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Volumn 112, Issue 5, 2015, Pages E478-E486

Osteocytes mediate the anabolic actions of canonical Wnt/β-catenin signaling in bone

Author keywords

Beta catenin; Bone anabolism; Canonical Wnt; Notch signaling; Osteocytes

Indexed keywords

ALKALINE PHOSPHATASE; BETA CATENIN; COLONY STIMULATING FACTOR 1; CYTOKINE; NOTCH RECEPTOR; OSTEOCALCIN; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PROCOLLAGEN; PROCOLLAGEN TYPE 1 AMINOPROPEPTIDE; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG; WNT PROTEIN;

EID: 84922309760     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1409857112     Document Type: Article
Times cited : (234)

References (51)
  • 1
    • 84885000875 scopus 로고    scopus 로고
    • Public health impact of osteoporosis
    • Cauley JA (2013) Public health impact of osteoporosis. J Gerontol A Biol Sci Med Sci 68(10):1243-1251.
    • (2013) J Gerontol A Biol Sci Med Sci , vol.68 , Issue.10 , pp. 1243-1251
    • Cauley, J.A.1
  • 2
    • 79251493453 scopus 로고    scopus 로고
    • The amazing osteocyte
    • Bonewald LF (2011) The amazing osteocyte. J Bone Miner Res 26(2):229-238.
    • (2011) J Bone Miner Res , vol.26 , Issue.2 , pp. 229-238
    • Bonewald, L.F.1
  • 3
    • 84893813155 scopus 로고    scopus 로고
    • Osteocyte-driven bone remodeling
    • Bellido T (2014) Osteocyte-driven bone remodeling. Calcif Tissue Int 94(1):25-34.
    • (2014) Calcif Tissue Int , vol.94 , Issue.1 , pp. 25-34
    • Bellido, T.1
  • 4
    • 84873558051 scopus 로고    scopus 로고
    • WNT signaling in bone homeostasis and disease: From human mutations to treatments
    • Baron R, Kneissel M (2013) WNT signaling in bone homeostasis and disease: From human mutations to treatments. Nat Med 19(2):179-192.
    • (2013) Nat Med , vol.19 , Issue.2 , pp. 179-192
    • Baron, R.1    Kneissel, M.2
  • 5
    • 0032406715 scopus 로고    scopus 로고
    • Mechanisms of Wnt signaling in development
    • Wodarz A, Nusse R (1998) Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol 14:59-88.
    • (1998) Annu Rev Cell Dev Biol , vol.14 , pp. 59-88
    • Wodarz, A.1    Nusse, R.2
  • 6
    • 18044386744 scopus 로고    scopus 로고
    • LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development
    • Gong Y, et al.; Osteoporosis-Pseudoglioma Syndrome Collaborative Group (2001) LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 107(4):513-523.
    • (2001) Cell , vol.107 , Issue.4 , pp. 513-523
    • Gong, Y.1
  • 7
    • 0037118285 scopus 로고    scopus 로고
    • High bone density due to a mutation in LDL-receptor-related protein 5
    • Boyden LM, et al. (2002) High bone density due to a mutation in LDL-receptor-related protein 5. N Engl J Med 346(20):1513-1521.
    • (2002) N Engl J Med , vol.346 , Issue.20 , pp. 1513-1521
    • Boyden, L.M.1
  • 8
    • 0036138175 scopus 로고    scopus 로고
    • A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait
    • Little RD, et al. (2002) A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait. Am J Hum Genet 70(1):11-19.
    • (2002) Am J Hum Genet , vol.70 , Issue.1 , pp. 11-19
    • Little, R.D.1
  • 9
    • 13444302715 scopus 로고    scopus 로고
    • Sequential roles of Hedgehog and Wnt signaling in osteoblast development
    • Hu H, et al. (2005) Sequential roles of Hedgehog and Wnt signaling in osteoblast development. Development 132(1):49-60.
    • (2005) Development , vol.132 , Issue.1 , pp. 49-60
    • Hu, H.1
  • 10
    • 17844372752 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis
    • Day TF, Guo X, Garrett-Beal L, Yang Y (2005) Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis. Dev Cell 8(5):739-750.
    • (2005) Dev Cell , vol.8 , Issue.5 , pp. 739-750
    • Day, T.F.1    Guo, X.2    Garrett-Beal, L.3    Yang, Y.4
  • 11
    • 17844363974 scopus 로고    scopus 로고
    • Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes
    • Hill TP, Spöter D, Taketo MM, Birchmeier W, Hartmann C (2005) Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes. Dev Cell 8(5):727-738.
    • (2005) Dev Cell , vol.8 , Issue.5 , pp. 727-738
    • Hill, T.P.1    Spöter, D.2    Taketo, M.M.3    Birchmeier, W.4    Hartmann, C.5
  • 12
    • 33748768971 scopus 로고    scopus 로고
    • Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors
    • Rodda SJ, McMahon AP (2006) Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors. Development 133(16):3231-3244.
    • (2006) Development , vol.133 , Issue.16 , pp. 3231-3244
    • Rodda, S.J.1    McMahon, A.P.2
  • 13
    • 20244373613 scopus 로고    scopus 로고
    • Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation
    • Glass DA, 2nd, et al. (2005) Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell 8(5):751-764.
    • (2005) Dev Cell , vol.8 , Issue.5 , pp. 751-764
    • Glass, D.A.1
  • 14
    • 20444376156 scopus 로고    scopus 로고
    • Essential role of beta-catenin in postnatal bone acquisition
    • Holmen SL, et al. (2005) Essential role of beta-catenin in postnatal bone acquisition. J Biol Chem 280(22):21162-21168.
    • (2005) J Biol Chem , vol.280 , Issue.22 , pp. 21162-21168
    • Holmen, S.L.1
  • 15
    • 77953407742 scopus 로고    scopus 로고
    • Osteocyte Wnt/beta-catenin signaling is required for normal bone homeostasis
    • Kramer I, et al. (2010) Osteocyte Wnt/beta-catenin signaling is required for normal bone homeostasis. Mol Cell Biol 30(12):3071-3085.
    • (2010) Mol Cell Biol , vol.30 , Issue.12 , pp. 3071-3085
    • Kramer, I.1
  • 16
    • 84893917461 scopus 로고    scopus 로고
    • Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts
    • Kode A, et al. (2014) Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts. Nature 506(7487):240-244.
    • (2014) Nature , vol.506 , Issue.7487 , pp. 240-244
    • Kode, A.1
  • 17
    • 26844521277 scopus 로고    scopus 로고
    • Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: A novel mechanism for hormonal control of osteoblastogenesis
    • Bellido T, et al. (2005) Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: A novel mechanism for hormonal control of osteoblastogenesis. Endocrinology 146(11):4577-4583.
    • (2005) Endocrinology , vol.146 , Issue.11 , pp. 4577-4583
    • Bellido, T.1
  • 18
    • 51449111663 scopus 로고    scopus 로고
    • Control of bone mass and remodeling by PTH receptor signaling in osteocytes
    • O'Brien CA, et al. (2008) Control of bone mass and remodeling by PTH receptor signaling in osteocytes. PLoS ONE 3(8):e2942.
    • (2008) PLoS ONE , vol.3 , Issue.8 , pp. e2942
    • O'Brien, C.A.1
  • 19
    • 79955578020 scopus 로고    scopus 로고
    • PTH receptor signaling in osteocytes governs periosteal bone formation and intracortical remodeling
    • Rhee Y, et al. (2011) PTH receptor signaling in osteocytes governs periosteal bone formation and intracortical remodeling. J Bone Miner Res 26(5):1035-1046.
    • (2011) J Bone Miner Res , vol.26 , Issue.5 , pp. 1035-1046
    • Rhee, Y.1
  • 20
    • 41949089764 scopus 로고    scopus 로고
    • Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin
    • Robling AG, et al. (2008) Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin. J Biol Chem 283(9):5866-5875.
    • (2008) J Biol Chem , vol.283 , Issue.9 , pp. 5866-5875
    • Robling, A.G.1
  • 21
    • 79960746000 scopus 로고    scopus 로고
    • Anabolic and catabolic regimens of human parathyroid hormone 1-34 elicit bone- and envelope-specific attenuation of skeletal effects in Sost-deficient mice
    • Robling AG, et al. (2011) Anabolic and catabolic regimens of human parathyroid hormone 1-34 elicit bone- and envelope-specific attenuation of skeletal effects in Sost-deficient mice. Endocrinology 152(8):2963-2975.
    • (2011) Endocrinology , vol.152 , Issue.8 , pp. 2963-2975
    • Robling, A.G.1
  • 22
    • 81155148568 scopus 로고    scopus 로고
    • Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading
    • Tu X, et al. (2012) Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading. Bone 50(1):209-217.
    • (2012) Bone , vol.50 , Issue.1 , pp. 209-217
    • Tu, X.1
  • 23
    • 18244403197 scopus 로고    scopus 로고
    • Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease
    • Balemans W, et al. (2002) Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease. J Med Genet 39(2):91-97.
    • (2002) J Med Genet , vol.39 , Issue.2 , pp. 91-97
    • Balemans, W.1
  • 24
    • 22244474640 scopus 로고    scopus 로고
    • Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease
    • Loots GG, et al. (2005) Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease. Genome Res 15(7):928-935.
    • (2005) Genome Res , vol.15 , Issue.7 , pp. 928-935
    • Loots, G.G.1
  • 25
    • 0035282968 scopus 로고    scopus 로고
    • Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)
    • Balemans W, et al. (2001) Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST). Hum Mol Genet 10(5):537-543.
    • (2001) Hum Mol Genet , vol.10 , Issue.5 , pp. 537-543
    • Balemans, W.1
  • 26
    • 0035089781 scopus 로고    scopus 로고
    • Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein
    • Brunkow ME, et al. (2001) Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein. Am J Hum Genet 68(3):577-589.
    • (2001) Am J Hum Genet , vol.68 , Issue.3 , pp. 577-589
    • Brunkow, M.E.1
  • 27
    • 34447526757 scopus 로고    scopus 로고
    • Novel LRP5 missense mutation in a patient with a high bone mass phenotype results in decreased DKK1-mediated inhibition of Wnt signaling
    • Balemans W, et al. (2007) Novel LRP5 missense mutation in a patient with a high bone mass phenotype results in decreased DKK1-mediated inhibition of Wnt signaling. J Bone Miner Res 22(5):708-716.
    • (2007) J Bone Miner Res , vol.22 , Issue.5 , pp. 708-716
    • Balemans, W.1
  • 28
    • 55249101949 scopus 로고    scopus 로고
    • The binding between sclerostin and LRP5 is altered by DKK1 and by high-bone mass LRP5 mutations
    • Balemans W, et al. (2008) The binding between sclerostin and LRP5 is altered by DKK1 and by high-bone mass LRP5 mutations. Calcif Tissue Int 82(6):445-453.
    • (2008) Calcif Tissue Int , vol.82 , Issue.6 , pp. 445-453
    • Balemans, W.1
  • 29
    • 84879159387 scopus 로고    scopus 로고
    • Sclerostin is expressed in osteoclasts from aged mice and reduces osteoclast-mediated stimulation of mineralization
    • Ota K, et al. (2013) Sclerostin is expressed in osteoclasts from aged mice and reduces osteoclast-mediated stimulation of mineralization. J Cell Biochem 114(8):1901-1907.
    • (2013) J Cell Biochem , vol.114 , Issue.8 , pp. 1901-1907
    • Ota, K.1
  • 30
    • 65549140672 scopus 로고    scopus 로고
    • Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer
    • Rodilla V, et al. (2009) Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer. Proc Natl Acad Sci USA 106(15):6315-6320.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.15 , pp. 6315-6320
    • Rodilla, V.1
  • 31
    • 33845892748 scopus 로고    scopus 로고
    • Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis
    • Estrach S, Ambler CA, Lo Celso C, Hozumi K, Watt FM(2006) Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis. Development 133(22):4427-4438.
    • (2006) Development , vol.133 , Issue.22 , pp. 4427-4438
    • Estrach, S.1    Ambler, C.A.2    Lo Celso, C.3    Hozumi, K.4    Watt, F.M.5
  • 32
    • 8644219672 scopus 로고    scopus 로고
    • LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis
    • Galceran J, Sustmann C, Hsu SC, Folberth S, Grosschedl R (2004) LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis. Genes Dev 18(22):2718-2723.
    • (2004) Genes Dev , vol.18 , Issue.22 , pp. 2718-2723
    • Galceran, J.1    Sustmann, C.2    Hsu, S.C.3    Folberth, S.4    Grosschedl, R.5
  • 33
    • 8644290897 scopus 로고    scopus 로고
    • WNT signaling, in synergy with T/TBX6, controls Notch signaling by regulating Dll1 expression in the presomitic mesoderm of mouse embryos
    • Hofmann M, et al. (2004) WNT signaling, in synergy with T/TBX6, controls Notch signaling by regulating Dll1 expression in the presomitic mesoderm of mouse embryos. Genes Dev 18(22):2712-2717.
    • (2004) Genes Dev , vol.18 , Issue.22 , pp. 2712-2717
    • Hofmann, M.1
  • 34
    • 84876705568 scopus 로고    scopus 로고
    • β-catenin promotes bone formation and suppresses bone resorption in postnatal growing mice
    • Chen J, Long F (2013) β-catenin promotes bone formation and suppresses bone resorption in postnatal growing mice. J Bone Miner Res 28(5):1160-1169.
    • (2013) J Bone Miner Res , vol.28 , Issue.5 , pp. 1160-1169
    • Chen, J.1    Long, F.2
  • 35
    • 84894467000 scopus 로고    scopus 로고
    • Deletion of a single β-catenin allele in osteocytes abolishes the bone anabolic response to loading
    • Javaheri B, et al. (2014) Deletion of a single β-catenin allele in osteocytes abolishes the bone anabolic response to loading. J Bone Miner Res 29(3):705-715.
    • (2014) J Bone Miner Res , vol.29 , Issue.3 , pp. 705-715
    • Javaheri, B.1
  • 36
    • 84868290353 scopus 로고    scopus 로고
    • Sclerostin and Dickkopf-1 as therapeutic targets in bone diseases
    • Ke HZ, Richards WG, Li X, Ominsky MS (2012) Sclerostin and Dickkopf-1 as therapeutic targets in bone diseases. Endocr Rev 33(5):747-783.
    • (2012) Endocr Rev , vol.33 , Issue.5 , pp. 747-783
    • Ke, H.Z.1    Richards, W.G.2    Li, X.3    Ominsky, M.S.4
  • 37
    • 80053518269 scopus 로고    scopus 로고
    • Sclerostin stimulates osteocyte support of osteoclast activity by a RANKL-dependent pathway
    • Wijenayaka AR, et al. (2011) Sclerostin stimulates osteocyte support of osteoclast activity by a RANKL-dependent pathway. PLoS ONE 6(10):e25900.
    • (2011) PLoS ONE , vol.6 , Issue.10 , pp. e25900
    • Wijenayaka, A.R.1
  • 38
    • 84905055066 scopus 로고    scopus 로고
    • Parathyroid hormone receptor signaling induces bone resorption in the adult skeleton by directly regulating the RANKL gene in osteocytes
    • Ben-awadh AN, et al. (2014) Parathyroid hormone receptor signaling induces bone resorption in the adult skeleton by directly regulating the RANKL gene in osteocytes. Endocrinology 155(8):2797-2809.
    • (2014) Endocrinology , vol.155 , Issue.8 , pp. 2797-2809
    • Ben-awadh, A.N.1
  • 39
    • 84885654460 scopus 로고    scopus 로고
    • Resorption controls bone anabolism driven by parathyroid hormone (PTH) receptor signaling in osteocytes
    • Rhee Y, et al. (2013) Resorption controls bone anabolism driven by parathyroid hormone (PTH) receptor signaling in osteocytes. J Biol Chem 288(41):29809-29820.
    • (2013) J Biol Chem , vol.288 , Issue.41 , pp. 29809-29820
    • Rhee, Y.1
  • 40
    • 80052303008 scopus 로고    scopus 로고
    • Parathyroid hormone receptor signaling in osteocytes increases the expression of fibroblast growth factor-23 in vitro and in vivo
    • Rhee Y, et al. (2011) Parathyroid hormone receptor signaling in osteocytes increases the expression of fibroblast growth factor-23 in vitro and in vivo. Bone 49(4):636-643.
    • (2011) Bone , vol.49 , Issue.4 , pp. 636-643
    • Rhee, Y.1
  • 41
    • 40449084522 scopus 로고    scopus 로고
    • Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation
    • Hilton MJ, et al. (2008) Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nat Med 14(3):306-314.
    • (2008) Nat Med , vol.14 , Issue.3 , pp. 306-314
    • Hilton, M.J.1
  • 42
    • 84859237565 scopus 로고    scopus 로고
    • Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1
    • Tu X, et al. (2012) Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1. PLoS Genet 8(3):e1002577.
    • (2012) PLoS Genet , vol.8 , Issue.3 , pp. e1002577
    • Tu, X.1
  • 43
    • 40449139405 scopus 로고    scopus 로고
    • Dimorphic effects of Notch signaling in bone homeostasis
    • Engin F, et al. (2008) Dimorphic effects of Notch signaling in bone homeostasis. Nat Med 14(3):299-305.
    • (2008) Nat Med , vol.14 , Issue.3 , pp. 299-305
    • Engin, F.1
  • 44
    • 77957671886 scopus 로고    scopus 로고
    • Osteosclerosis owing to Notch gain of function is solely Rbpj-dependent
    • Tao J, et al. (2010) Osteosclerosis owing to Notch gain of function is solely Rbpj-dependent. J Bone Miner Res 25(10):2175-2183.
    • (2010) J Bone Miner Res , vol.25 , Issue.10 , pp. 2175-2183
    • Tao, J.1
  • 45
    • 84872701013 scopus 로고    scopus 로고
    • Osteoblast lineage-specific effects of notch activation in the skeleton
    • Canalis E, Parker K, Feng JQ, Zanotti S (2013) Osteoblast lineage-specific effects of notch activation in the skeleton. Endocrinology 154(2):623-634.
    • (2013) Endocrinology , vol.154 , Issue.2 , pp. 623-634
    • Canalis, E.1    Parker, K.2    Feng, J.Q.3    Zanotti, S.4
  • 46
    • 84905673488 scopus 로고    scopus 로고
    • Temporal changes in systemic and local expression of bone turnover markers during six months of sclerostin antibody administration to ovariectomized rats
    • Stolina M, et al. (2014) Temporal changes in systemic and local expression of bone turnover markers during six months of sclerostin antibody administration to ovariectomized rats. Bone 67:305-313.
    • (2014) Bone , vol.67 , pp. 305-313
    • Stolina, M.1
  • 47
    • 84856160446 scopus 로고    scopus 로고
    • Cell autonomous requirement of connexin 43 for osteocyte survival: Consequences for endocortical resorption and periosteal bone formation
    • Bivi N, et al. (2012) Cell autonomous requirement of connexin 43 for osteocyte survival: Consequences for endocortical resorption and periosteal bone formation. J Bone Miner Res 27(2):374-389.
    • (2012) J Bone Miner Res , vol.27 , Issue.2 , pp. 374-389
    • Bivi, N.1
  • 48
    • 0033230616 scopus 로고    scopus 로고
    • Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene
    • Harada N, et al. (1999) Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene. EMBO J 18(21):5931-5942.
    • (1999) EMBO J , vol.18 , Issue.21 , pp. 5931-5942
    • Harada, N.1
  • 49
    • 2942711895 scopus 로고    scopus 로고
    • Skeletal unloading induces resistance to insulin-like growth factor-I (IGF-I) by inhibiting activation of the IGF-I signaling pathways
    • Sakata T, et al. (2004) Skeletal unloading induces resistance to insulin-like growth factor-I (IGF-I) by inhibiting activation of the IGF-I signaling pathways. J Bone Miner Res 19(3):436-446.
    • (2004) J Bone Miner Res , vol.19 , Issue.3 , pp. 436-446
    • Sakata, T.1
  • 50
    • 0032856213 scopus 로고    scopus 로고
    • Missing observations in bone histomorphometry on osteoporosis: Implications and suggestions for an approach
    • Hauge E, Mosekilde L, Melsen F (1999) Missing observations in bone histomorphometry on osteoporosis: Implications and suggestions for an approach. Bone 25(4):389-395.
    • (1999) Bone , vol.25 , Issue.4 , pp. 389-395
    • Hauge, E.1    Mosekilde, L.2    Melsen, F.3
  • 51
    • 84872866350 scopus 로고    scopus 로고
    • Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee
    • Dempster DW, et al. (2013) Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 28(1):2-17.
    • (2013) J Bone Miner Res , vol.28 , Issue.1 , pp. 2-17
    • Dempster, D.W.1


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