-
1
-
-
33847328289
-
The Bcl-2 apoptotic switch in cancer development and therapy
-
Adams JM, Cory S. The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene 2007; 26: 1324-1337.
-
(2007)
Oncogene
, vol.26
, pp. 1324-1337
-
-
Adams, J.M.1
Cory, S.2
-
2
-
-
0345256652
-
Cisplatin: Mode of cytotoxic action and molecular basis of resistance
-
Siddik ZH. Cisplatin: mode of cytotoxic action and molecular basis of resistance. Oncogene 2003; 22: 7265-7279.
-
(2003)
Oncogene
, vol.22
, pp. 7265-7279
-
-
Siddik, Z.H.1
-
3
-
-
33947324515
-
Absence of Bcl-xL downregulation in response to cisplatin is associated with chemoresistance in ovarian carcinoma cells
-
Villedieu M, Louis MH, Dutoit S, Brotin E, Lincet H, Duigou F et al. Absence of Bcl-xL downregulation in response to cisplatin is associated with chemoresistance in ovarian carcinoma cells. Gynecol Oncol 2007; 105: 31-44.
-
(2007)
Gynecol Oncol
, vol.105
, pp. 31-44
-
-
Villedieu, M.1
Louis, M.H.2
Dutoit, S.3
Brotin, E.4
Lincet, H.5
Duigou, F.6
-
4
-
-
0031939573
-
Bcl-2, bax, bcl-XL, and bcl-XS expression in normal and neoplastic ovarian tissues
-
Marone M, Scambia G, Mozzetti S, Ferrandina G, Iacovella S, De Pasqua A et al. Bcl-2, bax, bcl-XL, and bcl-XS expression in normal and neoplastic ovarian tissues. Clin Cancer Res 1998; 4: 517-524.
-
(1998)
Clin Cancer Res
, vol.4
, pp. 517-524
-
-
Marone, M.1
Scambia, G.2
Mozzetti, S.3
Ferrandina, G.4
Iacovella, S.5
De Pasqua, A.6
-
5
-
-
0037452759
-
PUMA mediates the apoptotic response to p53 in colorectal cancer cells
-
Yu J,Wang Z, Kinzler KW, Vogelstein B, Zhang L. PUMA mediates the apoptotic response to p53 in colorectal cancer cells. Proc Natl Acad Sci USA 2003; 100: 1931-1936.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 1931-1936
-
-
Yu, J.1
Wang, Z.2
Kinzler, K.W.3
Vogelstein, B.4
Zhang, L.5
-
6
-
-
34250880206
-
SMAC/Diablo mediates the proapoptotic function of PUMA by regulating PUMA-induced mitochondrial events.
-
Yu J, Wang P, Ming L, Wood MA, Zhang L. SMAC/Diablo mediates the proapoptotic function of PUMA by regulating PUMA-induced mitochondrial events. Oncogene 2007; 26: 4189-4198.
-
(2007)
Oncogene
, vol.26
, pp. 4189-4198
-
-
Yu, J.1
Wang, P.2
Ming, L.3
Wood, M.A.4
Zhang, L.5
-
7
-
-
84860847695
-
JNK- and Akt-mediated Puma expression in the apoptosis of cisplatin-resistant ovarian cancer cells
-
Zhao Z, Wang J, Tang J, Liu X, Zhong Q, Wang F et al. JNK- and Akt-mediated Puma expression in the apoptosis of cisplatin-resistant ovarian cancer cells. Biochem J 2012; 444: 291-301.
-
(2012)
Biochem J
, vol.444
, pp. 291-301
-
-
Zhao, Z.1
Wang, J.2
Tang, J.3
Liu, X.4
Zhong, Q.5
Wang, F.6
-
8
-
-
82855168143
-
The p53 upregulated modulator of apoptosis (PUMA) chemosensitizes intrinsically resistant ovarian cancer cells to cisplatin by lowering the threshold set by Bcl-x(L) and Mcl-1.
-
Yuan Z, Cao K, Lin C, Li L, Liu HY, Zhao XY et al. The p53 upregulated modulator of apoptosis (PUMA) chemosensitizes intrinsically resistant ovarian cancer cells to cisplatin by lowering the threshold set by Bcl-x(L) and Mcl-1. Mol Med 2011; 17: 1262-1274.
-
(2011)
Mol Med
, vol.17
, pp. 1262-1274
-
-
Yuan, Z.1
Cao, K.2
Lin, C.3
Li, L.4
Liu, H.Y.5
Zhao, X.Y.6
-
9
-
-
34247481285
-
Targeting checkpoint kinase 1 in cancer therapeutics
-
Tse AN, Carvajal R, Schwartz GK. Targeting checkpoint kinase 1 in cancer therapeutics. Clin Cancer Res 2007; 13: 1955-1960.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 1955-1960
-
-
Tse, A.N.1
Carvajal, R.2
Schwartz, G.K.3
-
10
-
-
0024916449
-
Evolution of family policy in the light of demographic development in West European countries
-
Gilliand P. Evolution of family policy in the light of demographic development in West European countries. Int Soc Secur Rev 1989; 42: 395-426.
-
(1989)
Int Soc Secur Rev
, vol.42
, pp. 395-426
-
-
Gilliand, P.1
-
11
-
-
0034655281
-
The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1
-
Busby EC, Leistritz DF, Abraham RT, Karnitz LM, Sarkaria JN. The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1. Cancer Res 2000; 60: 2108-2112.
-
(2000)
Cancer Res
, vol.60
, pp. 2108-2112
-
-
Busby, E.C.1
Leistritz, D.F.2
Abraham, R.T.3
Karnitz, L.M.4
Sarkaria, J.N.5
-
12
-
-
0042441979
-
Synergistic antileukemic interactions between 17-AAG and UCN-01 involve interruption of RAF/MEK- and AKTrelated pathways
-
Jia W, Yu C, Rahmani M, Krystal G, Sausville EA, Dent P et al. Synergistic antileukemic interactions between 17-AAG and UCN-01 involve interruption of RAF/MEK- and AKTrelated pathways. Blood 2003; 102: 1824-1832.
-
(2003)
Blood
, vol.102
, pp. 1824-1832
-
-
Jia, W.1
Yu, C.2
Rahmani, M.3
Krystal, G.4
Sausville, E.A.5
Dent, P.6
-
13
-
-
3042531148
-
Persistent activation of the Akt pathway in head and neck squamous cell carcinoma: A potential target for UCN-01
-
Amornphimoltham P, Sriuranpong V, Patel V, Benavides F, Conti CJ, Sauk J et al. Persistent activation of the Akt pathway in head and neck squamous cell carcinoma: a potential target for UCN-01. Clin Cancer Res 2004; 10(Part 1): 4029-4037.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 4029-4037
-
-
Amornphimoltham, P.1
Sriuranpong, V.2
Patel, V.3
Benavides, F.4
Conti, C.J.5
Sauk, J.6
-
14
-
-
0036729867
-
Inhibition of phosphatidylinositol 3-kinase-Akt signaling blocks growth, promotes apoptosis, and enhances sensitivity of small cell lung cancer cells to chemotherapy
-
Krystal GW, Sulanke G, Litz J. Inhibition of phosphatidylinositol 3-kinase-Akt signaling blocks growth, promotes apoptosis, and enhances sensitivity of small cell lung cancer cells to chemotherapy. Mol Cancer Ther 2002; 1: 913-922.
-
(2002)
Mol Cancer Ther
, vol.1
, pp. 913-922
-
-
Krystal, G.W.1
Sulanke, G.2
Litz, J.3
-
15
-
-
34548821574
-
MEK1/2 inhibitors potentiate UCN-01 lethality in human multiple myeloma cells through a Bim-dependent mechanism.
-
Pei XY, Dai Y, Tenorio S, Lu J, Harada H, Dent P et al. MEK1/2 inhibitors potentiate UCN-01 lethality in human multiple myeloma cells through a Bim-dependent mechanism. Blood 2007; 110: 2092-2101.
-
(2007)
Blood
, vol.110
, pp. 2092-2101
-
-
Pei, X.Y.1
Dai, Y.2
Tenorio, S.3
Lu, J.4
Harada, H.5
Dent, P.6
-
16
-
-
19944432818
-
The broad-range cyclin-dependent kinase inhibitor UCN-01 induces apoptosis in colon carcinoma cells through transcriptional suppression of the Bcl-x(L) protein
-
Bhonde MR, Hanski ML, Magrini R, Moorthy D, Muller A, Sausville EA et al. The broad-range cyclin-dependent kinase inhibitor UCN-01 induces apoptosis in colon carcinoma cells through transcriptional suppression of the Bcl-x(L) protein. Oncogene 2005; 24: 148-156.
-
(2005)
Oncogene
, vol.24
, pp. 148-156
-
-
Bhonde, M.R.1
Hanski, M.L.2
Magrini, R.3
Moorthy, D.4
Muller, A.5
Sausville, E.A.6
-
17
-
-
0034662619
-
Caspase-3 is essential for procaspase-9 processing and cisplatin-induced apoptosis of MCF-7 breast cancer cells
-
Blanc C, Deveraux QL, Krajewski S, Janicke RU, Porter AG, Reed JC et al. Caspase-3 is essential for procaspase-9 processing and cisplatin-induced apoptosis of MCF-7 breast cancer cells. Cancer Res 2000; 60: 4386-4390.
-
(2000)
Cancer Res
, vol.60
, pp. 4386-4390
-
-
Blanc, C.1
Deveraux, Q.L.2
Krajewski, S.3
Janicke, R.U.4
Porter, A.G.5
Reed, J.C.6
-
18
-
-
80052666457
-
Triggering of a novel intrinsic apoptosis pathway by the kinase inhibitor staurosporine: Activation of caspase- 9 in the absence of Apaf-1
-
Manns J, Daubrawa M, Driessen S, Paasch F, Hoffmann N, Loffler A et al. Triggering of a novel intrinsic apoptosis pathway by the kinase inhibitor staurosporine: activation of caspase- 9 in the absence of Apaf-1. FASEB J 2011; 25: 3250-3261.
-
(2011)
FASEB J
, vol.25
, pp. 3250-3261
-
-
Manns, J.1
Daubrawa, M.2
Driessen, S.3
Paasch, F.4
Hoffmann, N.5
Loffler, A.6
-
19
-
-
0033601746
-
Ordering the cytochrome c-initiated caspase cascade: Hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner
-
Slee EA, Harte MT, Kluck RM, Wolf BB, Casiano CA, Newmeyer DD et al. Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner. J Cell Biol 1999; 144: 281-292.
-
(1999)
J Cell Biol
, vol.144
, pp. 281-292
-
-
Slee, E.A.1
Harte, M.T.2
Kluck, R.M.3
Wolf, B.B.4
Casiano, C.A.5
Newmeyer, D.D.6
-
20
-
-
36348934636
-
Caspase-9-induced mitochondrial disruption through cleavage of anti-apoptotic BCL-2 family members
-
Chen M, Guerrero AD, Huang L, Shabier Z, Pan M, Tan TH et al. Caspase-9-induced mitochondrial disruption through cleavage of anti-apoptotic BCL-2 family members. J Biol Chem 2007; 282: 33888-33895.
-
(2007)
J Biol Chem
, vol.282
, pp. 33888-33895
-
-
Chen, M.1
Guerrero, A.D.2
Huang, L.3
Shabier, Z.4
Pan M.Tan, T.H.5
-
21
-
-
0031930688
-
Modulation of cell death by Bcl-XL through caspase interaction
-
Clem RJ, Cheng EH, Karp CL, Kirsch DG, Ueno K, Takahashi A et al. Modulation of cell death by Bcl-XL through caspase interaction. Proc Natl Acad Sci USA 1998; 95: 554-559.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 554-559
-
-
Clem, R.J.1
Cheng, E.H.2
Karp, C.L.3
Kirsch, D.G.4
Ueno, K.5
Takahashi, A.6
-
22
-
-
0032473496
-
Alphaviruses induce apoptosis in Bcl-2-overexpressing cells: Evidence for a caspase-mediated, proteolytic inactivation of Bcl-2
-
Grandgirard D, Studer E, Monney L, Belser T, Fellay I, Borner C et al. Alphaviruses induce apoptosis in Bcl-2-overexpressing cells: evidence for a caspase-mediated, proteolytic inactivation of Bcl-2. EMBO J 1998; 17: 1268-1278.
-
(1998)
EMBO J
, vol.17
, pp. 1268-1278
-
-
Grandgirard, D.1
Studer, E.2
Monney, L.3
Belser, T.4
Fellay, I.5
Borner, C.6
-
23
-
-
79551632028
-
Caspase-3 cleaves XIAP in a positive feedback loop to sensitize melanoma cells to TRAIL-induced apoptosis
-
Hornle M, Peters N, Thayaparasingham B, Vorsmann H, Kashkar H, Kulms D. Caspase-3 cleaves XIAP in a positive feedback loop to sensitize melanoma cells to TRAIL-induced apoptosis. Oncogene 2011; 30: 575-587.
-
(2011)
Oncogene
, vol.30
, pp. 575-587
-
-
Hornle, M.1
Peters, N.2
Thayaparasingham, B.3
Vorsmann, H.4
Kashkar, H.5
Kulms, D.6
-
24
-
-
0035282570
-
A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis
-
Srinivasula SM, Hegde R, Saleh A, Datta P, Shiozaki E, Chai J et al. A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis. Nature 2001; 410: 112-116.
-
(2001)
Nature
, vol.410
, pp. 112-116
-
-
Srinivasula, S.M.1
Hegde, R.2
Saleh, A.3
Datta, P.4
Shiozaki, E.5
Chai, J.6
-
25
-
-
78649684224
-
PUMA induction by FoxO3a mediates the anticancer activities of the broad-range kinase inhibitor UCN-01
-
Dudgeon C,Wang P, Sun X, Peng R, Sun Q, Yu J et al. PUMA induction by FoxO3a mediates the anticancer activities of the broad-range kinase inhibitor UCN-01. Mol Cancer Ther 2010; 9: 2893-2902.
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 2893-2902
-
-
Dudgeon, C.1
Wang, P.2
Sun, X.3
Peng, R.4
Sun, Q.5
Yu, J.6
-
26
-
-
0031213555
-
7-Hydroxystaurosporine (UCN-01) induces apoptosis in human colon carcinoma and leukemia cells independently of p53
-
Shao RG, Shimizu T, Pommier Y. 7-Hydroxystaurosporine (UCN-01) induces apoptosis in human colon carcinoma and leukemia cells independently of p53. Exp Cell Res 1997; 234: 388-397.
-
(1997)
Exp Cell Res
, vol.234
, pp. 388-397
-
-
Shao, R.G.1
Shimizu, T.2
Pommier, Y.3
-
27
-
-
33744942924
-
PUMA Dissociates Bax and Bcl-X(L) to induce apoptosis in colon cancer cells
-
Ming L, Wang P, Bank A, Yu J, Zhang L. PUMA Dissociates Bax and Bcl-X(L) to induce apoptosis in colon cancer cells. J Biol Chem 2006; 281: 16034-16042.
-
(2006)
J Biol Chem
, vol.281
, pp. 16034-16042
-
-
Ming, L.1
Wang, P.2
Bank, A.3
Yu, J.4
Zhang, L.5
-
29
-
-
58149101589
-
Caspase-mediated Bak activation and cytochrome c release during intrinsic apoptotic cell death in Jurkat cells
-
Shawgo ME, Shelton SN, Robertson JD. Caspase-mediated Bak activation and cytochrome c release during intrinsic apoptotic cell death in Jurkat cells. J Biol Chem 2008; 283: 35532-35538.
-
(2008)
J Biol Chem
, vol.283
, pp. 35532-35538
-
-
Shawgo, M.E.1
Shelton, S.N.2
Robertson, J.D.3
-
30
-
-
84855293917
-
Proapoptotic protein Smac mediates apoptosis in cisplatin-resistant ovarian cancer cells when treated with the anti-tumor agent AT101
-
Hu W, Wang F, Tang J, Liu X, Yuan Z, Nie C et al. Proapoptotic protein Smac mediates apoptosis in cisplatin-resistant ovarian cancer cells when treated with the anti-tumor agent AT101. J Biol Chem 2012; 287: 68-80.
-
(2012)
J Biol Chem
, vol.287
, pp. 68-80
-
-
Hu, W.1
Wang, F.2
Tang, J.3
Liu, X.4
Yuan, Z.5
Nie, C.6
-
31
-
-
79957851071
-
BIM-mediated AKT phosphorylation is a key modulator of arsenic trioxide-induced apoptosis in cisplatin-sensitive and -resistant ovarian cancer cells.
-
Yuan Z, Wang F, Zhao Z, Zhao X, Qiu J, Nie C et al. BIM-mediated AKT phosphorylation is a key modulator of arsenic trioxide-induced apoptosis in cisplatin-sensitive and -resistant ovarian cancer cells. PLoS One 2011; 6: e20586.
-
(2011)
PLoS One
, vol.6
, pp. e20586
-
-
Yuan, Z.1
Wang, F.2
Zhao, Z.3
Zhao, X.4
Qiu, J.5
Nie, C.6
-
32
-
-
84897448414
-
SKLB-163, a new benzothiazole-2-thiol derivative, exhibits potent anticancer activity by affecting RhoGDI/JNK-1 signaling pathway
-
Peng X, Xie G, Wang Z, Lin H, Zhou T, Xiang P et al. SKLB-163, a new benzothiazole-2-thiol derivative, exhibits potent anticancer activity by affecting RhoGDI/JNK-1 signaling pathway. Cell Death Dis 2014; 5: e1143.
-
(2014)
Cell Death Dis
, vol.5
, pp. e1143
-
-
Peng, X.1
Xie, G.2
Wang, Z.3
Lin, H.4
Zhou, T.5
Xiang, P.6
|