β2-glycoprotein I, lipopolysaccharide and endothelial TLR4: Three players in the two hit theory for anti-phospholipid-mediated thrombosis

Journal of Autoimmunity

Volumn 55, Issue 1, 2014, Pages 42-50

  Raschi, Elena ^a   Chighizola, Cecilia B ^a,b   Grossi, Claudia ^a   Ronda, Nicoletta ^c   Gatti, Rita ^c   Meroni, Pier Luigi ^a,b   Borghi, M Orietta ^a,b  

^a ISTITUTO AUXOLOGICO ITALIANO   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF PARMA   (Italy)

Author keywords

Anti 2 glycoprotein I antibodies; Endothelial cells; Innate immunity; LPS; Toll like receptor 4; 2 Glycoprotein I

Indexed keywords

BETA2 GLYCOPROTEIN 1; CELL ADHESION MOLECULE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; FLUORESCEIN ISOTHIOCYANATE; INTERCELLULAR ADHESION MOLECULE 1; LIPOPOLYSACCHARIDE; MONOCLONAL ANTIBODY; PHOSPHOLIPID ANTIBODY; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 4; PROTEIN BINDING; TLR4 PROTEIN, HUMAN;

ANIMAL CELL; ANTIGEN BINDING; ARTICLE; CELL ACTIVATION; CELL GRANULE; CELL MEMBRANE; CELL VIABILITY; CELLS; CHO CELL LINE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERNALIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; THROMBOSIS; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION; WESTERN BLOTTING; ANIMAL; BIOLOGICAL MODEL; CHEMICALLY INDUCED; CRICETULUS; GENETICS; HAMSTER; IMMUNOLOGY; PATHOLOGY;

ANIMALS; ANTIBODIES, ANTIPHOSPHOLIPID; BETA 2-GLYCOPROTEIN I; CHO CELLS; CRICETINAE; CRICETULUS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; LIPOPOLYSACCHARIDES; MODELS, IMMUNOLOGICAL; PROTEIN BINDING; THROMBOSIS; TOLL-LIKE RECEPTOR 4;

EID: 84922410809     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2014.03.001     Document Type: Article

References (26)

1. Meroni P.L., Borghi M.O., Raschi E., Tedesco F. Pathogenesis of the antiphospholipid syndrome (APS): understanding the antibodies. Nat Rev Rheumatol 2011, 7:330-339.
2. Giannakopoulos B., Krilis S.A. The pathogenesis of the antiphospholipid syndrome. NEngl J Med 2013, 368:1033-1044.
3. Fischetti F., Durigutto P., Pellis V., Debeus A., Macor P., Bulla R., et al. Thrombus formation induced by antibodies to beta2-glycoprotein I is complement dependent and requires a priming factor. Blood 2005, 106:2340-2346.
4. Agostinis C., Biffi S., Garrovo C., Durigutto P., Lorenzon A., Bek A., et al. Invivo distribution of beta2 glycoprotein I under various pathophysiological conditions. Blood 2011, 118:4231-4238.
5. Meroni P.L., Raschi E., Camera M., Testoni C., Nicoletti F., Tincani A., et al. Endothelial activation by aPL; a potential pathogenic mechanism for the clinical manifestations of the syndrome. JAutoimmun 2000, 15:237-240.
6. Meroni P., Ronda N., Raschi E., Borghi M.O. Humoral autoimmunity against endothelium: theory or reality?. Trends Immunol 2005, 26:275-281.
7. Allen K.L., Fonseca F.V., Betapudi V., Willard B., Zhang J., McCrae K.R. Anovel pathway for human endothelial cell activation by antiphospholipid/anti-β2 glycoprotein I antibodies. Blood 2012, 119:884-893.
8. Agar C., de Groot P.G., Mörgelin M., Monk S.D., van Os G., Levels J.H., et al. β2-Glycoprotein I: a novel component of innate immunity. Blood 2011, 117:6939-6947.
9. Laplante P., Amireault P., Subang R., Dieudé M., Levine J.S., Rauch J. Interaction of β2-glycoprotein I with lipopolysaccharide leads to Toll-like receptor 4 (TLR4)-dependent activation of macrophages. JBiol Chem 2011, 286:42494-42503.
10. La Rosa L., Meroni P.L., Tincani A., Balestrieri G., Faden D., Lojacono A., et al. Beta 2 glycoprotein I and placental anticoagulant protein I in placentae from patients with antiphospholipid syndrome. JRheumatol 1994, 21:1684-1693.
11. Rovere P., Manfredi A.A., Vallinoto C., Zimmermann V.S., Fascio U., Balestrieri G., et al. Dendritic cells preferentially internalize apoptotic cells opsonized by anti-beta2-glycoprotein I antibodies. JAutoimmun 1998, 11:403-411.
12. Lin W.S., Chen P.C., Yang C.D., Cho E., Hahn B.H., Grossman J., et al. Some antiphospholipid antibodies recognize conformational epitopes shared by beta2-glycoprotein I and the homologous catalytic domains of several serine proteases. Arthritis Rheum 2007, 56:1638-1647.
13. Cavazzana A., Pengo V., Tonello M., Noventa F., Grossi C., Borghi M.O. Anti-beta(2)-glycoprotein I ELISA assay: the influence of different antigen preparations. Thromb Haemost 2009, 101:789-791.
14. Johnstone A., Thorpe R. Immunochemistry in practice 1982, 258. Blackwell Scientific Publications, Oxford, p.
15. Gugliesi F., De Andrea M., Mondini M., Cappello P., Giovarelli M., Shoenfeld Y., et al. The proapoptotic activity of the Interferon-inducible gene IFI16 provides new insights into its etiopathogenetic role in autoimmunity. JAutoimmun 2010, 35:114-123.
16. Orlandini G., Ronda N., Gatti R., Gazzola G.C., Borghetti A. Receptor-ligand internalization. Techniques in confocal microscopy. Reliable Lab Solutions 2010, 175-188. Academic Press, Oxford. P.M. Conn (Ed.).
17. Del Papa N., Guidali L., Sala A., Buccellati C., Khamashta M.A., Ichikawa K., et al. Endothelial cells as target for antiphospholipid antibodies. Human polyclonal and monoclonal anti-beta 2-glycoprotein I antibodies react invitro with endothelial cells through adherent beta 2-glycoprotein I and induce endothelial activation. Arthritis Rheum 1997, 40:551-561.
18. Cockrell E., Espinola R.G., McCrae K.R. Annexin A2: biology and relevance to the antiphospholipid syndrome. Lupus 2008, 17:943-951.
19. Raschi E., Testoni C., Bosisio D., Borghi M.O., Koike T., Mantovani, et al. Arole of the MyD88 transduction signalling pathway in endothelial cell activation by antiphospholipid antibodies. Blood 2003, 101:3495-3500.
20. Poulton K., Rahman A., Giles I. Examining how antiphospholipid antibodies activate intracellular signaling pathways: a systematic review. Semin Arthritis Rheum 2012, 41:720-736.
21. Pierangeli S.S., Vega-Ostertag M.E., Raschi E., Liu X., Romay-Penabad Z., De Micheli V., et al. Toll like receptor 4 is involved in antiphospholipid-mediated thrombosis: invivo studies. Ann Rheum Dis 2007, 66:1327-1333.
22. Cruz-Tapias P., Blank M., Anaya J.M., Shoenfeld Y. Infections and vaccines in theetiology of antiphospholipid syndrome. Curr Opin Rheumatol 2012, 24:389-393.
23. Ortega-Hernandez O.D., Agmon-Levin N., Blank M., Asherson R.A., Shoenfeld Y. The physiopathology of the catastrophic antiphospholipid (Asherson's) syndrome: compelling evidence. JAutoimmun 2009, 32:1-6.
24. Willis R., Harris E.N., Pierangeli S.S. Pathogenesis of the antiphospholipid syndrome. Sem Thromb Haemost 2012, 38:305-321.
25. Hijiya N., Miyake K., Akashi S., Matsuura K., Higuchi Y., Yamamoto S. Possible involvement of toll-like receptor 4 in endothelial cell activation of larger vessels in response to lipopolysaccharide. Pathobiology 2002, 70:18-25.
26. Shoenfeld Y., Blank M., Cervera R., Font J., Raschi E., Meroni P.L. Infectious origin of the antiphospholipid syndrome. Ann Rheum Dis 2006, 65:2-6.