Myostatin stimulates, not inihibits, C2C12 myoblast proliferation

Endocrinology

Volumn 155, Issue 3, 2014, Pages 670-675

  Rodgers, Buel D ^a   Wiedeback, Benjamin D ^a   Hoversten, Knut E ^a   Jackson, Melissa F ^a   Walker, Ryan G ^b   Thompson, Thomas B ^b  

^a WASHINGTON STATE UNIVERSITY   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; MYOSTATIN; RECOMBINANT MYOSTATIN; RECOMBINANT PROTEIN; SB 505142; SMAD2 PROTEIN; SOMATOMEDIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOLOGICAL ACTIVITY; CELL DENSITY; CELL DIFFERENTIATION; CELL IMMORTALIZATION; CELL PROLIFERATION; CELL STRAIN C2C12; CULTURE MEDIUM; EUKARYOTE; MOUSE; MYOBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ANIMALS; CELL LINE; CELL PROLIFERATION; DIMERIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; INSULIN-LIKE GROWTH FACTOR I; LIGANDS; MICE; MYOBLASTS; MYOSTATIN; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84896816315     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2013-2107     Document Type: Article

References (29)

1. Rodgers BD, Garikipati DK. Clinical, agricultural, and evolutionary biology of myostatin: a comparative review. Endocr Rev. 2008; 29(5):513-534.
2. Bradley L, Yaworsky PJ, Walsh FS. Myostatin as a therapeutic target for musculoskeletal disease. Cell Mol Life Sci. 2008;65(14):2119-2124.
3. Han HQ, Mitch WE. Targeting the myostatin signaling pathway to treat muscle wasting diseases. Curr Opin Support Palliat Care. 2011;5(4):334-341.
4. Yaffe D, Saxel O. Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle. Nature. 1977; 270(5639):725-727. (Pubitemid 8239246)
5. Langley B, Thomas M, Bishop A, Sharma M, Gilmour S, Kambadur R. Myostatin inhibits myoblast differentiation by down-regulating MyoD expression. J Biol Chem. 2002;277:49831-49840. (Pubitemid 36014431)
6. Joulia D, Bernardi H, Garandel V, Rabenoelina F, Vernus B, Cabello G. Mechanisms involved in the inhibition of myoblast proliferation and differentiation by myostatin. Exp Cell Res. 2003;286(2):263-275. (Pubitemid 36566439)
7. Taylor WE, Bhasin S, Artaza J, et al. Myostatin inhibits cell proliferation and protein synthesis in C2C12 muscle cells. Am J Physiol Endocrinol Metab. 2001;280(2):E221-E228.
8. Thomas M, Langley B, Berry C, et al. Myostatin, a negative regulator of muscle growth, functions by inhibiting myoblast proliferation. J Biol Chem. 2000;275(51):40235-40243. (Pubitemid 32064654)
9. Manceau M, Gros J, Savage K, et al. Myostatin promotes the terminal differentiation of embryonic muscle progenitors. Genes Dev. 2008;22(5):668-681. (Pubitemid 351342438)
10. Garikipati DK, Rodgers BD. Myostatin stimulates myosatellite cell differentiation in a novel model system: evidence for gene subfunctionalization. Am J Physiol Regul Integr Comp Physiol. 2012; 302(9):R1059-R1066.
11. Garikipati DK, Rodgers BD. Myostatin inhibits myosatellite cell proliferation and consequently activates differentiation: evidence for endocrine-regulated transcript processing. J Endocrinol. 2012; 215(1):177-187.
12. Sato F, Kurokawa M, Yamauchi N, Hattori MA. Gene silencing of myostatin in differentiation of chicken embryonic myoblasts by small interfering RNA. Am J Physiol Cell Physiol. 2006;291(3): C538-C545. (Pubitemid 44343637)
13. McCroskery S, Thomas M, Maxwell L, Sharma M, Kambadur R. Myostatin negatively regulates satellite cell activation and self-renewal. J Cell Biol. 2003;162(6):1135-1147. (Pubitemid 37174195)
14. Ge X, McFarlane C, Vajjala A, et al. Smad3 signaling is required for satellite cell function and myogenic differentiation of myoblasts. Cell Res. 2011;21(11):1591-1604.
15. Cash JN, Rejon CA, McPherron AC, Bernard DJ, Thompson TB. The structure of myostatin:follistatin 288: insights into receptor utilization and heparin binding. EMBO J. 2009;28(17):2662-2676.
16. Schabort EJ, van der Merwe M, Loos B, Moore FP, Niesler CU. TGF-β's delay skeletal muscle progenitor cell differentiation in an isoform-independent manner. Exp Cell Res. 2009;315(3):373-384.
17. Haugk KL, Roeder RA, Garber MJ, Schelling GT. Regulation of muscle cell proliferation by extracts from crushed muscle. J Anim Sci. 1995;73(7):1972-1981.
18. Quinn LS, Steinmetz B, Maas A, Ong L, Kaleko M. Type-1 insulin-like growth factor receptor overexpression produces dual effects on myoblast proliferation and differentiation. J Cell Physiol. 1994; 159(3):387-398. (Pubitemid 24188978)
19. Attisano L, Wrana JL. Signal transduction by the TGF-β superfamily. Science. 2002;296(5573):1646-1647.
20. Lokireddy S, McFarlane C, Ge X, et al. Myostatin induces degradation of sarcomeric proteins through a Smad3 signaling mechanism during skeletal muscle wasting. Mol Endocrinol. 2011;25(11): 1936-1949.
21. Cash JN, Angerman EB, Kirby RJ, et al. Development of a small-molecule screening method for inhibitors of cellular response to myostatin and activin a. J Biomol Screen. 2013;18(7):837-844.
22. Ríos R, Carneiro I, Arce VM, Devesa J. Myostatin is an inhibitor of myogenic differentiation. Am J Physiol Cell Physiol. 2002;282(5): C993-C999. (Pubitemid 34663107)
23. Allen RE, Boxhorn LK. Inhibition of skeletal muscle satellite cell differentiation by transforming growth factor-β. J Cell Physiol. 1987;133(3):567-572. (Pubitemid 18014268)
24. Allen RE, Boxhorn LK. Regulation of skeletal muscle satellite cell proliferation and differentiation by transforming growth factor-β, insulin-like growth factor I, and fibroblast growth factor. J Cell Physiol. 1989;138(2):311-315. (Pubitemid 19061212)
25. Greene EA, Allen RE. Growth factor regulation of bovine satellite cell growth in vitro. J Anim Sci. 1991;69(1):146-152.
26. Hathaway MR, Hembree JR, Pampusch MS, Dayton WR. Effect of transforming growth factorß-1 on ovine satellite cell proliferation and fusion. J Cell Physiol. 1991;146(3):435-441. (Pubitemid 21910069)
27. Li Y, Foster W, Deasy BM, et al. Transforming growth factor-β1 induces the differentiation of myogenic cells into fibrotic cells in injured skeletal muscle: a key event in muscle fibrogenesis. Am J Pathol. 2004;164(3):1007-1019. (Pubitemid 38235482)
28. Zhu J, Li Y, Shen W, et al. Relationships between transforming growth factor-β1, myostatin, and decorin: implications for skeletal muscle fibrosis. J Biol Chem. 2007;282(35):25852-25863. (Pubitemid 47372849)
29. Li ZB, Kollias HD, Wagner KR. Myostatin directly regulates skeletal muscle fibrosis. J Biol Chem. 2008;283(28):19371-19378.