cells. Mech Ageing Dev (2008) [November 21, Epub ahead of print]
39. Oeseburg H., Iusuf D., van der Harst P., van Gilst W.H., Henning R.H., and Roks A.J. Bradykinin protects against oxidative stress-induced endothelial cell senescence. Hypertension 53 (2009) 417-422