Sesamin suppresses STZ induced INS-1 cell apoptosis through inhibition of NF-κB activation and regulation of Bcl-2 family protein expression

European Journal of Pharmacology

Volumn 750, Issue , 2015, Pages 52-58

  Zheng, Shuguo ^a   Zhao, Mengqiu ^a   Ren, Younan ^a   Wu, Yuanjie ^b   Yang, Jieren ^a  

^a WANNAN MEDICAL COLLEGE   (China)

^b ANHUI UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Apoptosis; Diabetes; INS 1 cells; Reactive oxygen species; Sesamin

Indexed keywords

I KAPPA B; LIPOCORTIN 5; MALONALDEHYDE; PROPIDIUM IODIDE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SESAMIN; STREPTOZOCIN; 1,3 DIOXOLANE DERIVATIVE; ANTIOXIDANT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; LIGNAN;

ANIMAL CELL; ANTIDIABETIC ACTIVITY; ANTIOXIDANT ASSAY; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFICACY; DRUG INHIBITION; DRUG MECHANISM; FLOW CYTOMETRY; INS 1 CELL LINE; INSULIN RELEASE; LIPID PEROXIDATION; MTT ASSAY; NONHUMAN; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING; ANIMAL; CELL LINE; CELL SURVIVAL; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; INTRACELLULAR SPACE; METABOLISM; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; SECRETION (PROCESS); SIGNAL TRANSDUCTION;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL LINE; CELL SURVIVAL; DIOXOLES; GENE EXPRESSION REGULATION; INSULIN; INSULIN-SECRETING CELLS; INTRACELLULAR SPACE; LIGNANS; MALONDIALDEHYDE; NF-KAPPA B; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; STREPTOZOCIN;

EID: 84922371203     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2015.01.031     Document Type: Article

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