Pioglitazone restores phagocyte mitochondrial oxidants and bactericidal capacity in chronic granulomatous disease

Journal of Allergy and Clinical Immunology

Volumn 135, Issue 2, 2015, Pages 517-527.e12

  Fernandez Boyanapalli, Ruby F ^a   Frasch, S Courtney ^a   Thomas, Stacey M ^a   Malcolm, Kenneth C ^b   Nicks, Michael ^a   Harbeck, Ronald J ^a,b   Jakubzick, Claudia V ^a   Nemenoff, Raphael ^c   Henson, Peter M ^a,b   Holland, Steven M ^d   Bratton, Donna L ^a  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^b DEPARTMENT OF MEDICINE   (United States)

^c UNIVERSITY OF DENVER   (United States)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Chronic granulomatous disease; mitochondria; oxidants; phagocytes; thioglitazones

Indexed keywords

ARACHIDONATE 15 LIPOXYGENASE; CYTOSOLIC PHOSPHOLIPASE A2; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIOGLITAZONE; PROSTAGLANDIN SYNTHASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; SUPEROXIDE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; CYBB PROTEIN, MOUSE; MEMBRANE PROTEIN; OXIDIZING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL CLEARANCE; BACTERICIDAL ACTIVITY; CHRONIC GRANULOMATOUS DISEASE; CONTROLLED STUDY; DOSE RESPONSE; EX VIVO STUDY; HOST RESISTANCE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE; MALE; MITOCHONDRION; MONOCYTE; MOUSE; NEUTROPHIL; NONHUMAN; PHAGOCYTE; PHAGOLYSOSOME; PRIORITY JOURNAL; SHORT COURSE THERAPY; SIGNAL TRANSDUCTION; STAPHYLOCOCCUS AUREUS; STEADY STATE; ANIMAL; DEFICIENCY; DISEASE MODEL; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; MICROBIOLOGY; PHAGOCYTOSIS;

ANIMALS; DISEASE MODELS, ANIMAL; GRANULOMATOUS DISEASE, CHRONIC; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; MITOCHONDRIA; MONOCYTES; NADPH OXIDASE; NEUTROPHILS; OXIDANTS; PHAGOCYTES; PHAGOCYTOSIS; PPAR GAMMA; REACTIVE OXYGEN SPECIES; STAPHYLOCOCCUS AUREUS; SUPEROXIDES; THIAZOLIDINEDIONES;

EID: 84922431955     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2014.10.034     Document Type: Article

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