Small molecules dorsomorphin and LDN-193189 inhibit myostatin/GDF8 signaling and promote functional myoblast differentiation

Journal of Biological Chemistry

Volumn 290, Issue 6, 2015, Pages 3390-3404

  Horbelt, Daniel ^a   Boergermann, Jan H ^a   Chaikuad, Apirat ^b   Alfano, Ivan ^b   Williams, Eleanor ^b   Lukonin, Ilya ^a   Timmel, Tobias ^c   Bullock, Alex N ^b   Knaus, Petra ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c Experimental and Clinical Research Center   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTAL STRUCTURE; MOLECULES;

GROWTH FACTOR; LIVE CELL MICROSCOPY; MYOGENESIS; MYOGENIC TRANSCRIPTION; MYOSTATIN; NEGATIVE REGULATORS; POTENT INHIBITOR; SMALL MOLECULES;

SIGNALING;

4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; 6 [4 (1 PIPERAZINYL)PHENYL] 3 (4 QUINOLINYL)PYRAZOLO[1,5 A]PYRIMIDINE; BONE MORPHOGENETIC PROTEIN RECEPTOR 1; DORSOMORPHIN; MYOSTATIN; PHOSPHOPROTEIN; PROCOLLAGEN C PROTEINASE; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSCRIPTION FACTOR; (6-(4-(2-PIPERIDIN-1-YLETHOXY)PHENYL))-3-PYRIDIN-4-YLPYRAZOLO(1,5-A)PYRIMIDINE; ACTIVIN RECEPTOR 2; ACTIVIN RECEPTOR TYPE II-A; PROTEIN BINDING; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE;

ARTICLE; CELL DIFFERENTIATION; CRYSTAL STRUCTURE; CRYSTALLIZATION; HUMAN; IC50; IN VITRO STUDY; IN VIVO STUDY; ISOTHERMAL TITRATION CALORIMETRY; MUSCLE DEVELOPMENT; MYOBLAST; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; WESTERN BLOTTING; AMINO ACID SEQUENCE; ANIMAL; BINDING SITE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; METABOLISM; MOLECULAR GENETICS; MOUSE; SF9 CELL LINE; SIGNAL TRANSDUCTION; SPODOPTERA;

ACTIVIN RECEPTORS, TYPE II; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL DIFFERENTIATION; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MYOBLASTS; MYOSTATIN; PROTEIN BINDING; PYRAZOLES; PYRIMIDINES; SF9 CELLS; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; SPODOPTERA; TRANSCRIPTION FACTORS;

EID: 84922390977     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.604397     Document Type: Article

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