메뉴 건너뛰기




Volumn 41, Issue 5, 2012, Pages 720-736

Examining How Antiphospholipid Antibodies Activate Intracellular Signaling Pathways: A Systematic Review

Author keywords

Antiphospholipid syndrome; Nuclear factor kappa B; Protein kinase; Toll like receptor

Indexed keywords

CELL SURFACE RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOLIPID ANTIBODY; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8;

EID: 84859420078     PISSN: 00490172     EISSN: 1532866X     Source Type: Journal    
DOI: 10.1016/j.semarthrit.2011.09.004     Document Type: Article
Times cited : (28)

References (49)
  • 2
    • 37349061734 scopus 로고    scopus 로고
    • A systematic review of secondary thromboprophylaxis in patients with antiphospholipid antibodies
    • RuizIrastorza G., Hunt B.J., Khamashta M.A. A systematic review of secondary thromboprophylaxis in patients with antiphospholipid antibodies. Arthritis Rheum 2007, 57(8):1487-1495.
    • (2007) Arthritis Rheum , vol.57 , Issue.8 , pp. 1487-1495
    • RuizIrastorza, G.1    Hunt, B.J.2    Khamashta, M.A.3
  • 3
    • 38149045141 scopus 로고    scopus 로고
    • The obstetric antiphospholipid syndrome
    • Derksen R.H., de Groot P.G. The obstetric antiphospholipid syndrome. J Reprod Immunol 2008, 77(1):41-50.
    • (2008) J Reprod Immunol , vol.77 , Issue.1 , pp. 41-50
    • Derksen, R.H.1    de Groot, P.G.2
  • 4
    • 31044449865 scopus 로고    scopus 로고
    • Antiphospholipid antibodies from patients with the antiphospholipid syndrome induce monocyte tissue factor expression through the simultaneous activation of NFkappaB/Rel proteins via the p38 mitogenactivated protein kinase pathway, and of the MEK-1/ERK pathway
    • LopezPedrera C., Buendia P., Cuadrado M.J., Siendones E., Aguirre M.A., Barbarroja N., et al. Antiphospholipid antibodies from patients with the antiphospholipid syndrome induce monocyte tissue factor expression through the simultaneous activation of NFkappaB/Rel proteins via the p38 mitogenactivated protein kinase pathway, and of the MEK-1/ERK pathway. Arthritis Rheum 2006, 54(1):301-311.
    • (2006) Arthritis Rheum , vol.54 , Issue.1 , pp. 301-311
    • LopezPedrera, C.1    Buendia, P.2    Cuadrado, M.J.3    Siendones, E.4    Aguirre, M.A.5    Barbarroja, N.6
  • 5
    • 0033586656 scopus 로고    scopus 로고
    • Antiphospholipid antibodies from antiphospholipid syndrome patients activate endothelial cells in vitro and in vivo
    • Pierangeli S.S., Colden-Stanfield M., Liu X., Barker J.H., Anderson G.L., Harris E.N. Antiphospholipid antibodies from antiphospholipid syndrome patients activate endothelial cells in vitro and in vivo. Circulation 1999, 99(15):1997-2002.
    • (1999) Circulation , vol.99 , Issue.15 , pp. 1997-2002
    • Pierangeli, S.S.1    Colden-Stanfield, M.2    Liu, X.3    Barker, J.H.4    Anderson, G.L.5    Harris, E.N.6
  • 6
    • 4444273214 scopus 로고    scopus 로고
    • Intracellular events in platelet activation induced by antiphospholipid antibodies in the presence of low doses of thrombin
    • Vega-Ostertag M., Harris E.N., Pierangeli S.S. Intracellular events in platelet activation induced by antiphospholipid antibodies in the presence of low doses of thrombin. Arthritis Rheum 2004, 50(9):2911-2919.
    • (2004) Arthritis Rheum , vol.50 , Issue.9 , pp. 2911-2919
    • Vega-Ostertag, M.1    Harris, E.N.2    Pierangeli, S.S.3
  • 7
    • 67650651969 scopus 로고    scopus 로고
    • Antiphospholipid antibodies induce a pro-inflammatory response in first trimester trophoblast via the TLR4/MyD88 pathway
    • Mulla M.J., Brosens J.J., Chamley L.W., Giles I., Pericleous C., Rahman A., et al. Antiphospholipid antibodies induce a pro-inflammatory response in first trimester trophoblast via the TLR4/MyD88 pathway. Am J Reprod Immunol 2009, 62(2):96-111.
    • (2009) Am J Reprod Immunol , vol.62 , Issue.2 , pp. 96-111
    • Mulla, M.J.1    Brosens, J.J.2    Chamley, L.W.3    Giles, I.4    Pericleous, C.5    Rahman, A.6
  • 9
    • 77249100694 scopus 로고    scopus 로고
    • Antibodies to serine proteases in the antiphospholipid syndrome
    • Chen P.P., Giles I. Antibodies to serine proteases in the antiphospholipid syndrome. Curr Rheumatol Rep 2010, 12(1):45-52.
    • (2010) Curr Rheumatol Rep , vol.12 , Issue.1 , pp. 45-52
    • Chen, P.P.1    Giles, I.2
  • 10
    • 34948903311 scopus 로고    scopus 로고
    • Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury
    • Redecha P., Tilley R., Tencati M., Salmon J.E., Kirchhofer D., Mackman N., et al. Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury. Blood 2007, 110(7):2423-2431.
    • (2007) Blood , vol.110 , Issue.7 , pp. 2423-2431
    • Redecha, P.1    Tilley, R.2    Tencati, M.3    Salmon, J.E.4    Kirchhofer, D.5    Mackman, N.6
  • 11
    • 55849112296 scopus 로고    scopus 로고
    • Neutrophil activation by the tissue factor/Factor VIIa/PAR2 axis mediates fetal death in a mouse model of antiphospholipid syndrome
    • Redecha P., Franzke C.W., Ruf W., Mackman N., Girardi G. Neutrophil activation by the tissue factor/Factor VIIa/PAR2 axis mediates fetal death in a mouse model of antiphospholipid syndrome. J Clin Invest 2008, 118(10):3453-3461.
    • (2008) J Clin Invest , vol.118 , Issue.10 , pp. 3453-3461
    • Redecha, P.1    Franzke, C.W.2    Ruf, W.3    Mackman, N.4    Girardi, G.5
  • 12
    • 0029790008 scopus 로고    scopus 로고
    • Antibodies to beta 2-glycoprotein I and clinical manifestations in patients with systemic lupus erythematosus
    • Tsutsumi A., Matsuura E., Ichikawa K., Fujisaku A., Mukai M., Kobayashi S., et al. Antibodies to beta 2-glycoprotein I and clinical manifestations in patients with systemic lupus erythematosus. Arthritis Rheum 1996, 39(9):1466-1474.
    • (1996) Arthritis Rheum , vol.39 , Issue.9 , pp. 1466-1474
    • Tsutsumi, A.1    Matsuura, E.2    Ichikawa, K.3    Fujisaku, A.4    Mukai, M.5    Kobayashi, S.6
  • 13
    • 33846243719 scopus 로고    scopus 로고
    • Current concepts on the pathogenesis of the antiphospholipid syndrome
    • Giannakopoulos B., Passam F., Rahgozar S., Krilis S.A. Current concepts on the pathogenesis of the antiphospholipid syndrome. Blood 2007, 109(2):422-430.
    • (2007) Blood , vol.109 , Issue.2 , pp. 422-430
    • Giannakopoulos, B.1    Passam, F.2    Rahgozar, S.3    Krilis, S.A.4
  • 14
    • 14944367961 scopus 로고    scopus 로고
    • Annexin A2 mediates endothelial cell activation by antiphospholipid/anti-beta2 glycoprotein I antibodies
    • Zhang J., McCrae K.R. Annexin A2 mediates endothelial cell activation by antiphospholipid/anti-beta2 glycoprotein I antibodies. Blood 2005, 105(5):1964-1969.
    • (2005) Blood , vol.105 , Issue.5 , pp. 1964-1969
    • Zhang, J.1    McCrae, K.R.2
  • 15
    • 27744494859 scopus 로고    scopus 로고
    • The binding site in {beta}2-glycoprotein I for ApoER2[prime] on platelets is located in domain V
    • van Lummel M., Pennings M.T., Derksen R.H., Urbanus R.T., Lutters B.C., Kaldenhoven N., et al. The binding site in {beta}2-glycoprotein I for ApoER2[prime] on platelets is located in domain V. J Biol Chem 2005, 280(44):36729-36736.
    • (2005) J Biol Chem , vol.280 , Issue.44 , pp. 36729-36736
    • van Lummel, M.1    Pennings, M.T.2    Derksen, R.H.3    Urbanus, R.T.4    Lutters, B.C.5    Kaldenhoven, N.6
  • 16
    • 0037528699 scopus 로고    scopus 로고
    • Role of the MyD88 transduction signaling pathway in endothelial activation by antiphospholipid antibodies
    • Raschi E., Testoni C., Bosisio D., Borghi M.O., Koike T., Mantovani A., et al. Role of the MyD88 transduction signaling pathway in endothelial activation by antiphospholipid antibodies. Blood 2003, 101(9):3495-3500.
    • (2003) Blood , vol.101 , Issue.9 , pp. 3495-3500
    • Raschi, E.1    Testoni, C.2    Bosisio, D.3    Borghi, M.O.4    Koike, T.5    Mantovani, A.6
  • 17
    • 18644361988 scopus 로고    scopus 로고
    • Involvement of p38 MAPK in the up-regulation of tissue factor on endothelial cells by antiphospholipid antibodies
    • Vega-Ostertag M., Casper K., Swerlick R., Ferrara D., Harris E.N., Pierangeli S.S. Involvement of p38 MAPK in the up-regulation of tissue factor on endothelial cells by antiphospholipid antibodies. Arthritis Rheum 2005, 52(5):1545-1554.
    • (2005) Arthritis Rheum , vol.52 , Issue.5 , pp. 1545-1554
    • Vega-Ostertag, M.1    Casper, K.2    Swerlick, R.3    Ferrara, D.4    Harris, E.N.5    Pierangeli, S.S.6
  • 19
    • 47749095519 scopus 로고    scopus 로고
    • Up-regulation of adhesion molecule expression and induction of TNF-alpha on vascular endothelial cells by antibody against human parvovirus B19 VP1 unique region protein
    • Tzang B.S., Tsai C.C., Chiu C.C., Shi J.Y., Hsu T.C. Up-regulation of adhesion molecule expression and induction of TNF-alpha on vascular endothelial cells by antibody against human parvovirus B19 VP1 unique region protein. Clin Chim Acta 2008, 395(1-2):77-83.
    • (2008) Clin Chim Acta , vol.395 , Issue.1-2 , pp. 77-83
    • Tzang, B.S.1    Tsai, C.C.2    Chiu, C.C.3    Shi, J.Y.4    Hsu, T.C.5
  • 20
    • 0035673283 scopus 로고    scopus 로고
    • Statins prevent endothelial cell activation induced by antiphospholipid (anti-beta2-glycoprotein I) antibodies: effect on the proadhesive and proinflammatory phenotype
    • Meroni P.L., Raschi E., Testoni C., Tincani A., Balestrieri G., Molteni R., et al. Statins prevent endothelial cell activation induced by antiphospholipid (anti-beta2-glycoprotein I) antibodies: effect on the proadhesive and proinflammatory phenotype. Arthritis Rheum 2001, 44(12):2870-2878.
    • (2001) Arthritis Rheum , vol.44 , Issue.12 , pp. 2870-2878
    • Meroni, P.L.1    Raschi, E.2    Testoni, C.3    Tincani, A.4    Balestrieri, G.5    Molteni, R.6
  • 21
    • 77953624768 scopus 로고    scopus 로고
    • Effects of polyclonal IgG derived from patients with different clinical types of the antiphospholipid syndrome on monocyte signaling pathways
    • Lambrianides A., Carroll C.J., Pierangeli S.S., Pericleous C., Branch W., Rice J., et al. Effects of polyclonal IgG derived from patients with different clinical types of the antiphospholipid syndrome on monocyte signaling pathways. J Immunol 2010, 184(12):6622-6628.
    • (2010) J Immunol , vol.184 , Issue.12 , pp. 6622-6628
    • Lambrianides, A.1    Carroll, C.J.2    Pierangeli, S.S.3    Pericleous, C.4    Branch, W.5    Rice, J.6
  • 22
    • 68549101842 scopus 로고    scopus 로고
    • The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration
    • Liberati A., Altman D.G., Tetzlaff J., Mulrow C., Gotzsche P.C., Ioannidis J.P., et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 2009, 339:b2700.
    • (2009) BMJ , vol.339
    • Liberati, A.1    Altman, D.G.2    Tetzlaff, J.3    Mulrow, C.4    Gotzsche, P.C.5    Ioannidis, J.P.6
  • 23
    • 33344458573 scopus 로고    scopus 로고
    • International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)
    • Miyakis S., Lockshin M.D., Atsumi T., Branch D.W., Brey R.L., Cervera R., et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 2006, 4(2):295-306.
    • (2006) J Thromb Haemost , vol.4 , Issue.2 , pp. 295-306
    • Miyakis, S.1    Lockshin, M.D.2    Atsumi, T.3    Branch, D.W.4    Brey, R.L.5    Cervera, R.6
  • 24
    • 78650831137 scopus 로고    scopus 로고
    • Toll-like receptor (TLR)-4 mediates anti-beta2GPI/beta2GPI-induced tissue factor expression in THP-1 cells
    • Zhou H., Yan Y., Xu G., Zhou B., Wen H., Guo D., et al. Toll-like receptor (TLR)-4 mediates anti-beta2GPI/beta2GPI-induced tissue factor expression in THP-1 cells. Clin Exp Immunol 2011, 163(2):189-198.
    • (2011) Clin Exp Immunol , vol.163 , Issue.2 , pp. 189-198
    • Zhou, H.1    Yan, Y.2    Xu, G.3    Zhou, B.4    Wen, H.5    Guo, D.6
  • 25
    • 34547733912 scopus 로고    scopus 로고
    • Anti-beta(2)-glycoprotein I antibodies induce monocyte release of tumor necrosis factor alpha and tissue factor by signal transduction pathways involving lipid rafts
    • Sorice M., Longo A., Capozzi A., Garofalo T., Misasi R., Alessandri C., et al. Anti-beta(2)-glycoprotein I antibodies induce monocyte release of tumor necrosis factor alpha and tissue factor by signal transduction pathways involving lipid rafts. Arthritis Rheum 2007, 56(8):2687-2697.
    • (2007) Arthritis Rheum , vol.56 , Issue.8 , pp. 2687-2697
    • Sorice, M.1    Longo, A.2    Capozzi, A.3    Garofalo, T.4    Misasi, R.5    Alessandri, C.6
  • 26
    • 79956312573 scopus 로고    scopus 로고
    • Toll-like receptor 2 mediates the activation of human monocytes and endothelial cells by antiphospholipid antibodies
    • Satta N., Kruithof E.K., Fickentscher C., Dunoyer-Geindre S., Boehlen F., Reber G., et al. Toll-like receptor 2 mediates the activation of human monocytes and endothelial cells by antiphospholipid antibodies. Blood 2011, 117(20):5523-5531.
    • (2011) Blood , vol.117 , Issue.20 , pp. 5523-5531
    • Satta, N.1    Kruithof, E.K.2    Fickentscher, C.3    Dunoyer-Geindre, S.4    Boehlen, F.5    Reber, G.6
  • 27
    • 33846899419 scopus 로고    scopus 로고
    • The role of TLR2 in the inflammatory activation of mouse fibroblasts by human antiphospholipid antibodies
    • Satta N., Dunoyer-Geindre S., Reber G., Fish R.J., Boehlen F., Kruithof E.K., et al. The role of TLR2 in the inflammatory activation of mouse fibroblasts by human antiphospholipid antibodies. Blood 2007, 109(4):1507-1514.
    • (2007) Blood , vol.109 , Issue.4 , pp. 1507-1514
    • Satta, N.1    Dunoyer-Geindre, S.2    Reber, G.3    Fish, R.J.4    Boehlen, F.5    Kruithof, E.K.6
  • 28
    • 77949262403 scopus 로고    scopus 로고
    • Human antiphospholipid antibodies induce TNFalpha in monocytes via Toll-like receptor 8
    • Doring Y., Hurst J., Lorenz M., Prinz N., Clemens N., Drechsler M.D., et al. Human antiphospholipid antibodies induce TNFalpha in monocytes via Toll-like receptor 8. Immunobiology 2010, 215(3):230-241.
    • (2010) Immunobiology , vol.215 , Issue.3 , pp. 230-241
    • Doring, Y.1    Hurst, J.2    Lorenz, M.3    Prinz, N.4    Clemens, N.5    Drechsler, M.D.6
  • 29
    • 67650067301 scopus 로고    scopus 로고
    • TLR7 and TLR8 ligands and antiphospholipid antibodies show synergistic effects on the induction of IL-1beta and caspase-1 in monocytes and dendritic cells
    • Hurst J., Prinz N., Lorenz M., Bauer S., Chapman J., Lackner K.J., et al. TLR7 and TLR8 ligands and antiphospholipid antibodies show synergistic effects on the induction of IL-1beta and caspase-1 in monocytes and dendritic cells. Immunobiology 2009, 214(8):683-691.
    • (2009) Immunobiology , vol.214 , Issue.8 , pp. 683-691
    • Hurst, J.1    Prinz, N.2    Lorenz, M.3    Bauer, S.4    Chapman, J.5    Lackner, K.J.6
  • 30
    • 34548079756 scopus 로고    scopus 로고
    • Role of p38 mitogen-activated protein kinase in antiphospholipid antibody-mediated thrombosis and endothelial cell activation
    • Vega-Ostertag M.E., Ferrara D.E., Romay-Penabad Z., Liu X., Taylor W.R., Colden-Stanfield M., et al. Role of p38 mitogen-activated protein kinase in antiphospholipid antibody-mediated thrombosis and endothelial cell activation. J Thromb Haemost 2007, 5(9):1828-1834.
    • (2007) J Thromb Haemost , vol.5 , Issue.9 , pp. 1828-1834
    • Vega-Ostertag, M.E.1    Ferrara, D.E.2    Romay-Penabad, Z.3    Liu, X.4    Taylor, W.R.5    Colden-Stanfield, M.6
  • 31
    • 17644365392 scopus 로고    scopus 로고
    • Role of reactive oxygen species and p38 MAPK in the induction of the pro-adhesive endothelial state mediated by IgG from patients with anti-phospholipid syndrome
    • Simoncini S., Sapet C., Camoin-Jau L., Bardin N., Harle J.R., Sampol J., et al. Role of reactive oxygen species and p38 MAPK in the induction of the pro-adhesive endothelial state mediated by IgG from patients with anti-phospholipid syndrome. Int Immunol 2005, 17(4):489-500.
    • (2005) Int Immunol , vol.17 , Issue.4 , pp. 489-500
    • Simoncini, S.1    Sapet, C.2    Camoin-Jau, L.3    Bardin, N.4    Harle, J.R.5    Sampol, J.6
  • 32
    • 28044433910 scopus 로고    scopus 로고
    • Antiphospholipid antibodies, thrombin and LPS activate brain endothelial cells and Ras-dependent pathways through distinct mechanisms
    • Aronovich R., Gurwitz D., Kloog Y., Chapman J. Antiphospholipid antibodies, thrombin and LPS activate brain endothelial cells and Ras-dependent pathways through distinct mechanisms. Immunobiology 2005, 210(10):781-788.
    • (2005) Immunobiology , vol.210 , Issue.10 , pp. 781-788
    • Aronovich, R.1    Gurwitz, D.2    Kloog, Y.3    Chapman, J.4
  • 33
    • 8344267910 scopus 로고    scopus 로고
    • The p38 mitogen-activated protein kinase (MAPK) pathway mediates induction of the tissue factor gene in monocytes stimulated with human monoclonal anti-beta2Glycoprotein I antibodies
    • Bohgaki M., Atsumi T., Yamashita Y., Yasuda S., Sakai Y., Furusaki A., et al. The p38 mitogen-activated protein kinase (MAPK) pathway mediates induction of the tissue factor gene in monocytes stimulated with human monoclonal anti-beta2Glycoprotein I antibodies. Int Immunol 2004, 16(11):1633-1641.
    • (2004) Int Immunol , vol.16 , Issue.11 , pp. 1633-1641
    • Bohgaki, M.1    Atsumi, T.2    Yamashita, Y.3    Yasuda, S.4    Sakai, Y.5    Furusaki, A.6
  • 34
    • 78751699828 scopus 로고    scopus 로고
    • Plasma gelsolin facilitates interaction between beta2 glycoprotein I and alpha5beta1 integrin
    • Bohgaki M., Matsumoto M., Atsumi T., Kondo T., Yasuda S., Horita T., et al. Plasma gelsolin facilitates interaction between beta2 glycoprotein I and alpha5beta1 integrin. J Cell Mol Med 2011, 15(1):141-151.
    • (2011) J Cell Mol Med , vol.15 , Issue.1 , pp. 141-151
    • Bohgaki, M.1    Matsumoto, M.2    Atsumi, T.3    Kondo, T.4    Yasuda, S.5    Horita, T.6
  • 35
    • 33750091036 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression in monocytes from patients with primary antiphospholipid syndrome
    • Cuadrado M.J., Buendia P., Velasco F., Aguirre M.A., Barbarroja N., Torres L.A., et al. Vascular endothelial growth factor expression in monocytes from patients with primary antiphospholipid syndrome. J Thromb Haemost 2006, 4(11):2461-2469.
    • (2006) J Thromb Haemost , vol.4 , Issue.11 , pp. 2461-2469
    • Cuadrado, M.J.1    Buendia, P.2    Velasco, F.3    Aguirre, M.A.4    Barbarroja, N.5    Torres, L.A.6
  • 36
  • 37
    • 77449133188 scopus 로고    scopus 로고
    • {beta}2 Glycoprotein I ({beta}2GPI) binds platelet factor 4 (PF4): implications for the pathogenesis of antiphospholipid syndrome
    • Sikara M.P., Routsias J.G., Samiotaki M., Panayotou G., Moutsopoulos H.M., Vlachoyiannopoulos P.G. {beta}2 Glycoprotein I ({beta}2GPI) binds platelet factor 4 (PF4): implications for the pathogenesis of antiphospholipid syndrome. Blood 2010, 115(3):713-723.
    • (2010) Blood , vol.115 , Issue.3 , pp. 713-723
    • Sikara, M.P.1    Routsias, J.G.2    Samiotaki, M.3    Panayotou, G.4    Moutsopoulos, H.M.5    Vlachoyiannopoulos, P.G.6
  • 38
    • 33747023522 scopus 로고    scopus 로고
    • Anti-beta2-glycoprotein I antibodies in complex with beta2-glycoprotein I can activate platelets in a dysregulated manner via glycoprotein Ib-IX-V
    • Shi T., Giannakopoulos B., Yan X., Yu P., Berndt M.C., Andrews R.K., et al. Anti-beta2-glycoprotein I antibodies in complex with beta2-glycoprotein I can activate platelets in a dysregulated manner via glycoprotein Ib-IX-V. Arthritis Rheum 2006, 54(8):2558-2567.
    • (2006) Arthritis Rheum , vol.54 , Issue.8 , pp. 2558-2567
    • Shi, T.1    Giannakopoulos, B.2    Yan, X.3    Yu, P.4    Berndt, M.C.5    Andrews, R.K.6
  • 40
    • 77958183207 scopus 로고    scopus 로고
    • Vimentin/cardiolipin complex as a new antigenic target of the antiphospholipid syndrome
    • Ortona E., Capozzi A., Colasanti T., Conti F., Alessandri C., Longo A., et al. Vimentin/cardiolipin complex as a new antigenic target of the antiphospholipid syndrome. Blood 2010, 116(16):2960-2967.
    • (2010) Blood , vol.116 , Issue.16 , pp. 2960-2967
    • Ortona, E.1    Capozzi, A.2    Colasanti, T.3    Conti, F.4    Alessandri, C.5    Longo, A.6
  • 42
    • 0036847630 scopus 로고    scopus 로고
    • NFkappaB is an essential intermediate in the activation of endothelial cells by anti-beta(2)-glycoprotein 1 antibodies
    • Dunoyer-Geindre S., de Moerloose P., Galve-de Rochemonteix B., Reber G., Kruithof E.K. NFkappaB is an essential intermediate in the activation of endothelial cells by anti-beta(2)-glycoprotein 1 antibodies. Thromb Haemost 2002, 88(5):851-857.
    • (2002) Thromb Haemost , vol.88 , Issue.5 , pp. 851-857
    • Dunoyer-Geindre, S.1    de Moerloose, P.2    Galve-de Rochemonteix, B.3    Reber, G.4    Kruithof, E.K.5
  • 43
    • 0033832202 scopus 로고    scopus 로고
    • Functional analyses of patient-derived IgG monoclonal anticardiolipin antibodies using in vivo thrombosis and in vivo microcirculation models
    • Pierangeli S.S., Liu X., Espinola R., Olee T., Zhu M., Harris N.E., et al. Functional analyses of patient-derived IgG monoclonal anticardiolipin antibodies using in vivo thrombosis and in vivo microcirculation models. Thromb Haemost 2000, 84(3):388-395.
    • (2000) Thromb Haemost , vol.84 , Issue.3 , pp. 388-395
    • Pierangeli, S.S.1    Liu, X.2    Espinola, R.3    Olee, T.4    Zhu, M.5    Harris, N.E.6
  • 44
    • 65249133581 scopus 로고    scopus 로고
    • Thrombin binding predicts the effects of sequence changes in a human monoclonal antiphospholipid antibody on its in vivo biologic actions
    • Giles I., Pericleous C., Liu X., Ehsanullah J., Clarke L., Brogan P., et al. Thrombin binding predicts the effects of sequence changes in a human monoclonal antiphospholipid antibody on its in vivo biologic actions. J Immunol 2009, 182(8):4836-4843.
    • (2009) J Immunol , vol.182 , Issue.8 , pp. 4836-4843
    • Giles, I.1    Pericleous, C.2    Liu, X.3    Ehsanullah, J.4    Clarke, L.5    Brogan, P.6
  • 45
  • 47
    • 51849152401 scopus 로고    scopus 로고
    • Proteomic analysis in monocytes of antiphospholipid syndrome patients: Deregulation of proteins related to the development of thrombosis
    • López-Pedrera C., Cuadrado M., Herández V., Buendïa P., Aguirre M., Barbarroja N., et al. Proteomic analysis in monocytes of antiphospholipid syndrome patients: Deregulation of proteins related to the development of thrombosis. Arthritis Rheum 2008, 58(9):2835-2844.
    • (2008) Arthritis Rheum , vol.58 , Issue.9 , pp. 2835-2844
    • López-Pedrera, C.1    Cuadrado, M.2    Herández, V.3    Buendïa, P.4    Aguirre, M.5    Barbarroja, N.6
  • 48
    • 59649127763 scopus 로고    scopus 로고
    • Inhibition of p38: has the fat lady sung?
    • Genovese M.C. Inhibition of p38: has the fat lady sung?. Arthritis Rheum 2009, 60(2):317-320.
    • (2009) Arthritis Rheum , vol.60 , Issue.2 , pp. 317-320
    • Genovese, M.C.1
  • 49
    • 59649114148 scopus 로고    scopus 로고
    • Evaluation of the efficacy and safety of pamapimod, a p38 MAP kinase inhibitor, in a double-blind, methotrexate-controlled study of patients with active rheumatoid arthritis
    • Cohen S.B., Cheng T.T., Chindalore V., Damjanov N., Burgos-Vargas R., Delora P., et al. Evaluation of the efficacy and safety of pamapimod, a p38 MAP kinase inhibitor, in a double-blind, methotrexate-controlled study of patients with active rheumatoid arthritis. Arthritis Rheum 2009, 60(2):335-344.
    • (2009) Arthritis Rheum , vol.60 , Issue.2 , pp. 335-344
    • Cohen, S.B.1    Cheng, T.T.2    Chindalore, V.3    Damjanov, N.4    Burgos-Vargas, R.5    Delora, P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.